{"id":"https://openalex.org/W3027561996","doi":null,"title":"Aberrant RASSF5 gene transcribed region hypermethylation in pediatric hepatoblastomas.","display_name":"Aberrant RASSF5 gene transcribed region hypermethylation in pediatric hepatoblastomas.","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W3027561996","mag":"3027561996","pmid":"https://pubmed.ncbi.nlm.nih.gov/31949741","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6962826"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:5916179","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6962826","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6962826","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016391952","display_name":"Gongbao Liu","orcid":"https://orcid.org/0000-0001-7788-1879","observed_orcids":["https://orcid.org/0000-0001-7788-1879"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210159329","display_name":"Children's Hospital of Fudan University","ror":"https://ror.org/05n13be63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159329"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Gongbao Liu","raw_affiliation_strings":["Department of Pediatric Surgery, Children's Hospital of Fudan University, Shanghai Key Laboratory of Birth Defects, Key Laboratory of Neonatal Disease, Ministry of Health 399 Wan Yuan Road, Shanghai 201102, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Surgery, Children's Hospital of Fudan University, Shanghai Key Laboratory of Birth Defects, Key Laboratory of Neonatal Disease, Ministry of Health 399 Wan Yuan Road, Shanghai 201102, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210159329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040265925","display_name":"Baihui Liu","orcid":"https://orcid.org/0000-0001-7027-1779","observed_orcids":["https://orcid.org/0000-0001-7027-1779","https://orcid.org/0009-0003-2008-6972"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210159329","display_name":"Children's Hospital of Fudan University","ror":"https://ror.org/05n13be63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159329"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Baihui Liu","raw_affiliation_strings":["Department of Pediatric Surgery, Children's Hospital of Fudan University, Shanghai Key Laboratory of Birth Defects, Key Laboratory of Neonatal Disease, Ministry of Health 399 Wan Yuan Road, Shanghai 201102, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Surgery, Children's Hospital of Fudan University, Shanghai Key Laboratory of Birth Defects, Key Laboratory of Neonatal Disease, Ministry of Health 399 Wan Yuan Road, Shanghai 201102, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210159329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076356039","display_name":"Shan Zheng","orcid":"https://orcid.org/0000-0002-9712-4573","observed_orcids":["https://orcid.org/0000-0002-9712-4573"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210159329","display_name":"Children's Hospital of Fudan University","ror":"https://ror.org/05n13be63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159329"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shan Zheng","raw_affiliation_strings":["Department of Pediatric Surgery, Children's Hospital of Fudan University, Shanghai Key Laboratory of Birth Defects, Key Laboratory of Neonatal Disease, Ministry of Health 399 Wan Yuan Road, Shanghai 201102, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Surgery, Children's Hospital of Fudan University, Shanghai Key Laboratory of Birth Defects, Key Laboratory of Neonatal Disease, Ministry of Health 399 Wan Yuan Road, Shanghai 201102, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210159329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102420267","display_name":"Kuiran Dong","orcid":"https://orcid.org/0009-0003-1462-9846","observed_orcids":["https://orcid.org/0009-0003-1462-9846","https://orcid.org/0000-0003-1154-4110"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210159329","display_name":"Children's Hospital of Fudan University","ror":"https://ror.org/05n13be63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159329"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kuiran Dong","raw_affiliation_strings":["Department of Pediatric Surgery, Children's Hospital of Fudan University, Shanghai Key Laboratory of Birth Defects, Key Laboratory of Neonatal Disease, Ministry of Health 399 Wan Yuan Road, Shanghai 201102, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Surgery, Children's Hospital of Fudan University, Shanghai Key Laboratory of Birth Defects, Key Laboratory of Neonatal Disease, Ministry of Health 399 Wan Yuan Road, Shanghai 201102, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210159329"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080545858","display_name":"Rui Dong","orcid":"https://orcid.org/0000-0001-9645-4768","observed_orcids":["https://orcid.org/0000-0001-9645-4768"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210159329","display_name":"Children's Hospital of Fudan University","ror":"https://ror.org/05n13be63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159329"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui Dong","raw_affiliation_strings":["Department of Pediatric Surgery, Children's Hospital of Fudan University, Shanghai Key Laboratory of Birth Defects, Key Laboratory of Neonatal Disease, Ministry of Health 399 Wan Yuan Road, Shanghai 201102, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Surgery, Children's Hospital of Fudan University, Shanghai Key Laboratory of Birth Defects, Key Laboratory of Neonatal Disease, Ministry of Health 399 Wan Yuan Road, Shanghai 201102, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210159329"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1561,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.40644517,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"11","issue":"7","first_page":"3612","last_page":"3617"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rassf5","display_name":"RASSF5","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hepatoblastoma","display_name":"hepatoblastoma","score":0.9169999957084656},{"id":"https://openalex.org/keywords/dna-hypermethylation","display_name":"DNA hypermethylation","score":0.8529999852180481},{"id":"https://openalex.org/keywords/promoter-methylation","display_name":"promoter methylation","score":0.6159999966621399},{"id":"https://openalex.org/keywords/epigenetic-silencing","display_name":"epigenetic silencing","score":0.859000027179718},{"id":"https://openalex.org/keywords/gene-downregulation","display_name":"gene downregulation","score":0.7570000290870667},{"id":"https://openalex.org/keywords/pediatric-liver-cancer","display_name":"pediatric liver cancer","score":0.6930000185966492}],"concepts":[{"id":"https://openalex.org/C2776304256","wikidata":"https://www.wikidata.org/wiki/Q1607658","display_name":"Hepatoblastoma","level":2,"score":0.9605566263198853},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.7962732911109924},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.7486384510993958},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5790754556655884},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5767863988876343},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4750511646270752},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.44327160716056824},{"id":"https://openalex.org/C121912465","wikidata":"https://www.wikidata.org/wiki/Q3589153","display_name":"Epigenomics","level":5,"score":0.44050168991088867},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4398380517959595},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.25100332498550415},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18947261571884155},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12128356099128723}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:5916179","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6962826","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:31949741","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31949741","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental pathology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6962826","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6962826/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},{"id":"mag:3027561996","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31949741","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5916179","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6962826","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1535501944","https://openalex.org/W1974937624","https://openalex.org/W1987824602","https://openalex.org/W1990365668","https://openalex.org/W2009469854","https://openalex.org/W2010838797","https://openalex.org/W2017502278","https://openalex.org/W2029742174","https://openalex.org/W2029868343","https://openalex.org/W2038835900","https://openalex.org/W2055986128","https://openalex.org/W2062461447","https://openalex.org/W2065498897","https://openalex.org/W2070393186","https://openalex.org/W2085413010","https://openalex.org/W2086105525","https://openalex.org/W2088232329","https://openalex.org/W2100870777","https://openalex.org/W2114570899","https://openalex.org/W2124844649","https://openalex.org/W2127132611","https://openalex.org/W2127192982","https://openalex.org/W2131128934","https://openalex.org/W2132909064","https://openalex.org/W2141737525","https://openalex.org/W2149432374","https://openalex.org/W2460054528","https://openalex.org/W2531375093","https://openalex.org/W2591904920","https://openalex.org/W2940729906"],"related_works":["https://openalex.org/W1974937624","https://openalex.org/W1992591047","https://openalex.org/W2115014783","https://openalex.org/W2086062087","https://openalex.org/W1537112530","https://openalex.org/W2082827623","https://openalex.org/W1964646880","https://openalex.org/W2306227551","https://openalex.org/W2586755482","https://openalex.org/W2080560721"],"abstract_inverted_index":{"BACKGROUND:":[0],"Aberrant":[1],"DNA":[2],"methylation":[3,42,51,106],"plays":[4],"an":[5],"important":[6],"role":[7],"in":[8,43,53,81,96,116],"cancer":[9],"and":[10,21],"has":[11],"been":[12,34],"recognized":[13],"to":[14,16,36,111],"contribute":[15,110],"the":[17,50,54,82,97],"activity":[18],"of":[19,23,56,91,107],"oncogenes":[20],"inactivity":[22],"tumor":[24],"suppressor":[25],"genes.":[26],"RAS":[27],"association":[28],"domain":[29],"family":[30],"(RASSF)":[31],"members":[32],"have":[33],"shown":[35],"be":[37],"epigenetically":[38],"silenced":[39],"by":[40],"promoter":[41],"cancers,":[44],"including":[45],"hepatoblastoma.":[46,117],"METHODS:":[47],"We":[48],"assessed":[49],"patterns":[52],"gene":[55,84],"RASSF5":[57,83,92,108],"from":[58,63],"hepatoblastoma":[59,98],"tissue":[60],"samples":[61],"harvested":[62],"patients":[64],"using":[65],"high-throughput":[66],"mass":[67,75],"spectrometry":[68],"on":[69],"a":[70],"matrix-assisted":[71],"laser":[72],"desorption/ionization":[73],"time-of-flight":[74],"array.":[76],"RESULTS:":[77],"Hypermethylation":[78],"was":[79,87],"found":[80],"transcribed":[85],"regionand":[86],"correlated":[88],"with":[89],"downregulation":[90],"RNA":[93],"expression":[94,115],"levels":[95],"samples.":[99],"CONCLUSIONS:":[100],"The":[101],"results":[102],"indicate":[103],"that":[104],"aberrant":[105],"may":[109],"its":[112],"downregulated":[113],"mRNA":[114]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-05-29T00:00:00"}
