{"id":"https://openalex.org/W3029907884","doi":"https://doi.org/10.1080/13813455.2020.1771377","title":"Screening inhibitory effects of selected flavonoids on human recombinant aldose reductase enzyme: in vitro and in silico study","display_name":"Screening inhibitory effects of selected flavonoids on human recombinant aldose reductase enzyme: in vitro and in silico study","publication_year":2020,"publication_date":"2020-05-28","ids":{"openalex":"https://openalex.org/W3029907884","doi":"https://doi.org/10.1080/13813455.2020.1771377","mag":"3029907884","pmid":"https://pubmed.ncbi.nlm.nih.gov/32463711"},"language":"en","primary_location":{"id":"doi:10.1080/13813455.2020.1771377","doi":"https://doi.org/10.1080/13813455.2020.1771377","is_oa":false,"landing_page_url":"https://doi.org/10.1080/13813455.2020.1771377","pdf_url":null,"source":{"id":"https://openalex.org/S19783875","display_name":"Archives of Physiology and Biochemistry","issn_l":"0778-3124","issn":["0778-3124","1381-3455","1744-4160"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Physiology and Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/20.500.12501/2917","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016389125","display_name":"Veysel \u00c7omakl\u0131","orcid":"https://orcid.org/0000-0003-2109-6702","observed_orcids":["https://orcid.org/0000-0003-2109-6702"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Veysel Comakli","raw_affiliation_strings":["Nutrition and Dietetics Department, High School of Health, Agri Ibrahim Cecen University, Agri, Turkey;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutrition and Dietetics Department, High School of Health, Agri Ibrahim Cecen University, Agri, Turkey;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058579086","display_name":"\u015eevki Adem","orcid":"https://orcid.org/0000-0003-2146-5870","observed_orcids":["https://orcid.org/0000-0003-2146-5870"]},"institutions":[{"id":"https://openalex.org/I224962290","display_name":"\u00c7ank\u0131r\u0131 Karatekin University","ror":"https://ror.org/011y7xt38","country_code":"TR","type":"education","lineage":["https://openalex.org/I224962290"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Sevki Adem","raw_affiliation_strings":["Department of Chemistry, Faculty of Science, Cankiri Karatekin University, Cankiri, Turkey;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Science, Cankiri Karatekin University, Cankiri, Turkey;","institution_ids":["https://openalex.org/I224962290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079013191","display_name":"Aykut \u00d6ztek\u0456n","orcid":"https://orcid.org/0000-0003-1418-179X","observed_orcids":["https://orcid.org/0000-0003-1418-179X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aykut Oztekin","raw_affiliation_strings":["Medical Services and Techniques Department, Vocational School of Health Services, Agri Ibrahim Cecen University, Agri, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Services and Techniques Department, Vocational School of Health Services, Agri Ibrahim Cecen University, Agri, Turkey","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018489969","display_name":"Ramazan Demirda\u011f","orcid":"https://orcid.org/0000-0003-3493-7056","observed_orcids":["https://orcid.org/0000-0003-3493-7056"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ramazan Demirdag","raw_affiliation_strings":["Nutrition and Dietetics Department, High School of Health, Agri Ibrahim Cecen University, Agri, Turkey;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutrition and Dietetics Department, High School of Health, Agri Ibrahim Cecen University, Agri, Turkey;","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5016389125"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7985,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.6130207,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"128","issue":"5","first_page":"1368","last_page":"1374"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12533","display_name":"Aldose Reductase and Taurine","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12533","display_name":"Aldose Reductase and Taurine","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aldose-reductase","display_name":"aldose reductase","score":0.9509999752044678},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.9039999842643738},{"id":"https://openalex.org/keywords/enzyme-inhibition","display_name":"enzyme inhibition","score":0.9490000009536743},{"id":"https://openalex.org/keywords/polyol-pathway","display_name":"polyol pathway","score":0.8949999809265137},{"id":"https://openalex.org/keywords/syringic-acid","display_name":"syringic acid","score":0.984000027179718},{"id":"https://openalex.org/keywords/diosmetin","display_name":"diosmetin","score":0.9829999804496765},{"id":"https://openalex.org/keywords/myricetin","display_name":"myricetin","score":1.0},{"id":"https://openalex.org/keywords/competitive-inhibition","display_name":"competitive inhibition","score":0.9179999828338623},{"id":"https://openalex.org/keywords/ic50","display_name":"IC50","score":0.7360000014305115},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.6140000224113464},{"id":"https://openalex.org/keywords/diabetes-complications","display_name":"diabetes complications","score":0.8619999885559082},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.7710000276565552}],"concepts":[{"id":"https://openalex.org/C2776439734","wikidata":"https://www.wikidata.org/wiki/Q414213","display_name":"Aldose reductase","level":3,"score":0.9581433534622192},{"id":"https://openalex.org/C2779383672","wikidata":"https://www.wikidata.org/wiki/Q408428","display_name":"Syringic acid","level":4,"score":0.8379262685775757},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.7139104604721069},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6887412071228027},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.653175950050354},{"id":"https://openalex.org/C2778173338","wikidata":"https://www.wikidata.org/wiki/Q951449","display_name":"Myricetin","level":5,"score":0.6449262499809265},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.5978440642356873},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5831831693649292},{"id":"https://openalex.org/C2910800646","wikidata":"https://www.wikidata.org/wiki/Q414213","display_name":"Aldehyde Reductase","level":4,"score":0.49454066157341003},{"id":"https://openalex.org/C136502266","wikidata":"https://www.wikidata.org/wiki/Q7226667","display_name":"Polyol pathway","level":4,"score":0.4629315733909607},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.43230095505714417},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.42803728580474854},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.4100683629512787},{"id":"https://openalex.org/C2779054382","wikidata":"https://www.wikidata.org/wiki/Q72185287","display_name":"Flavonoid","level":3,"score":0.29900062084198},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17723608016967773},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.15481248497962952},{"id":"https://openalex.org/C2778362808","wikidata":"https://www.wikidata.org/wiki/Q375837","display_name":"Gallic acid","level":3,"score":0.08603090047836304},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0644054114818573},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C2777810353","wikidata":"https://www.wikidata.org/wiki/Q393336","display_name":"Kaempferol","level":4,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000449","descriptor_name":"Aldehyde Reductase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005707","descriptor_name":"Gallic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009249","descriptor_name":"NADP","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047309","descriptor_name":"Flavones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1080/13813455.2020.1771377","doi":"https://doi.org/10.1080/13813455.2020.1771377","is_oa":false,"landing_page_url":"https://doi.org/10.1080/13813455.2020.1771377","pdf_url":null,"source":{"id":"https://openalex.org/S19783875","display_name":"Archives of Physiology and Biochemistry","issn_l":"0778-3124","issn":["0778-3124","1381-3455","1744-4160"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Physiology and Biochemistry","raw_type":"journal-article"},{"id":"pmid:32463711","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32463711","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of physiology and biochemistry","raw_type":"Journal Article"},{"id":"pmh:oai:acikerisim.agri.edu.tr:20.500.12501/2917","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.12501/2917","pdf_url":null,"source":{"id":"https://openalex.org/S7407055365","display_name":"A\u011fr\u0131 \u0130brahim \u00c7e\u00e7en University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pubmed","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:acikerisim.agri.edu.tr:20.500.12501/2917","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.12501/2917","pdf_url":null,"source":{"id":"https://openalex.org/S7407055365","display_name":"A\u011fr\u0131 \u0130brahim \u00c7e\u00e7en University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pubmed","raw_type":"article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W71411399","https://openalex.org/W592303347","https://openalex.org/W1638882029","https://openalex.org/W1643236558","https://openalex.org/W1658873127","https://openalex.org/W1718201877","https://openalex.org/W1953554152","https://openalex.org/W1970384279","https://openalex.org/W1973039222","https://openalex.org/W1975818407","https://openalex.org/W1975856506","https://openalex.org/W1978206480","https://openalex.org/W1979963035","https://openalex.org/W1985210336","https://openalex.org/W2010450492","https://openalex.org/W2014571078","https://openalex.org/W2018058695","https://openalex.org/W2024586219","https://openalex.org/W2028644941","https://openalex.org/W2034607700","https://openalex.org/W2043701349","https://openalex.org/W2043828707","https://openalex.org/W2077547064","https://openalex.org/W2081561608","https://openalex.org/W2094884005","https://openalex.org/W2111793581","https://openalex.org/W2116335574","https://openalex.org/W2119122217","https://openalex.org/W2119202170","https://openalex.org/W2125717840","https://openalex.org/W2126346844","https://openalex.org/W2128555061","https://openalex.org/W2134487855","https://openalex.org/W2136857696","https://openalex.org/W2139126548","https://openalex.org/W2154789716","https://openalex.org/W2159021220","https://openalex.org/W2162768694","https://openalex.org/W2504725357","https://openalex.org/W2581365657","https://openalex.org/W2586821419","https://openalex.org/W2594746652","https://openalex.org/W2618417695","https://openalex.org/W2940071317","https://openalex.org/W2944914009","https://openalex.org/W2947708799","https://openalex.org/W2967220133","https://openalex.org/W4210953420","https://openalex.org/W4243714145","https://openalex.org/W4252280335","https://openalex.org/W4255564469"],"related_works":["https://openalex.org/W2063827390","https://openalex.org/W1970989289","https://openalex.org/W2361377332","https://openalex.org/W4224011185","https://openalex.org/W2021815935","https://openalex.org/W2258276285","https://openalex.org/W3185434110","https://openalex.org/W3020078129","https://openalex.org/W2023019493","https://openalex.org/W2102401076"],"abstract_inverted_index":{"Aldose":[0],"reductase":[1],"(AR)":[2],"is":[3],"the":[4,8,33,93,114,120,131,141],"first":[5],"enzyme":[6,25,48,116],"of":[7,38,55,119,143],"polyol":[9],"pathway":[10],"that":[11,130],"has":[12,20],"physiological":[13],"importance":[14],"under":[15],"hyperglycaemic":[16],"conditions.":[17],"The":[18,52],"article":[19],"been":[21],"focussed":[22],"on":[23,41,57],"AR":[24,46,144],"inhibition":[26,59],"by":[27],"selected":[28],"compounds.":[29,121],"For":[30],"this":[31],"purpose,":[32],"in":[34,123,126,140],"vitro":[35,124],"inhibitory":[36],"effects":[37],"various":[39],"compounds":[40,56],"commercially":[42],"available":[43],"recombinant":[44],"human":[45],"(rAR)":[47],"activity":[49],"were":[50,61,110],"investigated.":[51],"IC50":[53],"values":[54,97],"rAR":[58,89],"effect":[60],"found":[62],"for":[63],"6-hydroxy":[64,132],"flavone,":[65],"syringic":[66,85],"acid,":[67],"diosmetin,":[68],"6-fluoroflavone,":[69],"7-hydroxy-4\u2032-nitroisoflavone,":[70],"myricetin":[71],"as":[72],"2.05,":[73],"2.97,":[74],"15.75,":[75],"16.1,":[76],"49.5,":[77],"and":[78,84,101,125],"63":[79],"\u00b5M,":[80],"respectively.":[81],"6-Hydroxy":[82],"flavone":[83,133],"acid":[86],"competitively":[87],"inhibited":[88],"with":[90,95],"respect":[91],"to":[92,112,146],"NADPH":[94],"Ki":[96],"0.509":[98],"\u00b1":[99,103],"0.036":[100],"0.842":[102],"0.012":[104],"\u00b5M.":[105],"In":[106],"addition,":[107],"docking":[108],"studies":[109],"performed":[111],"evaluate":[113],"potential":[115],"binding":[117],"positions":[118],"Our":[122],"silico":[127],"results":[128],"indicated":[129],"may":[134],"be":[135],"a":[136],"good":[137],"lead":[138],"compound":[139],"development":[142],"inhibitors":[145],"prevent":[147],"diabetic":[148],"complications.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-06-05T00:00:00"}
