{"id":"https://openalex.org/W3028680491","doi":"https://doi.org/10.1093/nar/gkaa537","title":"Orthogonal tuning of gene expression noise using CRISPR\u2013Cas","display_name":"Orthogonal tuning of gene expression noise using CRISPR\u2013Cas","publication_year":2020,"publication_date":"2020-06-18","ids":{"openalex":"https://openalex.org/W3028680491","doi":"https://doi.org/10.1093/nar/gkaa537","mag":"3028680491","pmid":"https://pubmed.ncbi.nlm.nih.gov/32556171","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7367205"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkaa537","doi":"https://doi.org/10.1093/nar/gkaa537","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkaa537","pdf_url":"https://academic.oup.com/nar/article-pdf/48/13/7606/33508149/gkaa537.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/article-pdf/48/13/7606/33508149/gkaa537.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103131994","display_name":"Fan Wu","orcid":"https://orcid.org/0000-0002-8284-4631","observed_orcids":["https://orcid.org/0000-0002-8284-4631"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fan Wu","raw_affiliation_strings":["Department of Biomedical Engineering, University of California Davis, Davis, CA 95616, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of California Davis, Davis, CA 95616, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012995172","display_name":"Jiyoung Shim","orcid":"https://orcid.org/0000-0001-6973-9530","observed_orcids":["https://orcid.org/0000-0001-6973-9530"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiyoung Shim","raw_affiliation_strings":["Department of Biomedical Engineering, University of California Davis, Davis, CA 95616, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of California Davis, Davis, CA 95616, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011963844","display_name":"Ting Gong","orcid":"https://orcid.org/0000-0001-7268-9693","observed_orcids":["https://orcid.org/0000-0001-7268-9693"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ting Gong","raw_affiliation_strings":["Department of Biomedical Engineering, University of California Davis, Davis, CA 95616, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of California Davis, Davis, CA 95616, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013292013","display_name":"Cheemeng Tan","orcid":"https://orcid.org/0000-0003-1049-1192","observed_orcids":["https://orcid.org/0000-0003-1049-1192"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Cheemeng Tan","raw_affiliation_strings":["Department of Biomedical Engineering, University of California Davis, Davis, CA 95616, USA"],"raw_orcid":"https://orcid.org/0000-0003-1049-1192","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of California Davis, Davis, CA 95616, USA","institution_ids":["https://openalex.org/I84218800"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5013292013"],"corresponding_institution_ids":["https://openalex.org/I84218800"],"apc_list":{"value":3992,"currency":"USD","value_usd":3992},"apc_paid":{"value":3992,"currency":"USD","value_usd":3992},"fwci":0.5678,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.58916047,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"48","issue":"13","first_page":"7606","last_page":"7606"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.6973000168800354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.6973000168800354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.2517000138759613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11513","display_name":"stochastic dynamics and bifurcation","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/3109","display_name":"Statistical and Nonlinear Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stochastic-gene-expression","display_name":"stochastic gene expression","score":0.9869999885559082},{"id":"https://openalex.org/keywords/crispr-cas-systems","display_name":"CRISPR-Cas","score":0.9559999704360962},{"id":"https://openalex.org/keywords/transcriptional-noise","display_name":"transcriptional noise","score":0.503000020980835},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.3490000069141388}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8077494502067566},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.6391940712928772},{"id":"https://openalex.org/C98108389","wikidata":"https://www.wikidata.org/wiki/Q412563","display_name":"CRISPR","level":3,"score":0.6078388690948486},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5393971800804138},{"id":"https://openalex.org/C189819185","wikidata":"https://www.wikidata.org/wiki/Q384283","display_name":"Subgenomic mRNA","level":4,"score":0.535769522190094},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.5103206038475037},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4878987967967987},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.44637805223464966},{"id":"https://openalex.org/C186310378","wikidata":"https://www.wikidata.org/wiki/Q941796","display_name":"Psychological repression","level":4,"score":0.4446662664413452},{"id":"https://openalex.org/C161733203","wikidata":"https://www.wikidata.org/wiki/Q911828","display_name":"Reporter gene","level":4,"score":0.43656644225120544},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.422812283039093},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4148062467575073},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.2951069176197052}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1093/nar/gkaa537","doi":"https://doi.org/10.1093/nar/gkaa537","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkaa537","pdf_url":"https://academic.oup.com/nar/article-pdf/48/13/7606/33508149/gkaa537.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7367205","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7367205","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"},{"id":"pmid:32556171","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32556171","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt1w57x5cc","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/1w57x5cc","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nucleic acids research, vol 48, iss 13","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt75n803x4","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/75n803x4","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nucleic acids research, vol 48, iss 13","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt1w57x5cc","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/1w57x5cc","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nucleic Acids Research, vol 48, iss 13","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1093/nar/gkaa537","doi":"https://doi.org/10.1093/nar/gkaa537","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkaa537","pdf_url":"https://academic.oup.com/nar/article-pdf/48/13/7606/33508149/gkaa537.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3028680491.pdf"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1645305843","https://openalex.org/W1938292773","https://openalex.org/W1978329448","https://openalex.org/W1979302584","https://openalex.org/W1982860140","https://openalex.org/W1984429906","https://openalex.org/W1988791304","https://openalex.org/W2008867005","https://openalex.org/W2013115758","https://openalex.org/W2020596227","https://openalex.org/W2041477913","https://openalex.org/W2044692345","https://openalex.org/W2059053384","https://openalex.org/W2067432938","https://openalex.org/W2075230442","https://openalex.org/W2081382181","https://openalex.org/W2091198609","https://openalex.org/W2096015757","https://openalex.org/W2101749257","https://openalex.org/W2107342968","https://openalex.org/W2111014820","https://openalex.org/W2111165959","https://openalex.org/W2111167674","https://openalex.org/W2114870653","https://openalex.org/W2120932131","https://openalex.org/W2127013070","https://openalex.org/W2149242848","https://openalex.org/W2156781574","https://openalex.org/W2171280873","https://openalex.org/W2770003333","https://openalex.org/W2796434788","https://openalex.org/W2808828797","https://openalex.org/W2809899191","https://openalex.org/W2951527048"],"related_works":["https://openalex.org/W7032900382","https://openalex.org/W7004900625","https://openalex.org/W2769031084","https://openalex.org/W3019206167","https://openalex.org/W7128649166","https://openalex.org/W4298010148","https://openalex.org/W3116413150","https://openalex.org/W3106778587","https://openalex.org/W3116576262","https://openalex.org/W3000149627"],"abstract_inverted_index":{"Nucleic":[0],"Acids":[1],"Research,":[2],"2020,":[3],"https://doi.org/10.1093/nar/gkaa451":[4],"The":[5,26],"first":[6],"version":[7],"of":[8],"this":[9],"article":[10],"inadvertently":[11],"neglected":[12],"to":[13],"include":[14],"Ting":[15],"Gong":[16],"as":[17],"third":[18],"author.":[19],"This":[20],"has":[21],"now":[22],"been":[23],"corrected":[24],"online.":[25],"authors":[27],"regret":[28],"the":[29],"error.":[30]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2020-06-05T00:00:00"}