{"id":"https://openalex.org/W3029430596","doi":null,"title":"MSCRAMM Proteins Linked to Immune Cell Recruitment in Influenza and Bacterial Super-Infection","display_name":"MSCRAMM Proteins Linked to Immune Cell Recruitment in Influenza and Bacterial Super-Infection","publication_year":2019,"publication_date":"2019-04-01","ids":{"openalex":"https://openalex.org/W3029430596","mag":"3029430596"},"language":"en","primary_location":{"id":"pmh:oai:d-scholarship.pitt.edu:38731","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/38731/1/Bacterial%20Superinfection%20Poster.pdf","pdf_url":"http://d-scholarship.pitt.edu/38731/1/Bacterial%20Superinfection%20Poster.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Conference or Workshop Item"},"volume":null,"type":"conference-paper","indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://d-scholarship.pitt.edu/38731/1/Bacterial%20Superinfection%20Poster.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Sarah Chu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sarah Chu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076278523","display_name":"Jennifer A. Grousd","orcid":"https://orcid.org/0000-0002-7418-4741","observed_orcids":["https://orcid.org/0000-0002-7418-4741"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jennifer A. Grousd","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7418-4741","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5085072225","display_name":"John F. Alcorn","orcid":"https://orcid.org/0000-0001-5997-7711","observed_orcids":["https://orcid.org/0000-0001-5997-7711"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John F. Alcorn","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5997-7711","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.37621622,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.007799999788403511,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mscramms","display_name":"MSCRAMMs","score":0.8270000219345093},{"id":"https://openalex.org/keywords/methicillin-resistant-staphylococcus-aureus","display_name":"methicillin-resistant Staphylococcus aureus","score":0.9150000214576721},{"id":"https://openalex.org/keywords/community-associated-mrsa","display_name":"community-acquired MRSA","score":0.9100000262260437},{"id":"https://openalex.org/keywords/clfb","display_name":"clfB","score":0.8519999980926514},{"id":"https://openalex.org/keywords/immune-cell-recruitment","display_name":"immune cell recruitment","score":0.8730000257492065},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.8109999895095825},{"id":"https://openalex.org/keywords/lymphocytes","display_name":"lymphocytes","score":0.9620000123977661},{"id":"https://openalex.org/keywords/eosinophils","display_name":"eosinophils","score":1.0},{"id":"https://openalex.org/keywords/bacterial-adhesion","display_name":"bacterial adhesion","score":0.6729999780654907},{"id":"https://openalex.org/keywords/pulmonary-infection","display_name":"pulmonary infection","score":0.5569999814033508},{"id":"https://openalex.org/keywords/secondary-bacterial-pneumonia","display_name":"secondary bacterial pneumonia","score":0.6449999809265137}],"concepts":[{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6902233362197876},{"id":"https://openalex.org/C2777914695","wikidata":"https://www.wikidata.org/wiki/Q12192","display_name":"Pneumonia","level":2,"score":0.6814724206924438},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5904229283332825},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.5601248145103455},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.5360192656517029},{"id":"https://openalex.org/C2776460866","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogen","level":2,"score":0.5261877775192261},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5105499029159546},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4820909798145294},{"id":"https://openalex.org/C2777052132","wikidata":"https://www.wikidata.org/wiki/Q595158","display_name":"Methicillin-resistant Staphylococcus aureus","level":4,"score":0.45127078890800476},{"id":"https://openalex.org/C2993183539","wikidata":"https://www.wikidata.org/wiki/Q754447","display_name":"Respiratory infection","level":3,"score":0.432400643825531},{"id":"https://openalex.org/C2776345407","wikidata":"https://www.wikidata.org/wiki/Q3776920","display_name":"Bacterial pneumonia","level":3,"score":0.4101925194263458},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35092711448669434},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.335411012172699},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.2437707781791687},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07690709829330444},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:d-scholarship.pitt.edu:38731","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/38731/1/Bacterial%20Superinfection%20Poster.pdf","pdf_url":"http://d-scholarship.pitt.edu/38731/1/Bacterial%20Superinfection%20Poster.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Conference or Workshop Item"},{"id":"mag:3029430596","doi":null,"is_oa":false,"landing_page_url":"http://d-scholarship.pitt.edu/38731/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:d-scholarship.pitt.edu:38731","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/38731/1/Bacterial%20Superinfection%20Poster.pdf","pdf_url":"http://d-scholarship.pitt.edu/38731/1/Bacterial%20Superinfection%20Poster.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Conference or Workshop Item"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2531555172","display_name":"Influenza A Inhibits TH17 Host Defense Against Bacterial Pneumonia","funder_award_id":"R01HL107380","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000893128","display_name":"Immunology of Infections Disease Renewal 2023","funder_award_id":"T32AI060525","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3029430596.pdf","grobid_xml":"https://content.openalex.org/works/W3029430596.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4313365846","https://openalex.org/W1586842765","https://openalex.org/W7027884723","https://openalex.org/W4416553057","https://openalex.org/W2724689522","https://openalex.org/W2914363011","https://openalex.org/W7005655658","https://openalex.org/W4293567416","https://openalex.org/W4225318360","https://openalex.org/W2514912167"],"abstract_inverted_index":{"Influenza":[0],"is":[1,29,59,64,82],"one":[2],"of":[3,21,43,52,152,158],"the":[4,30,39,118,131,150,163],"most":[5,31],"common":[6,32],"human":[7],"respiratory":[8],"illnesses,":[9],"but":[10],"when":[11],"paired":[12],"with":[13],"secondary":[14,33],"bacterial":[15,34],"pneumonia":[16,35,54,75],"(super-infection),":[17],"it":[18],"increases":[19,156],"rates":[20,51],"hospitalization":[22],"and":[23,38,55,76,101,141,160],"death.":[24],"Methicillin-resistant":[25],"Staphylococcus":[26],"aureus":[27],"(MRSA)":[28],"following":[36],"influenza,":[37],"increase":[40],"in":[41,117,127,130,162,175,179],"prevalence":[42],"community-acquired":[44],"MRSA":[45,53,58,140],"(CA-MRSA)":[46],"has":[47],"led":[48],"to":[49,66,70,79],"increasing":[50],"influenza":[56],"super-infections.":[57],"a":[60],"gram-positive":[61],"bacterium":[62],"that":[63,112,122,147,169],"resistant":[65],"many":[67],"antibiotics,":[68],"leading":[69],"limited":[71],"clinical":[72],"interventions":[73],"for":[74],"super-infection.":[77,166],"Attachment":[78],"host":[80],"cells":[81],"controlled":[83],"by":[84],"staphylococcal":[85],"surface":[86],"proteins":[87,124],"called":[88],"MSCRAMMs":[89,170],"(Microbial":[90],"Surface":[91],"Components":[92],"Recognizing":[93],"Adhesive":[94],"Matrix":[95],"Molecules).":[96],"Clumping":[97],"Factor":[98],"B":[99],"(ClfB)":[100],"Serine-aspartate":[102],"repeat-containing":[103],"protein":[104],"D":[105],"(SdrD)":[106],"are":[107],"two":[108],"MSCRAMM":[109],"family":[110],"members":[111],"have":[113,125,145],"known":[114],"colonization":[115],"roles":[116,126],"nose.":[119],"We":[120,144],"hypothesize":[121],"these":[123],"causing":[128],"infection":[129],"lung":[132,164],"as":[133],"well.":[134],"In":[135],"comparing":[136],"wild":[137],"type":[138],"(WT)":[139],"mutated":[142],"strains,":[143],"found":[146],"SdrD":[148],"decreases":[149],"recruitment":[151,157,178],"neutrophils":[153],"whereas":[154],"ClfB":[155],"lymphocytes":[159],"eosinophils":[161],"during":[165,181],"This":[167],"suggests":[168],"play":[171],"an":[172],"important":[173],"role":[174],"immune":[176],"cell":[177],"lungs":[180],"infection.":[182]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-06-05T00:00:00"}