{"id":"https://openalex.org/W3028566271","doi":null,"title":"MicroRNA-142-3p inhibits proliferation and induces apoptosis by targeting the high-mobility group box 1 via the Wnt/\u03b2-catenin signaling pathway in glioma.","display_name":"MicroRNA-142-3p inhibits proliferation and induces apoptosis by targeting the high-mobility group box 1 via the Wnt/\u03b2-catenin signaling pathway in glioma.","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W3028566271","mag":"3028566271","pmid":"https://pubmed.ncbi.nlm.nih.gov/31949846","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6962963"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:5916315","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6962963","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6962963","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100424958","display_name":"Chong V. Li","orcid":"https://orcid.org/0000-0003-2823-7360","observed_orcids":["https://orcid.org/0000-0003-2823-7360","https://orcid.org/0000-0003-4340-7436"]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chong Li","raw_affiliation_strings":["Department of Neurosurgery, Chinese PLA General Hospital Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Chinese PLA General Hospital Beijing, China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103162613","display_name":"Shiyu Feng","orcid":"https://orcid.org/0009-0001-3060-541X","observed_orcids":["https://orcid.org/0009-0001-3060-541X"]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shiyu Feng","raw_affiliation_strings":["Department of Neurosurgery, Chinese PLA General Hospital Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Chinese PLA General Hospital Beijing, China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100411137","display_name":"Ling Chen","orcid":"https://orcid.org/0000-0003-1485-1626","observed_orcids":["https://orcid.org/0000-0003-1485-1626","https://orcid.org/0000-0002-0150-4433","https://orcid.org/0000-0003-2336-2779"]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ling Chen","raw_affiliation_strings":["Department of Neurosurgery, Chinese PLA General Hospital Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Chinese PLA General Hospital Beijing, China","institution_ids":["https://openalex.org/I2802939634"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2802939634"],"apc_list":null,"apc_paid":null,"fwci":0.302,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.45202533,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"11","issue":"9","first_page":"4493","last_page":"4502"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hmgb1","display_name":"HMGB1","score":0.925000011920929},{"id":"https://openalex.org/keywords/glioma","display_name":"glioma","score":0.8529999852180481},{"id":"https://openalex.org/keywords/wnt-beta-catenin-signaling","display_name":"Wnt/\u03b2-catenin signaling","score":0.9559999704360962},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8370000123977661},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9929999709129333},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.921999990940094},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.8769999742507935},{"id":"https://openalex.org/keywords/tumor-suppressor-microrna","display_name":"tumor suppressor microRNA","score":0.8389999866485596},{"id":"https://openalex.org/keywords/microrna-target-regulation","display_name":"microRNA target regulation","score":0.6809999942779541}],"concepts":[{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.8107465505599976},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.7782221436500549},{"id":"https://openalex.org/C2775934118","wikidata":"https://www.wikidata.org/wiki/Q424169","display_name":"Propidium iodide","level":4,"score":0.7718195915222168},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5945041179656982},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.5889182090759277},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5873062014579773},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5802544951438904},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5674432516098022},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.4955326318740845},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4844474792480469},{"id":"https://openalex.org/C88634738","wikidata":"https://www.wikidata.org/wiki/Q24769543","display_name":"Annexin","level":3,"score":0.46814969182014465},{"id":"https://openalex.org/C2780545709","wikidata":"https://www.wikidata.org/wiki/Q21130552","display_name":"HMGB1","level":3,"score":0.46306198835372925},{"id":"https://openalex.org/C30145163","wikidata":"https://www.wikidata.org/wiki/Q384104","display_name":"Catenin","level":4,"score":0.45128071308135986},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38073107600212097},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.354690819978714},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.21962863206863403},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.14509320259094238},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05617457628250122},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:5916315","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6962963","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:31949846","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31949846","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental pathology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6962963","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6962963/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},{"id":"mag:3028566271","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31949846","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5916315","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6962963","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W148937266","https://openalex.org/W160565749","https://openalex.org/W1532588118","https://openalex.org/W1928785194","https://openalex.org/W1997951995","https://openalex.org/W2006247279","https://openalex.org/W2010573862","https://openalex.org/W2014649281","https://openalex.org/W2017927877","https://openalex.org/W2037878614","https://openalex.org/W2040212491","https://openalex.org/W2047230902","https://openalex.org/W2052094075","https://openalex.org/W2074113548","https://openalex.org/W2075035271","https://openalex.org/W2084335435","https://openalex.org/W2086551357","https://openalex.org/W2091416541","https://openalex.org/W2104958914","https://openalex.org/W2110881853","https://openalex.org/W2116126240","https://openalex.org/W2135818780","https://openalex.org/W2143758659","https://openalex.org/W2148977460","https://openalex.org/W2151182769","https://openalex.org/W2161619169","https://openalex.org/W2193521649","https://openalex.org/W2230420449","https://openalex.org/W2292817566","https://openalex.org/W2414059429","https://openalex.org/W2509412261","https://openalex.org/W2546422624","https://openalex.org/W2566753678","https://openalex.org/W2587151574","https://openalex.org/W2604973399","https://openalex.org/W2614770255","https://openalex.org/W2734616814","https://openalex.org/W2736032066","https://openalex.org/W2766901760","https://openalex.org/W2786576778","https://openalex.org/W2790059016","https://openalex.org/W2791579928","https://openalex.org/W2792082902","https://openalex.org/W4230172521"],"related_works":["https://openalex.org/W4387774958","https://openalex.org/W2929044810","https://openalex.org/W2344056558","https://openalex.org/W3032300160","https://openalex.org/W2029888594","https://openalex.org/W3187260913","https://openalex.org/W2112795018","https://openalex.org/W2390527994","https://openalex.org/W2687798390","https://openalex.org/W2999246191"],"abstract_inverted_index":{"BACKGROUND:":[0],"Glioma":[1],"is":[2],"one":[3],"of":[4,21,41,46,61,99,127,151,212,219,227],"the":[5,19,36,44,82,125,195,207,215,224],"most":[6],"common":[7],"brain":[8],"tumors.":[9],"Copious":[10],"microRNAs":[11],"have":[12],"been":[13,26],"identified":[14],"as":[15,28],"critical":[16],"regulators":[17],"in":[18,32,43,140,166,181,199,214],"development":[20,45],"glioma.":[22,232],"MicroRNA-142-3p":[23],"(miR-142-3p)":[24],"has":[25],"reported":[27],"a":[29,74,149,203],"tumor":[30],"suppressor":[31],"some":[33],"malignancies.":[34],"However,":[35],"roles":[37,208],"and":[38,63,73,86,104,130,160,174,188,209,217,222,229],"molecular":[39,210],"mechanisms":[40],"miR-142-3p":[42,62,85,157,170,213,228],"glioma":[47,141,167,182,200,220],"are":[48],"poorly":[49],"defined.":[50],"METHODS:":[51],"An":[52],"RT-qPCR":[53],"assay":[54,77,92],"was":[55,93,109,119,137,148],"carried":[56],"out":[57],"to":[58,80,95],"detect":[59],"expressions":[60],"high-mobility":[64],"group":[65],"box":[66],"1":[67],"(HMGB1)":[68],"mRNA.":[69],"A":[70,89],"bioinformatic":[71],"analysis":[72],"luciferase":[75],"reporter":[76],"were":[78],"used":[79],"explore":[81],"interaction":[83],"between":[84],"HMGB1":[87,147,165,180,193,230],"3'UTR.":[88],"Western":[90],"blot":[91],"performed":[94],"examine":[96],"protein":[97],"expression":[98,136],"HMGB1,":[100],"c-myc,":[101],"cleaved":[102],"caspase-3,":[103],"\u03b2-catenin.":[105],"Cell":[106],"proliferative":[107],"ability":[108],"assessed":[110],"by":[111,163,178,191],"an":[112],"MTS":[113],"assay.":[114],"The":[115],"cell":[116],"apoptotic":[117],"rate":[118],"measured":[120],"using":[121],"flow":[122],"cytometry":[123],"via":[124,194],"double-staining":[126],"Annexin":[128],"V-FITC":[129],"propidium":[131],"iodide":[132],"(PI).":[133],"RESULTS:":[134],"MiR-142-3p":[135,185],"remarkably":[138],"reduced":[139],"tissues.":[142],"Mechanical":[143],"analyses":[144],"showed":[145],"that":[146,156],"target":[150],"miR-142-3p.":[152],"Functional":[153],"investigations":[154],"revealed":[155],"suppressed":[158],"proliferation":[159,187,216],"induced":[161],"apoptosis":[162,190,218],"targeting":[164,179,192],"cells.":[168,183],"Moreover,":[169],"inactivated":[171],"Wnt/\u03b2-catenin":[172,196],"signaling":[173,177,197],"activated":[175],"caspase-3":[176],"CONCLUSION:":[184],"inhibits":[186],"induces":[189],"pathway":[198],"cells,":[201],"providing":[202],"deep":[204],"exploration":[205],"into":[206],"basis":[211],"cells":[221],"highlighting":[223],"therapeutical":[225],"values":[226],"for":[231]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-05-29T00:00:00"}