{"id":"https://openalex.org/W302735525","doi":null,"title":"Comparative treatment planning in radiotherapy and clinical impact of proton relative biological effectiveness.","display_name":"Comparative treatment planning in radiotherapy and clinical impact of proton relative biological effectiveness.","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W302735525","mag":"302735525"},"language":"en","primary_location":{"id":"mag:302735525","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/theses/ETH/8645","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019823326","display_name":"Jonas Johansson","orcid":"https://orcid.org/0000-0002-4083-8102","observed_orcids":["https://orcid.org/0000-0002-4083-8102"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jonas Johansson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4083-8102","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5019823326"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/proton-therapy","display_name":"proton therapy","score":0.8420000076293945},{"id":"https://openalex.org/keywords/relative-biological-effectiveness","display_name":"relative biological effectiveness","score":0.9449999928474426},{"id":"https://openalex.org/keywords/linear-energy-transfer","display_name":"linear energy transfer","score":0.7799999713897705},{"id":"https://openalex.org/keywords/spread-out-bragg-peak","display_name":"spread-out Bragg peak","score":0.8519999980926514},{"id":"https://openalex.org/keywords/dose-volume-histograms","display_name":"dose-volume histograms","score":0.7730000019073486},{"id":"https://openalex.org/keywords/normal-tissue-complication-probability","display_name":"normal tissue complication probability","score":0.8410000205039978},{"id":"https://openalex.org/keywords/tumor-control-probability","display_name":"tumor control probability","score":0.9769999980926514},{"id":"https://openalex.org/keywords/spinal-cord","display_name":"spinal cord","score":0.7129999995231628},{"id":"https://openalex.org/keywords/hypopharyngeal-cancer","display_name":"hypopharyngeal cancer","score":0.9819999933242798},{"id":"https://openalex.org/keywords/treatment-planning","display_name":"treatment planning","score":0.4399999976158142},{"id":"https://openalex.org/keywords/organs-at-risk-sparing","display_name":"organs at risk sparing","score":0.5139999985694885}],"concepts":[{"id":"https://openalex.org/C11928243","wikidata":"https://www.wikidata.org/wiki/Q1360981","display_name":"Relative biological effectiveness","level":3,"score":0.8715904951095581},{"id":"https://openalex.org/C2781298738","wikidata":"https://www.wikidata.org/wiki/Q18041535","display_name":"Sobp","level":4,"score":0.7893867492675781},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.6686681509017944},{"id":"https://openalex.org/C201645570","wikidata":"https://www.wikidata.org/wiki/Q830637","display_name":"Radiation treatment planning","level":3,"score":0.6408312320709229},{"id":"https://openalex.org/C86611320","wikidata":"https://www.wikidata.org/wiki/Q1699996","display_name":"Linear energy transfer","level":3,"score":0.5778685808181763},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.571722686290741},{"id":"https://openalex.org/C2780944729","wikidata":"https://www.wikidata.org/wiki/Q897227","display_name":"Bragg peak","level":3,"score":0.5620835423469543},{"id":"https://openalex.org/C2779244869","wikidata":"https://www.wikidata.org/wiki/Q507667","display_name":"Proton therapy","level":3,"score":0.5544473528862},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5035530924797058},{"id":"https://openalex.org/C54516573","wikidata":"https://www.wikidata.org/wiki/Q2294","display_name":"Proton","level":2,"score":0.37136393785476685},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.2183641493320465},{"id":"https://openalex.org/C153385146","wikidata":"https://www.wikidata.org/wiki/Q18335","display_name":"Radiation","level":2,"score":0.20886516571044922},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.20871126651763916},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.09089592099189758},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:302735525","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/theses/ETH/8645","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":218,"referenced_works":["https://openalex.org/W38060568","https://openalex.org/W94492760","https://openalex.org/W112183016","https://openalex.org/W610185530","https://openalex.org/W1493947647","https://openalex.org/W1537138986","https://openalex.org/W1965619896","https://openalex.org/W1966749611","https://openalex.org/W1967394365","https://openalex.org/W1967967795","https://openalex.org/W1968426660","https://openalex.org/W1969214546","https://openalex.org/W1969613627","https://openalex.org/W1969699382","https://openalex.org/W1970870816","https://openalex.org/W1971747664","https://openalex.org/W1972072864","https://openalex.org/W1973773962","https://openalex.org/W1974414960","https://openalex.org/W1974426821","https://openalex.org/W1974908209","https://openalex.org/W1975292370","https://openalex.org/W1977499373","https://openalex.org/W1977728181","https://openalex.org/W1977764193","https://openalex.org/W1978136469","https://openalex.org/W1978867862","https://openalex.org/W1979964027","https://openalex.org/W1980027490","https://openalex.org/W1982972017","https://openalex.org/W1984487972","https://openalex.org/W1985182870","https://openalex.org/W1985750332","https://openalex.org/W1986376168","https://openalex.org/W1986565583","https://openalex.org/W1987006437","https://openalex.org/W1987723986","https://openalex.org/W1988062703","https://openalex.org/W1988505823","https://openalex.org/W1990580354","https://openalex.org/W1990886090","https://openalex.org/W1991566473","https://openalex.org/W1991770039","https://openalex.org/W1993687688","https://openalex.org/W1994000794","https://openalex.org/W1994439728","https://openalex.org/W1994702068","https://openalex.org/W1996065749","https://openalex.org/W1996809772","https://openalex.org/W2001507652","https://openalex.org/W2003043687","https://openalex.org/W2004006404","https://openalex.org/W2004156023","https://openalex.org/W2005012329","https://openalex.org/W2005348841","https://openalex.org/W2005730371","https://openalex.org/W2005887998","https://openalex.org/W2007018464","https://openalex.org/W2011051681","https://openalex.org/W2011533561","https://openalex.org/W2012053317","https://openalex.org/W2012188643","https://openalex.org/W2012303495","https://openalex.org/W2014775907","https://openalex.org/W2014850260","https://openalex.org/W2015096497","https://openalex.org/W2017872025","https://openalex.org/W2018523975","https://openalex.org/W2019850432","https://openalex.org/W2020573763","https://openalex.org/W2022985124","https://openalex.org/W2024061066","https://openalex.org/W2024355000","https://openalex.org/W2026132872","https://openalex.org/W2028802781","https://openalex.org/W2029753133","https://openalex.org/W2030899899","https://openalex.org/W2031553538","https://openalex.org/W2031586753","https://openalex.org/W2032968239","https://openalex.org/W2033909579","https://openalex.org/W2034538145","https://openalex.org/W2034976475","https://openalex.org/W2035121339","https://openalex.org/W2035306925","https://openalex.org/W2036282507","https://openalex.org/W2037773986","https://openalex.org/W2037803738","https://openalex.org/W2037822151","https://openalex.org/W2038133499","https://openalex.org/W2038137317","https://openalex.org/W2038370575","https://openalex.org/W2039397666","https://openalex.org/W2039697444","https://openalex.org/W2040145532","https://openalex.org/W2041019407","https://openalex.org/W2042975860","https://openalex.org/W2043078580","https://openalex.org/W2044240160","https://openalex.org/W2044390588","https://openalex.org/W2045352770","https://openalex.org/W2046772982","https://openalex.org/W2048582281","https://openalex.org/W2050690352","https://openalex.org/W2053700561","https://openalex.org/W2054545149","https://openalex.org/W2054946224","https://openalex.org/W2055553106","https://openalex.org/W2055752524","https://openalex.org/W2057655643","https://openalex.org/W2058069994","https://openalex.org/W2058751082","https://openalex.org/W2060017885","https://openalex.org/W2060396831","https://openalex.org/W2062322391","https://openalex.org/W2063124234","https://openalex.org/W2063740564","https://openalex.org/W2064062152","https://openalex.org/W2066931804","https://openalex.org/W2067093997","https://openalex.org/W2067398055","https://openalex.org/W2067450972","https://openalex.org/W2067834214","https://openalex.org/W2068878119","https://openalex.org/W2069769646","https://openalex.org/W2070066324","https://openalex.org/W2072087143","https://openalex.org/W2073573762","https://openalex.org/W2073632607","https://openalex.org/W2075349568","https://openalex.org/W2075833875","https://openalex.org/W2076464942","https://openalex.org/W2078028017","https://openalex.org/W2078569105","https://openalex.org/W2079709620","https://openalex.org/W2081426891","https://openalex.org/W2082441060","https://openalex.org/W2082617025","https://openalex.org/W2083533227","https://openalex.org/W2083549164","https://openalex.org/W2084174155","https://openalex.org/W2084720089","https://openalex.org/W2085045272","https://openalex.org/W2085231006","https://openalex.org/W2085409346","https://openalex.org/W2085796495","https://openalex.org/W2086479790","https://openalex.org/W2088299281","https://openalex.org/W2089969159","https://openalex.org/W2090095394","https://openalex.org/W2091608575","https://openalex.org/W2094515352","https://openalex.org/W2094615071","https://openalex.org/W2095105968","https://openalex.org/W2095148496","https://openalex.org/W2095167815","https://openalex.org/W2095610022","https://openalex.org/W2097615309","https://openalex.org/W2098112001","https://openalex.org/W2099042561","https://openalex.org/W2099560937","https://openalex.org/W2100592197","https://openalex.org/W2101459435","https://openalex.org/W2102918890","https://openalex.org/W2109037291","https://openalex.org/W2109871948","https://openalex.org/W2111346473","https://openalex.org/W2114036513","https://openalex.org/W2115936968","https://openalex.org/W2119074094","https://openalex.org/W2120046399","https://openalex.org/W2120610803","https://openalex.org/W2122835483","https://openalex.org/W2124143747","https://openalex.org/W2125452425","https://openalex.org/W2128531204","https://openalex.org/W2129252368","https://openalex.org/W2129479916","https://openalex.org/W2130647939","https://openalex.org/W2131847947","https://openalex.org/W2133684889","https://openalex.org/W2133768227","https://openalex.org/W2134393828","https://openalex.org/W2136931271","https://openalex.org/W2139389882","https://openalex.org/W2141184197","https://openalex.org/W2143356157","https://openalex.org/W2143472867","https://openalex.org/W2144212200","https://openalex.org/W2144822758","https://openalex.org/W2146014652","https://openalex.org/W2149875856","https://openalex.org/W2150090970","https://openalex.org/W2151415400","https://openalex.org/W2151879780","https://openalex.org/W2155603346","https://openalex.org/W2155811892","https://openalex.org/W2157655290","https://openalex.org/W2158110394","https://openalex.org/W2158120559","https://openalex.org/W2167510967","https://openalex.org/W2168517539","https://openalex.org/W2169550280","https://openalex.org/W2170317803","https://openalex.org/W2170560268","https://openalex.org/W2172010587","https://openalex.org/W2232271406","https://openalex.org/W2232320085","https://openalex.org/W2249865061","https://openalex.org/W2277883626","https://openalex.org/W2328386299","https://openalex.org/W2332829713","https://openalex.org/W2334191077","https://openalex.org/W2355419393","https://openalex.org/W2397662473","https://openalex.org/W2400629513","https://openalex.org/W2419252679","https://openalex.org/W2589583141"],"related_works":["https://openalex.org/W2029765949","https://openalex.org/W1471606524","https://openalex.org/W2960320388","https://openalex.org/W6986818808","https://openalex.org/W2005775826","https://openalex.org/W1966814267","https://openalex.org/W2756319474","https://openalex.org/W7008234327","https://openalex.org/W2572695447","https://openalex.org/W2406988819"],"abstract_inverted_index":{"Currently,":[0],"most":[1],"clinical":[2,129,173,365],"range-modulated":[3],"proton":[4,132,366],"beams":[5],"are":[6,190,253,309,373],"assumed":[7],"to":[8,291,349],"have":[9,312],"a":[10,89,94,115,128,177,328,340,345,351,362],"fixed":[11],"overall":[12],"relative":[13],"biological":[14],"effectiveness":[15],"(RBE)":[16],"of":[17,63,121,153,257,322,326,354],"1.1.":[18],"However,":[19,270],"it":[20,357],"is":[21,135,141,218,233,358],"well":[22],"known":[23],"that":[24,189],"the":[25,31,48,68,108,151,172,186,198,206,215,222,226,238,250,258,262,267,275,283,319,323,334,377],"RBE":[26,43,96,125,144,167,207,263,285,288,307,330,347,353],"increases":[27],"with":[28,98,201],"depth":[29],"in":[30,65,114,185,229,255,261,295,301,343,364],"spread-out":[32],"Bragg":[33],"peak":[34],"(SOBP)":[35],"and":[36,59,150,158,182,243,311],"becomes":[37],"about":[38],"10%":[39],"higher":[40,192],"than":[41,193],"mid-SOBP":[42],"at":[44,67,213],"2":[45,57],"mm":[46,236],"from":[47],"distal":[49,69],"edge":[50,70],"(Paganetti":[51],"2003":[52],"Technol.":[53],"Cancer":[54,75],"Res.":[55],"Treat.":[56],"413-26)":[58],"can":[60],"reach":[61],"values":[62,252,273,308],"1.3-1.4":[64],"vitro":[66,302],"(Robertson":[71],"et":[72,79],"al":[73,80],"1975":[74],"35":[76],"1664-77,":[77],"Courdi":[78],"1994":[81],"Br.":[82],"J.":[83],"Radiol.":[84],"67":[85],"800-4).":[86],"We":[87],"present":[88],"fast":[90],"method":[91],"for":[92,112,171,210,221,266,274,294],"applying":[93,122,282,350],"variable":[95,124,166,223,268,284,329,346],"correction":[97,126,168,363],"linear":[99],"energy":[100],"transfer":[101],"(LET)":[102],"dependent":[103],"tissue-specific":[104],"parameters":[105],"based":[106],"on":[107,127,300],"alpharef/betaref":[109],"ratios":[110],"suitable":[111],"implementation":[113],"treatment":[116,139],"planning":[117,239],"system.":[118],"The":[119,138,165],"influence":[120],"this":[123,230,298],"multiple":[130],"beam":[131],"dose":[133,146,200],"plan":[134,140],"presented":[136],"here.":[137],"evaluated":[142],"by":[143,196],"weighted":[145,208,264],"volume":[147,241],"histograms":[148],"(DVHs)":[149],"calculation":[152],"tumour":[154],"control":[155],"probability":[156,162],"(TCP)":[157],"normal":[159,277],"tissue":[160,278,306],"complication":[161],"(NTCP)":[163],"values.":[164],"yields":[169],"DVHs":[170,265],"target":[174,240,378],"volumes":[175],"(CTVs),":[176],"primary":[178],"advanced":[179],"hypopharynx":[180],"cancer":[181],"subclinical":[183],"disease":[184],"lymph":[187],"nodes,":[188],"slightly":[191],"those":[194],"achieved":[195],"multiplying":[197],"absorbed":[199],"RBE=1.1.":[202],"Although,":[203],"more":[204],"importantly,":[205],"DVH":[209],"an":[211],"organ":[212],"risk,":[214],"spinal":[216,227],"cord":[217,228],"considerably":[219],"increased":[220],"RBE.":[224,269],"As":[225,287],"particular":[231],"case":[232],"located":[234,374],"8":[235],"behind":[237,376],"(PTV)":[242],"hence":[244],"receives":[245],"only":[246],"low":[247],"total":[248],"doses,":[249],"NTCP":[251,272],"zero":[254],"spite":[256],"significant":[259,341],"increase":[260],"high":[271],"non-target":[276],"were":[279],"obtained":[280,336],"when":[281,370],"correction.":[286,331],"variations":[289],"tend":[290],"be":[292,315],"smaller":[293],"vivo":[296],"systems,":[297],"study-based":[299],"data":[303],"since":[304],"human":[305],"scarce":[310],"large":[313],"uncertainties-can":[314],"interpreted":[316],"as":[317],"showing":[318],"upper":[320],"limits":[321],"possible":[324],"effects":[325],"utilizing":[327],"In":[332],"conclusion,":[333],"results":[335],"here":[337],"still":[338],"indicate":[339],"difference":[342],"introducing":[344],"compared":[348],"generic":[352],"1.1,":[355],"suggesting":[356],"worth":[359],"considering":[360],"such":[361],"therapy":[367],"planning,":[368],"especially":[369],"risk":[371],"organs":[372],"immediately":[375],"volume.":[379]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}
