{"id":"https://openalex.org/W3025835913","doi":"https://doi.org/10.1096/fasebj.26.1_supplement.897.4","title":"Ion channel regulation by the Lkb1\u2010AMPK signalling pathway: the key to carotid body activation by hypoxia and metabolic homeostasis at the whole body level","display_name":"Ion channel regulation by the Lkb1\u2010AMPK signalling pathway: the key to carotid body activation by hypoxia and metabolic homeostasis at the whole body level","publication_year":2012,"publication_date":"2012-04-01","ids":{"openalex":"https://openalex.org/W3025835913","doi":"https://doi.org/10.1096/fasebj.26.1_supplement.897.4","mag":"3025835913"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.26.1_supplement.897.4","doi":"https://doi.org/10.1096/fasebj.26.1_supplement.897.4","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.26.1_supplement.897.4","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040302772","display_name":"A. Mark Evans","orcid":"https://orcid.org/0000-0002-4650-7208","observed_orcids":["https://orcid.org/0000-0002-4650-7208"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A. Mark Evans","raw_affiliation_strings":["<!--<label><sup>1</sup></label>--> Centre for Integrative Physiology University of Edinburgh Edinburgh United Kingdom","1--> Centre for Integrative Physiology University of Edinburgh Edinburgh United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>1</sup></label>--> Centre for Integrative Physiology University of Edinburgh Edinburgh United Kingdom","institution_ids":["https://openalex.org/I98677209"]},{"raw_affiliation_string":"1--> Centre for Integrative Physiology University of Edinburgh Edinburgh United Kingdom","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046976143","display_name":"David Grahame Hardie","orcid":"https://orcid.org/0000-0002-8373-7379","observed_orcids":["https://orcid.org/0000-0002-8373-7379"]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D. Grahame Hardie","raw_affiliation_strings":["<!--<label><sup>2</sup></label>--> College of Life Sciences University of Dundee Dundee United Kingdom","2--> College of Life Sciences University of Dundee Dundee United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>2</sup></label>--> College of Life Sciences University of Dundee Dundee United Kingdom","institution_ids":["https://openalex.org/I177639307"]},{"raw_affiliation_string":"2--> College of Life Sciences University of Dundee Dundee United Kingdom","institution_ids":["https://openalex.org/I177639307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021541994","display_name":"Chris Peers","orcid":"https://orcid.org/0000-0002-8354-346X","observed_orcids":["https://orcid.org/0000-0002-8354-346X"]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Chris Peers","raw_affiliation_strings":["<!--<label><sup>3</sup></label>--> Division of Cardiovascular and Neuronal Remodelling University of Leeds Leeds United Kingdom","3--> Division of Cardiovascular and Neuronal Remodelling University of Leeds Leeds United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>3</sup></label>--> Division of Cardiovascular and Neuronal Remodelling University of Leeds Leeds United Kingdom","institution_ids":["https://openalex.org/I130828816"]},{"raw_affiliation_string":"3--> Division of Cardiovascular and Neuronal Remodelling University of Leeds Leeds United Kingdom","institution_ids":["https://openalex.org/I130828816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014560370","display_name":"Prem Kumar","orcid":"https://orcid.org/0000-0001-7524-6046","observed_orcids":["https://orcid.org/0000-0001-7524-6046"]},"institutions":[{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Prem Kumar","raw_affiliation_strings":["<!--<label><sup>4</sup></label>--> School of Clinical and Experimental Medicine University of Birmingham Birmingham United Kingdom","4--> School of Clinical and Experimental Medicine University of Birmingham Birmingham United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>4</sup></label>--> School of Clinical and Experimental Medicine University of Birmingham Birmingham United Kingdom","institution_ids":["https://openalex.org/I79619799"]},{"raw_affiliation_string":"4--> School of Clinical and Experimental Medicine University of Birmingham Birmingham United Kingdom","institution_ids":["https://openalex.org/I79619799"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044742154","display_name":"Christopher N. Wyatt","orcid":"https://orcid.org/0000-0003-1935-0900","observed_orcids":["https://orcid.org/0000-0003-1935-0900"]},"institutions":[{"id":"https://openalex.org/I19648265","display_name":"Wright State University","ror":"https://ror.org/04qk6pt94","country_code":"US","type":"education","lineage":["https://openalex.org/I19648265"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher N. Wyatt","raw_affiliation_strings":["<!--<label><sup>5</sup></label>--> Department of Neuroscience, Cell Biology and Physiology Wright State University Dayton OH","5--> Department of Neuroscience, Cell Biology and Physiology Wright State University Dayton OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>5</sup></label>--> Department of Neuroscience, Cell Biology and Physiology Wright State University Dayton OH","institution_ids":["https://openalex.org/I19648265"]},{"raw_affiliation_string":"5--> Department of Neuroscience, Cell Biology and Physiology Wright State University Dayton OH","institution_ids":["https://openalex.org/I19648265"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.31103896,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liver-kinase-b1","display_name":"LKB1","score":0.8550000190734863},{"id":"https://openalex.org/keywords/ampk","display_name":"AMPK","score":0.8799999952316284},{"id":"https://openalex.org/keywords/carotid-body","display_name":"carotid body","score":0.9750000238418579},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.9729999899864197},{"id":"https://openalex.org/keywords/ion-channels","display_name":"ion channels","score":0.597000002861023},{"id":"https://openalex.org/keywords/bk-channels","display_name":"BK channels","score":0.9940000176429749},{"id":"https://openalex.org/keywords/task-3","display_name":"TASK-3","score":0.7229999899864197},{"id":"https://openalex.org/keywords/task-1","display_name":"TASK-1","score":0.5569999814033508},{"id":"https://openalex.org/keywords/ventilatory-response","display_name":"ventilatory response","score":0.5979999899864197},{"id":"https://openalex.org/keywords/metabolic-homeostasis","display_name":"metabolic homeostasis","score":0.7699999809265137},{"id":"https://openalex.org/keywords/mitochondrial-oxidative-phosphorylation","display_name":"mitochondrial oxidative phosphorylation","score":0.7379999756813049},{"id":"https://openalex.org/keywords/aicar","display_name":"AICAR","score":0.8230000138282776},{"id":"https://openalex.org/keywords/a769662","display_name":"A769662","score":0.9559999704360962},{"id":"https://openalex.org/keywords/oxygen-sensing","display_name":"oxygen sensing","score":0.4410000145435333}],"concepts":[{"id":"https://openalex.org/C2780124434","wikidata":"https://www.wikidata.org/wiki/Q12357464","display_name":"AMPK","level":4,"score":0.9148530960083008},{"id":"https://openalex.org/C2778113364","wikidata":"https://www.wikidata.org/wiki/Q1532008","display_name":"Carotid body","level":3,"score":0.7729630470275879},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.6630338430404663},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6056215763092041},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5580633282661438},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.46071040630340576},{"id":"https://openalex.org/C2776780712","wikidata":"https://www.wikidata.org/wiki/Q295240","display_name":"AMP-activated protein kinase","level":5,"score":0.4504304528236389},{"id":"https://openalex.org/C2491326","wikidata":"https://www.wikidata.org/wiki/Q5377024","display_name":"Energy homeostasis","level":3,"score":0.4494200050830841},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.41788867115974426},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.4101560413837433},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.40620601177215576},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.35751211643218994},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33147215843200684},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24459588527679443},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.24347850680351257},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18773487210273743},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.15021070837974548},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10739126801490784},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09968569874763489},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.26.1_supplement.897.4","doi":"https://doi.org/10.1096/fasebj.26.1_supplement.897.4","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.26.1_supplement.897.4","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7246000170707703,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1968885616","https://openalex.org/W2158940337","https://openalex.org/W2936877229","https://openalex.org/W2074432652","https://openalex.org/W2068027702","https://openalex.org/W4380715198","https://openalex.org/W4283694682","https://openalex.org/W2566029648","https://openalex.org/W2113166898","https://openalex.org/W3176682503"],"abstract_inverted_index":{"Our":[0],"recent":[1],"investigations":[2],"provide":[3],"further":[4],"support":[5],"for":[6,142],"the":[7,31,52,113,124,136,146,159],"proposal":[8],"that,":[9],"consequent":[10],"to":[11,129,151],"inhibition":[12],"of":[13,18,33,41,51,103,112,119,127],"mitochondrial":[14],"oxidative":[15],"phosphorylation,":[16],"activation":[17],"AMP\u2010activated":[19],"protein":[20],"kinase":[21],"(AMPK)":[22],"mediates":[23],"carotid":[24,68,92,147],"body":[25,69,93,161],"excitation":[26],"by":[27,78,145],"hypoxia.":[28,130],"Consistent":[29],"with":[30],"effects":[32],"hypoxia,":[34],"intracellular":[35],"dialysis":[36],"from":[37],"a":[38],"patch":[39],"pipette":[40],"an":[42],"active":[43],"(thiophosphorylated)":[44],"recombinant":[45],"AMPK":[46,53],"heterotrimer":[47],"(\u03b12\u03b22\u03b31)":[48],"or":[49,109],"application":[50],"activators":[54],"AICAR":[55],"and":[56,62,80,116,149,154],"A769662:":[57],"(1)":[58],"Inhibited":[59,74],"BKCa":[60],"currents":[61,65,76],"TASK":[63],"K+":[64],"in":[66,87,105],"rat":[67],"type":[70,106],"I":[71,107],"cells;":[72,89],"(2)":[73],"whole\u2010cell":[75],"carried":[77],"KCa1.1":[79],"TASK3,":[81],"but":[82],"not":[83],"TASK1":[84],"channels":[85],"expressed":[86],"HEK293":[88],"(3)":[90],"Triggered":[91],"activation.":[94],"Furthermore,":[95],"preliminary":[96],"data":[97],"suggest":[98],"that":[99,135],"either":[100],"conditional":[101],"knockout":[102,111],"Lkb1":[104],"cells":[108],"global":[110],"catalytic":[114],"\u03b11":[115],"\u03b12":[117],"subunit":[118],"AMPK,":[120],"respectively,":[121],"markedly":[122],"attenuated":[123],"ventilatory":[125],"response":[126],"mice":[128],"Accumulating":[131],"evidence":[132],"therefore":[133,155],"suggests":[134],"Lkb1\u2010AMPK":[137],"signalling":[138],"pathway":[139],"is":[140],"necessary":[141],"hypoxia\u2010response":[143],"coupling":[144],"body,":[148],"serves":[150],"regulate":[152],"oxygen":[153],"energy":[156],"supply":[157],"at":[158],"whole":[160],"level.":[162]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2020-05-21T00:00:00"}
