{"id":"https://openalex.org/W3025960907","doi":null,"title":"Targeting of senescence and metabolic disorders.","display_name":"Targeting of senescence and metabolic disorders.","publication_year":2016,"publication_date":"2016-09-01","ids":{"openalex":"https://openalex.org/W3025960907","mag":"3025960907","pmid":"https://pubmed.ncbi.nlm.nih.gov/30557486"},"language":"ja","primary_location":{"id":"pmid:30557486","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30557486","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nihon rinsho. Japanese journal of clinical medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023132059","display_name":"Kei Takahashi","orcid":"https://orcid.org/0000-0002-7455-0465","observed_orcids":["https://orcid.org/0000-0002-7455-0465"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kei Takahashi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5072098701","display_name":"Hideki Katagiri","orcid":"https://orcid.org/0000-0002-2786-8569","observed_orcids":["https://orcid.org/0000-0002-2786-8569"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hideki Katagiri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.27759163,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"74","issue":"9","first_page":"1513","last_page":"1517"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.9990000128746033},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9869999885559082},{"id":"https://openalex.org/keywords/senotherapy","display_name":"senotherapy","score":0.8370000123977661},{"id":"https://openalex.org/keywords/senolytics","display_name":"senolytics","score":0.9070000052452087},{"id":"https://openalex.org/keywords/pancreatic-beta-cells","display_name":"pancreatic beta cells","score":0.9409999847412109},{"id":"https://openalex.org/keywords/senescence-associated-beta-galactosidase","display_name":"senescence-associated \u03b2-galactosidase","score":0.9350000023841858},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.8339999914169312},{"id":"https://openalex.org/keywords/p16","display_name":"p16","score":0.9990000128746033},{"id":"https://openalex.org/keywords/telomere-shortening","display_name":"telomere shortening","score":0.9269999861717224},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.890999972820282},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.8759999871253967},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.47600001096725464},{"id":"https://openalex.org/keywords/metabolic-disorders","display_name":"metabolic disorders","score":0.6520000100135803}],"concepts":[{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.8425700664520264},{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.7683128118515015},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.7022144794464111},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6562575697898865},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.5991498231887817},{"id":"https://openalex.org/C2908780919","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Cellular Aging","level":4,"score":0.5604739785194397},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5469375848770142},{"id":"https://openalex.org/C2779523775","wikidata":"https://www.wikidata.org/wiki/Q9075999","display_name":"Cellular senescence","level":4,"score":0.5368779897689819},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.49394041299819946},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4907277822494507},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44784796237945557},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.423747718334198},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.4164397120475769},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3898193836212158},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34419387578964233},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29824942350387573},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.16771098971366882},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.13301151990890503},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1271781325340271},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11191770434379578}],"mesh":[{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008136","descriptor_name":"Longevity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008659","descriptor_name":"Metabolic Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016615","descriptor_name":"Telomere","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017667","descriptor_name":"Adipocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:30557486","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30557486","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nihon rinsho. Japanese journal of clinical medicine","raw_type":"Journal Article"},{"id":"mag:3025960907","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30557486","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4221006698","https://openalex.org/W1908141864","https://openalex.org/W4392606646","https://openalex.org/W2971121994","https://openalex.org/W7128184418","https://openalex.org/W4415733958","https://openalex.org/W4239831377","https://openalex.org/W4393206600","https://openalex.org/W4323256426","https://openalex.org/W3188031952"],"abstract_inverted_index":{"Type":[0],"2":[1],"diabetes":[2,28,38],"is":[3,11,29,113],"a":[4,45,114],"major":[5],"threat":[6],"to":[7,31,62,117],"human":[8],"lifespan,":[9],"and":[10,20,53,72,77,95,104,112],"caused":[12,41],"by":[13,44],"tissue":[14],"dysfunction":[15],"in":[16,37,42,50,60],"insulin":[17,21],"sensitive":[18],"tissues":[19,52],"secreting":[22],"pancreatic":[23,54,78],"P":[24],"cells.":[25,56],"Prevalence":[26],"of":[27,47,88,97],"known":[30],"increase":[32],"with":[33],"age.":[34],"Tissue":[35],"dysfunctions":[36],"may":[39],"be":[40],"part":[43],"convergence":[46],"cellular":[48,64],"senescence":[49,58,89],"adipose":[51],"p":[55,79,91],"Cellular":[57],"occurs":[59],"response":[61],"various":[63],"stressors,":[65],"such":[66,101],"as":[67,102],"telomere":[68],"erosion,":[69],"DNA":[70],"damage":[71],"oxidative":[73],"stress.":[74],"Senescent":[75],"adipocytes":[76],"cells":[80],"adopt":[81],"several":[82],"unique":[83],"characteristics":[84],"including":[85],"enzymatic":[86],"activity":[87],"associated":[90],"galactosidase(SA-":[92],"f":[93],"-GAL)":[94],"upregulation":[96],"cell":[98],"cycle":[99],"inhibitors":[100],"p53":[103],"p16.":[105],"Senotherapies":[106],"are":[107],"therapies":[108],"targeting":[109],"senescent":[110],"cells,":[111],"promising":[115],"strategy":[116],"overcome":[118],"diabetes.":[119]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-05-21T00:00:00"}