{"id":"https://openalex.org/W3028908282","doi":null,"title":"Early tocilizumab treatment could improve survival among COVID-19 patients.","display_name":"Early tocilizumab treatment could improve survival among COVID-19 patients.","publication_year":2020,"publication_date":"2020-05-01","ids":{"openalex":"https://openalex.org/W3028908282","mag":"3028908282","pmid":"https://pubmed.ncbi.nlm.nih.gov/32456769"},"language":"en","primary_location":{"id":"pmid:32456769","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32456769","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental rheumatology","raw_type":"Letter"},"volume":null,"type":"letter","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087580172","display_name":"Llu\u00eds Campins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134155","display_name":"Hospital de Matar\u00f3","ror":"https://ror.org/04cy4z909","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210134155"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Lluis Campins","raw_affiliation_strings":["Department of Pharmacy, Hospital de Matar\u00f3, CSdM, Matar\u00f3, Barcelona, Spain. lcampins@csdm.cat"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Hospital de Matar\u00f3, CSdM, Matar\u00f3, Barcelona, Spain. lcampins@csdm.cat","institution_ids":["https://openalex.org/I4210134155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049569800","display_name":"Ram\u00f3n Boixeda","orcid":"https://orcid.org/0000-0002-5330-9971","observed_orcids":["https://orcid.org/0000-0002-5330-9971"]},"institutions":[{"id":"https://openalex.org/I4210134155","display_name":"Hospital de Matar\u00f3","ror":"https://ror.org/04cy4z909","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210134155"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ramon Boixeda","raw_affiliation_strings":["Department of Internal Medicine, Hospital de Matar\u00f3, CSDM, Matar\u00f3, Barcelona; Grup d'Estudi al Maresme de la Pneum\u00f2nia Adquirida en la Comunitat i la MPOC (GEMP@C), Matar\u00f3, Barcelona; and Universidad de Barcelona, CIBERES Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Hospital de Matar\u00f3, CSDM, Matar\u00f3, Barcelona; Grup d'Estudi al Maresme de la Pneum\u00f2nia Adquirida en la Comunitat i la MPOC (GEMP@C), Matar\u00f3, Barcelona; and Universidad de Barcelona, CIBERES Barcelona, Spain","institution_ids":["https://openalex.org/I4210134155","https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063451896","display_name":"Laia P\u00e9rez-Cord\u00f3n","orcid":"https://orcid.org/0000-0002-1595-7759","observed_orcids":["https://orcid.org/0000-0002-1595-7759"]},"institutions":[{"id":"https://openalex.org/I4210134155","display_name":"Hospital de Matar\u00f3","ror":"https://ror.org/04cy4z909","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210134155"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Laia Perez-Cordon","raw_affiliation_strings":["Department of Pharmacy, Hospital de Matar\u00f3, CSdM, Matar\u00f3, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Hospital de Matar\u00f3, CSdM, Matar\u00f3, Barcelona, Spain","institution_ids":["https://openalex.org/I4210134155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036523683","display_name":"Raquel Ar\u00e1nega","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134155","display_name":"Hospital de Matar\u00f3","ror":"https://ror.org/04cy4z909","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210134155"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Raquel Aranega","raw_affiliation_strings":["Department of Internal Medicine, Hospital de Matar\u00f3, CSDM, Matar\u00f3, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Hospital de Matar\u00f3, CSDM, Matar\u00f3, Barcelona, Spain","institution_ids":["https://openalex.org/I4210134155"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Carlos Lopera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134155","display_name":"Hospital de Matar\u00f3","ror":"https://ror.org/04cy4z909","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210134155"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Carlos Lopera","raw_affiliation_strings":["Department of Internal Medicine, Hospital de Matar\u00f3, CSDM, Matar\u00f3, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Hospital de Matar\u00f3, CSDM, Matar\u00f3, Barcelona, Spain","institution_ids":["https://openalex.org/I4210134155"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060814299","display_name":"Llu\u00eds Force","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170486558","display_name":"Universitat Pompeu Fabra","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]},{"id":"https://openalex.org/I4210134155","display_name":"Hospital de Matar\u00f3","ror":"https://ror.org/04cy4z909","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210134155"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Lluis Force","raw_affiliation_strings":["Department of Internal Medicine, Hospital de Matar\u00f3, CSDM, Matar\u00f3, Barcelona, and ESCS-TCMM, Pompeu Fabra University, Matar\u00f3, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Hospital de Matar\u00f3, CSDM, Matar\u00f3, Barcelona, and ESCS-TCMM, Pompeu Fabra University, Matar\u00f3, Barcelona, Spain","institution_ids":["https://openalex.org/I170486558","https://openalex.org/I4210134155"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"38","issue":"3","first_page":"578","last_page":"578"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tocilizumab","display_name":"tocilizumab","score":0.9990000128746033},{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9990000128746033},{"id":"https://openalex.org/keywords/early-treatment","display_name":"early treatment","score":0.6830000281333923},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.9710000157356262},{"id":"https://openalex.org/keywords/il-6-receptor-inhibition","display_name":"IL-6 receptor inhibition","score":0.703000009059906},{"id":"https://openalex.org/keywords/cytokine-storm","display_name":"cytokine storm","score":0.9129999876022339}],"concepts":[{"id":"https://openalex.org/C2777178219","wikidata":"https://www.wikidata.org/wiki/Q425154","display_name":"Tocilizumab","level":3,"score":0.9669700264930725},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9668045043945312},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.7975987195968628},{"id":"https://openalex.org/C3006700255","wikidata":"https://www.wikidata.org/wiki/Q81068910","display_name":"2019-20 coronavirus outbreak","level":3,"score":0.6682921648025513},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.6144669651985168},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5060686469078064},{"id":"https://openalex.org/C2778137277","wikidata":"https://www.wikidata.org/wiki/Q16532287","display_name":"Betacoronavirus","level":5,"score":0.4386626183986664},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.43419256806373596},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.35013705492019653},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.12676087021827698},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C116675565","wikidata":"https://www.wikidata.org/wiki/Q3241045","display_name":"Outbreak","level":2,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000073640","descriptor_name":"Betacoronavirus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000305","descriptor_name":"Adrenal Cortex Hormones","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011024","descriptor_name":"Pneumonia, Viral","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018352","descriptor_name":"Coronavirus Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D058873","descriptor_name":"Pandemics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:32456769","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32456769","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental rheumatology","raw_type":"Letter"},{"id":"mag:3028908282","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32456769/","pdf_url":null,"source":{"id":"https://openalex.org/S165438840","display_name":"Clinical and Experimental Rheumatology","issn_l":"0392-856X","issn":["0392-856X","1593-098X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321666","host_organization_name":"Springer Vienna","host_organization_lineage":["https://openalex.org/P4310321666","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Vienna","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Clinical and Experimental Rheumatology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4206262493","https://openalex.org/W3094239899","https://openalex.org/W3115933152","https://openalex.org/W7037417038","https://openalex.org/W6903735139","https://openalex.org/W4225316810","https://openalex.org/W4388485155","https://openalex.org/W3196605965","https://openalex.org/W3092623037","https://openalex.org/W3173522473"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":19}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-06-05T00:00:00"}