{"id":"https://openalex.org/W3026051697","doi":"https://doi.org/10.1111/bjd.19229","title":"Dimethyl fumarate modulates the Treg\u2013Th17 cell axis in patients with psoriasis*","display_name":"Dimethyl fumarate modulates the Treg\u2013Th17 cell axis in patients with psoriasis*","publication_year":2020,"publication_date":"2020-05-21","ids":{"openalex":"https://openalex.org/W3026051697","doi":"https://doi.org/10.1111/bjd.19229","mag":"3026051697","pmid":"https://pubmed.ncbi.nlm.nih.gov/32438447"},"language":"en","primary_location":{"id":"doi:10.1111/bjd.19229","doi":"https://doi.org/10.1111/bjd.19229","is_oa":false,"landing_page_url":"https://doi.org/10.1111/bjd.19229","pdf_url":null,"source":{"id":"https://openalex.org/S45720283","display_name":"British Journal of Dermatology","issn_l":"0007-0963","issn":["0007-0963","1365-2133"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Dermatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070551011","display_name":"Jamal Sulaimani","orcid":"https://orcid.org/0000-0001-5828-2571","observed_orcids":["https://orcid.org/0000-0001-5828-2571"]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"J. Sulaimani","raw_affiliation_strings":["School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland"],"raw_orcid":"https://orcid.org/0000-0001-5828-2571","affiliations":[{"raw_affiliation_string":"School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140829171","display_name":"Deborah Cluxton","orcid":"https://orcid.org/0000-0001-5630-6074","observed_orcids":["https://orcid.org/0000-0001-5630-6074"]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"D. Cluxton","raw_affiliation_strings":["School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland"],"raw_orcid":"https://orcid.org/0000-0001-5630-6074","affiliations":[{"raw_affiliation_string":"School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020971003","display_name":"Julianne Clowry","orcid":"https://orcid.org/0000-0002-8526-4966","observed_orcids":["https://orcid.org/0000-0002-8526-4966"]},"institutions":[{"id":"https://openalex.org/I4210115218","display_name":"St. Vincent's University Hospital","ror":"https://ror.org/029tkqm80","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210115218"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"J. Clowry","raw_affiliation_strings":["Dermatology Research, Education and Research Centre, St. Vincent's University Hospital, Dublin 4, Ireland"],"raw_orcid":"https://orcid.org/0000-0002-8526-4966","affiliations":[{"raw_affiliation_string":"Dermatology Research, Education and Research Centre, St. Vincent's University Hospital, Dublin 4, Ireland","institution_ids":["https://openalex.org/I4210115218"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079499350","display_name":"Andreea Petrasca","orcid":"https://orcid.org/0000-0002-0420-5252","observed_orcids":["https://orcid.org/0000-0002-0420-5252"]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"A. Petrasca","raw_affiliation_strings":["School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland"],"raw_orcid":"https://orcid.org/0000-0002-0420-5252","affiliations":[{"raw_affiliation_string":"School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013664005","display_name":"Oonagh E. Molloy","orcid":"https://orcid.org/0000-0002-2964-8914","observed_orcids":["https://orcid.org/0000-0002-2964-8914"]},"institutions":[{"id":"https://openalex.org/I4210115218","display_name":"St. Vincent's University Hospital","ror":"https://ror.org/029tkqm80","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210115218"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"O.E. Molloy","raw_affiliation_strings":["Dermatology Research, Education and Research Centre, St. Vincent's University Hospital, Dublin 4, Ireland"],"raw_orcid":"https://orcid.org/0000-0002-2964-8914","affiliations":[{"raw_affiliation_string":"Dermatology Research, Education and Research Centre, St. Vincent's University Hospital, Dublin 4, Ireland","institution_ids":["https://openalex.org/I4210115218"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085166738","display_name":"Barry Moran","orcid":"https://orcid.org/0000-0002-8243-1079","observed_orcids":["https://orcid.org/0000-0002-8243-1079"]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"B. Moran","raw_affiliation_strings":["School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland"],"raw_orcid":"https://orcid.org/0000-0002-8243-1079","affiliations":[{"raw_affiliation_string":"School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025987766","display_name":"Cheryl M. Sweeney","orcid":"https://orcid.org/0000-0002-0051-0372","observed_orcids":["https://orcid.org/0000-0002-0051-0372"]},"institutions":[{"id":"https://openalex.org/I4210115218","display_name":"St. Vincent's University Hospital","ror":"https://ror.org/029tkqm80","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210115218"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"C.M. Sweeney","raw_affiliation_strings":["Dermatology Research, Education and Research Centre, St. Vincent's University Hospital, Dublin 4, Ireland"],"raw_orcid":"https://orcid.org/0000-0002-0051-0372","affiliations":[{"raw_affiliation_string":"Dermatology Research, Education and Research Centre, St. Vincent's University Hospital, Dublin 4, Ireland","institution_ids":["https://openalex.org/I4210115218"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084844808","display_name":"Anna Malara","orcid":"https://orcid.org/0000-0002-1948-5568","observed_orcids":["https://orcid.org/0000-0002-1948-5568"]},"institutions":[{"id":"https://openalex.org/I4210115218","display_name":"St. Vincent's University Hospital","ror":"https://ror.org/029tkqm80","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210115218"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"A. Malara","raw_affiliation_strings":["Dermatology Research, Education and Research Centre, St. Vincent's University Hospital, Dublin 4, Ireland"],"raw_orcid":"https://orcid.org/0000-0002-1948-5568","affiliations":[{"raw_affiliation_string":"Dermatology Research, Education and Research Centre, St. Vincent's University Hospital, Dublin 4, Ireland","institution_ids":["https://openalex.org/I4210115218"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083116931","display_name":"Nuala McNicholas","orcid":"https://orcid.org/0000-0002-7962-7687","observed_orcids":["https://orcid.org/0000-0002-7962-7687"]},"institutions":[{"id":"https://openalex.org/I4210115218","display_name":"St. Vincent's University Hospital","ror":"https://ror.org/029tkqm80","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210115218"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"N. McNicholas","raw_affiliation_strings":["Department of Neurology, St. Vincent's University Hospital, Dublin 4, Ireland"],"raw_orcid":"https://orcid.org/0000-0002-7962-7687","affiliations":[{"raw_affiliation_string":"Department of Neurology, St. Vincent's University Hospital, Dublin 4, Ireland","institution_ids":["https://openalex.org/I4210115218"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103168335","display_name":"Christopher McGuigan","orcid":"https://orcid.org/0000-0003-0109-9877","observed_orcids":["https://orcid.org/0000-0003-0109-9877"]},"institutions":[{"id":"https://openalex.org/I4210115218","display_name":"St. Vincent's University Hospital","ror":"https://ror.org/029tkqm80","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210115218"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"C. McGuigan","raw_affiliation_strings":["Department of Neurology, St. Vincent's University Hospital, Dublin 4, Ireland"],"raw_orcid":"https://orcid.org/0000-0003-0109-9877","affiliations":[{"raw_affiliation_string":"Department of Neurology, St. Vincent's University Hospital, Dublin 4, Ireland","institution_ids":["https://openalex.org/I4210115218"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073196144","display_name":"Brian Kirby","orcid":"https://orcid.org/0000-0001-7596-892X","observed_orcids":["https://orcid.org/0000-0001-7596-892X"]},"institutions":[{"id":"https://openalex.org/I4210115218","display_name":"St. Vincent's University Hospital","ror":"https://ror.org/029tkqm80","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210115218"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"B. Kirby","raw_affiliation_strings":["Department of Dermatology, St. Vincent's University Hospital, Dublin 4, Ireland"],"raw_orcid":"https://orcid.org/0000-0001-7596-892X","affiliations":[{"raw_affiliation_string":"Department of Dermatology, St. Vincent's University Hospital, Dublin 4, Ireland","institution_ids":["https://openalex.org/I4210115218"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035915158","display_name":"Jean M. Fletcher","orcid":"https://orcid.org/0000-0002-0670-6659","observed_orcids":["https://orcid.org/0000-0002-0670-6659"]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]}],"countries":["IE"],"is_corresponding":true,"raw_author_name":"J.M. Fletcher","raw_affiliation_strings":["School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland","School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland"],"raw_orcid":"https://orcid.org/0000-0002-0670-6659","affiliations":[{"raw_affiliation_string":"School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468"]},{"raw_affiliation_string":"School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5035915158"],"corresponding_institution_ids":["https://openalex.org/I205274468"],"apc_list":{"value":2850,"currency":"GBP","value_usd":4000},"apc_paid":null,"fwci":1.6261,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.84231004,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"184","issue":"3","first_page":"495","last_page":"503"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dimethyl-fumarate","display_name":"dimethyl fumarate","score":1.0},{"id":"https://openalex.org/keywords/psoriasis","display_name":"psoriasis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9559999704360962},{"id":"https://openalex.org/keywords/th17-cells","display_name":"Th17 cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.7699999809265137},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8840000033378601},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.5400000214576721},{"id":"https://openalex.org/keywords/t-cell-proliferation","display_name":"T cell proliferation","score":0.8569999933242798},{"id":"https://openalex.org/keywords/il-17","display_name":"IL-17","score":0.9169999957084656},{"id":"https://openalex.org/keywords/il-22","display_name":"IL-22","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gm-csf","display_name":"GM-CSF","score":0.9459999799728394},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.734000027179718}],"concepts":[{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.523335874080658},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49665385484695435},{"id":"https://openalex.org/C2780564577","wikidata":"https://www.wikidata.org/wiki/Q179945","display_name":"Psoriasis","level":2,"score":0.42635706067085266},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.3015337586402893},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000069462","descriptor_name":"Dimethyl Fumarate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011565","descriptor_name":"Psoriasis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058504","descriptor_name":"Th17 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/bjd.19229","doi":"https://doi.org/10.1111/bjd.19229","is_oa":false,"landing_page_url":"https://doi.org/10.1111/bjd.19229","pdf_url":null,"source":{"id":"https://openalex.org/S45720283","display_name":"British Journal of Dermatology","issn_l":"0007-0963","issn":["0007-0963","1365-2133"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Dermatology","raw_type":"journal-article"},{"id":"pmid:32438447","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32438447","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The British journal of dermatology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.979200005531311,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320318570","display_name":"Saudi Arabian Cultural Bureau","ror":"https://ror.org/044weyr28"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1549187729","https://openalex.org/W1967446605","https://openalex.org/W1968195247","https://openalex.org/W1972403093","https://openalex.org/W1978094617","https://openalex.org/W1982598880","https://openalex.org/W1992776568","https://openalex.org/W1998017118","https://openalex.org/W2002344508","https://openalex.org/W2013810114","https://openalex.org/W2017215675","https://openalex.org/W2021705440","https://openalex.org/W2027129171","https://openalex.org/W2028479792","https://openalex.org/W2031818503","https://openalex.org/W2045806831","https://openalex.org/W2047484285","https://openalex.org/W2068690343","https://openalex.org/W2082618741","https://openalex.org/W2083147134","https://openalex.org/W2086700154","https://openalex.org/W2097593378","https://openalex.org/W2140184624","https://openalex.org/W2149538662","https://openalex.org/W2152100400","https://openalex.org/W2153242844","https://openalex.org/W2155691943","https://openalex.org/W2205231349","https://openalex.org/W2336862132","https://openalex.org/W2343323874","https://openalex.org/W2359919307","https://openalex.org/W2477545080","https://openalex.org/W2519889757","https://openalex.org/W2594894796","https://openalex.org/W2599441629","https://openalex.org/W2612052367","https://openalex.org/W2653859450","https://openalex.org/W2791287085","https://openalex.org/W2794813666","https://openalex.org/W2807674960","https://openalex.org/W2996366052"],"related_works":["https://openalex.org/W4252660195","https://openalex.org/W1943407914","https://openalex.org/W4250086772","https://openalex.org/W3084004015","https://openalex.org/W2795256497","https://openalex.org/W2594894796","https://openalex.org/W2904461264","https://openalex.org/W2155691943","https://openalex.org/W2996366052","https://openalex.org/W7204201225"],"abstract_inverted_index":{"BACKGROUND:":[0],"Dimethyl":[1],"fumarate":[2],"(DMF)":[3],"is":[4,36,236],"the":[5,16,55,74,132,149,180,186,193,210,245],"active":[6],"ingredient":[7],"of":[8,18,27,57,76,81,101,134,170,183,188,195,212,244,248],"Skilarence\u2122":[9],"and":[10,20,62,109,111,139,148,154,168,172,227],"Tecfidera\u2122,":[11],"which":[12,68],"are":[13],"used":[14],"for":[15,32],"treatment":[17],"psoriasis":[19,93,123],"multiple":[21,225],"sclerosis,":[22],"respectively.":[23],"Various":[24],"immunomodulatory":[25],"mechanisms":[26],"action":[28],"have":[29],"been":[30],"identified":[31],"DMF;":[33],"however,":[34],"it":[35],"still":[37],"unclear":[38],"what":[39],"effects":[40,56,100,182,247],"DMF":[41,102,126,164,196,208,249],"exerts":[42],"in":[43,45,60,63,73,89,103,131,142,161,174,192,218,222,228,239],"vivo":[44,61],"patients":[46,91,121,219,223],"with":[47,92,97,122,125,163,220,224,254],"psoriasis.":[48,77],"OBJECTIVES:":[49],"In":[50,120],"this":[51,235],"study":[52],"we":[53,127],"examined":[54,85],"DMF,":[58],"both":[59],"vitro,":[64],"on":[65,105,250],"T":[66,135,143,158,256],"cells,":[67],"play":[69],"a":[70,140,242],"key":[71],"role":[72],"pathogenesis":[75],"METHODS:":[78],"The":[79,99],"frequency":[80,133,187],"T-cell":[82,106],"subsets":[83],"was":[84],"by":[86,116],"flow":[87,117],"cytometry":[88],"untreated":[90],"or":[94],"those":[95],"treated":[96,124],"DMF.":[98,184],"vitro":[104,162],"survival,":[107],"activation":[108,171],"proliferation,":[110],"cell-surface":[112],"thiols":[113],"were":[114],"assessed":[115],"cytometry.":[118],"RESULTS:":[119],"observed":[128],"an":[129],"increase":[130],"regulatory":[136],"(Treg)":[137],"cells":[138,147,159,190,214,217,252],"decrease":[141],"helper":[144],"(Th)17":[145],"lineage":[146],"associated":[150],"cytokines":[151],"interleukin-17,":[152],"interleukin-22":[153],"granulocyte-macrophage":[155],"colony-stimulating":[156],"factor.":[157],"cultured":[160],"exhibited":[165],"reduced":[166],"viability,":[167],"inhibition":[169],"proliferation":[173],"response":[175],"to":[176,179,198,202,215],"stimulation":[177],"due":[178,197],"oxidative":[181,205],"However,":[185],"Treg":[189,213,251],"increased":[191],"presence":[194],"their":[199],"heightened":[200],"ability":[201],"resist":[203],"DMF-induced":[204],"stress.":[206],"CONCLUSIONS:":[207],"enhanced":[209],"ratio":[211],"Th17":[216],"psoriasis,":[221],"sclerosis":[226],"vitro.":[229],"Furthermore,":[230],"our":[231],"data":[232],"suggest":[233],"that":[234],"at":[237],"least":[238],"part":[240],"as":[241],"result":[243],"differential":[246],"compared":[253],"conventional":[255],"cells.":[257]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-05-29T00:00:00"}
