{"id":"https://openalex.org/W3025714432","doi":null,"title":"Chemo-embolization in the treatment of hepatocellular carcinoma: should we switch to charged particles in our countries? About 102 procedures of a North African radiology center.","display_name":"Chemo-embolization in the treatment of hepatocellular carcinoma: should we switch to charged particles in our countries? About 102 procedures of a North African radiology center.","publication_year":2018,"publication_date":"2018-07-01","ids":{"openalex":"https://openalex.org/W3025714432","mag":"3025714432","pmid":"https://pubmed.ncbi.nlm.nih.gov/30430488"},"language":"en","primary_location":{"id":"pmid:30430488","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30430488","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"La Tunisie medicale","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035436904","display_name":"L Charrada","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leila Ben Farhat Charrada","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103611146","display_name":"Hayfa Romdhane","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hayfa Romdhane","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037213354","display_name":"Zeineb Mzoughi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zeineb Mzoughi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109266459","display_name":"Meriem Cheikh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Meriem Cheikh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020013048","display_name":"Ghofrane Talbi","orcid":"https://orcid.org/0000-0001-6195-4789","observed_orcids":["https://orcid.org/0000-0001-6195-4789"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ghofrane Talbi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5103805664","display_name":"In\u00e8s Marzouk","orcid":"https://orcid.org/0000-0001-8394-6966","observed_orcids":["https://orcid.org/0000-0001-8394-6966"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ines Marzouk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"96","issue":"7","first_page":"437","last_page":"441"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/transarterial-chemoembolization","display_name":"transarterial chemoembolization","score":0.9860000014305115},{"id":"https://openalex.org/keywords/lipiodol","display_name":"lipiodol","score":0.7289999723434448},{"id":"https://openalex.org/keywords/charged-microparticles","display_name":"charged microparticles","score":0.8859999775886536},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.7200000286102295},{"id":"https://openalex.org/keywords/post-embolization-complications","display_name":"post-embolization complications","score":0.7829999923706055},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.9269999861717224},{"id":"https://openalex.org/keywords/recurrence","display_name":"recurrence","score":0.5529999732971191},{"id":"https://openalex.org/keywords/developing-countries","display_name":"developing countries","score":0.5370000004768372},{"id":"https://openalex.org/keywords/north-africa","display_name":"North Africa","score":0.777999997138977}],"concepts":[{"id":"https://openalex.org/C2778448856","wikidata":"https://www.wikidata.org/wiki/Q4205889","display_name":"Lipiodol","level":3,"score":0.9911407232284546},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.8224601745605469},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8195301294326782},{"id":"https://openalex.org/C2776035437","wikidata":"https://www.wikidata.org/wiki/Q1144114","display_name":"Embolization","level":2,"score":0.5845276117324829},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.550930380821228},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.5401081442832947},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.4838511049747467},{"id":"https://openalex.org/C102652120","wikidata":"https://www.wikidata.org/wiki/Q2419430","display_name":"Therapeutic effect","level":2,"score":0.45907992124557495},{"id":"https://openalex.org/C2776231280","wikidata":"https://www.wikidata.org/wiki/Q623031","display_name":"Liver cancer","level":3,"score":0.43174001574516296},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3266296088695526},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30600547790527344},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000352","descriptor_name":"Africa, Northern","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004998","descriptor_name":"Ethiodized Oil","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008863","descriptor_name":"Microspheres","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010818","descriptor_name":"Practice Patterns, Physicians'","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016461","descriptor_name":"Chemoembolization, Therapeutic","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D016461","descriptor_name":"Chemoembolization, Therapeutic","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016461","descriptor_name":"Chemoembolization, Therapeutic","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018787","descriptor_name":"Radiation Oncology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018787","descriptor_name":"Radiation Oncology","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:30430488","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30430488","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"La Tunisie medicale","raw_type":"Comparative Study"},{"id":"mag:3025714432","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30430488","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3166317980","https://openalex.org/W4407263147","https://openalex.org/W2405712563","https://openalex.org/W4367321469","https://openalex.org/W2093270520","https://openalex.org/W2011897106","https://openalex.org/W2003195150","https://openalex.org/W2041584518","https://openalex.org/W2098195152","https://openalex.org/W7217945136"],"abstract_inverted_index":{"BACKGROUND:":[0],"Hepatocellular":[1],"carcinoma":[2],"(HCC)":[3],"is":[4,207],"a":[5,76,115],"public":[6],"health":[7,215],"problem":[8],"in":[9,119,126,145,172],"african":[10],"countries.":[11,232],"The":[12,31,65,131,154,185,202],"chemoembolization":[13,110,125,182],"(CE)":[14],"could":[15],"represent":[16],"the":[17,68,84,94,100,137,180,191,205,217,226,229],"only":[18],"therapeutic":[19,101],"strategy.":[20],"Two":[21],"methods":[22],"can":[23],"be":[24,209,222],"proposed:":[25],"charged":[26,44,117,143],"microparticles":[27,45,118],"and":[28,41,46,123,142,149,152,188],"lipiodol":[29,47,124,196],"chemoembolization.":[30,48],"purpose":[32],"of":[33,67,93,106,109,147,174,190,204,228],"this":[34],"study":[35,54],"was":[36,55,70,114,133,158],"to":[37,80,98,195,208,221,225],"compare":[38],"results,":[39],"morbidity":[40,187],"survival":[42,156,175,189],"between":[43,136,179],"METHODS:":[49],"A":[50,104],"5":[51],"years":[52],"retrospective,":[53],"conducted":[56],"including":[57],"62":[58],"patients":[59,73],"with":[60,116,167],"HCC":[61],"treated":[62],"by":[63,74],"chemioembolization.":[64],"efficacy":[66],"treatment":[69],"evaluated":[71],"for":[72,91,163],"performing":[75],"computed":[77],"tomography":[78],"four":[79],"six":[81],"weeks":[82],"after":[83],"act.":[85],"We":[86],"used":[87],"\u00ab":[88],"European":[89],"Association":[90],"Study":[92],"Liver":[95],"\u00bb":[96],"criteria":[97],"evaluate":[99],"outcome.":[102],"RESULTS:":[103],"total":[105],"102":[107],"sessions":[108],"were":[111],"performed.":[112],"This":[113],"70":[120],"cases":[121,128],"(68.6%)":[122],"32":[127],"(31.3":[129],"%).":[130],"difference":[132,171],"not":[134],"significant":[135,170],"two":[138,181,192],"CE":[139,193,218],"techniques":[140,165,194],"(lipiodol":[141],"microparticles)":[144],"terms":[146,173],"complete":[148],"objective":[150],"response":[151],"complications.":[153],"mean":[155],"rate":[157],"30":[159],"months":[160],"\u00b1":[161],"4":[162],"all":[164],"combined,":[166],"no":[168],"statistically":[169],"time":[176],"without":[177],"recurrence":[178],"techniques.":[183],"CONCLUSION:":[184],"efficacy,":[186],"or":[197],"microfilled":[198],"particles":[199],"are":[200],"comparable.":[201],"selectivity":[203],"technique":[206],"taken":[210],"into":[211],"consideration.":[212],"For":[213],"economic":[214],"purposes,":[216],"lipiodol\u00e9e":[219],"appears":[220],"more":[223],"adapted":[224],"context":[227],"developing":[230],"African":[231]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-05-21T00:00:00"}