{"id":"https://openalex.org/W3028613610","doi":"https://doi.org/10.1093/jb/mvaa061","title":"The coupling of translational control and stress responses","display_name":"The coupling of translational control and stress responses","publication_year":2020,"publication_date":"2020-05-27","ids":{"openalex":"https://openalex.org/W3028613610","doi":"https://doi.org/10.1093/jb/mvaa061","mag":"3028613610","pmid":"https://pubmed.ncbi.nlm.nih.gov/32484875"},"language":"en","primary_location":{"id":"doi:10.1093/jb/mvaa061","doi":"https://doi.org/10.1093/jb/mvaa061","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jb/mvaa061","pdf_url":null,"source":{"id":"https://openalex.org/S184547178","display_name":"The Journal of Biochemistry","issn_l":"0021-924X","issn":["0021-924X","1756-2651"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Biochemistry","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076366653","display_name":"Ryan Houston","orcid":"https://orcid.org/0000-0001-9494-2514","observed_orcids":["https://orcid.org/0000-0001-9494-2514"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan Houston","raw_affiliation_strings":["Aging Institute, Department of Medicine, University of Pittsburgh, 100 Technology Drive, Pittsburgh, PA, 15219 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aging Institute, Department of Medicine, University of Pittsburgh, 100 Technology Drive, Pittsburgh, PA, 15219 USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055915480","display_name":"Shiori Sekine","orcid":"https://orcid.org/0000-0001-9962-833X","observed_orcids":["https://orcid.org/0000-0001-9962-833X"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shiori Sekine","raw_affiliation_strings":["Aging Institute, Department of Medicine, University of Pittsburgh, 100 Technology Drive, Pittsburgh, PA, 15219 USA","Division of Cardiology, Department of Medicine, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aging Institute, Department of Medicine, University of Pittsburgh, 100 Technology Drive, Pittsburgh, PA, 15219 USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Division of Cardiology, Department of Medicine, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078318814","display_name":"Yusuke Sekine","orcid":"https://orcid.org/0000-0003-0345-1416","observed_orcids":["https://orcid.org/0000-0003-0345-1416"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yusuke Sekine","raw_affiliation_strings":["Aging Institute, Department of Medicine, University of Pittsburgh, 100 Technology Drive, Pittsburgh, PA, 15219 USA","Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA"],"raw_orcid":"https://orcid.org/0000-0003-0345-1416","affiliations":[{"raw_affiliation_string":"Aging Institute, Department of Medicine, University of Pittsburgh, 100 Technology Drive, Pittsburgh, PA, 15219 USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5078318814"],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":{"value":3276,"currency":"USD","value_usd":3276},"apc_paid":null,"fwci":0.2439,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.20389666,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"168","issue":"2","first_page":"93","last_page":"102"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.5015000104904175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.5015000104904175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.44679999351501465,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.0210999995470047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/integrated-stress-response","display_name":"integrated stress response","score":0.9559999704360962},{"id":"https://openalex.org/keywords/nucleolar-stress-response","display_name":"nucleolar stress response","score":0.9990000128746033},{"id":"https://openalex.org/keywords/translational-control","display_name":"translational regulation","score":0.9020000100135803},{"id":"https://openalex.org/keywords/stress-adaptation","display_name":"stress adaptation","score":0.5239999890327454},{"id":"https://openalex.org/keywords/ribosome-biogenesis","display_name":"ribosome biogenesis","score":0.8230000138282776},{"id":"https://openalex.org/keywords/nucleolus","display_name":"nucleolus","score":0.718999981880188},{"id":"https://openalex.org/keywords/stress-responsive-transcription-factors","display_name":"stress-responsive transcription factors","score":0.8309999704360962},{"id":"https://openalex.org/keywords/mrna-translation","display_name":"mRNA translation","score":0.656000018119812}],"concepts":[{"id":"https://openalex.org/C183873130","wikidata":"https://www.wikidata.org/wiki/Q30869","display_name":"Nucleolus","level":3,"score":0.6995523571968079},{"id":"https://openalex.org/C88478588","wikidata":"https://www.wikidata.org/wiki/Q42244","display_name":"Ribosome","level":4,"score":0.6578823328018188},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.6566200256347656},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.6495925188064575},{"id":"https://openalex.org/C2779638656","wikidata":"https://www.wikidata.org/wiki/Q6043166","display_name":"Integrated stress response","level":5,"score":0.6285345554351807},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.6202528476715088},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5471280813217163},{"id":"https://openalex.org/C77430603","wikidata":"https://www.wikidata.org/wiki/Q166992","display_name":"Internal ribosome entry site","level":5,"score":0.46490585803985596},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.4616031050682068},{"id":"https://openalex.org/C117838200","wikidata":"https://www.wikidata.org/wiki/Q14592582","display_name":"Stress granule","level":5,"score":0.4451940953731537},{"id":"https://openalex.org/C4718897","wikidata":"https://www.wikidata.org/wiki/Q5408698","display_name":"Eukaryotic translation","level":5,"score":0.44069185853004456},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4302275478839874},{"id":"https://openalex.org/C39685955","wikidata":"https://www.wikidata.org/wiki/Q3455905","display_name":"Translational regulation","level":5,"score":0.4239363372325897},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34580352902412415},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.34454402327537537},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.25832635164260864},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15675589442253113},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.07315590977668762},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/jb/mvaa061","doi":"https://doi.org/10.1093/jb/mvaa061","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jb/mvaa061","pdf_url":null,"source":{"id":"https://openalex.org/S184547178","display_name":"The Journal of Biochemistry","issn_l":"0021-924X","issn":["0021-924X","1756-2651"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Biochemistry","raw_type":"journal-article"},{"id":"pmid:32484875","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32484875","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310174","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":74,"referenced_works":["https://openalex.org/W955991595","https://openalex.org/W1533132945","https://openalex.org/W1546139069","https://openalex.org/W1963731318","https://openalex.org/W1973568206","https://openalex.org/W1999962568","https://openalex.org/W2002373110","https://openalex.org/W2025483501","https://openalex.org/W2046278771","https://openalex.org/W2048642489","https://openalex.org/W2051299739","https://openalex.org/W2058056744","https://openalex.org/W2067040999","https://openalex.org/W2069501602","https://openalex.org/W2084929037","https://openalex.org/W2086699218","https://openalex.org/W2102049218","https://openalex.org/W2105515478","https://openalex.org/W2107405224","https://openalex.org/W2109535551","https://openalex.org/W2118061721","https://openalex.org/W2131651601","https://openalex.org/W2141836580","https://openalex.org/W2160718564","https://openalex.org/W2161764950","https://openalex.org/W2253619593","https://openalex.org/W2283649807","https://openalex.org/W2341404981","https://openalex.org/W2413047328","https://openalex.org/W2427010553","https://openalex.org/W2474866772","https://openalex.org/W2518855060","https://openalex.org/W2518959324","https://openalex.org/W2553622516","https://openalex.org/W2618870156","https://openalex.org/W2735295607","https://openalex.org/W2756821926","https://openalex.org/W2775790403","https://openalex.org/W2794506661","https://openalex.org/W2800107604","https://openalex.org/W2803484355","https://openalex.org/W2806793653","https://openalex.org/W2809836824","https://openalex.org/W2809852917","https://openalex.org/W2840677322","https://openalex.org/W2884910505","https://openalex.org/W2887287746","https://openalex.org/W2889300844","https://openalex.org/W2898847657","https://openalex.org/W2904037237","https://openalex.org/W2906537904","https://openalex.org/W2912998668","https://openalex.org/W2917382201","https://openalex.org/W2940064563","https://openalex.org/W2941675075","https://openalex.org/W2942134847","https://openalex.org/W2942723805","https://openalex.org/W2955366227","https://openalex.org/W2955962786","https://openalex.org/W2956385297","https://openalex.org/W2966957401","https://openalex.org/W2973552995","https://openalex.org/W2984765289","https://openalex.org/W2990720509","https://openalex.org/W2991612307","https://openalex.org/W3004510051","https://openalex.org/W3005263787","https://openalex.org/W3009398305","https://openalex.org/W3010473434","https://openalex.org/W3011397951","https://openalex.org/W3012687886","https://openalex.org/W3216175899","https://openalex.org/W4240290525","https://openalex.org/W4248965642"],"related_works":["https://openalex.org/W2940950898","https://openalex.org/W3049255949","https://openalex.org/W3012131425","https://openalex.org/W4200138877","https://openalex.org/W4396769577","https://openalex.org/W4381851525","https://openalex.org/W4410343782","https://openalex.org/W4328049394","https://openalex.org/W4413969287","https://openalex.org/W2773247080"],"abstract_inverted_index":{"The":[0],"translation":[1,37,43,62],"of":[2,28,85,91,111,132],"messenger":[3],"RNA":[4],"(mRNA)":[5],"into":[6,17],"protein":[7],"is":[8,20],"a":[9,24,33],"multistep":[10],"process":[11],"by":[12,38,115],"which":[13,112],"genetic":[14],"information":[15],"transcribed":[16],"an":[18],"mRNA":[19],"decoded":[21],"to":[22,88],"produce":[23],"specific":[25],"polypeptide":[26],"chain":[27],"amino":[29],"acids.":[30],"Ribosomes":[31],"play":[32],"central":[34],"role":[35],"in":[36,55,64],"coordinately":[39],"working":[40],"with":[41,78],"various":[42,116],"regulatory":[44],"factors":[45],"and":[46,72,104,118,135,137,141],"aminoacyl-transfer":[47],"RNAs.":[48],"Various":[49],"stresses":[50],"attenuate":[51],"the":[52,56,61,65,83,89,99,105,128,133],"ribosomal":[53],"synthesis":[54],"nucleolus":[57],"as":[58,60],"well":[59],"rate":[63],"cytosol.":[66],"To":[67],"efficiently":[68],"reallocate":[69],"cellular":[70],"energy":[71],"resources,":[73],"mammalian":[74],"cells":[75],"are":[76,113],"endowed":[77],"mechanisms":[79,131],"that":[80],"directly":[81],"link":[82],"suppression":[84],"translation-related":[86],"processes":[87],"activation":[90],"stress":[92,101,107],"adaptation":[93],"programmes.":[94],"This":[95],"review":[96],"focuses":[97],"on":[98],"integrated":[100],"response":[102,108],"(ISR)":[103],"nucleolar":[106],"(NSR)":[109],"both":[110],"activated":[114],"stressors":[117],"selectively":[119],"upregulate":[120],"stress-responsive":[121],"transcription":[122],"factors.":[123],"Emerging":[124],"findings":[125],"have":[126],"delineated":[127],"detailed":[129],"molecular":[130],"ISR":[134],"NSR":[136],"expanded":[138],"their":[139],"physiological":[140],"pathological":[142],"significances.":[143]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-06-05T00:00:00"}