{"id":"https://openalex.org/W3027877124","doi":"https://doi.org/10.1134/s0006297920050041","title":"Immune Response and Protective Efficacy of Inactivated and Live Influenza Vaccines Against Homologous and Heterosubtypic Challenge","display_name":"Immune Response and Protective Efficacy of Inactivated and Live Influenza Vaccines Against Homologous and Heterosubtypic Challenge","publication_year":2020,"publication_date":"2020-05-01","ids":{"openalex":"https://openalex.org/W3027877124","doi":"https://doi.org/10.1134/s0006297920050041","mag":"3027877124","pmid":"https://pubmed.ncbi.nlm.nih.gov/32571185"},"language":"en","primary_location":{"id":"doi:10.1134/s0006297920050041","doi":"https://doi.org/10.1134/s0006297920050041","is_oa":false,"landing_page_url":"https://doi.org/10.1134/s0006297920050041","pdf_url":null,"source":{"id":"https://openalex.org/S71215691","display_name":"Biochemistry (Moscow)","issn_l":"0006-2979","issn":["0006-2979","0320-9725","1608-3040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320267","host_organization_name":"Pleiades Publishing","host_organization_lineage":["https://openalex.org/P4310320267","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Pleiades Publishing","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry (Moscow)","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109575410","display_name":"Elizaveta Yu. Boravleva","orcid":"https://orcid.org/0000-0001-8491-4640","observed_orcids":["https://orcid.org/0000-0001-8491-4640"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"E. Y. Boravleva","raw_affiliation_strings":["Chumakov Federal Scientific Center for Research and Development of Immune and Biological Products, Russian Academy of Sciences, Moscow, 108819, Russia","Chumakov Federal Scientific Center for Research and Development of Immune and Biological Products, Russian Academy of Sciences, 108819, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chumakov Federal Scientific Center for Research and Development of Immune and Biological Products, Russian Academy of Sciences, Moscow, 108819, Russia","institution_ids":["https://openalex.org/I1313323035"]},{"raw_affiliation_string":"Chumakov Federal Scientific Center for Research and Development of Immune and Biological Products, Russian Academy of Sciences, 108819, Moscow, Russia","institution_ids":["https://openalex.org/I1313323035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072878843","display_name":"\u041b\u0443\u043d\u0438\u0446\u0438\u043d \u0410\u043d\u0434\u0440\u0435\u0439 \u0412\u043b\u0430\u0434\u0438\u043c\u0438\u0440\u043e\u0432\u0438\u0447","orcid":"https://orcid.org/0000-0002-5043-446X","observed_orcids":["https://orcid.org/0000-0002-5043-446X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. V. Lunitsin","raw_affiliation_strings":["FSBSI Federal Research Center for Virology and Microbiology, Volginsky, Vladimir Region, 601125, Russia","FSBSI Federal Research Center for Virology and Microbiology, 601125, Volginsky, Vladimir Region, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FSBSI Federal Research Center for Virology and Microbiology, Volginsky, Vladimir Region, 601125, Russia","institution_ids":[]},{"raw_affiliation_string":"FSBSI Federal Research Center for Virology and Microbiology, 601125, Volginsky, Vladimir Region, Russia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015894304","display_name":"Alexander P Kaplun","orcid":"https://orcid.org/0000-0002-5600-8648","observed_orcids":["https://orcid.org/0000-0002-5600-8648"]},"institutions":[{"id":"https://openalex.org/I208875869","display_name":"Moscow State University of Fine Chemical Technologies","ror":"https://ror.org/04aty2659","country_code":"RU","type":"education","lineage":["https://openalex.org/I208875869"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A. P. Kaplun","raw_affiliation_strings":["Lomonosov Moscow University of Fine Chemical Technology, Moscow, 119571, Russia","Lomonosov Moscow University of Fine Chemical Technology, 119571, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lomonosov Moscow University of Fine Chemical Technology, Moscow, 119571, Russia","institution_ids":["https://openalex.org/I208875869"]},{"raw_affiliation_string":"Lomonosov Moscow University of Fine Chemical Technology, 119571, Moscow, Russia","institution_ids":["https://openalex.org/I208875869"]}]},{"author_position":"middle","author":{"id":null,"display_name":"N. V. Bykova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I208875869","display_name":"Moscow State University of Fine Chemical Technologies","ror":"https://ror.org/04aty2659","country_code":"RU","type":"education","lineage":["https://openalex.org/I208875869"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"N. V. Bykova","raw_affiliation_strings":["Lomonosov Moscow University of Fine Chemical Technology, Moscow, 119571, Russia","Lomonosov Moscow University of Fine Chemical Technology, 119571, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lomonosov Moscow University of Fine Chemical Technology, Moscow, 119571, Russia","institution_ids":["https://openalex.org/I208875869"]},{"raw_affiliation_string":"Lomonosov Moscow University of Fine Chemical Technology, 119571, Moscow, Russia","institution_ids":["https://openalex.org/I208875869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091808110","display_name":"Igor V. Krasilnikov","orcid":"https://orcid.org/0000-0002-5048-7828","observed_orcids":["https://orcid.org/0000-0002-5048-7828"]},"institutions":[{"id":"https://openalex.org/I64264942","display_name":"Federal Medical-Biological Agency","ror":"https://ror.org/052ay8m85","country_code":"RU","type":"government","lineage":["https://openalex.org/I64264942"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"I. V. Krasilnikov","raw_affiliation_strings":["Saint Petersburg Institute of Vaccines and Sera, FMBA, St.-Petersburg, 198320, Russia","Saint Petersburg Institute of Vaccines and Sera, FMBA, 198320, St.-Petersburg, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Saint Petersburg Institute of Vaccines and Sera, FMBA, St.-Petersburg, 198320, Russia","institution_ids":["https://openalex.org/I64264942"]},{"raw_affiliation_string":"Saint Petersburg Institute of Vaccines and Sera, FMBA, 198320, St.-Petersburg, Russia","institution_ids":["https://openalex.org/I64264942"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033864258","display_name":"A. S. Gambaryan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"A. S. Gambaryan","raw_affiliation_strings":["Chumakov Federal Scientific Center for Research and Development of Immune and Biological Products, Russian Academy of Sciences, Moscow, 108819, Russia. al.gambaryan@gmail.com","Chumakov Federal Scientific Center for Research and Development of Immune and Biological Products, Russian Academy of Sciences, 108819, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chumakov Federal Scientific Center for Research and Development of Immune and Biological Products, Russian Academy of Sciences, Moscow, 108819, Russia. al.gambaryan@gmail.com","institution_ids":["https://openalex.org/I1313323035"]},{"raw_affiliation_string":"Chumakov Federal Scientific Center for Research and Development of Immune and Biological Products, Russian Academy of Sciences, 108819, Moscow, Russia","institution_ids":["https://openalex.org/I1313323035"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5033864258"],"corresponding_institution_ids":["https://openalex.org/I1313323035"],"apc_list":null,"apc_paid":null,"fwci":0.5237,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.61542107,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"85","issue":"5","first_page":"553","last_page":"566"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/influenza-vaccination","display_name":"influenza vaccination","score":0.7940000295639038},{"id":"https://openalex.org/keywords/inactivated-whole-virion-vaccine","display_name":"inactivated whole-virion vaccine","score":0.9210000038146973},{"id":"https://openalex.org/keywords/split-vaccine","display_name":"split vaccine","score":0.9350000023841858},{"id":"https://openalex.org/keywords/protein-subunit-vaccines","display_name":"subunit vaccine","score":0.9670000076293945},{"id":"https://openalex.org/keywords/live-attenuated-vaccine","display_name":"live attenuated vaccine","score":0.9079999923706055},{"id":"https://openalex.org/keywords/adjuvants","display_name":"adjuvants","score":0.8799999952316284},{"id":"https://openalex.org/keywords/heterosubtypic-protection","display_name":"heterosubtypic protection","score":0.8180000185966492},{"id":"https://openalex.org/keywords/h5n1-avian-influenza","display_name":"H5N1 avian influenza","score":0.8610000014305115},{"id":"https://openalex.org/keywords/h1n1-influenza","display_name":"H1N1 influenza","score":0.9980000257492065},{"id":"https://openalex.org/keywords/homologous-challenge","display_name":"homologous challenge","score":0.6480000019073486},{"id":"https://openalex.org/keywords/antibody-isotypes","display_name":"antibody isotypes","score":0.5830000042915344},{"id":"https://openalex.org/keywords/igg1-igg2a-ratio","display_name":"IgG1/IgG2a ratio","score":0.8989999890327454},{"id":"https://openalex.org/keywords/vaccine-immunogenicity","display_name":"vaccine immunogenicity","score":0.777999997138977},{"id":"https://openalex.org/keywords/protective-efficacy","display_name":"protective efficacy","score":0.7300000190734863},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.8450000286102295}],"concepts":[{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.8244638442993164},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.7489349842071533},{"id":"https://openalex.org/C519248777","wikidata":"https://www.wikidata.org/wiki/Q160122","display_name":"Influenza A virus subtype H5N1","level":3,"score":0.6984399557113647},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6961303949356079},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.6493269801139832},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.583113431930542},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5480822920799255},{"id":"https://openalex.org/C133239900","wikidata":"https://www.wikidata.org/wiki/Q2043512","display_name":"Live attenuated influenza vaccine","level":4,"score":0.5412745475769043},{"id":"https://openalex.org/C2780689484","wikidata":"https://www.wikidata.org/wiki/Q383260","display_name":"Influenza vaccine","level":3,"score":0.522020161151886},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5162248611450195},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4855934977531433},{"id":"https://openalex.org/C2776872762","wikidata":"https://www.wikidata.org/wiki/Q3560939","display_name":"Inactivated vaccine","level":3,"score":0.45820215344429016},{"id":"https://openalex.org/C2780441014","wikidata":"https://www.wikidata.org/wiki/Q7907952","display_name":"Vaccine efficacy","level":3,"score":0.42734676599502563},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3877951502799988}],"mesh":[{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007109","descriptor_name":"Immunity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D007252","descriptor_name":"Influenza Vaccines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014611","descriptor_name":"Vaccination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015164","descriptor_name":"Vaccines, Inactivated","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053118","descriptor_name":"Influenza A Virus, H1N1 Subtype","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D053118","descriptor_name":"Influenza A Virus, H1N1 Subtype","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D053124","descriptor_name":"Influenza A Virus, H5N1 Subtype","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D053124","descriptor_name":"Influenza A Virus, H5N1 Subtype","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1134/s0006297920050041","doi":"https://doi.org/10.1134/s0006297920050041","is_oa":false,"landing_page_url":"https://doi.org/10.1134/s0006297920050041","pdf_url":null,"source":{"id":"https://openalex.org/S71215691","display_name":"Biochemistry (Moscow)","issn_l":"0006-2979","issn":["0006-2979","0320-9725","1608-3040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320267","host_organization_name":"Pleiades Publishing","host_organization_lineage":["https://openalex.org/P4310320267","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Pleiades Publishing","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry (Moscow)","raw_type":"journal-article"},{"id":"pmid:32571185","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32571185","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry. Biokhimiia","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8199999928474426}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":84,"referenced_works":["https://openalex.org/W29983323","https://openalex.org/W69286211","https://openalex.org/W430093909","https://openalex.org/W1502090161","https://openalex.org/W1587032376","https://openalex.org/W1589952240","https://openalex.org/W1694578293","https://openalex.org/W1773462395","https://openalex.org/W1886211768","https://openalex.org/W1940590686","https://openalex.org/W1972645614","https://openalex.org/W1975444185","https://openalex.org/W1984012953","https://openalex.org/W1988554741","https://openalex.org/W1997414761","https://openalex.org/W1998032364","https://openalex.org/W2000931015","https://openalex.org/W2004229171","https://openalex.org/W2023143192","https://openalex.org/W2026897086","https://openalex.org/W2029220396","https://openalex.org/W2029935398","https://openalex.org/W2030315639","https://openalex.org/W2040635697","https://openalex.org/W2041252187","https://openalex.org/W2041319603","https://openalex.org/W2044475029","https://openalex.org/W2064731597","https://openalex.org/W2073301645","https://openalex.org/W2074937710","https://openalex.org/W2087557652","https://openalex.org/W2097034992","https://openalex.org/W2100814541","https://openalex.org/W2105225614","https://openalex.org/W2105574883","https://openalex.org/W2106183630","https://openalex.org/W2107106096","https://openalex.org/W2110934884","https://openalex.org/W2111693224","https://openalex.org/W2112594941","https://openalex.org/W2113747628","https://openalex.org/W2118884356","https://openalex.org/W2121984102","https://openalex.org/W2123737591","https://openalex.org/W2134231495","https://openalex.org/W2137312416","https://openalex.org/W2159880992","https://openalex.org/W2170354602","https://openalex.org/W2253235861","https://openalex.org/W2342136111","https://openalex.org/W2412614179","https://openalex.org/W2525353844","https://openalex.org/W2530113419","https://openalex.org/W2559971146","https://openalex.org/W2566790981","https://openalex.org/W2604860767","https://openalex.org/W2613742837","https://openalex.org/W2625413132","https://openalex.org/W2734381755","https://openalex.org/W2737786308","https://openalex.org/W2767396239","https://openalex.org/W2781520831","https://openalex.org/W2785073138","https://openalex.org/W2793097075","https://openalex.org/W2793767391","https://openalex.org/W2793921967","https://openalex.org/W2794060446","https://openalex.org/W2794338384","https://openalex.org/W2795611591","https://openalex.org/W2796989115","https://openalex.org/W2799871299","https://openalex.org/W2885858846","https://openalex.org/W2915616958","https://openalex.org/W2995171498","https://openalex.org/W2995274127","https://openalex.org/W2996177208","https://openalex.org/W2998062811","https://openalex.org/W2998306132","https://openalex.org/W2998914842","https://openalex.org/W3002936250","https://openalex.org/W3103807539","https://openalex.org/W4210978978","https://openalex.org/W4229810677","https://openalex.org/W4256272408"],"related_works":["https://openalex.org/W1502090161","https://openalex.org/W2108953411","https://openalex.org/W3032114176","https://openalex.org/W2891415141","https://openalex.org/W2149093119","https://openalex.org/W1988401450","https://openalex.org/W1977483997","https://openalex.org/W2029369547","https://openalex.org/W1981776490","https://openalex.org/W2091193271"],"abstract_inverted_index":{"Inactivated":[0],"(whole-virion,":[1],"split,":[2],"subunit,":[3],"and":[4,7,19,23,32,57,124,143,162],"adjuvanted)":[5],"vaccines":[6,174],"live":[8,44,134],"attenuated":[9],"vaccine":[10,49,79,97,151],"were":[11,39,165],"tested":[12,117,132],"in":[13,35,167],"parallel":[14],"to":[15,94,99,184],"compare":[16],"their":[17],"immunogenicity":[18],"protective":[20,111],"efficacy.":[21],"Homologous":[22],"heterosubtypic":[24,133,181],"protection":[25,60,138,154],"against":[26,61,139],"the":[27,62,65,77,86,91,95,105,110,114,120,131,140,177,180],"challenge":[28,63,142,178],"with":[29,43,64,128,171,179],"influenza":[30],"H5N1":[31,48,141],"H1N1":[33,150],"viruses":[34,135],"a":[36,51,73,100],"mouse":[37,146],"model":[38],"studied.":[40],"Single":[41],"immunization":[42,170],"or":[45],"inactivated":[46,149],"whole-virion":[47],"elicited":[50],"high":[52],"level":[53],"of":[54,72,76,90,113,130,160],"serum":[55],"antibodies":[56],"provided":[58,136],"complete":[59],"lethal":[66],"A/Chicken/Kurgan/3/05":[67],"(H5N1)":[68],"virus,":[69],"whereas":[70],"application":[71],"single":[74],"dose":[75],"split":[78,96],"was":[80],"much":[81],"less":[82],"effective.":[83],"Adjuvants":[84],"increased":[85,104],"antibody":[87,106],"levels.":[88],"Addition":[89],"Iso-SANP":[92],"adjuvant":[93],"led":[98],"paradoxical":[101],"outcome:":[102],"it":[103],"levels":[107],"but":[108],"reduced":[109,145],"effect":[112],"vaccine.":[115],"All":[116],"adjuvants":[118],"shifted":[119],"ratio":[121],"between":[122],"IgG1":[123],"IgG2a":[125],"antibodies.":[126],"Immunization":[127],"any":[129],"partial":[137],"significantly":[144],"mortality,":[147],"while":[148],"offered":[152],"no":[153],"at":[155],"all.":[156],"More":[157],"severe":[158],"course":[159],"illness":[161],"earlier":[163],"death":[164],"observed":[166],"mice":[168],"after":[169],"adjuvanted":[172],"subunit":[173],"followed":[175],"by":[176],"virus":[182],"compared":[183],"challenged":[185],"unvaccinated":[186],"animals.":[187]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-05-29T00:00:00"}
