{"id":"https://openalex.org/W3029565249","doi":"https://doi.org/10.1021/acs.joc.0c00554","title":"Sulfone-Mediated S N Ar Reaction as a Powerful Tool for the Synthesis of 4-Quinolinyl Ethers and More\u2014Application to the Synthesis of HCV NS3/4a Protease Inhibitor BI 201420","display_name":"Sulfone-Mediated S N Ar Reaction as a Powerful Tool for the Synthesis of 4-Quinolinyl Ethers and More\u2014Application to the Synthesis of HCV NS3/4a Protease Inhibitor BI 201420","publication_year":2020,"publication_date":"2020-05-28","ids":{"openalex":"https://openalex.org/W3029565249","doi":"https://doi.org/10.1021/acs.joc.0c00554","mag":"3029565249","pmid":"https://pubmed.ncbi.nlm.nih.gov/32462862"},"language":"en","primary_location":{"id":"doi:10.1021/acs.joc.0c00554","doi":"https://doi.org/10.1021/acs.joc.0c00554","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.joc.0c00554","pdf_url":null,"source":{"id":"https://openalex.org/S205050996","display_name":"The Journal of Organic Chemistry","issn_l":"0022-3263","issn":["0022-3263","1520-6904"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Organic Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001935532","display_name":"Nitinchandra D. Patel","orcid":"https://orcid.org/0000-0001-9571-6658","observed_orcids":["https://orcid.org/0000-0001-9571-6658"]},"institutions":[{"id":"https://openalex.org/I4210160255","display_name":"Boehringer Ingelheim (United States)","ror":"https://ror.org/05kffp613","country_code":"US","type":"company","lineage":["https://openalex.org/I1330995197","https://openalex.org/I4210160255"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nitinchandra D. Patel","raw_affiliation_strings":["Chemical Development US, Boehringer-Ingelheim Pharmaceuticals Inc., 900 Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877-0368, United States"],"raw_orcid":"https://orcid.org/0000-0001-9571-6658","affiliations":[{"raw_affiliation_string":"Chemical Development US, Boehringer-Ingelheim Pharmaceuticals Inc., 900 Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877-0368, United States","institution_ids":["https://openalex.org/I4210160255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052368006","display_name":"Xudong Wei","orcid":"https://orcid.org/0000-0001-5228-0006","observed_orcids":["https://orcid.org/0000-0001-5228-0006"]},"institutions":[{"id":"https://openalex.org/I4210160255","display_name":"Boehringer Ingelheim (United States)","ror":"https://ror.org/05kffp613","country_code":"US","type":"company","lineage":["https://openalex.org/I1330995197","https://openalex.org/I4210160255"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xudong Wei","raw_affiliation_strings":["Chemical Development US, Boehringer-Ingelheim Pharmaceuticals Inc., 900 Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877-0368, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Development US, Boehringer-Ingelheim Pharmaceuticals Inc., 900 Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877-0368, United States","institution_ids":["https://openalex.org/I4210160255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068242826","display_name":"Denis P. Byrne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160255","display_name":"Boehringer Ingelheim (United States)","ror":"https://ror.org/05kffp613","country_code":"US","type":"company","lineage":["https://openalex.org/I1330995197","https://openalex.org/I4210160255"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Denis Byrne","raw_affiliation_strings":["Chemical Development US, Boehringer-Ingelheim Pharmaceuticals Inc., 900 Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877-0368, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Development US, Boehringer-Ingelheim Pharmaceuticals Inc., 900 Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877-0368, United States","institution_ids":["https://openalex.org/I4210160255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067972336","display_name":"B. A. Narayanan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160255","display_name":"Boehringer Ingelheim (United States)","ror":"https://ror.org/05kffp613","country_code":"US","type":"company","lineage":["https://openalex.org/I1330995197","https://openalex.org/I4210160255"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bikshandarkoil A. Narayanan","raw_affiliation_strings":["Chemical Development US, Boehringer-Ingelheim Pharmaceuticals Inc., 900 Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877-0368, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Development US, Boehringer-Ingelheim Pharmaceuticals Inc., 900 Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877-0368, United States","institution_ids":["https://openalex.org/I4210160255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029773364","display_name":"Scott J. Pennino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160255","display_name":"Boehringer Ingelheim (United States)","ror":"https://ror.org/05kffp613","country_code":"US","type":"company","lineage":["https://openalex.org/I1330995197","https://openalex.org/I4210160255"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott Pennino","raw_affiliation_strings":["Material and Analytical Sciences US, Boehringer-Ingelheim Pharmaceuticals Inc., 900 Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877-0368, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Material and Analytical Sciences US, Boehringer-Ingelheim Pharmaceuticals Inc., 900 Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877-0368, United States","institution_ids":["https://openalex.org/I4210160255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008484332","display_name":"Max Sarvestani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160255","display_name":"Boehringer Ingelheim (United States)","ror":"https://ror.org/05kffp613","country_code":"US","type":"company","lineage":["https://openalex.org/I1330995197","https://openalex.org/I4210160255"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Max Sarvestani","raw_affiliation_strings":["Chemical Development US, Boehringer-Ingelheim Pharmaceuticals Inc., 900 Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877-0368, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Development US, Boehringer-Ingelheim Pharmaceuticals Inc., 900 Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877-0368, United States","institution_ids":["https://openalex.org/I4210160255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062522093","display_name":"Anjan K. Saha","orcid":"https://orcid.org/0000-0001-6721-1599","observed_orcids":["https://orcid.org/0000-0001-6721-1599"]},"institutions":[{"id":"https://openalex.org/I4210160255","display_name":"Boehringer Ingelheim (United States)","ror":"https://ror.org/05kffp613","country_code":"US","type":"company","lineage":["https://openalex.org/I1330995197","https://openalex.org/I4210160255"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anjan Saha","raw_affiliation_strings":["Chemical Development US, Boehringer-Ingelheim Pharmaceuticals Inc., 900 Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877-0368, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Development US, Boehringer-Ingelheim Pharmaceuticals Inc., 900 Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877-0368, United States","institution_ids":["https://openalex.org/I4210160255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047441048","display_name":"Nizar Haddad","orcid":"https://orcid.org/0000-0001-7068-7897","observed_orcids":["https://orcid.org/0000-0001-7068-7897"]},"institutions":[{"id":"https://openalex.org/I4210160255","display_name":"Boehringer Ingelheim (United States)","ror":"https://ror.org/05kffp613","country_code":"US","type":"company","lineage":["https://openalex.org/I1330995197","https://openalex.org/I4210160255"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nizar Haddad","raw_affiliation_strings":["Chemical Development US, Boehringer-Ingelheim Pharmaceuticals Inc., 900 Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877-0368, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Development US, Boehringer-Ingelheim Pharmaceuticals Inc., 900 Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877-0368, United States","institution_ids":["https://openalex.org/I4210160255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065603743","display_name":"Suresh R. Kapadia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160255","display_name":"Boehringer Ingelheim (United States)","ror":"https://ror.org/05kffp613","country_code":"US","type":"company","lineage":["https://openalex.org/I1330995197","https://openalex.org/I4210160255"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suresh Kapadia","raw_affiliation_strings":["Chemical Development US, Boehringer-Ingelheim Pharmaceuticals Inc., 900 Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877-0368, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Development US, Boehringer-Ingelheim Pharmaceuticals Inc., 900 Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877-0368, United States","institution_ids":["https://openalex.org/I4210160255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073947489","display_name":"Jon C. Lorenz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160255","display_name":"Boehringer Ingelheim (United States)","ror":"https://ror.org/05kffp613","country_code":"US","type":"company","lineage":["https://openalex.org/I1330995197","https://openalex.org/I4210160255"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jon C. Lorenz","raw_affiliation_strings":["Chemical Development US, Boehringer-Ingelheim Pharmaceuticals Inc., 900 Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877-0368, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Development US, Boehringer-Ingelheim Pharmaceuticals Inc., 900 Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877-0368, United States","institution_ids":["https://openalex.org/I4210160255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067945758","display_name":"Philomen DeCroos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160255","display_name":"Boehringer Ingelheim (United States)","ror":"https://ror.org/05kffp613","country_code":"US","type":"company","lineage":["https://openalex.org/I1330995197","https://openalex.org/I4210160255"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philomen DeCroos","raw_affiliation_strings":["Chemical Development US, Boehringer-Ingelheim Pharmaceuticals Inc., 900 Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877-0368, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Development US, Boehringer-Ingelheim Pharmaceuticals Inc., 900 Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877-0368, United States","institution_ids":["https://openalex.org/I4210160255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045542548","display_name":"Andrew Ye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160255","display_name":"Boehringer Ingelheim (United States)","ror":"https://ror.org/05kffp613","country_code":"US","type":"company","lineage":["https://openalex.org/I1330995197","https://openalex.org/I4210160255"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Ye","raw_affiliation_strings":["Chemical Development US, Boehringer-Ingelheim Pharmaceuticals Inc., 900 Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877-0368, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Development US, Boehringer-Ingelheim Pharmaceuticals Inc., 900 Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877-0368, United States","institution_ids":["https://openalex.org/I4210160255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107906793","display_name":"Heewon Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160255","display_name":"Boehringer Ingelheim (United States)","ror":"https://ror.org/05kffp613","country_code":"US","type":"company","lineage":["https://openalex.org/I1330995197","https://openalex.org/I4210160255"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heewon Lee","raw_affiliation_strings":["Chemical Development US, Boehringer-Ingelheim Pharmaceuticals Inc., 900 Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877-0368, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Development US, Boehringer-Ingelheim Pharmaceuticals Inc., 900 Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877-0368, United States","institution_ids":["https://openalex.org/I4210160255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012238419","display_name":"Nelu Grinberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160255","display_name":"Boehringer Ingelheim (United States)","ror":"https://ror.org/05kffp613","country_code":"US","type":"company","lineage":["https://openalex.org/I1330995197","https://openalex.org/I4210160255"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nelu Grinberg","raw_affiliation_strings":["Chemical Development US, Boehringer-Ingelheim Pharmaceuticals Inc., 900 Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877-0368, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Development US, Boehringer-Ingelheim Pharmaceuticals Inc., 900 Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877-0368, United States","institution_ids":["https://openalex.org/I4210160255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039230809","display_name":"Azad Hossain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160255","display_name":"Boehringer Ingelheim (United States)","ror":"https://ror.org/05kffp613","country_code":"US","type":"company","lineage":["https://openalex.org/I1330995197","https://openalex.org/I4210160255"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Azad Hossain","raw_affiliation_strings":["Chemical Development US, Boehringer-Ingelheim Pharmaceuticals Inc., 900 Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877-0368, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Development US, Boehringer-Ingelheim Pharmaceuticals Inc., 900 Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877-0368, United States","institution_ids":["https://openalex.org/I4210160255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041730568","display_name":"Carl A. Busacca","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160255","display_name":"Boehringer Ingelheim (United States)","ror":"https://ror.org/05kffp613","country_code":"US","type":"company","lineage":["https://openalex.org/I1330995197","https://openalex.org/I4210160255"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carl A. Busacca","raw_affiliation_strings":["Chemical Development US, Boehringer-Ingelheim Pharmaceuticals Inc., 900 Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877-0368, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Development US, Boehringer-Ingelheim Pharmaceuticals Inc., 900 Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877-0368, United States","institution_ids":["https://openalex.org/I4210160255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102991656","display_name":"Nathan K. Yee","orcid":"https://orcid.org/0000-0003-1188-6313","observed_orcids":["https://orcid.org/0000-0003-1188-6313"]},"institutions":[{"id":"https://openalex.org/I4210160255","display_name":"Boehringer Ingelheim (United States)","ror":"https://ror.org/05kffp613","country_code":"US","type":"company","lineage":["https://openalex.org/I1330995197","https://openalex.org/I4210160255"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathan K. Yee","raw_affiliation_strings":["Chemical Development US, Boehringer-Ingelheim Pharmaceuticals Inc., 900 Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877-0368, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Development US, Boehringer-Ingelheim Pharmaceuticals Inc., 900 Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877-0368, United States","institution_ids":["https://openalex.org/I4210160255"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015397568","display_name":"Chris H. Senanayake","orcid":"https://orcid.org/0009-0009-3170-0687","observed_orcids":["https://orcid.org/0009-0009-3170-0687"]},"institutions":[{"id":"https://openalex.org/I4210160255","display_name":"Boehringer Ingelheim (United States)","ror":"https://ror.org/05kffp613","country_code":"US","type":"company","lineage":["https://openalex.org/I1330995197","https://openalex.org/I4210160255"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chris H. Senanayake","raw_affiliation_strings":["Chemical Development US, Boehringer-Ingelheim Pharmaceuticals Inc., 900 Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877-0368, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Development US, Boehringer-Ingelheim Pharmaceuticals Inc., 900 Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877-0368, United States","institution_ids":["https://openalex.org/I4210160255"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5001935532","https://openalex.org/A5052368006"],"corresponding_institution_ids":["https://openalex.org/I4210160255"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":0.8196,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.64236673,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"85","issue":"13","first_page":"8339","last_page":"8351"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12189","display_name":"Sulfur-Based Synthesis Techniques","score":0.8324999809265137,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12189","display_name":"Sulfur-Based Synthesis Techniques","score":0.8324999809265137,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10701","display_name":"Radical Photochemical Reactions","score":0.03720000013709068,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10548","display_name":"Catalytic Cross-Coupling Reactions","score":0.02070000022649765,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nucleophilic-aromatic-substitution","display_name":"nucleophilic aromatic substitution","score":0.777999997138977},{"id":"https://openalex.org/keywords/alcohol-nucleophiles","display_name":"alcohol nucleophiles","score":0.6039999723434448},{"id":"https://openalex.org/keywords/convergent-synthesis","display_name":"convergent synthesis","score":0.8370000123977661},{"id":"https://openalex.org/keywords/hcv-ns3-4a-protease-inhibitors","display_name":"HCV NS3/4A protease inhibitors","score":0.9390000104904175},{"id":"https://openalex.org/keywords/antiviral-drug-synthesis","display_name":"antiviral drug synthesis","score":0.8629999756813049}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9293285608291626},{"id":"https://openalex.org/C2778806918","wikidata":"https://www.wikidata.org/wiki/Q411193","display_name":"Sulfone","level":2,"score":0.6817654371261597},{"id":"https://openalex.org/C2781143361","wikidata":"https://www.wikidata.org/wiki/Q55761529","display_name":"Protease inhibitor (pharmacology)","level":5,"score":0.5324854254722595},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.5302398204803467},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.5216115713119507},{"id":"https://openalex.org/C9061509","wikidata":"https://www.wikidata.org/wiki/Q901713","display_name":"Nucleophilic aromatic substitution","level":3,"score":0.5171393752098083},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4985227584838867},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.475498765707016},{"id":"https://openalex.org/C114373084","wikidata":"https://www.wikidata.org/wiki/Q273499","display_name":"Chemical synthesis","level":3,"score":0.44952598214149475},{"id":"https://openalex.org/C39409265","wikidata":"https://www.wikidata.org/wiki/Q2687640","display_name":"Convergent synthesis","level":2,"score":0.4411274790763855},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.31179264187812805},{"id":"https://openalex.org/C135731615","wikidata":"https://www.wikidata.org/wiki/Q658656","display_name":"Nucleophilic substitution","level":2,"score":0.19127190113067627},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.12899050116539001},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11895176768302917},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.10735583305358887},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.10526502132415771},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.08979898691177368},{"id":"https://openalex.org/C111368507","wikidata":"https://www.wikidata.org/wiki/Q43518","display_name":"Oceanography","level":1,"score":0.0},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.0},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004987","descriptor_name":"Ethers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004987","descriptor_name":"Ethers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004987","descriptor_name":"Ethers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006526","descriptor_name":"Hepatitis C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006526","descriptor_name":"Hepatitis C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006526","descriptor_name":"Hepatitis C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011480","descriptor_name":"Protease Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011480","descriptor_name":"Protease Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011480","descriptor_name":"Protease Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013450","descriptor_name":"Sulfones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013450","descriptor_name":"Sulfones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013450","descriptor_name":"Sulfones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017361","descriptor_name":"Viral Nonstructural Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017361","descriptor_name":"Viral Nonstructural Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017361","descriptor_name":"Viral Nonstructural Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.joc.0c00554","doi":"https://doi.org/10.1021/acs.joc.0c00554","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.joc.0c00554","pdf_url":null,"source":{"id":"https://openalex.org/S205050996","display_name":"The Journal of Organic Chemistry","issn_l":"0022-3263","issn":["0022-3263","1520-6904"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Organic Chemistry","raw_type":"journal-article"},{"id":"pmid:32462862","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32462862","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of organic chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"score":0.5,"id":"https://metadata.un.org/sdg/6","display_name":"Clean water and sanitation"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W233628489","https://openalex.org/W587715566","https://openalex.org/W629958046","https://openalex.org/W1011544408","https://openalex.org/W1543830028","https://openalex.org/W1946779581","https://openalex.org/W1967747460","https://openalex.org/W1968305342","https://openalex.org/W1972601647","https://openalex.org/W1973888259","https://openalex.org/W1974165684","https://openalex.org/W1985108907","https://openalex.org/W1988704207","https://openalex.org/W1989953280","https://openalex.org/W1995753428","https://openalex.org/W1999886247","https://openalex.org/W1999906396","https://openalex.org/W2000100631","https://openalex.org/W2008771542","https://openalex.org/W2013238307","https://openalex.org/W2017201840","https://openalex.org/W2034661714","https://openalex.org/W2051527307","https://openalex.org/W2055339263","https://openalex.org/W2058290489","https://openalex.org/W2066757175","https://openalex.org/W2073208182","https://openalex.org/W2078412236","https://openalex.org/W2094381379","https://openalex.org/W2104500118","https://openalex.org/W2112356673","https://openalex.org/W2116064503","https://openalex.org/W2116271171","https://openalex.org/W2116430617","https://openalex.org/W2132611443","https://openalex.org/W2134696651","https://openalex.org/W2140688181","https://openalex.org/W2142684817","https://openalex.org/W2153714862","https://openalex.org/W2153859082","https://openalex.org/W2155995906","https://openalex.org/W2161037600","https://openalex.org/W2180058325","https://openalex.org/W2315544071","https://openalex.org/W2318588945","https://openalex.org/W2323574745","https://openalex.org/W2328969115","https://openalex.org/W2343921671","https://openalex.org/W2397157851","https://openalex.org/W2545740250","https://openalex.org/W2589384309","https://openalex.org/W2591108500","https://openalex.org/W2951889286","https://openalex.org/W2952560936","https://openalex.org/W2986412627","https://openalex.org/W3000686634","https://openalex.org/W3144160803","https://openalex.org/W3148829675","https://openalex.org/W4237383881","https://openalex.org/W4251038450","https://openalex.org/W4251170600"],"related_works":["https://openalex.org/W2394655196","https://openalex.org/W2606553273","https://openalex.org/W1989537433","https://openalex.org/W1977343486","https://openalex.org/W2030950590","https://openalex.org/W2027787668","https://openalex.org/W2055045045","https://openalex.org/W2952634657","https://openalex.org/W2952118622","https://openalex.org/W4256250189"],"abstract_inverted_index":{"An":[0],"efficient":[1],"general":[2],"methodology":[3],"for":[4],"the":[5],"synthesis":[6,48],"of":[7,20,26,49,53],"4-quinolinyl":[8,21],"ethers":[9],"is":[10],"demonstrated":[11],"via":[12],"a":[13,24,35,46,50],"highly":[14],"reactive":[15],"S":[16],"N":[17],"Ar":[18],"reaction":[19],"sulfones":[22],"with":[23,34],"range":[25],"structurally":[27],"diversified":[28],"1\u00b0,":[29],"2\u00b0,":[30],"and":[31,39],"3\u00b0":[32],"alcohols":[33],"wide":[36],"substrate":[37],"scope":[38],"high":[40],"yields.":[41],"By":[42],"adapting":[43],"this":[44],"methodology,":[45],"convergent":[47],"complex":[51],"target":[52],"HCV":[54],"NS3/4a":[55],"protease":[56],"inhibitor":[57],"BI":[58],"201420":[59],"was":[60],"accomplished.":[61]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2}],"updated_date":"2026-10-02T10:15:12.560889","created_date":"2025-10-10T00:00:00"}
