{"id":"https://openalex.org/W302802154","doi":null,"title":"All-trans retinoic acid modulates Fas antigen expression and affects cell proliferation and apoptosis in combination with anti-Fas monoclonal antibody in the human myeloma cell line, U266B1.","display_name":"All-trans retinoic acid modulates Fas antigen expression and affects cell proliferation and apoptosis in combination with anti-Fas monoclonal antibody in the human myeloma cell line, U266B1.","publication_year":1998,"publication_date":"1998-06-01","ids":{"openalex":"https://openalex.org/W302802154","mag":"302802154","pmid":"https://pubmed.ncbi.nlm.nih.gov/9620283"},"language":"en","primary_location":{"id":"pmid:9620283","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9620283","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental hematology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"T Okamura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T Okamura","raw_affiliation_strings":["Department of Hematology, Tokyo Women's Medical College, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Tokyo Women's Medical College, Japan","institution_ids":["https://openalex.org/I4210136522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088475877","display_name":"Moe Masuda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Masuda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109094651","display_name":"Yukari Arai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Arai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109849279","display_name":"Chiharu Ishida","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Ishida","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043935014","display_name":"K Shudou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Shudou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5003596492","display_name":"Hiroyuki Mizoguchi","orcid":"https://orcid.org/0000-0001-6993-4184","observed_orcids":["https://orcid.org/0000-0001-6993-4184"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Mizoguchi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2907,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.45179754,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"26","issue":"6","first_page":"501","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.6381999850273132,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.6381999850273132,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.3037000000476837,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.050599999725818634,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/all-trans-retinoic-acid","display_name":"all-trans retinoic acid","score":1.0},{"id":"https://openalex.org/keywords/fas-antigen","display_name":"Fas antigen","score":0.8809999823570251},{"id":"https://openalex.org/keywords/anti-fas-monoclonal-antibody","display_name":"anti-Fas monoclonal antibody","score":0.9390000104904175},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.8420000076293945},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9599999785423279},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.75},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.9850000143051147},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.8019999861717224}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6941313743591309},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.5600047707557678},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.5582418441772461},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5517180562019348},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5299616456031799},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.47487494349479675},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.46261125802993774},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4521331191062927},{"id":"https://openalex.org/C2779963572","wikidata":"https://www.wikidata.org/wiki/Q29417","display_name":"Tretinoin","level":4,"score":0.4103415608406067},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.41002315282821655},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3893508315086365},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.331863671541214},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22681763768196106},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1021101176738739},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007641","descriptor_name":"Keratolytic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019014","descriptor_name":"fas Receptor","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:9620283","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9620283","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental hematology","raw_type":"Journal Article"},{"id":"mag:302802154","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9620283","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2403444701","https://openalex.org/W2409858545","https://openalex.org/W2153923717","https://openalex.org/W2024551869","https://openalex.org/W2411607875","https://openalex.org/W2055192493","https://openalex.org/W2160683030","https://openalex.org/W329959312","https://openalex.org/W2185575110","https://openalex.org/W2062735780"],"abstract_inverted_index":{"All-trans":[0],"retinoic":[1],"acid":[2],"(ATRA)":[3],"is":[4],"a":[5,110],"vitamin":[6],"A":[7],"derivative":[8],"that":[9,27,55,83,97,142,161],"induces":[10],"the":[11,30,36,45,78,89,143,173,179],"differentiation":[12],"of":[13,32,38,47,64,112,147,175,181],"myeloid":[14],"leukemia":[15],"cells":[16,57,66,107,119,154],"in":[17,20,62,88,106,135,153,162],"vitro":[18],"and":[19,35,42,61,101,115,170,183],"vivo.":[21],"Several":[22],"investigators":[23],"have":[24],"recently":[25],"reported":[26,54],"ATRA":[28,84,116,129,171],"downregulates":[29],"production":[31],"interleukin-6":[33],"(IL-6)":[34],"expression":[37,87,180],"IL-6":[39],"receptor":[40],"(IL-6R)":[41],"also":[43,52,126],"inhibits":[44],"proliferation":[46],"myeloma":[48,56,91],"cells.":[49,137],"It":[50],"has":[51],"been":[53],"express":[58],"Fas":[59,86,182],"antigen,":[60],"some":[63],"these":[65],"apoptosis":[67,99,176],"was":[68,150],"induced":[69],"by":[70,177,185],"treatment":[71,123,166],"with":[72,118,156,167],"anti-Fas":[73,113,168],"monoclonal":[74],"antibody":[75],"(mAb).":[76],"In":[77],"present":[79],"study,":[80],"we":[81],"demonstrated":[82],"increased":[85],"human":[90],"cell":[92],"line,":[93],"U266B1.":[94],"We":[95,125],"observed":[96],"both":[98],"induction":[100,174],"growth":[102],"inhibition":[103],"were":[104],"enhanced":[105],"exposed":[108,120],"to":[109,121],"combination":[111],"mAb":[114,169],"compared":[117],"either":[122],"alone.":[124],"examined":[127],"whether":[128],"modulated":[130],"bcl-2,":[131],"an":[132],"anti-apoptosis":[133],"protein,":[134],"U266B1":[136,163],"Flow":[138],"cytometry":[139],"analysis":[140],"revealed":[141],"mean":[144],"fluorescence":[145],"intensity":[146],"bcl-2":[148,184],"protein":[149],"slightly":[151],"decreased":[152],"treated":[155],"ATRA.":[157,186],"These":[158],"results":[159],"indicate":[160],"cells,":[164],"combined":[165],"enhances":[172],"modulating":[178]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
