{"id":"https://openalex.org/W3027469462","doi":null,"title":"Proteomic identification of candidate plasma biomarkers for preeclampsia in women with pregnancy-induced hypertension.","display_name":"Proteomic identification of candidate plasma biomarkers for preeclampsia in women with pregnancy-induced hypertension.","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W3027469462","mag":"3027469462","pmid":"https://pubmed.ncbi.nlm.nih.gov/31966374","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6965753"},"language":"en","primary_location":{"id":"pmid:31966374","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31966374","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental pathology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6965753/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041008314","display_name":"Zhixiong Mei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210146956","display_name":"Third Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/04tm3k558","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146956"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhixiong Mei","raw_affiliation_strings":["Department of Obstetrics, The Third Affiliated Hospital, Sun Yat-sen University Guangzhou 510630, Guangdong, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics, The Third Affiliated Hospital, Sun Yat-sen University Guangzhou 510630, Guangdong, P. R. China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210146956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072019950","display_name":"Shuisheng Zhou","orcid":"https://orcid.org/0000-0003-4764-9483","observed_orcids":["https://orcid.org/0000-0003-4764-9483"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210146956","display_name":"Third Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/04tm3k558","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146956"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuisheng Zhou","raw_affiliation_strings":["Department of Obstetrics, The Third Affiliated Hospital, Sun Yat-sen University Guangzhou 510630, Guangdong, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics, The Third Affiliated Hospital, Sun Yat-sen University Guangzhou 510630, Guangdong, P. R. China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210146956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039302881","display_name":"Baoqin Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210146956","display_name":"Third Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/04tm3k558","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146956"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Baoqin Huang","raw_affiliation_strings":["Department of Obstetrics, The Third Affiliated Hospital, Sun Yat-sen University Guangzhou 510630, Guangdong, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics, The Third Affiliated Hospital, Sun Yat-sen University Guangzhou 510630, Guangdong, P. R. China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210146956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101956348","display_name":"Ying Mo","orcid":"https://orcid.org/0000-0002-8468-0044","observed_orcids":["https://orcid.org/0000-0002-8468-0044"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210146956","display_name":"Third Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/04tm3k558","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146956"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Mo","raw_affiliation_strings":["Department of Obstetrics, The Third Affiliated Hospital, Sun Yat-sen University Guangzhou 510630, Guangdong, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics, The Third Affiliated Hospital, Sun Yat-sen University Guangzhou 510630, Guangdong, P. R. China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210146956"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042174869","display_name":"Hongyin Hou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210146956","display_name":"Third Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/04tm3k558","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146956"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongyin Hou","raw_affiliation_strings":["Department of Obstetrics, The Third Affiliated Hospital, Sun Yat-sen University Guangzhou 510630, Guangdong, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics, The Third Affiliated Hospital, Sun Yat-sen University Guangzhou 510630, Guangdong, P. R. China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210146956"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3041,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.58319379,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"10","issue":"10","first_page":"10383","last_page":"10391"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12464","display_name":"Neurological Complications and Syndromes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/preeclampsia","display_name":"preeclampsia","score":1.0},{"id":"https://openalex.org/keywords/gestational-hypertension","display_name":"gestational hypertension","score":0.8489999771118164},{"id":"https://openalex.org/keywords/plasma-biomarkers","display_name":"plasma biomarkers","score":0.996999979019165},{"id":"https://openalex.org/keywords/early-diagnosis","display_name":"early diagnosis","score":0.6520000100135803},{"id":"https://openalex.org/keywords/differentially-expressed-proteins","display_name":"differentially expressed proteins","score":0.9240000247955322},{"id":"https://openalex.org/keywords/apolipoprotein-a-i","display_name":"apolipoprotein A-I","score":0.9369999766349792},{"id":"https://openalex.org/keywords/fetuin-a","display_name":"fetuin-A","score":0.890999972820282},{"id":"https://openalex.org/keywords/complement-factor-i","display_name":"complement factor I","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cd5l","display_name":"CD5L","score":0.8870000243186951},{"id":"https://openalex.org/keywords/paraoxonase-1","display_name":"paraoxonase 1","score":0.9480000138282776},{"id":"https://openalex.org/keywords/haptoglobin","display_name":"haptoglobin","score":0.9449999928474426},{"id":"https://openalex.org/keywords/proteomic-biomarker-discovery","display_name":"proteomic biomarker discovery","score":0.6169999837875366}],"concepts":[{"id":"https://openalex.org/C37501387","wikidata":"https://www.wikidata.org/wiki/Q18030661","display_name":"PON1","level":4,"score":0.8127108812332153},{"id":"https://openalex.org/C2776509667","wikidata":"https://www.wikidata.org/wiki/Q7135605","display_name":"Paraoxonase","level":3,"score":0.795924186706543},{"id":"https://openalex.org/C2779476363","wikidata":"https://www.wikidata.org/wiki/Q14864935","display_name":"Clusterin","level":3,"score":0.7420051097869873},{"id":"https://openalex.org/C206396517","wikidata":"https://www.wikidata.org/wiki/Q422025","display_name":"Haptoglobin","level":2,"score":0.7297293543815613},{"id":"https://openalex.org/C2777218350","wikidata":"https://www.wikidata.org/wiki/Q61335","display_name":"Preeclampsia","level":3,"score":0.6372730731964111},{"id":"https://openalex.org/C62746215","wikidata":"https://www.wikidata.org/wiki/Q14890615","display_name":"Apolipoprotein B","level":3,"score":0.5468525290489197},{"id":"https://openalex.org/C2780745583","wikidata":"https://www.wikidata.org/wiki/Q1316030","display_name":"Apolipoprotein A1","level":4,"score":0.47932422161102295},{"id":"https://openalex.org/C178596410","wikidata":"https://www.wikidata.org/wiki/Q5275273","display_name":"Difference gel electrophoresis","level":4,"score":0.4421072006225586},{"id":"https://openalex.org/C2776474381","wikidata":"https://www.wikidata.org/wiki/Q409414","display_name":"Hemopexin","level":4,"score":0.4261835217475891},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.42592793703079224},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40346288681030273},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3906099796295166},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.38900262117385864},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3695412576198578},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3197682797908783},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30763930082321167},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.289963960647583},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19942837953567505},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.12421539425849915},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.12165012955665588},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10790055990219116},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.0},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.0},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmid:31966374","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31966374","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental pathology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6965753","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6965753/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},{"id":"mag:3027469462","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31966374","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6965753","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6965753/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1535567348","https://openalex.org/W1893364625","https://openalex.org/W1902057567","https://openalex.org/W1926780910","https://openalex.org/W1974527643","https://openalex.org/W1989682760","https://openalex.org/W1993963367","https://openalex.org/W2006522274","https://openalex.org/W2031923120","https://openalex.org/W2043308363","https://openalex.org/W2044226717","https://openalex.org/W2054022111","https://openalex.org/W2055710073","https://openalex.org/W2064551554","https://openalex.org/W2078132907","https://openalex.org/W2094275557","https://openalex.org/W2095195639","https://openalex.org/W2130446505","https://openalex.org/W2136648677","https://openalex.org/W2144795336","https://openalex.org/W2150789214","https://openalex.org/W2154121772","https://openalex.org/W2160016599","https://openalex.org/W2175423397","https://openalex.org/W2185489582","https://openalex.org/W2279020730","https://openalex.org/W2334236439","https://openalex.org/W2407887585","https://openalex.org/W2514741724","https://openalex.org/W3149679521"],"related_works":["https://openalex.org/W4401327238","https://openalex.org/W2586899188","https://openalex.org/W2078661519","https://openalex.org/W2961405397","https://openalex.org/W1593203226","https://openalex.org/W2100428319","https://openalex.org/W2147381416","https://openalex.org/W2575747793","https://openalex.org/W7219052146","https://openalex.org/W4229042851"],"abstract_inverted_index":{"Preeclampsia":[0],"(PE),":[1],"a":[2,38,67,104],"complication":[3],"of":[4,10,34,85,106,109,124,126,171,194],"pregnancy,":[5],"is":[6],"the":[7,31,43,54,82,168,183],"leading":[8],"cause":[9],"maternal":[11,20],"and":[12,15,17,21,48,74,114,164,185,206],"perinatal":[13],"morbidity":[14],"mortality":[16],"seriously":[18],"impacts":[19],"child":[22],"health.":[23],"This":[24],"study":[25],"aimed":[26],"to":[27,93,189],"characterize":[28],"biomarkers":[29,193],"for":[30,211],"early":[32],"diagnosis":[33],"PE.":[35,121,195,213],"We":[36,52,80,102],"performed":[37],"comparative":[39],"proteomic":[40],"analysis":[41],"on":[42],"plasma":[44,55,192,198],"obtained":[45],"from":[46],"PE":[47,100],"healthy":[49],"pregnant":[50],"women.":[51],"analyzed":[53,81],"samples":[56],"using":[57],"two-dimensional":[58],"differential":[59,169],"gel":[60],"electrophoresis":[61],"(2D-DIGE)":[62],"coupled":[63],"with":[64,120],"Ultraflex":[65,186],"III,":[66],"MALDI-TOF-TOF":[68],"(matrix-assisted":[69],"laser":[70],"desorption/ionization-time-of-flight)":[71],"mass":[72,132],"spectrometer":[73],"identified":[75,103],"differentially":[76],"expressed":[77],"proteins":[78,174],"(DEPs).":[79],"abundance":[83],"levels":[84],"these":[86,127,172],"DEPs":[87,128],"by":[88,131,177],"enzyme-linked":[89],"immunosorbent":[90],"assay":[91],"(ELISA)":[92],"further":[94],"confirm":[95],"their":[96],"role":[97],"as":[98],"putative":[99],"biomarkers.":[101],"total":[105],"56":[107],"DEPs,":[108],"which":[110],"48":[111],"were":[112,116,129,208],"down-regulated":[113],"8":[115,125,173],"up-regulated":[117],"in":[118],"women":[119],"The":[122],"identities":[123],"characterized":[130],"spectrum":[133],"analysis,":[134],"including":[135],"LG3BP":[136],"(lectin,":[137],"galactoside-binding,":[138],"soluble,":[139],"3":[140],"binding":[141],"protein),":[142],"APOA1":[143],"(apolipoprotein":[144],"A-I),":[145],"FETUA":[146],"(alpha-2-HS-glycoprotein),":[147],"CFAI":[148],"(complement":[149],"factor":[150],"I),":[151],"CD5L":[152],"(CD5":[153],"antigen-like),":[154],"K2C6A":[155],"(keratin,":[156],"type":[157],"II":[158],"cytoskeletal":[159],"6A),":[160],"PON1":[161,205],"(paraoxonase/arylesterase":[162],"1)":[163],"HP1":[165,207],"(haptoglobin).":[166],"Finally,":[167],"expression":[170],"was":[175],"verified":[176],"ELISA.":[178],"In":[179],"summary,":[180],"we":[181],"applied":[182],"2D-DIGE":[184],"III-TOF/TOF":[187],"platform":[188],"identify":[190],"potential":[191],"Of":[196],"these,":[197],"LG3BP,":[199],"APOA1,":[200],"FETUA,":[201],"CFAI,":[202],"CD5L,":[203],"K2C6A,":[204],"promising":[209],"candidates":[210],"predicting":[212]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-05-29T00:00:00"}
