{"id":"https://openalex.org/W3027814383","doi":"https://doi.org/10.1016/j.peptides.2020.170332","title":"Pituitary adenylate cyclase-activating polypeptide: Protective effects in stroke and dementia","display_name":"Pituitary adenylate cyclase-activating polypeptide: Protective effects in stroke and dementia","publication_year":2020,"publication_date":"2020-05-21","ids":{"openalex":"https://openalex.org/W3027814383","doi":"https://doi.org/10.1016/j.peptides.2020.170332","mag":"3027814383","pmid":"https://pubmed.ncbi.nlm.nih.gov/32445876"},"language":"en","primary_location":{"id":"doi:10.1016/j.peptides.2020.170332","doi":"https://doi.org/10.1016/j.peptides.2020.170332","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.peptides.2020.170332","pdf_url":null,"source":{"id":"https://openalex.org/S120382301","display_name":"Peptides","issn_l":"0196-9781","issn":["0196-9781","1873-5169"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Peptides","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022254575","display_name":"Naoko Nonaka","orcid":"https://orcid.org/0000-0002-5088-1526","observed_orcids":["https://orcid.org/0000-0002-5088-1526"]},"institutions":[{"id":"https://openalex.org/I119182057","display_name":"SHOWA Medical University","ror":"https://ror.org/04mzk4q39","country_code":"JP","type":"education","lineage":["https://openalex.org/I119182057"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Naoko Nonaka","raw_affiliation_strings":["Department of Oral Anatomy and Developmental Biology, Showa University School of Dentistry, Shinagawa-ku, Tokyo, Japan. Electronic address: choku@dent.showa-u.ac.jp","Department of Oral Anatomy and Developmental Biology, Showa University School of Dentistry, Shinagawa-ku, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Anatomy and Developmental Biology, Showa University School of Dentistry, Shinagawa-ku, Tokyo, Japan. Electronic address: choku@dent.showa-u.ac.jp","institution_ids":["https://openalex.org/I119182057"]},{"raw_affiliation_string":"Department of Oral Anatomy and Developmental Biology, Showa University School of Dentistry, Shinagawa-ku, Tokyo, Japan","institution_ids":["https://openalex.org/I119182057"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054959155","display_name":"William A. Banks","orcid":"https://orcid.org/0000-0002-0496-3619","observed_orcids":["https://orcid.org/0000-0002-0496-3619"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William A. Banks","raw_affiliation_strings":["Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA. Electronic address: wabanks1@uw.edu","Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA. Electronic address: wabanks1@uw.edu","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020196813","display_name":"Seiji Shioda","orcid":"https://orcid.org/0000-0002-4164-6743","observed_orcids":["https://orcid.org/0000-0002-4164-6743"]},"institutions":[{"id":"https://openalex.org/I36296616","display_name":"Hoshi University","ror":"https://ror.org/01mrvbd33","country_code":"JP","type":"education","lineage":["https://openalex.org/I36296616"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Seiji Shioda","raw_affiliation_strings":["Global Research Center for Innovative Life Science, Peptide Drug Innovation, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Shinagawa-ku, Tokyo, Japan. Electronic address: shioda@hoshi.ac.jp","Global Research Center for Innovative Life Science, Peptide Drug Innovation, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Shinagawa-ku, Tokyo, Japan"],"raw_orcid":"https://orcid.org/0000-0002-4164-6743","affiliations":[{"raw_affiliation_string":"Global Research Center for Innovative Life Science, Peptide Drug Innovation, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Shinagawa-ku, Tokyo, Japan. Electronic address: shioda@hoshi.ac.jp","institution_ids":["https://openalex.org/I36296616"]},{"raw_affiliation_string":"Global Research Center for Innovative Life Science, Peptide Drug Innovation, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Shinagawa-ku, Tokyo, Japan","institution_ids":["https://openalex.org/I36296616"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5022254575"],"corresponding_institution_ids":["https://openalex.org/I119182057"],"apc_list":{"value":2700,"currency":"USD","value_usd":2700},"apc_paid":null,"fwci":0.2767,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.20190641,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"130","issue":null,"first_page":"170332","last_page":"170332"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13505","display_name":"Apelin-related biomedical research","score":0.00930000003427267,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pituitary-adenylate-cyclase-activating-polypeptide","display_name":"pituitary adenylate cyclase-activating polypeptide","score":0.9760000109672546},{"id":"https://openalex.org/keywords/pacap","display_name":"PACAP","score":0.984000027179718},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.8849999904632568},{"id":"https://openalex.org/keywords/dementia","display_name":"dementia","score":0.921999990940094},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.9120000004768372},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8659999966621399},{"id":"https://openalex.org/keywords/neurotrophins","display_name":"neurotrophins","score":0.8539999723434448},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.8859999775886536}],"concepts":[{"id":"https://openalex.org/C180526460","wikidata":"https://www.wikidata.org/wiki/Q356240","display_name":"Adenylate kinase","level":3,"score":0.891956090927124},{"id":"https://openalex.org/C2780069284","wikidata":"https://www.wikidata.org/wiki/Q5198121","display_name":"Cyclase","level":3,"score":0.7453808188438416},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.5887582302093506},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.570767343044281},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5186237692832947},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5164359211921692},{"id":"https://openalex.org/C2779496938","wikidata":"https://www.wikidata.org/wiki/Q14907479","display_name":"Pituitary adenylate cyclase-activating peptide","level":5,"score":0.5014140605926514},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44814133644104004},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.38071197271347046},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32852062582969666},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.27836906909942627},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.27375921607017517},{"id":"https://openalex.org/C8330315","wikidata":"https://www.wikidata.org/wiki/Q414964","display_name":"Vasoactive intestinal peptide","level":4,"score":0.16526326537132263},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.12120568752288818},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007858","descriptor_name":"Learning","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008568","descriptor_name":"Memory","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D051219","descriptor_name":"Pituitary Adenylate Cyclase-Activating Polypeptide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051219","descriptor_name":"Pituitary Adenylate Cyclase-Activating Polypeptide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051219","descriptor_name":"Pituitary Adenylate Cyclase-Activating Polypeptide","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.peptides.2020.170332","doi":"https://doi.org/10.1016/j.peptides.2020.170332","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.peptides.2020.170332","pdf_url":null,"source":{"id":"https://openalex.org/S120382301","display_name":"Peptides","issn_l":"0196-9781","issn":["0196-9781","1873-5169"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Peptides","raw_type":"journal-article"},{"id":"pmid:32445876","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32445876","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Peptides","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W84036141","https://openalex.org/W1194913466","https://openalex.org/W1907212729","https://openalex.org/W1939739037","https://openalex.org/W1965397665","https://openalex.org/W1967076681","https://openalex.org/W1968537133","https://openalex.org/W1973349296","https://openalex.org/W1973432238","https://openalex.org/W1981423842","https://openalex.org/W1985876429","https://openalex.org/W1991399785","https://openalex.org/W1996920444","https://openalex.org/W1997975361","https://openalex.org/W1998391893","https://openalex.org/W2000572114","https://openalex.org/W2002783887","https://openalex.org/W2011378958","https://openalex.org/W2011431839","https://openalex.org/W2015267279","https://openalex.org/W2027404254","https://openalex.org/W2031147341","https://openalex.org/W2032994377","https://openalex.org/W2033650768","https://openalex.org/W2034355463","https://openalex.org/W2037647894","https://openalex.org/W2044669233","https://openalex.org/W2051616273","https://openalex.org/W2059111801","https://openalex.org/W2063024845","https://openalex.org/W2067856703","https://openalex.org/W2083985100","https://openalex.org/W2088836474","https://openalex.org/W2089822614","https://openalex.org/W2090023607","https://openalex.org/W2091611675","https://openalex.org/W2094715296","https://openalex.org/W2098511020","https://openalex.org/W2105647466","https://openalex.org/W2118578503","https://openalex.org/W2139560403","https://openalex.org/W2146032033","https://openalex.org/W2151616817","https://openalex.org/W2151875422","https://openalex.org/W2156979070","https://openalex.org/W2167275747","https://openalex.org/W2169222199","https://openalex.org/W2170104232","https://openalex.org/W2286831469","https://openalex.org/W2528945697","https://openalex.org/W2556225042","https://openalex.org/W2606478035","https://openalex.org/W2621998352","https://openalex.org/W2746652197","https://openalex.org/W2892180966","https://openalex.org/W2897815863","https://openalex.org/W2909990629","https://openalex.org/W2990442936","https://openalex.org/W6639686555"],"related_works":["https://openalex.org/W3109965321","https://openalex.org/W2083985100","https://openalex.org/W2063024845","https://openalex.org/W1973349296","https://openalex.org/W4399915809","https://openalex.org/W3030862618","https://openalex.org/W2207507355","https://openalex.org/W2528585653","https://openalex.org/W2343013641","https://openalex.org/W4243429363"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-05-29T00:00:00"}
