{"id":"https://openalex.org/W3027675334","doi":null,"title":"Expression of CYP1B1 and B7-H3 significantly correlates with poor prognosis in colorectal cancer patients.","display_name":"Expression of CYP1B1 and B7-H3 significantly correlates with poor prognosis in colorectal cancer patients.","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W3027675334","mag":"3027675334","pmid":"https://pubmed.ncbi.nlm.nih.gov/31938380","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6958278"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:5913072","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6958278","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6958278","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022845900","display_name":"Xingxiang Liu","orcid":"https://orcid.org/0009-0003-4374-2899","observed_orcids":["https://orcid.org/0009-0003-4374-2899"]},"institutions":[{"id":"https://openalex.org/I4210094071","display_name":"Taizhou Second People's Hospital","ror":"https://ror.org/00mdxnh77","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210094071"]},{"id":"https://openalex.org/I4210124971","display_name":"Second Affiliated Hospital of Soochow University","ror":"https://ror.org/02xjrkt08","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124971"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xingxiang Liu","raw_affiliation_strings":["Department of Oncology, The Second Affiliated Hospital of Soochow University Suzhou, Jiangsu Province, China","Department of Oncology, The Second People's Hospital of Taizhou Taizhou, Jiangsu Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, The Second Affiliated Hospital of Soochow University Suzhou, Jiangsu Province, China","institution_ids":["https://openalex.org/I4210124971"]},{"raw_affiliation_string":"Department of Oncology, The Second People's Hospital of Taizhou Taizhou, Jiangsu Province, China","institution_ids":["https://openalex.org/I4210094071"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115602070","display_name":"Fang Wang","orcid":"https://orcid.org/0000-0002-8808-8531","observed_orcids":["https://orcid.org/0000-0002-8808-8531"]},"institutions":[{"id":"https://openalex.org/I4210114781","display_name":"Wuxi Fourth People's Hospital","ror":"https://ror.org/02ar02c28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210114781"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fang Wang","raw_affiliation_strings":["Department of Oncology, The Affiliated Hospital of Jiangnan University Wuxi, Jiangsu Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, The Affiliated Hospital of Jiangnan University Wuxi, Jiangsu Province, China","institution_ids":["https://openalex.org/I4210114781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100780676","display_name":"Jingyi Wu","orcid":"https://orcid.org/0000-0003-0047-6378","observed_orcids":["https://orcid.org/0000-0003-0047-6378"]},"institutions":[{"id":"https://openalex.org/I4210114781","display_name":"Wuxi Fourth People's Hospital","ror":"https://ror.org/02ar02c28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210114781"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingyi Wu","raw_affiliation_strings":["Department of Oncology, The Affiliated Hospital of Jiangnan University Wuxi, Jiangsu Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, The Affiliated Hospital of Jiangnan University Wuxi, Jiangsu Province, China","institution_ids":["https://openalex.org/I4210114781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100458374","display_name":"Ting Zhang","orcid":"https://orcid.org/0000-0003-4229-6332","observed_orcids":["https://orcid.org/0000-0003-4229-6332","https://orcid.org/0009-0008-7298-923X"]},"institutions":[{"id":"https://openalex.org/I4210114781","display_name":"Wuxi Fourth People's Hospital","ror":"https://ror.org/02ar02c28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210114781"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ting Zhang","raw_affiliation_strings":["Department of Oncology, The Affiliated Hospital of Jiangnan University Wuxi, Jiangsu Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, The Affiliated Hospital of Jiangnan University Wuxi, Jiangsu Province, China","institution_ids":["https://openalex.org/I4210114781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100724433","display_name":"Fen Liu","orcid":"https://orcid.org/0009-0003-5325-1604","observed_orcids":["https://orcid.org/0009-0003-5325-1604"]},"institutions":[{"id":"https://openalex.org/I4210114781","display_name":"Wuxi Fourth People's Hospital","ror":"https://ror.org/02ar02c28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210114781"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fen Liu","raw_affiliation_strings":["Department of Oncology, The Affiliated Hospital of Jiangnan University Wuxi, Jiangsu Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, The Affiliated Hospital of Jiangnan University Wuxi, Jiangsu Province, China","institution_ids":["https://openalex.org/I4210114781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008924675","display_name":"Yong Mao","orcid":"https://orcid.org/0000-0001-9268-4523","observed_orcids":["https://orcid.org/0000-0001-9268-4523"]},"institutions":[{"id":"https://openalex.org/I4210114781","display_name":"Wuxi Fourth People's Hospital","ror":"https://ror.org/02ar02c28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210114781"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yong Mao","raw_affiliation_strings":["Department of Oncology, The Affiliated Hospital of Jiangnan University Wuxi, Jiangsu Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, The Affiliated Hospital of Jiangnan University Wuxi, Jiangsu Province, China","institution_ids":["https://openalex.org/I4210114781"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100640562","display_name":"Dong Hua","orcid":"https://orcid.org/0000-0001-9906-3252","observed_orcids":["https://orcid.org/0000-0001-9906-3252"]},"institutions":[{"id":"https://openalex.org/I4210114781","display_name":"Wuxi Fourth People's Hospital","ror":"https://ror.org/02ar02c28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210114781"]},{"id":"https://openalex.org/I4210124971","display_name":"Second Affiliated Hospital of Soochow University","ror":"https://ror.org/02xjrkt08","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124971"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dong Hua","raw_affiliation_strings":["Department of Oncology, The Second Affiliated Hospital of Soochow University Suzhou, Jiangsu Province, China","Department of Oncology, The Affiliated Hospital of Jiangnan University Wuxi, Jiangsu Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, The Second Affiliated Hospital of Soochow University Suzhou, Jiangsu Province, China","institution_ids":["https://openalex.org/I4210124971"]},{"raw_affiliation_string":"Department of Oncology, The Affiliated Hospital of Jiangnan University Wuxi, Jiangsu Province, China","institution_ids":["https://openalex.org/I4210114781"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2087,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.53362615,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"11","issue":"5","first_page":"2654","last_page":"2664"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.614300012588501,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.614300012588501,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.13809999823570251,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.019099999219179153,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyp1b1","display_name":"CYP1B1","score":0.9860000014305115},{"id":"https://openalex.org/keywords/b7-h3","display_name":"B7-H3","score":0.9940000176429749},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9900000095367432},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9229999780654907},{"id":"https://openalex.org/keywords/tumor-immune-evasion","display_name":"tumor immune evasion","score":0.7300000190734863},{"id":"https://openalex.org/keywords/xenobiotic-metabolism","display_name":"xenobiotic metabolism","score":0.7870000004768372},{"id":"https://openalex.org/keywords/tumor-metabolism","display_name":"cancer metabolism","score":0.6669999957084656},{"id":"https://openalex.org/keywords/t-cell-suppression","display_name":"T cell suppression","score":0.5429999828338623}],"concepts":[{"id":"https://openalex.org/C155701950","wikidata":"https://www.wikidata.org/wiki/Q14905165","display_name":"CYP1B1","level":4,"score":0.8566114902496338},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7690160274505615},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.6637454032897949},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6199888586997986},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4978766441345215},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.48743799328804016},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4860408902168274},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.48544198274612427},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.46756964921951294},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.44763195514678955},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.42332857847213745},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3678486943244934},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32158297300338745},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.27958065271377563},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22921845316886902},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11273840069770813},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.0640486478805542},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:5913072","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6958278","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:31938380","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31938380","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental pathology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6958278","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6958278/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},{"id":"mag:3027675334","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31938380","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5913072","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6958278","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1802772100","https://openalex.org/W1940428882","https://openalex.org/W1961726172","https://openalex.org/W1975039948","https://openalex.org/W1980365515","https://openalex.org/W2010647349","https://openalex.org/W2019820468","https://openalex.org/W2027098629","https://openalex.org/W2055084808","https://openalex.org/W2072005443","https://openalex.org/W2077522929","https://openalex.org/W2117692326","https://openalex.org/W2121988130","https://openalex.org/W2125624761","https://openalex.org/W2153240160","https://openalex.org/W2166519309","https://openalex.org/W2170025804","https://openalex.org/W2329582831","https://openalex.org/W2333305684","https://openalex.org/W2344434481","https://openalex.org/W2376873601","https://openalex.org/W2554977516","https://openalex.org/W2560441966","https://openalex.org/W2731232150","https://openalex.org/W2917837889"],"related_works":["https://openalex.org/W2036489403","https://openalex.org/W2794741215","https://openalex.org/W4412737663","https://openalex.org/W2155916504","https://openalex.org/W2072005443","https://openalex.org/W2076308913","https://openalex.org/W2595417850","https://openalex.org/W2886280572","https://openalex.org/W3124864575","https://openalex.org/W2901178385"],"abstract_inverted_index":{"Cytochrome":[0],"P450":[1],"1B1":[2],"(CYP1B1)":[3],"is":[4,12,212],"a":[5,32,54,168,201,213],"phase":[6],"I":[7],"xenobiotic-metabolizing":[8],"enzyme":[9],"(XME)":[10],"that":[11,133,165,197],"overexpressed":[13],"in":[14,25,35,47,80,104,142,182,220,223],"colorectal":[15,148],"cancer":[16],"(CRC)":[17],"tissue,":[18],"but":[19],"the":[20,59,66,90],"prognosis":[21,60,206],"value":[22],"of":[23,43,61,153,207],"CYP1B1":[24,76,93,135,154,166,174,198,217],"CRC":[26,62,84,107,143,183,189,208],"remains":[27],"elusive.":[28],"Additionally,":[29],"B7-H3":[30,78,95,137,180,219],"has":[31],"key":[33],"role":[34],"tumor":[36,69,72],"cell":[37,108,190],"immune":[38],"evasion":[39],"by":[40],"inhibiting":[41],"functions":[42],"T":[44],"cells.":[45],"Thus,":[46],"this":[48],"study,":[49],"we":[50,88],"aimed":[51],"to":[52,64,115,146],"identify":[53],"new":[55],"marker":[56],"for":[57,128,205],"predicting":[58],"and":[63,71,77,87,94,100,121,136,161,186,210,218,222],"study":[65],"relationship":[67,91],"between":[68,92,216],"metabolism":[70],"immunity.":[73],"We":[74,131],"analyzed":[75],"expression":[79,96,138,152,175,181],"231":[81],"patients":[82],"with":[83,158,179],"using":[85,97],"immunohistochemistry,":[86],"investigated":[89],"real-time":[98],"PCR":[99],"Western":[101],"blot":[102],"analysis":[103,112,163],"two":[105,187],"human":[106,188],"lines.":[109,191],"Kaplan-Meier":[110],"survival":[111,118],"was":[113,126,155,167,176],"used":[114],"calculate":[116],"overall":[117],"(OS)":[119],"rates,":[120],"Cox":[122],"proportional":[123],"regression":[124],"model":[125],"performed":[127],"multivariate":[129,162],"analysis.":[130],"found":[132],"both":[134],"were":[139],"aberrantly":[140],"increased":[141],"tissues":[144,184],"compared":[145],"normal":[147],"tissues.":[149],"Moreover,":[150],"high":[151],"significantly":[156,177],"correlated":[157,178],"poor":[159],"OS,":[160],"indicated":[164],"valuable":[169],"independent":[170],"prognostic":[171],"biomarker.":[172],"Furthermore,":[173],"samples":[185],"In":[192],"conclusion,":[193],"these":[194],"results":[195],"indicate":[196],"may":[199],"be":[200],"novel":[202],"predictive":[203],"biomarker":[204],"patients,":[209],"there":[211],"strong":[214],"correlation":[215],"vivo":[221],"vitro.":[224]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-05-29T00:00:00"}