{"id":"https://openalex.org/W3028735488","doi":"https://doi.org/10.3760/cma.j.issn.1001-9030.2017.05.046","title":"The expression and significance of Kiss1 protein in colon adenoma and colon carcinoma","display_name":"The expression and significance of Kiss1 protein in colon adenoma and colon carcinoma","publication_year":2017,"publication_date":"2017-05-08","ids":{"openalex":"https://openalex.org/W3028735488","doi":"https://doi.org/10.3760/cma.j.issn.1001-9030.2017.05.046","mag":"3028735488"},"language":"en","primary_location":{"id":"mag:3028735488","doi":"https://doi.org/10.3760/cma.j.issn.1001-9030.2017.05.046","is_oa":false,"landing_page_url":"http://rs.yiigle.com/CN421213201705/989397.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764660617","display_name":"Zhonghua shiyan waike zazhi","issn_l":"1001-9030","issn":["1001-9030"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4320800525","host_organization_name":"Chinese Medical Association","host_organization_lineage":["https://openalex.org/P4320800525"],"host_organization_lineage_names":["Chinese Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhonghua shiyan waike zazhi","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061349095","display_name":"Xiao\u2010Ming Meng","orcid":"https://orcid.org/0000-0002-1166-561X","observed_orcids":["https://orcid.org/0000-0002-1166-561X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiao\u2010Ming Meng","raw_affiliation_strings":["Department of Gastroenterology, the No. 252 Hospital of PLA, Baoding 071000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, the No. 252 Hospital of PLA, Baoding 071000, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100747264","display_name":"Aimin Wang","orcid":"https://orcid.org/0000-0002-5484-9494","observed_orcids":["https://orcid.org/0000-0002-5484-9494"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aimin Wang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5484-9494","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050569120","display_name":"Liwei Fan","orcid":"https://orcid.org/0000-0003-1979-2514","observed_orcids":["https://orcid.org/0000-0003-1979-2514"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liwei Fan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5100341839","display_name":"Xun\ufffd Li","orcid":"https://orcid.org/0000-0001-6862-7692","observed_orcids":["https://orcid.org/0000-0001-6862-7692"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xun\ufffd Li","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6862-7692","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.24662554,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":"5","first_page":"866","last_page":"868"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.6913999915122986,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.6913999915122986,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.036400001496076584,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.02370000071823597,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kiss1","display_name":"KISS1","score":0.9620000123977661},{"id":"https://openalex.org/keywords/gpr54","display_name":"GPR54","score":0.6290000081062317},{"id":"https://openalex.org/keywords/colorectal-adenoma","display_name":"colorectal adenoma","score":0.906000018119812},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9769999980926514},{"id":"https://openalex.org/keywords/adenoma-carcinoma-sequence","display_name":"adenoma-carcinoma sequence","score":0.8450000286102295},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.6200000047683716},{"id":"https://openalex.org/keywords/protein-expression","display_name":"protein expression","score":0.7919999957084656},{"id":"https://openalex.org/keywords/mrna-expression","display_name":"mRNA expression","score":0.8320000171661377},{"id":"https://openalex.org/keywords/tubular-adenoma","display_name":"tubular adenoma","score":0.9100000262260437},{"id":"https://openalex.org/keywords/villous-adenoma","display_name":"villous adenoma","score":0.9980000257492065}],"concepts":[{"id":"https://openalex.org/C2776861080","wikidata":"https://www.wikidata.org/wiki/Q2825480","display_name":"Colorectal adenoma","level":4,"score":0.8564234972000122},{"id":"https://openalex.org/C2777428134","wikidata":"https://www.wikidata.org/wiki/Q272741","display_name":"Adenoma","level":2,"score":0.7137481570243835},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6331768035888672},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.619726836681366},{"id":"https://openalex.org/C2780914348","wikidata":"https://www.wikidata.org/wiki/Q2825480","display_name":"Villous adenoma","level":3,"score":0.5860965251922607},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5681003928184509},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5647947788238525},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5020239353179932},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.42772233486175537},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.39580997824668884},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.10422757267951965}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:3028735488","doi":"https://doi.org/10.3760/cma.j.issn.1001-9030.2017.05.046","is_oa":false,"landing_page_url":"http://rs.yiigle.com/CN421213201705/989397.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764660617","display_name":"Zhonghua shiyan waike zazhi","issn_l":"1001-9030","issn":["1001-9030"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4320800525","host_organization_name":"Chinese Medical Association","host_organization_lineage":["https://openalex.org/P4320800525"],"host_organization_lineage_names":["Chinese Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhonghua shiyan waike zazhi","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3028966201","https://openalex.org/W2090431316","https://openalex.org/W1906281121","https://openalex.org/W3031554739","https://openalex.org/W2591423758","https://openalex.org/W2390846327","https://openalex.org/W3030747437","https://openalex.org/W3029612848","https://openalex.org/W2772550836","https://openalex.org/W1502302078"],"abstract_inverted_index":{"Objective\r\nTo":[0],"investigate":[1],"the":[2,27,34,105,141,147,153,159],"expression":[3,30,46,75,108,148],"and":[4,12,15,29,57,64,87,93,115,129,140,158],"significance":[5],"of":[6,31,48,77,85,125,137,143,149,155,161],"Kiss1":[7,32,49,78,106,150],"protein":[8,50,79],"in":[9,33,51,80,117],"colon":[10,13,37,40,43],"adenoma":[11,56,86,89,128,139,157],"carcinoma.\r\n\r\n\r\nMethods\r\nImmunohistochemistry":[14],"real-time":[16],"fluorescent":[17],"quantitative":[18],"polymerase":[19],"chain":[20],"reaction":[21],"(FQ-PCR)":[22],"were":[23],"used":[24],"to":[25],"detect":[26],"location":[28],"20":[35],"normal":[36,52,118],"mucosae,":[38],"30":[39],"carcinomae,":[41],"80":[42],"adenomae.\r\n\r\n\r\nResults\r\nThe":[44],"positive":[45,74],"rate":[47,76,109],"colorectal":[53,55,58,119,130,138,144,156,162],"mucosa,":[54,120],"carcinoma":[59],"tissues":[60],"was":[61,90,110],"93.3%,":[62],"58.8%":[63],"5.0%":[65],"respectively,":[66,95],"with":[67,96,135],"significant":[68,97],"differences":[69,98],"among":[70,99],"them":[71,100],"(P=0.005).":[72,101],"The":[73],"tubular":[81,121],"adenoma,":[82,122,126],"mixed":[83,123],"pattern":[84,124],"villous":[88,127],"80.0%,":[91],"66.7%":[92],"35.0%":[94],"FQ-PCR":[102],"showed":[103],"that":[104],"mRNA":[107],"28.85\u00b18.34,":[111],"14.61\u00b11.65,":[112],"7.58\u00b11.31,":[113],"2.26\u00b11.56":[114],"0.50\u00b10.40":[116],"carcinoma,":[131],"respectively.\r\n\r\n\r\nConclusion\r\nKiss1":[132],"is":[133],"correlated":[134],"canceration":[136],"development":[142,160],"carcinoma.":[145],"Detecting":[146],"can":[151],"evaluate":[152],"progression":[154],"carcinoma.\r\n\r\n\r\nKey":[163],"words:":[164],"\r\nColorectal":[165],"adenoma;\u00a0Colorectal":[166],"carcinoma;\u00a0Kiss1":[167]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2020-06-05T00:00:00"}