{"id":"https://openalex.org/W3025367668","doi":null,"title":"New approaches to the detection of echinocandin resistance in Candida glabrata in clinical diagnostic laboratories","display_name":"New approaches to the detection of echinocandin resistance in Candida glabrata in clinical diagnostic laboratories","publication_year":2019,"publication_date":"2019-10-29","ids":{"openalex":"https://openalex.org/W3025367668","mag":"3025367668"},"language":"en","primary_location":{"id":"pmh:oai:uwe-repository.worktribe.com:1490747","doi":null,"is_oa":true,"landing_page_url":"https://uwe-repository.worktribe.com/1490747/1/New%20approaches%20to%20the%20detection%20of%20echinocandin%20resistance%20in%20Candida%20glabrata%20in%20clinical%20diagnostic%20laboratories","pdf_url":"https://uwe-repository.worktribe.com/preview/4187819/Final%20Approved%20Version%20-%20Mark%20Fraser%20%28redacted%29.pdf","source":{"id":"https://openalex.org/S4306401464","display_name":"UWE Research Repository (UWE Bristol)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I178535277","host_organization_name":"University of the West of England","host_organization_lineage":["https://openalex.org/I178535277"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://uwe-repository.worktribe.com/preview/4187819/Final%20Approved%20Version%20-%20Mark%20Fraser%20%28redacted%29.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020225909","display_name":"Mark Fraser","orcid":"https://orcid.org/0000-0003-4474-2391","observed_orcids":["https://orcid.org/0000-0003-4474-2391"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Mark Fraser","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4474-2391","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5020225909"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12167","display_name":"Bacterial Identification and Susceptibility Testing","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12668","display_name":"Yeasts and Rust Fungi Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/candida-glabrata","display_name":"Candida glabrata","score":0.921999990940094},{"id":"https://openalex.org/keywords/echinocandin-resistance","display_name":"echinocandin resistance","score":0.9990000128746033},{"id":"https://openalex.org/keywords/candidemia","display_name":"candidemia","score":0.847000002861023},{"id":"https://openalex.org/keywords/pyrosequencing-assay","display_name":"pyrosequencing assay","score":0.8240000009536743},{"id":"https://openalex.org/keywords/proteomics","display_name":"proteomics","score":0.796999990940094},{"id":"https://openalex.org/keywords/maldi-tof-mass-spectrometry","display_name":"MALDI-TOF mass spectrometry","score":0.871999979019165},{"id":"https://openalex.org/keywords/lc-ms-ms","display_name":"LC-MS/MS","score":0.9300000071525574},{"id":"https://openalex.org/keywords/bloodstream-infection","display_name":"bloodstream infection","score":0.699999988079071},{"id":"https://openalex.org/keywords/antifungal-prophylaxis","display_name":"antifungal prophylaxis","score":0.7860000133514404}],"concepts":[{"id":"https://openalex.org/C2779320740","wikidata":"https://www.wikidata.org/wiki/Q3718510","display_name":"Echinocandin","level":4,"score":0.9805637001991272},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.7380644083023071},{"id":"https://openalex.org/C2780670043","wikidata":"https://www.wikidata.org/wiki/Q139137","display_name":"Candida glabrata","level":3,"score":0.7208515405654907},{"id":"https://openalex.org/C2910751997","wikidata":"https://www.wikidata.org/wiki/Q3718510","display_name":"Echinocandins","level":5,"score":0.5263563394546509},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5092202425003052},{"id":"https://openalex.org/C2779020398","wikidata":"https://www.wikidata.org/wiki/Q6827850","display_name":"Micafungin","level":4,"score":0.4994664192199707},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.4717569947242737},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43109530210494995},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4282929599285126},{"id":"https://openalex.org/C2780161414","wikidata":"https://www.wikidata.org/wiki/Q29887808","display_name":"Invasive candidiasis","level":4,"score":0.4232720136642456},{"id":"https://openalex.org/C2780402444","wikidata":"https://www.wikidata.org/wiki/Q420875","display_name":"Caspofungin","level":4,"score":0.367800772190094},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.34207043051719666},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.29605746269226074},{"id":"https://openalex.org/C2780651595","wikidata":"https://www.wikidata.org/wiki/Q411478","display_name":"Fluconazole","level":3,"score":0.17253655195236206}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:uwe-repository.worktribe.com:1490747","doi":null,"is_oa":true,"landing_page_url":"https://uwe-repository.worktribe.com/1490747/1/New%20approaches%20to%20the%20detection%20of%20echinocandin%20resistance%20in%20Candida%20glabrata%20in%20clinical%20diagnostic%20laboratories","pdf_url":"https://uwe-repository.worktribe.com/preview/4187819/Final%20Approved%20Version%20-%20Mark%20Fraser%20%28redacted%29.pdf","source":{"id":"https://openalex.org/S4306401464","display_name":"UWE Research Repository (UWE Bristol)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I178535277","host_organization_name":"University of the West of England","host_organization_lineage":["https://openalex.org/I178535277"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:3025367668","doi":null,"is_oa":false,"landing_page_url":"https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.809196","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:uwe-repository.worktribe.com:1490747","doi":null,"is_oa":true,"landing_page_url":"https://uwe-repository.worktribe.com/1490747/1/New%20approaches%20to%20the%20detection%20of%20echinocandin%20resistance%20in%20Candida%20glabrata%20in%20clinical%20diagnostic%20laboratories","pdf_url":"https://uwe-repository.worktribe.com/preview/4187819/Final%20Approved%20Version%20-%20Mark%20Fraser%20%28redacted%29.pdf","source":{"id":"https://openalex.org/S4306401464","display_name":"UWE Research Repository (UWE Bristol)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I178535277","host_organization_name":"University of the West of England","host_organization_lineage":["https://openalex.org/I178535277"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3025367668.pdf","grobid_xml":"https://content.openalex.org/works/W3025367668.grobid-xml"},"referenced_works_count":69,"referenced_works":["https://openalex.org/W82223681","https://openalex.org/W1537111008","https://openalex.org/W1903151974","https://openalex.org/W1966144900","https://openalex.org/W1967386649","https://openalex.org/W1976229528","https://openalex.org/W1977181213","https://openalex.org/W1981214602","https://openalex.org/W1984516995","https://openalex.org/W1989074451","https://openalex.org/W1989847835","https://openalex.org/W1992670593","https://openalex.org/W2018096570","https://openalex.org/W2021465218","https://openalex.org/W2023096047","https://openalex.org/W2032525833","https://openalex.org/W2034564818","https://openalex.org/W2034990238","https://openalex.org/W2045468010","https://openalex.org/W2069172362","https://openalex.org/W2077538707","https://openalex.org/W2079811704","https://openalex.org/W2086734098","https://openalex.org/W2093186353","https://openalex.org/W2099230922","https://openalex.org/W2101785863","https://openalex.org/W2104558568","https://openalex.org/W2107094766","https://openalex.org/W2109797999","https://openalex.org/W2120122292","https://openalex.org/W2121905369","https://openalex.org/W2125672511","https://openalex.org/W2155860425","https://openalex.org/W2159338055","https://openalex.org/W2161066622","https://openalex.org/W2161710216","https://openalex.org/W2163845340","https://openalex.org/W2167509781","https://openalex.org/W2181262698","https://openalex.org/W2277606936","https://openalex.org/W2292034632","https://openalex.org/W2328787315","https://openalex.org/W2509356873","https://openalex.org/W2516050586","https://openalex.org/W2519633773","https://openalex.org/W2521771323","https://openalex.org/W2551752066","https://openalex.org/W2555650279","https://openalex.org/W2580163702","https://openalex.org/W2586970551","https://openalex.org/W2614979625","https://openalex.org/W2617242205","https://openalex.org/W2739660851","https://openalex.org/W2740085246","https://openalex.org/W2749738959","https://openalex.org/W2753636679","https://openalex.org/W2755980749","https://openalex.org/W2773217499","https://openalex.org/W2779634641","https://openalex.org/W2781712060","https://openalex.org/W2790911203","https://openalex.org/W2791951886","https://openalex.org/W2810748079","https://openalex.org/W2892078430","https://openalex.org/W2898755211","https://openalex.org/W2909920047","https://openalex.org/W2931967872","https://openalex.org/W2942596495","https://openalex.org/W2945334029"],"related_works":["https://openalex.org/W2945334029","https://openalex.org/W2507370632","https://openalex.org/W1984516995","https://openalex.org/W4404252125","https://openalex.org/W1964521129","https://openalex.org/W2749738959","https://openalex.org/W2128917111","https://openalex.org/W2903636233","https://openalex.org/W2586952978","https://openalex.org/W7071779249"],"abstract_inverted_index":{"Candidaemia":[0],"is":[1,31,66,275],"widely":[2],"reported":[3],"as":[4,34,47,62,127,195],"the":[5,41,56,72,88,110,116,148,156,171,180,201,206,210,252,260,263,284,296],"fourth":[6],"most":[7],"common":[8],"form":[9],"of":[10,15,17,24,43,58,71,91,150,158,164,182,208,213,254,262,271,288],"bloodstream":[11,151],"infection":[12],"worldwide.":[13],"Reports":[14],"cases":[16],"candidaemia":[18],"whilst":[19],"patients":[20],"are":[21,27,229],"in":[22,95,109,170,268,292,295],"receipt":[23],"antifungal":[25,45,60,77,103,193,203],"therapy":[26],"increasing,":[28],"and":[29,38,55,82,143,188,258],"this":[30,119],"especially":[32],"relevant":[33],"prescribing":[35],"practices":[36],"change":[37],"develop.":[39],"Given":[40],"elevation":[42],"echinocandin":[44,59,102,202,289],"agents":[46,54,61,104],"first":[48],"line":[49],"treatment":[50],"options":[51],"over":[52],"triazole":[53],"use":[57],"prophylactic":[63],"agents,":[64,204],"it":[65],"important":[67],"to":[68,98,101,124,140,178,191,232,237,256,282],"maintain":[69,238],"awareness":[70],"potential":[73,117,181],"difficulties":[74],"surrounding":[75],"emergent":[76],"resistance.This":[78],"study":[79,174,221,278],"has":[80,175,222],"designed":[81],"created":[83],"a":[84,106,128,233,239],"suitable":[85],"assay":[86,154],"for":[87,118,147],"specific":[89],"detection":[90,122],"FKS":[92],"gene":[93],"mutations":[94],"Candida":[96],"glabrata":[97,199,294],"indicate":[99,192],"resistance":[100,194,274,290],"using":[105,185,226],"pyrosequencing-based":[107],"platform":[108],"clinical":[111,172,241,265],"diagnostic":[112,234,266],"laboratory.":[113],"There":[114],"exists":[115],"rapid":[120],"molecular":[121],"system":[123],"be":[125],"used":[126],"screening":[129],"tool":[130],"which":[131],"would":[132],"help":[133],"provide":[134],"clinicians":[135],"with":[136,200],"essential":[137],"information":[138],"required":[139],"make":[141],"appropriate":[142],"accurate":[144],"therapeutic":[145],"decisions":[146],"management":[149],"infections.":[152],"This":[153,220,277],"allows":[155],"reporting":[157,168],"these":[159],"results":[160],"within":[161],"4":[162],"hours":[163],"isolation":[165],"greatly":[166],"improving":[167],"times":[169],"laboratory.This":[173],"also":[176,279],"attempted":[177],"demonstrate":[179],"proteomic":[183],"approaches,":[184],"LC":[186],"MS/MS":[187],"MALDI-TOF":[189],"MS,":[190],"demonstrated":[196],"by":[197,205],"C.":[198,293],"identification":[207],"proteins,":[209],"changing":[211],"patterns":[212,248],"protein":[214],"presence,":[215],"absence":[216],"or":[217,246],"relative":[218],"abundance.":[219],"solely":[223],"focused":[224],"on":[225],"techniques":[227],"that":[228],"realistically":[230],"accessible":[231],"microbiology":[235],"laboratory":[236,267],"true":[240],"impact.":[242],"No":[243],"readily":[244],"identifiable":[245],"reproducible":[247],"were":[249],"found,":[250],"however":[251],"importance":[253],"continuing":[255],"adapt":[257],"modify":[259],"capabilities":[261],"modern":[264],"an":[269],"era":[270],"increasing":[272],"antimicrobial":[273],"highlighted.":[276],"provided":[280],"data":[281],"support":[283],"continual":[285],"low":[286],"level":[287],"prevalent":[291],"United":[297],"Kingdom.":[298]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2020-05-21T00:00:00"}