{"id":"https://openalex.org/W3028660484","doi":"https://doi.org/10.1111/pai.13296","title":"Respiratory viruses are associated with serum metabolome among infants hospitalized for bronchiolitis: A multicenter study","display_name":"Respiratory viruses are associated with serum metabolome among infants hospitalized for bronchiolitis: A multicenter study","publication_year":2020,"publication_date":"2020-05-27","ids":{"openalex":"https://openalex.org/W3028660484","doi":"https://doi.org/10.1111/pai.13296","mag":"3028660484","pmid":"https://pubmed.ncbi.nlm.nih.gov/32460384","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7704725"},"language":"en","primary_location":{"id":"doi:10.1111/pai.13296","doi":"https://doi.org/10.1111/pai.13296","is_oa":false,"landing_page_url":"https://doi.org/10.1111/pai.13296","pdf_url":null,"source":{"id":"https://openalex.org/S191932905","display_name":"Pediatric Allergy and Immunology","issn_l":"0905-6157","issn":["0905-6157","1399-3038"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Allergy and Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC7704725","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022701134","display_name":"Michimasa Fujiogi","orcid":"https://orcid.org/0000-0002-4179-3612","observed_orcids":["https://orcid.org/0000-0002-4179-3612"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michimasa Fujiogi","raw_affiliation_strings":["Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"],"raw_orcid":"https://orcid.org/0000-0002-4179-3612","affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062152763","display_name":"Carlos A. Camargo","orcid":"https://orcid.org/0000-0002-5071-7654","observed_orcids":["https://orcid.org/0000-0002-5071-7654"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlos A. Camargo","raw_affiliation_strings":["Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015707369","display_name":"Yoshihiko Raita","orcid":"https://orcid.org/0000-0002-5805-9369","observed_orcids":["https://orcid.org/0000-0002-5805-9369"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yoshihiko Raita","raw_affiliation_strings":["Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"],"raw_orcid":"https://orcid.org/0000-0002-5805-9369","affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001781304","display_name":"Yury A. Bochkov","orcid":"https://orcid.org/0000-0003-2618-4496","observed_orcids":["https://orcid.org/0000-0003-2618-4496"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yury A. Bochkov","raw_affiliation_strings":["Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013823897","display_name":"James E. Gern","orcid":"https://orcid.org/0000-0002-6667-4708","observed_orcids":["https://orcid.org/0000-0002-6667-4708"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James E. Gern","raw_affiliation_strings":["Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA","Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030118245","display_name":"Jonathan M. Mansbach","orcid":"https://orcid.org/0000-0002-9176-0325","observed_orcids":["https://orcid.org/0000-0002-9176-0325"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan M. Mansbach","raw_affiliation_strings":["Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061988295","display_name":"Pedro A. Piedra","orcid":"https://orcid.org/0000-0002-5839-0879","observed_orcids":["https://orcid.org/0000-0002-5839-0879"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pedro A. Piedra","raw_affiliation_strings":["Departments of Molecular Virology and Microbiology and Pediatrics, Baylor College of Medicine, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Molecular Virology and Microbiology and Pediatrics, Baylor College of Medicine, Houston, TX, USA","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030095688","display_name":"Kohei Hasegawa","orcid":"https://orcid.org/0000-0002-5739-7999","observed_orcids":["https://orcid.org/0000-0002-5739-7999"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kohei Hasegawa","raw_affiliation_strings":["Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5022701134"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"],"apc_list":{"value":4300,"currency":"USD","value_usd":4300},"apc_paid":null,"fwci":2.8092,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.91287636,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"31","issue":"7","first_page":"755","last_page":"766"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11243","display_name":"Respiratory viral infections research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11243","display_name":"Respiratory viral infections research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bronchiolitis","display_name":"bronchiolitis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/respiratory-syncytial-virus","display_name":"respiratory syncytial virus","score":0.9750000238418579},{"id":"https://openalex.org/keywords/respiratory-syncytial-virus-a","display_name":"respiratory syncytial virus A","score":0.8600000143051147},{"id":"https://openalex.org/keywords/rhinovirus","display_name":"rhinovirus","score":0.8199999928474426},{"id":"https://openalex.org/keywords/serum-metabolome","display_name":"serum metabolome","score":0.9409999847412109},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.7049999833106995},{"id":"https://openalex.org/keywords/sphingolipids","display_name":"sphingolipids","score":0.9610000252723694},{"id":"https://openalex.org/keywords/l-carnitine","display_name":"L-carnitine","score":0.9350000023841858},{"id":"https://openalex.org/keywords/glycerophosphocholine","display_name":"glycerophosphocholine","score":0.9760000109672546},{"id":"https://openalex.org/keywords/recurrent-wheezing","display_name":"recurrent wheezing","score":0.9660000205039978},{"id":"https://openalex.org/keywords/positive-pressure-ventilation","display_name":"positive pressure ventilation","score":0.9729999899864197},{"id":"https://openalex.org/keywords/infant-hospitalization","display_name":"infant hospitalization","score":0.5929999947547913},{"id":"https://openalex.org/keywords/virus-host-interactions","display_name":"host-virus interaction","score":0.515999972820282}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9406106472015381},{"id":"https://openalex.org/C2778821649","wikidata":"https://www.wikidata.org/wiki/Q424227","display_name":"Bronchiolitis","level":3,"score":0.9024190902709961},{"id":"https://openalex.org/C135870905","wikidata":"https://www.wikidata.org/wiki/Q903667","display_name":"Metabolome","level":3,"score":0.7611647248268127},{"id":"https://openalex.org/C2992435398","wikidata":"https://www.wikidata.org/wiki/Q6934595","display_name":"Multicenter study","level":3,"score":0.5572910308837891},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.5434414148330688},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.4479205906391144},{"id":"https://openalex.org/C2776178081","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Respiratory disease","level":3,"score":0.4149051010608673},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35020825266838074},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.32797133922576904},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25776219367980957},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.11215364933013916},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.11088520288467407},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001988","descriptor_name":"Bronchiolitis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D001988","descriptor_name":"Bronchiolitis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001988","descriptor_name":"Bronchiolitis","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D002331","descriptor_name":"Carnitine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006760","descriptor_name":"Hospitalization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012135","descriptor_name":"Respiratory Sounds","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D012136","descriptor_name":"Respiratory Syncytial Viruses","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D012229","descriptor_name":"Rhinovirus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013107","descriptor_name":"Sphingolipids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018357","descriptor_name":"Respiratory Syncytial Virus Infections","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018357","descriptor_name":"Respiratory Syncytial Virus Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1111/pai.13296","doi":"https://doi.org/10.1111/pai.13296","is_oa":false,"landing_page_url":"https://doi.org/10.1111/pai.13296","pdf_url":null,"source":{"id":"https://openalex.org/S191932905","display_name":"Pediatric Allergy and Immunology","issn_l":"0905-6157","issn":["0905-6157","1399-3038"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Allergy and Immunology","raw_type":"journal-article"},{"id":"pmid:32460384","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32460384","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:7373631","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC7704725","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:7704725","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7704725/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Pediatr Allergy Immunol","raw_type":"Text"},{"id":"pmh:oai:HAL:hal-05787871v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-05787871","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pediatric Allergy and Immunology, 2020, 31 (7), pp.755-766. &#x27E8;10.1111/pai.13296&#x27E9;","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:7373631","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC7704725","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G14387232","display_name":"Airway dual-transcriptomics in bronchiolitis and risk of asthma: MARC-35 cohort","funder_award_id":"R01AI137091","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2327143177","display_name":"Nasal microRNA during bronchiolitis and age 6y asthma phenotypes: MARC-35 cohort","funder_award_id":"R01AI127507","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3020830901","display_name":"Host genetics, early-life microbiome, and childhood asthma: MARC-43 Boston","funder_award_id":"UG3OD023253","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3052087465","display_name":"Cytokines & transcriptomes in rhinovirus bronchiolitis and risk of incident asthma","funder_award_id":"R21HL129909","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5137392487","display_name":"Infant specific-IgE, rhinovirus-C bronchiolitis, and incident asthma in MARC-35","funder_award_id":"R01AI114552","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6602906469","display_name":"Viral persistence & the microbiome in bronchiolitis and risk of recurrent wheeze","funder_award_id":"R01AI108588","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6889001707","display_name":"Airway metagenome & metabolome in bronchiolitis and risk of asthma: MARC-35 cohort","funder_award_id":"R01AI134940","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7427679082","display_name":"Prospective Cohort Study of Severe Bronchiolitis and Risk of Recurrent Wheezing","funder_award_id":"U01AI087881","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000073196","display_name":null,"funder_award_id":"UG3/UH3OD-023253","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000875329","display_name":"Host genetics, early-life microbiome, and childhood asthma: MARC-43 Boston","funder_award_id":"UH3OD023253","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000883814","display_name":"Interactions Between the Microbiome, Immunity and Respiratory Health in Traditional Agrarian and Suburban children","funder_award_id":"U19AI104317","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1967190893","https://openalex.org/W2012568595","https://openalex.org/W2039231408","https://openalex.org/W2042459131","https://openalex.org/W2043387305","https://openalex.org/W2105754568","https://openalex.org/W2114191153","https://openalex.org/W2156304672","https://openalex.org/W2168924121","https://openalex.org/W2171592697","https://openalex.org/W2399764698","https://openalex.org/W2559974100","https://openalex.org/W2614636468","https://openalex.org/W2775180852","https://openalex.org/W2781086241","https://openalex.org/W2805658801","https://openalex.org/W2874045491","https://openalex.org/W2889790259","https://openalex.org/W2890965384","https://openalex.org/W2908905692","https://openalex.org/W2909260982","https://openalex.org/W2909840165","https://openalex.org/W2910786449","https://openalex.org/W2926371467","https://openalex.org/W2950985821","https://openalex.org/W2953466678","https://openalex.org/W2988176110","https://openalex.org/W2997436599","https://openalex.org/W3007217927","https://openalex.org/W3016758330"],"related_works":["https://openalex.org/W2781086241","https://openalex.org/W2953466678","https://openalex.org/W3095851051","https://openalex.org/W2909840165","https://openalex.org/W4213365323","https://openalex.org/W4376132947","https://openalex.org/W2901816723","https://openalex.org/W2518261009","https://openalex.org/W7162770440","https://openalex.org/W3126728242"],"abstract_inverted_index":{"BACKGROUND:":[0],"Bronchiolitis":[1],"is":[2,22],"the":[3,10,16,25,50,75,90,104,130,153,156,177,225],"leading":[4],"cause":[5],"of":[6,18,132,144,179,213,218],"infant":[7],"hospitalizations":[8],"in":[9,53,74,113,163],"United":[11],"States.":[12],"Growing":[13],"evidence":[14],"supports":[15],"heterogeneity":[17],"bronchiolitis.":[19,65,219],"However,":[20],"little":[21],"known":[23],"about":[24],"interrelationships":[26],"between":[27,92,228],"major":[28],"respiratory":[29],"viruses":[30,198],"(and":[31],"their":[32,200],"species),":[33],"host":[34,230],"systemic":[35,231],"metabolism,":[36],"and":[37,60,77,97,119,199,215,233],"disease":[38],"pathobiology.":[39,235],"METHODS:":[40],"In":[41,103,121,152],"an":[42],"ongoing":[43],"multicenter":[44],"prospective":[45],"cohort":[46],"study,":[47],"we":[48,107],"profiled":[49],"serum":[51,68,204],"metabolome":[52],"113":[54],"infants":[55],"(63":[56],"RSV-only,":[57],"21":[58],"RV-A,":[59],"29":[61],"RV-C)":[62],"hospitalized":[63],"with":[64,95,129,176,210],"We":[66,87],"identified":[67,108],"metabolites":[69,94,125,158,171],"that":[70,207],"are":[71,208],"most":[72],"discriminatory":[73,93,110,157],"RSV-RV-A":[76,105],"RSV-RV-C":[78,154],"comparisons":[79],"using":[80],"sparse":[81],"partial":[82],"least":[83],"squares":[84],"discriminant":[85],"analysis.":[86],"then":[88],"investigated":[89],"association":[91],"acute":[96,214],"chronic":[98,216],"outcomes.":[99],"RESULTS:":[100],"<":[101],"0.05).":[102],"comparison,":[106,155],"30":[109],"metabolites,":[111],"predominantly":[112],"lipid":[114,164],"metabolism":[115,165],"pathways":[116],"(eg,":[117,135,166,181],"sphingolipids":[118],"carnitines).":[120],"multivariable":[122],"models,":[123],"these":[124],"were":[126,159,172],"significantly":[127,174],"associated":[128,175,209],"risk":[131,178],"clinical":[133],"outcomes":[134,180],"tricosanoyl":[136],"sphingomyelin,":[137],"OR":[138,183],"for":[139,184],"recurrent":[140],"wheezing":[141],"at":[142],"age":[143],"3":[145],"years":[146],"=":[147,191],"1.50;":[148],"95%":[149,193],"CI:":[150,194],"1.05-2.15).":[151],"also":[160,173],"primarily":[161],"involved":[162],"glycerophosphocholines":[167],"[GPCs],":[168],"12,13-diHome).":[169],"These":[170],"1-stearoyl-2-linoleoyl-GPC,":[182],"positive":[185],"pressure":[186],"ventilation":[187],"use":[188],"during":[189],"hospitalization":[190],"0.47;":[192],"0.28-0.78).":[195],"CONCLUSION:":[196],"Respiratory":[197],"species":[201],"had":[202],"distinct":[203],"metabolomic":[205],"signatures":[206],"differential":[211],"risks":[212],"morbidities":[217],"Our":[220],"findings":[221],"advance":[222],"research":[223],"into":[224],"complex":[226],"interrelations":[227],"viruses,":[229],"response,":[232],"bronchiolitis":[234]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2020-06-05T00:00:00"}
