{"id":"https://openalex.org/W3028406367","doi":"https://doi.org/10.1016/s0016-5085(20)32654-8","title":"Mo1113 GENOTYPING OF NUDT15 R139C PRIOR TO THIOPURINE TREATMENT REDUCES INCIDENCE OF LEUKOPENIA IN JAPANESE PATIENTS WITH INFLAMMATORY BOWEL DISEASES.","display_name":"Mo1113 GENOTYPING OF NUDT15 R139C PRIOR TO THIOPURINE TREATMENT REDUCES INCIDENCE OF LEUKOPENIA IN JAPANESE PATIENTS WITH INFLAMMATORY BOWEL DISEASES.","publication_year":2020,"publication_date":"2020-05-01","ids":{"openalex":"https://openalex.org/W3028406367","doi":"https://doi.org/10.1016/s0016-5085(20)32654-8","mag":"3028406367"},"language":"en","primary_location":{"id":"doi:10.1016/s0016-5085(20)32654-8","doi":"https://doi.org/10.1016/s0016-5085(20)32654-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0016-5085(20)32654-8","pdf_url":null,"source":{"id":"https://openalex.org/S143352558","display_name":"Gastroenterology","issn_l":"0016-5085","issn":["0016-5085","1528-0012"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034412681","display_name":"Yoichi Kakuta","orcid":"https://orcid.org/0000-0002-7042-009X","observed_orcids":["https://orcid.org/0000-0002-7042-009X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yoichi Kakuta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082467421","display_name":"Yushi Inomata","orcid":"https://orcid.org/0000-0003-0566-2559","observed_orcids":["https://orcid.org/0000-0003-0566-2559"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yushi Inomata","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Daisuke Okamoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daisuke Okamoto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113855635","display_name":"Takeru Nakano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takeru Nakano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050265017","display_name":"Yasuhiro Izumiyama","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yasuhiro Izumiyama","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015058164","display_name":"Ryo Ichikawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ryo Ichikawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063199955","display_name":"Rintaro Moroi","orcid":"https://orcid.org/0000-0002-6759-0135","observed_orcids":["https://orcid.org/0000-0002-6759-0135"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rintaro Moroi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040076561","display_name":"Masatake Kuroha","orcid":"https://orcid.org/0000-0001-7614-9977","observed_orcids":["https://orcid.org/0000-0001-7614-9977"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masatake Kuroha","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113889891","display_name":"Yoshitake Kanazawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yoshitake Kanazawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071040721","display_name":"Hisashi Shiga","orcid":"https://orcid.org/0000-0001-6623-2603","observed_orcids":["https://orcid.org/0000-0001-6623-2603"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hisashi Shiga","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043020113","display_name":"Yoshitaka Kinouchi","orcid":"https://orcid.org/0000-0002-3368-8855","observed_orcids":["https://orcid.org/0000-0002-3368-8855"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yoshitaka Kinouchi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5044706381","display_name":"Atsushi Masamune","orcid":"https://orcid.org/0000-0001-7184-7282","observed_orcids":["https://orcid.org/0000-0001-7184-7282"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Atsushi Masamune","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"158","issue":"6","first_page":"S","last_page":"792"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.6669999957084656,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.6669999957084656,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.2904999852180481,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nudt15","display_name":"NUDT15","score":0.9520000219345093},{"id":"https://openalex.org/keywords/thiopurine-therapy","display_name":"thiopurine therapy","score":0.8619999885559082},{"id":"https://openalex.org/keywords/leukopenia","display_name":"leukopenia","score":0.9570000171661377},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.9819999933242798},{"id":"https://openalex.org/keywords/thiopurine-toxicity","display_name":"thiopurine toxicity","score":0.5519999861717224},{"id":"https://openalex.org/keywords/japanese-patients","display_name":"Japanese patients","score":0.6230000257492065}],"concepts":[{"id":"https://openalex.org/C70917649","wikidata":"https://www.wikidata.org/wiki/Q94307","display_name":"Thiopurine methyltransferase","level":4,"score":0.9667776823043823},{"id":"https://openalex.org/C2780873365","wikidata":"https://www.wikidata.org/wiki/Q496812","display_name":"Leukopenia","level":3,"score":0.9154499769210815},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7870017886161804},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.7199752330780029},{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.6509116291999817},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6417131423950195},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6390913724899292},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.4571346044540405},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.1561991274356842},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.14584454894065857},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07005774974822998},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06475260853767395},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.05120953917503357},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s0016-5085(20)32654-8","doi":"https://doi.org/10.1016/s0016-5085(20)32654-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0016-5085(20)32654-8","pdf_url":null,"source":{"id":"https://openalex.org/S143352558","display_name":"Gastroenterology","issn_l":"0016-5085","issn":["0016-5085","1528-0012"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2605484031","https://openalex.org/W4396642618","https://openalex.org/W2336779009","https://openalex.org/W2943626098","https://openalex.org/W4213135366","https://openalex.org/W3026503101","https://openalex.org/W2784861588","https://openalex.org/W3029081290","https://openalex.org/W2607401310","https://openalex.org/W2621222150"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2020-05-29T00:00:00"}