{"id":"https://openalex.org/W3029199262","doi":"https://doi.org/10.3760/cma.j.issn.1003-9279.2017.03.003","title":"The influence of pVR-IL15 gene adjuvant on immunization with recombinant viruses expressing HBsAg","display_name":"The influence of pVR-IL15 gene adjuvant on immunization with recombinant viruses expressing HBsAg","publication_year":2017,"publication_date":"2017-06-30","ids":{"openalex":"https://openalex.org/W3029199262","doi":"https://doi.org/10.3760/cma.j.issn.1003-9279.2017.03.003","mag":"3029199262"},"language":"en","primary_location":{"id":"mag:3029199262","doi":"https://doi.org/10.3760/cma.j.issn.1003-9279.2017.03.003","is_oa":false,"landing_page_url":"http://rs.yiigle.com/CN112866201703/994813.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764522840","display_name":"Chinese Journal of Clinical Hepatology","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310311885","host_organization_name":"Editorial Department of Journal of Clinical Hepatology","host_organization_lineage":["https://openalex.org/P4310311885"],"host_organization_lineage_names":["Editorial Department of Journal of Clinical Hepatology"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Chinese Journal of Clinical Hepatology","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056078332","display_name":"Rui Pan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184490438","display_name":"Chinese Center For Disease Control and Prevention","ror":"https://ror.org/04wktzw65","country_code":"CN","type":"government","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4391768093","display_name":"State Key Laboratory of Infectious Disease Prevention and Control","ror":"https://ror.org/04bhsv505","country_code":"CN","type":"facility","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210151987","https://openalex.org/I4391768093"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui Pan","raw_affiliation_strings":["State Key Laboratory for Infectious Disease Control and Prevention, Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory for Infectious Disease Control and Prevention, Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China","institution_ids":["https://openalex.org/I184490438","https://openalex.org/I4391768093"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039902970","display_name":"Bing He","orcid":"https://orcid.org/0000-0002-8564-0933","observed_orcids":["https://orcid.org/0000-0002-8564-0933"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bing He","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8564-0933","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076698976","display_name":"Guomin Chen","orcid":"https://orcid.org/0000-0003-0753-9415","observed_orcids":["https://orcid.org/0000-0003-0753-9415"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guomin Chen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0753-9415","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5076369731","display_name":"Shengli Bi","orcid":"https://orcid.org/0000-0002-0380-5790","observed_orcids":["https://orcid.org/0000-0002-0380-5790"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shengli Bi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0380-5790","affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.35552768,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"03","first_page":"195","last_page":"197"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9487000107765198,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9487000107765198,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.033399999141693115,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatitis-b-surface-antigen","display_name":"hepatitis B surface antigen","score":0.7360000014305115},{"id":"https://openalex.org/keywords/recombinant-adenovirus","display_name":"recombinant adenovirus","score":0.7239999771118164},{"id":"https://openalex.org/keywords/dna-vaccine","display_name":"DNA vaccine","score":0.9580000042915344},{"id":"https://openalex.org/keywords/sequential-immunization","display_name":"sequential vaccination","score":0.7099999785423279},{"id":"https://openalex.org/keywords/humoral-immune-response","display_name":"humoral immune response","score":0.9629999995231628},{"id":"https://openalex.org/keywords/cell-mediated-immunity","display_name":"cell-mediated immunity","score":0.9900000095367432},{"id":"https://openalex.org/keywords/vaccine-adjuvants","display_name":"vaccine adjuvants","score":0.6370000243186951}],"concepts":[{"id":"https://openalex.org/C2779053233","wikidata":"https://www.wikidata.org/wiki/Q731235","display_name":"ELISPOT","level":4,"score":0.8435370922088623},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7053481936454773},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.6962845325469971},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6080066561698914},{"id":"https://openalex.org/C2777410769","wikidata":"https://www.wikidata.org/wiki/Q2282887","display_name":"HBsAg","level":4,"score":0.5825808048248291},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.5479731559753418},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5115112066268921},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.43817493319511414},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.410762757062912},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.37199825048446655},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2697756886482239},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.126580148935318},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.10358256101608276},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.046406179666519165}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:3029199262","doi":"https://doi.org/10.3760/cma.j.issn.1003-9279.2017.03.003","is_oa":false,"landing_page_url":"http://rs.yiigle.com/CN112866201703/994813.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764522840","display_name":"Chinese Journal of Clinical Hepatology","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310311885","host_organization_name":"Editorial Department of Journal of Clinical Hepatology","host_organization_lineage":["https://openalex.org/P4310311885"],"host_organization_lineage_names":["Editorial Department of Journal of Clinical Hepatology"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Chinese Journal of Clinical Hepatology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3029073387","https://openalex.org/W2161265490","https://openalex.org/W2367956858","https://openalex.org/W3029875671","https://openalex.org/W2367954236","https://openalex.org/W2334764031","https://openalex.org/W4415971267","https://openalex.org/W2371750971","https://openalex.org/W2797395146","https://openalex.org/W2366741998"],"abstract_inverted_index":{"Objective\r\nTo":[0],"explore":[1],"the":[2,9,73,85,94,99],"influence":[3],"of":[4,12,66,84],"pVR-IL15":[5,78,89],"gene":[6,43,90],"adjuvant":[7,44,91],"on":[8],"immune":[10,49,70,74,95],"responses":[11,50,71,96],"different":[13],"immunization":[14,17],"strategies.\r\n\r\n\r\nMethods\r\nThe":[15],"sequential":[16],"strategies":[18],"were":[19,51,79],"used":[20],"in":[21,72],"BALB/c":[22],"mice":[23],"with":[24,41,77,87],"a":[25,42],"DNA":[26],"vaccine,":[27],"recombinant":[28,34,100],"modified":[29],"vaccinia":[30],"virus":[31,107],"Ankara":[32],"and":[33,39,47,59,68],"adenovirus":[35],"expressing":[36,102],"HBsAg":[37],"respectively":[38],"combined":[40,76],"pVR-IL15.":[45],"Cellular":[46],"humoral":[48,67],"evaluated":[52],"by":[53,98],"IFN-\u03b3":[54],"enzyme-linked":[55,60],"immunospot":[56],"assay":[57,62],"(ELISPOT)":[58],"immunosorbent":[61],"(ELISA),":[63],"respectively.\r\n\r\n\r\nResults\r\nThe":[64],"levels":[65],"cellular":[69],"groups":[75],"significantly":[80],"higher":[81],"than":[82],"those":[83],"non-combined":[86],"pVR-IL15.\r\n\r\n\r\nConclusions\r\nThe":[88],"can":[92],"enhance":[93],"induced":[97],"viruses":[101],"HBsAg.\r\n\r\n\r\nKey":[103],"words:":[104],"\r\npVR-IL15;\u00a0Gene":[105],"adjuvant;\u00a0Recombinant":[106]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2020-06-05T00:00:00"}
