{"id":"https://openalex.org/W3025924909","doi":"https://doi.org/10.26355/eurrev_201906_18032","title":"MiR-124 inhibits spinal neuronal apoptosis through binding to GCH1.","display_name":"MiR-124 inhibits spinal neuronal apoptosis through binding to GCH1.","publication_year":2019,"publication_date":"2019-06-01","ids":{"openalex":"https://openalex.org/W3025924909","doi":"https://doi.org/10.26355/eurrev_201906_18032","mag":"3025924909","pmid":"https://pubmed.ncbi.nlm.nih.gov/31210282"},"language":"en","primary_location":{"id":"pmid:31210282","doi":"https://doi.org/10.26355/eurrev_201906_18032","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31210282","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European review for medical and pharmacological sciences","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086875568","display_name":"Shuhui Yuan","orcid":"https://orcid.org/0000-0002-6362-9493","observed_orcids":["https://orcid.org/0000-0002-6362-9493"]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"S Yuan","raw_affiliation_strings":["Qingdao University, Qingdao, China. txfbhm@163.com","Qingdao University, Qingdao, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Qingdao University, Qingdao, China. txfbhm@163.com","institution_ids":["https://openalex.org/I108688024"]},{"raw_affiliation_string":"Qingdao University, Qingdao, China","institution_ids":["https://openalex.org/I108688024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114033148","display_name":"Wang Yx","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y-X Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090441917","display_name":"Gong Ph","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P-H Gong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"C-Y Meng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C-Y Meng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9965,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.72890353,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"23","issue":"11","first_page":"4564","last_page":"4574"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.8838000297546387,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.8838000297546387,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.09839999675750732,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gtp-cyclohydrolase-i","display_name":"GTP cyclohydrolase I","score":0.9330000281333923},{"id":"https://openalex.org/keywords/spinal-cord-injury","display_name":"spinal cord injury","score":0.8600000143051147},{"id":"https://openalex.org/keywords/neuronal-apoptosis","display_name":"neuronal apoptosis","score":0.9539999961853027},{"id":"https://openalex.org/keywords/tetrahydrobiopterin","display_name":"tetrahydrobiopterin","score":0.9610000252723694},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.8859999775886536},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.703000009059906},{"id":"https://openalex.org/keywords/microrna-target-regulation","display_name":"microRNA target regulation","score":0.5080000162124634},{"id":"https://openalex.org/keywords/motor-recovery","display_name":"motor recovery","score":0.8859999775886536},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.6769999861717224},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.3880000114440918},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.5899999737739563},{"id":"https://openalex.org/keywords/spinal-neurons","display_name":"spinal cord neurons","score":0.4180000126361847}],"concepts":[{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.7423093914985657},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7025904655456543},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.6141718626022339},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5981462597846985},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.5518308281898499},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5192592144012451},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.5170605778694153},{"id":"https://openalex.org/C2776145790","wikidata":"https://www.wikidata.org/wiki/Q419808","display_name":"Tetrahydrobiopterin","level":4,"score":0.515021800994873},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4711636006832123},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.44707977771759033},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3276582360267639},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27147141098976135},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19740110635757446},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16843241453170776},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15634161233901978},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.09115001559257507},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006136","descriptor_name":"GTP Cyclohydrolase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006136","descriptor_name":"GTP Cyclohydrolase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013119","descriptor_name":"Spinal Cord Injuries","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013119","descriptor_name":"Spinal Cord Injuries","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013119","descriptor_name":"Spinal Cord Injuries","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020127","descriptor_name":"Recovery of Function","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061251","descriptor_name":"Primary Cell Culture","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:31210282","doi":"https://doi.org/10.26355/eurrev_201906_18032","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31210282","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European review for medical and pharmacological sciences","raw_type":"Journal Article"},{"id":"mag:3025924909","doi":"https://doi.org/10.26355/eurrev_201906_18032","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31210282","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2913279959","https://openalex.org/W4293562355","https://openalex.org/W3025776315","https://openalex.org/W2990486948","https://openalex.org/W3033262840","https://openalex.org/W3185687700","https://openalex.org/W2619868785","https://openalex.org/W3117143025","https://openalex.org/W4319242924","https://openalex.org/W3130941317"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"explore":[2,17],"the":[3,11,39,52,80,87,92,103,126,129,143,146,150,158,162,165,168,178,186,189,206,209,228,234,246,253,264,283,302,319,326,331,342,347,354,367,375,391,413,422,436,441],"effect":[4,40,424],"of":[5,27,41,47,60,167,213,237,266,271,308,344,425,438],"micro":[6],"ribonucleic":[7],"acid":[8],"(miR)-124":[9],"on":[10,43],"spinal":[12,28,67,217,240,322,333,349,362],"neuronal":[13,323,334,350,363,402],"apoptosis":[14,113,364,403],"and":[15,38,62,79,97,106,122,142,202,226,244,268,311,380,396,427],"to":[16,252,408],"its":[18],"related":[19],"mechanism.":[20],"MATERIALS":[21],"AND":[22],"METHODS:":[23],"The":[24,56,110,306,410],"rat":[25],"model":[26,187],"cord":[29,68,218,241],"injury":[30],"(SCI)":[31],"was":[32,35,49,84,100,192,220,258,280,298,338],"established,":[33],"agomir-124":[34,42,196,207],"injected":[36],"intrathecally":[37],"motor":[44],"function":[45],"recovery":[46],"rats":[48],"evaluated":[50],"using":[51,86,102,157,177,285],"Basso-Beattie-Bresnahan":[53],"(BBB)":[54],"score.":[55],"gene":[57],"expression":[58,211,265,270],"levels":[59],"miR-124":[61,96,267,316,327,360,372,386,428],"GTP-cyclohydrolase":[63],"1":[64],"(GCH1)":[65],"in":[66,112,114,128,133,145,149,152,164,185,195,216,239,282,404,412,435,440],"tissues":[69,219,242],"were":[70,117,136,155,175],"detected":[71,85,101,137,156,176],"via":[72,119,138],"quantitative":[73],"Reverse":[74],"Transcription-Polymerase":[75],"Chain":[76],"Reaction":[77],"(qRT-PCR),":[78],"correlation":[81,89,255,262],"between":[82,95,263],"them":[83],"Pearson":[88,254],"coefficient.":[90],"Then,":[91],"direct":[93],"interaction":[94],"GCH1":[98,238,272,289,345,355,368,388],"mRNA":[99,235,269],"TargetScan":[104,286],"software":[105,287],"luciferase":[107,303],"reporter":[108,304],"assay.":[109,305],"changes":[111,127,144,163],"each":[115,134,153],"group":[116,135,154,197],"examined":[118],"flow":[120,309],"cytometry":[121,310],"Western":[123,312],"blotting.":[124],"Moreover,":[125,336],"tetrahydrobiopterin":[130],"(BH4)":[131],"content":[132],"high-performance":[139],"liquid":[140],"chromatography,":[141],"nitrite":[147,378,394],"level":[148,212,236],"supernatant":[151],"Griess":[159],"reagent.":[160],"Finally,":[161],"activity":[166,382],"inducible":[169],"nitric":[170],"oxide":[171],"synthase":[172],"(iNOS)":[173],"protein":[174],"iNOS":[179,381,397],"kit.":[180],"RESULTS:":[181],"Compared":[182],"with":[183],"that":[184,288,315,341,359],"group,":[188,208],"BBB":[190],"score":[191],"significantly":[193,221,317],"increased":[194,222,330,390],"at":[198,223,230,248],"21,":[199],"28,":[200],"35":[201],"42":[203],"d.":[204,250],"In":[205,352],"relative":[210],"miR":[214],"124":[215],"7-28":[224],"d":[225],"reached":[227],"peak":[229],"21":[231,249],"d,":[232],"while":[233,325,383],"declined":[243],"touched":[245],"bottom":[247],"According":[251],"coefficient,":[256],"there":[257],"a":[259,292,418,431],"significant":[260],"negative":[261],"(r":[273],"=-":[274],"0.87,":[275],"p":[276],"=":[277],"1.5e-6).":[278],"It":[279],"found":[281,340],"prediction":[284],"might":[290],"be":[291],"potential":[293,432],"target":[294],"for":[295,421],"miR-124,":[296,426],"which":[297],"further":[299],"verified":[300],"by":[301,365,406],"results":[307,411],"blotting":[313],"showed":[314],"reduced":[318,346],"LPS-induced":[320,348],"primary":[321,332],"apoptosis,":[324],"inhibitor":[328],"remarkably":[329,373,389],"apoptosis.":[335,351],"it":[337],"also":[339],"knockout":[343],"addition,":[353],"overexpression":[356],"assay":[357],"revealed":[358],"inhibited":[361],"suppressing":[366],"expression.":[369],"LPS":[370,384],"+":[371,385,387],"decreased":[374],"BH4":[376,392],"content,":[377,393],"level,":[379,395],"activity.":[398],"CONCLUSIONS:":[399],"MiR-124":[400],"inhibits":[401],"SCI":[405,439],"binding":[407],"GCH1.":[409],"present":[414],"study":[415],"may":[416,429],"provide":[417],"new":[419],"mechanism":[420],"therapeutic":[423,433],"have":[430],"value":[434],"treatment":[437],"future.":[442]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-05-21T00:00:00"}
