{"id":"https://openalex.org/W3025607488","doi":"https://doi.org/10.1016/j.ijbiomac.2020.05.097","title":"Development of glucose oxidase-immobilized alginate nanoparticles for enhanced glucose-triggered insulin delivery in diabetic mice","display_name":"Development of glucose oxidase-immobilized alginate nanoparticles for enhanced glucose-triggered insulin delivery in diabetic mice","publication_year":2020,"publication_date":"2020-05-16","ids":{"openalex":"https://openalex.org/W3025607488","doi":"https://doi.org/10.1016/j.ijbiomac.2020.05.097","mag":"3025607488","pmid":"https://pubmed.ncbi.nlm.nih.gov/32428589"},"language":"en","primary_location":{"id":"doi:10.1016/j.ijbiomac.2020.05.097","doi":"https://doi.org/10.1016/j.ijbiomac.2020.05.097","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ijbiomac.2020.05.097","pdf_url":null,"source":{"id":"https://openalex.org/S83853393","display_name":"International Journal of Biological Macromolecules","issn_l":"0141-8130","issn":["0141-8130","1879-0003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Biological Macromolecules","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084193336","display_name":"Zhihua Chai","orcid":"https://orcid.org/0000-0001-6634-6328","observed_orcids":["https://orcid.org/0000-0001-6634-6328"]},"institutions":[{"id":"https://openalex.org/I132210918","display_name":"North China Institute of Science and Technology","ror":"https://ror.org/0096c7651","country_code":"CN","type":"education","lineage":["https://openalex.org/I132210918"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhihua Chai","raw_affiliation_strings":["Department of Environmental Engineering, North China Institute of Science and Technology, PO Box 206, Yanjiao, Beijing 101601, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Engineering, North China Institute of Science and Technology, PO Box 206, Yanjiao, Beijing 101601, PR China","institution_ids":["https://openalex.org/I132210918"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060503737","display_name":"Huiyu Dong","orcid":"https://orcid.org/0000-0003-4736-5325","observed_orcids":["https://orcid.org/0000-0003-4736-5325"]},"institutions":[{"id":"https://openalex.org/I132210918","display_name":"North China Institute of Science and Technology","ror":"https://ror.org/0096c7651","country_code":"CN","type":"education","lineage":["https://openalex.org/I132210918"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huiyu Dong","raw_affiliation_strings":["Department of Environmental Engineering, North China Institute of Science and Technology, PO Box 206, Yanjiao, Beijing 101601, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Engineering, North China Institute of Science and Technology, PO Box 206, Yanjiao, Beijing 101601, PR China","institution_ids":["https://openalex.org/I132210918"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101624326","display_name":"Xiaoyu Sun","orcid":"https://orcid.org/0009-0004-5077-0393","observed_orcids":["https://orcid.org/0009-0004-5077-0393","https://orcid.org/0000-0002-7166-2170"]},"institutions":[{"id":"https://openalex.org/I132210918","display_name":"North China Institute of Science and Technology","ror":"https://ror.org/0096c7651","country_code":"CN","type":"education","lineage":["https://openalex.org/I132210918"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoyu Sun","raw_affiliation_strings":["Department of Environmental Engineering, North China Institute of Science and Technology, PO Box 206, Yanjiao, Beijing 101601, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Engineering, North China Institute of Science and Technology, PO Box 206, Yanjiao, Beijing 101601, PR China","institution_ids":["https://openalex.org/I132210918"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089554500","display_name":"Yiting Fan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I132210918","display_name":"North China Institute of Science and Technology","ror":"https://ror.org/0096c7651","country_code":"CN","type":"education","lineage":["https://openalex.org/I132210918"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiting Fan","raw_affiliation_strings":["Department of Environmental Engineering, North China Institute of Science and Technology, PO Box 206, Yanjiao, Beijing 101601, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Engineering, North China Institute of Science and Technology, PO Box 206, Yanjiao, Beijing 101601, PR China","institution_ids":["https://openalex.org/I132210918"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107274803","display_name":"Yanxia Wang","orcid":"https://orcid.org/0009-0007-0194-5478","observed_orcids":["https://orcid.org/0009-0007-0194-5478"]},"institutions":[{"id":"https://openalex.org/I132210918","display_name":"North China Institute of Science and Technology","ror":"https://ror.org/0096c7651","country_code":"CN","type":"education","lineage":["https://openalex.org/I132210918"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yanxia Wang","raw_affiliation_strings":["Department of Environmental Engineering, North China Institute of Science and Technology, PO Box 206, Yanjiao, Beijing 101601, PR China. Electronic address: wangyanxia@ncist.edu.cn","Department of Environmental Engineering, North China Institute of Science and Technology, PO Box 206, Yanjiao, Beijing 101601, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Engineering, North China Institute of Science and Technology, PO Box 206, Yanjiao, Beijing 101601, PR China. Electronic address: wangyanxia@ncist.edu.cn","institution_ids":["https://openalex.org/I132210918"]},{"raw_affiliation_string":"Department of Environmental Engineering, North China Institute of Science and Technology, PO Box 206, Yanjiao, Beijing 101601, PR China","institution_ids":["https://openalex.org/I132210918"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058049916","display_name":"Fan Huang","orcid":"https://orcid.org/0000-0001-9029-8805","observed_orcids":["https://orcid.org/0000-0001-9029-8805"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Fan Huang","raw_affiliation_strings":["Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Science & Peking Union Medical College, PR China. Electronic address: huangfanforever@126.com","Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Science & Peking Union Medical College, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Science & Peking Union Medical College, PR China. Electronic address: huangfanforever@126.com","institution_ids":["https://openalex.org/I200296433"]},{"raw_affiliation_string":"Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Science & Peking Union Medical College, PR China","institution_ids":["https://openalex.org/I200296433"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5058049916","https://openalex.org/A5107274803"],"corresponding_institution_ids":["https://openalex.org/I132210918","https://openalex.org/I200296433"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":1.9976,"has_fulltext":false,"cited_by_count":50,"citation_normalized_percentile":{"value":0.85881971,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"159","issue":null,"first_page":"640","last_page":"647"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.3434999883174896,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.3434999883174896,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.29809999465942383,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.1940000057220459,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucose-oxidase","display_name":"glucose oxidase","score":0.9869999885559082},{"id":"https://openalex.org/keywords/alginate-nanoparticles","display_name":"alginate nanoparticles","score":0.9769999980926514},{"id":"https://openalex.org/keywords/insulin-delivery","display_name":"insulin delivery","score":0.781000018119812},{"id":"https://openalex.org/keywords/glucose-responsive-drug-release","display_name":"glucose-responsive drug release","score":0.8230000138282776},{"id":"https://openalex.org/keywords/enzyme-immobilization","display_name":"enzyme immobilization","score":0.7269999980926514},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.4399999976158142},{"id":"https://openalex.org/keywords/subcutaneous-insulin-injection","display_name":"subcutaneous insulin injection","score":0.7149999737739563},{"id":"https://openalex.org/keywords/hypoglycemic-effect","display_name":"hypoglycemic effect","score":0.9020000100135803},{"id":"https://openalex.org/keywords/biocompatibility","display_name":"biocompatibility","score":0.9300000071525574},{"id":"https://openalex.org/keywords/nanoparticle-cytotoxicity","display_name":"nanoparticle cytotoxicity","score":0.7020000219345093}],"concepts":[{"id":"https://openalex.org/C2777197210","wikidata":"https://www.wikidata.org/wiki/Q419321","display_name":"Glucose oxidase","level":3,"score":0.9453478455543518},{"id":"https://openalex.org/C2777230088","wikidata":"https://www.wikidata.org/wiki/Q864426","display_name":"Biocompatibility","level":2,"score":0.828762948513031},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6871975660324097},{"id":"https://openalex.org/C2777734296","wikidata":"https://www.wikidata.org/wiki/Q408739","display_name":"Phenylboronic acid","level":3,"score":0.609583854675293},{"id":"https://openalex.org/C2994527087","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin delivery","level":4,"score":0.6031562089920044},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5881503224372864},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.433085173368454},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3402862548828125},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.2421020269393921},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.19076964259147644},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.1557525396347046},{"id":"https://openalex.org/C160756335","wikidata":"https://www.wikidata.org/wiki/Q669391","display_name":"Biosensor","level":2,"score":0.13063931465148926},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.10719278454780579},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10687294602394104},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09672227501869202},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.09355437755584717},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.06651487946510315},{"id":"https://openalex.org/C2781232474","wikidata":"https://www.wikidata.org/wiki/Q124407","display_name":"Type 1 diabetes","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000464","descriptor_name":"Alginates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004800","descriptor_name":"Enzymes, Immobilized","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005949","descriptor_name":"Glucose Oxidase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006461","descriptor_name":"Hemolysis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017550","descriptor_name":"Spectroscopy, Fourier Transform Infrared","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019468","descriptor_name":"Disease Management","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D065546","descriptor_name":"Drug Liberation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ijbiomac.2020.05.097","doi":"https://doi.org/10.1016/j.ijbiomac.2020.05.097","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ijbiomac.2020.05.097","pdf_url":null,"source":{"id":"https://openalex.org/S83853393","display_name":"International Journal of Biological Macromolecules","issn_l":"0141-8130","issn":["0141-8130","1879-0003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Biological Macromolecules","raw_type":"journal-article"},{"id":"pmid:32428589","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32428589","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of biological macromolecules","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7246000170707703,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4568616629","display_name":null,"funder_award_id":"BJ2019202","funder_id":"https://openalex.org/F4320329838","funder_display_name":"Colleges and Universities in Hebei Province Science and Technology Research Project"},{"id":"https://openalex.org/G8266282097","display_name":null,"funder_award_id":"51803057","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321106","display_name":"Ministry of Education of the People's Republic of China","ror":"https://ror.org/01mv9t934"},{"id":"https://openalex.org/F4320329838","display_name":"Colleges and Universities in Hebei Province Science and Technology Research Project","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1584289121","https://openalex.org/W1965170935","https://openalex.org/W1967534960","https://openalex.org/W1973360240","https://openalex.org/W1983354866","https://openalex.org/W1996610205","https://openalex.org/W2015700034","https://openalex.org/W2021743109","https://openalex.org/W2046623184","https://openalex.org/W2047419112","https://openalex.org/W2047780947","https://openalex.org/W2050900356","https://openalex.org/W2075563824","https://openalex.org/W2077192663","https://openalex.org/W2084718630","https://openalex.org/W2094100188","https://openalex.org/W2223905458","https://openalex.org/W2250131397","https://openalex.org/W2316031239","https://openalex.org/W2319428597","https://openalex.org/W2339900585","https://openalex.org/W2529783956","https://openalex.org/W2561427044","https://openalex.org/W2562177069","https://openalex.org/W2566028517","https://openalex.org/W2569734753","https://openalex.org/W2605083153","https://openalex.org/W2609222169","https://openalex.org/W2735294868","https://openalex.org/W2756216140","https://openalex.org/W2757650562","https://openalex.org/W2759705666","https://openalex.org/W2766256264","https://openalex.org/W2791355251","https://openalex.org/W2802346576","https://openalex.org/W2890631174","https://openalex.org/W2897480646","https://openalex.org/W2900475493","https://openalex.org/W2904333462","https://openalex.org/W2917269741","https://openalex.org/W2935779035","https://openalex.org/W2980632691","https://openalex.org/W3005959924","https://openalex.org/W3006700008","https://openalex.org/W3010031762","https://openalex.org/W3011136951","https://openalex.org/W3012115543"],"related_works":["https://openalex.org/W4391680944","https://openalex.org/W7084126738","https://openalex.org/W2900475493","https://openalex.org/W3097660206","https://openalex.org/W3042277017","https://openalex.org/W4385406987","https://openalex.org/W4378227948","https://openalex.org/W4324018724","https://openalex.org/W4402850403","https://openalex.org/W7165769236"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":12}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-05-21T00:00:00"}