{"id":"https://openalex.org/W3029136355","doi":"https://doi.org/10.3760/cma.j.issn.1001-4497.2013.10.012","title":"Dexmedetomidine on the clinical studies of cerebral injury affect in infant after cardiopulmonary bypass","display_name":"Dexmedetomidine on the clinical studies of cerebral injury affect in infant after cardiopulmonary bypass","publication_year":2013,"publication_date":"2013-10-25","ids":{"openalex":"https://openalex.org/W3029136355","doi":"https://doi.org/10.3760/cma.j.issn.1001-4497.2013.10.012","mag":"3029136355"},"language":"en","primary_location":{"id":"mag:3029136355","doi":"https://doi.org/10.3760/cma.j.issn.1001-4497.2013.10.012","is_oa":false,"landing_page_url":"http://rs.yiigle.com/CN11243420132910/494533.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2765059052","display_name":"Chinese Journal of Thoracic and Cardiovaescular Surgery","issn_l":"1001-4497","issn":["1001-4497"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4320800525","host_organization_name":"Chinese Medical Association","host_organization_lineage":["https://openalex.org/P4320800525"],"host_organization_lineage_names":["Chinese Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Chinese Journal of Thoracic and Cardiovaescular Surgery","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014866622","display_name":"Yongsheng Qiu","orcid":"https://orcid.org/0000-0001-5804-5402","observed_orcids":["https://orcid.org/0000-0001-5804-5402"]},"institutions":[{"id":"https://openalex.org/I4210107961","display_name":"Zhengzhou Children's Hospital","ror":"https://ror.org/01jfd9z49","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210107961"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongsheng Qiu","raw_affiliation_strings":["Zhengzhou Children\u2032s Hospital,Zhengzhou 450053,China"],"raw_orcid":"https://orcid.org/0000-0001-5804-5402","affiliations":[{"raw_affiliation_string":"Zhengzhou Children\u2032s Hospital,Zhengzhou 450053,China","institution_ids":["https://openalex.org/I4210107961"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102976166","display_name":"Yingping Jia","orcid":"https://orcid.org/0000-0003-1934-6223","observed_orcids":["https://orcid.org/0000-0003-1934-6223"]},"institutions":[{"id":"https://openalex.org/I4210107961","display_name":"Zhengzhou Children's Hospital","ror":"https://ror.org/01jfd9z49","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210107961"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yingping Jia","raw_affiliation_strings":["Zhengzhou Children\u2032s Hospital,Zhengzhou 450053,China"],"raw_orcid":"https://orcid.org/0000-0003-1934-6223","affiliations":[{"raw_affiliation_string":"Zhengzhou Children\u2032s Hospital,Zhengzhou 450053,China","institution_ids":["https://openalex.org/I4210107961"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210107961"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.49771623,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"29","issue":"10","first_page":"617","last_page":"619"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9375,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9375,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11055","display_name":"Cardiac and Coronary Surgery Techniques","score":0.02850000001490116,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12963","display_name":"Anesthesia and Neurotoxicity Research","score":0.01119999960064888,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dexmedetomidine","display_name":"dexmedetomidine","score":1.0},{"id":"https://openalex.org/keywords/cardiopulmonary-bypass","display_name":"cardiopulmonary bypass","score":0.9520000219345093},{"id":"https://openalex.org/keywords/cerebral-injury","display_name":"cerebral injury","score":0.765999972820282},{"id":"https://openalex.org/keywords/infants","display_name":"infants","score":0.6850000023841858},{"id":"https://openalex.org/keywords/congenital-heart-disease","display_name":"congenital heart disease","score":0.9940000176429749},{"id":"https://openalex.org/keywords/s100beta-protein","display_name":"S100\u03b2 protein","score":0.9229999780654907},{"id":"https://openalex.org/keywords/neuron-specific-enolase","display_name":"neuron-specific enolase","score":0.9909999966621399},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8870000243186951},{"id":"https://openalex.org/keywords/perioperative-hemodynamics","display_name":"perioperative hemodynamics","score":0.6240000128746033}],"concepts":[{"id":"https://openalex.org/C2781302539","wikidata":"https://www.wikidata.org/wiki/Q412133","display_name":"Dexmedetomidine","level":3,"score":0.9622175693511963},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9041567444801331},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.786827802658081},{"id":"https://openalex.org/C2778881276","wikidata":"https://www.wikidata.org/wiki/Q552304","display_name":"Cardiopulmonary bypass","level":2,"score":0.7587891221046448},{"id":"https://openalex.org/C31174226","wikidata":"https://www.wikidata.org/wiki/Q64855140","display_name":"Perioperative","level":2,"score":0.7506442070007324},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.6220654845237732},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.523460328578949},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.5172812938690186},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.4497872292995453},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1650715470314026},{"id":"https://openalex.org/C2776814716","wikidata":"https://www.wikidata.org/wiki/Q574801","display_name":"Sedation","level":2,"score":0.15300902724266052}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:3029136355","doi":"https://doi.org/10.3760/cma.j.issn.1001-4497.2013.10.012","is_oa":false,"landing_page_url":"http://rs.yiigle.com/CN11243420132910/494533.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2765059052","display_name":"Chinese Journal of Thoracic and Cardiovaescular Surgery","issn_l":"1001-4497","issn":["1001-4497"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4320800525","host_organization_name":"Chinese Medical Association","host_organization_lineage":["https://openalex.org/P4320800525"],"host_organization_lineage_names":["Chinese Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Chinese Journal of Thoracic and Cardiovaescular Surgery","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3031518176","https://openalex.org/W2365608655","https://openalex.org/W7213964796","https://openalex.org/W2743991666","https://openalex.org/W2373886615","https://openalex.org/W3032269890","https://openalex.org/W3011679942","https://openalex.org/W3032644274","https://openalex.org/W2586728706","https://openalex.org/W4223598499"],"abstract_inverted_index":{"Objective":[0],"To":[1],"observe":[2],"the":[3,45,66,69,77,83,86,99,102,140,162,215,228],"effect":[4],"of":[5,7,19,47,104,117,218],"application":[6],"dexmedetomidine":[8,36,52],"on":[9],"cerebral":[10,229],"injury":[11],"in":[12,76,124,143,156,164,177,188,193,201,222],"infants":[13],"after":[14,224],"cardiopulmonary":[15,225],"bypass.Methods":[16],"60":[17],"cases":[18],"congenital":[20],"heart":[21,194],"disease":[22],"were":[23,121,158,186,199],"divided":[24],"into":[25],"3":[26,125,141],"groups,each":[27],"group":[28,49,70,91,151,171,178],"20":[29],"infants,namely":[30],"D1,D2":[31],"and":[32,62,89,146,154,173,180,197,220],"N":[33,72,179],"group.Group":[34],"D1":[35,181,191],"1.0\u03bcg/kg,in":[37],"0.2\u03bcg":[38],"\u00b7":[39,41,57,59],"kg-1":[40,58],"h-1":[42],"intravenous":[43,73],"infusion,until":[44],"end":[46,103],"operation;":[48],"D2":[50,189],"with":[51,170],"0.5":[53],"\u03bcg/kg,in":[54],"0.1":[55],"\u03bcg":[56],"h-1,drug":[60],"concentration":[61],"injection":[63],"speed":[64,81],"was":[65,82,135,206],"same":[67,84],"as":[68,85],"D1.Group":[71],"normal":[74],"saline":[75],"whole":[78],"operation":[79,100],"process,infusion":[80],"experimental":[87,90],"group,anesthesia":[88],"agreement.Take":[92],"blood":[93],"samples":[94],"sent":[95],"to":[96],"laboratory":[97],"before":[98],"(T1),at":[101],"CPB":[105,107],"(T2),after":[106],"2":[108],"h":[109,111,113],"(T3),6":[110],"(T4),24":[112],"(T5)":[114],"respectively,colleced":[115],"records":[116],"perioperative":[118,204],"data.Results":[119],"There":[120],"no":[122,136],"significant":[123,208],"groups,for":[126],"infant's":[127],"age,weight,operation":[128],"time,CPB":[129],"time":[130],"difference":[131,138],"(P":[132,148,166,182,209],"\uff1e0.05).In":[133],"T1,there":[134],"statistical":[137],"between":[139],"groups":[142],"S-100\u03b2":[144,219],"protein":[145,153],"NSE":[147,155,174,221],"\uff1e":[149,210],"0.05).In":[150,168],"N,S-100\u03b2":[152],"T2,T3,T4,T5":[157],"increased":[159,175],"significantly":[160,176],"than":[161,190],"level":[163],"T1":[165],"\uff1c":[167,183],"T2,compared":[169],"D2,S-100\u03b2":[172],"0.01),and":[184],"there":[185],"more":[187],"group.Differences":[192],"rate,blood":[195],"pressure":[196],"hemodynamics":[198],"observed":[200],"infant":[202,223],"during":[203],"period":[205],"not":[207],"0.05).Conclusion":[211],"Dexmedetomidine":[212],"can":[213],"reduce":[214],"ascensional":[216],"range":[217],"bypass,and":[226],"relieve":[227],"injury.\r\n\r\nKey":[230],"words:":[231],"\r\nDexmedetomidine;\u00a0":[232],"Infant":[233],";\u00a0":[234,236],"Child":[235],"Cardiopulmonary":[237],"bypass;\u00a0":[238],"Brain":[239],"injuries":[240]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2020-06-05T00:00:00"}