{"id":"https://openalex.org/W3025224973","doi":"https://doi.org/10.4268/cjcmm20160625","title":"Metabolomics analysis of Tripterygium wilfordii formulation based on theory of detoxicity compatibility","display_name":"Metabolomics analysis of Tripterygium wilfordii formulation based on theory of detoxicity compatibility","publication_year":2016,"publication_date":"2016-03-15","ids":{"openalex":"https://openalex.org/W3025224973","doi":"https://doi.org/10.4268/cjcmm20160625","mag":"3025224973","pmid":"https://pubmed.ncbi.nlm.nih.gov/28875681"},"language":"zh","primary_location":{"id":"doi:10.4268/cjcmm20160625","doi":"https://doi.org/10.4268/cjcmm20160625","is_oa":false,"landing_page_url":"https://doi.org/10.4268/cjcmm20160625","pdf_url":null,"source":{"id":"https://openalex.org/S2756327665","display_name":"China Journal of Chinese Materia Medica","issn_l":"1001-5302","issn":["1001-5302"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["medline","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4320800687","host_organization_name":"Chinese Pharmaceutical Association","host_organization_lineage":["https://openalex.org/P4320800687"],"host_organization_lineage_names":["Chinese Pharmaceutical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"China Journal of Chinese Materia Medica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101681513","display_name":"Tong Xie","orcid":"https://orcid.org/0000-0003-0791-8853","observed_orcids":["https://orcid.org/0000-0003-0791-8853","https://orcid.org/0009-0006-6737-5116"]},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tong Xie","raw_affiliation_strings":["Jiangsu Key Laboratory of Pediatric Respiratory Disease, Institute of Pediatrics, Nanjing University of Chinese Medicine, Nanjing 210023, China","The First College of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Key Laboratory of Pediatric Respiratory Disease, Institute of Pediatrics, Nanjing University of Chinese Medicine, Nanjing 210023, China","institution_ids":["https://openalex.org/I131434179"]},{"raw_affiliation_string":"The First College of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China","institution_ids":["https://openalex.org/I131434179"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102015137","display_name":"Xueping Zhou","orcid":"https://orcid.org/0000-0001-7170-0192","observed_orcids":["https://orcid.org/0000-0001-7170-0192","https://orcid.org/0000-0001-7807-9968"]},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xue-Ping Zhou","raw_affiliation_strings":["The First College of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First College of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China","institution_ids":["https://openalex.org/I131434179"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021778891","display_name":"Lili Lin","orcid":"https://orcid.org/0000-0002-5527-2850","observed_orcids":["https://orcid.org/0000-0002-5527-2850"]},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li-Li Lin","raw_affiliation_strings":["Jiangsu Key Laboratory of Pediatric Respiratory Disease, Institute of Pediatrics, Nanjing University of Chinese Medicine, Nanjing 210023, China","The First College of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Key Laboratory of Pediatric Respiratory Disease, Institute of Pediatrics, Nanjing University of Chinese Medicine, Nanjing 210023, China","institution_ids":["https://openalex.org/I131434179"]},{"raw_affiliation_string":"The First College of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China","institution_ids":["https://openalex.org/I131434179"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113571377","display_name":"Jianya Xu","orcid":"https://orcid.org/0000-0002-1471-3939","observed_orcids":["https://orcid.org/0000-0002-1471-3939"]},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian-Ya Xu","raw_affiliation_strings":["Jiangsu Key Laboratory of Pediatric Respiratory Disease, Institute of Pediatrics, Nanjing University of Chinese Medicine, Nanjing 210023, China","The First College of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Key Laboratory of Pediatric Respiratory Disease, Institute of Pediatrics, Nanjing University of Chinese Medicine, Nanjing 210023, China","institution_ids":["https://openalex.org/I131434179"]},{"raw_affiliation_string":"The First College of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China","institution_ids":["https://openalex.org/I131434179"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113956095","display_name":"Cunsi Shen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cun-Si Shen","raw_affiliation_strings":["Jiangsu Key Laboratory of Pediatric Respiratory Disease, Institute of Pediatrics, Nanjing University of Chinese Medicine, Nanjing 210023, China","The First College of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Key Laboratory of Pediatric Respiratory Disease, Institute of Pediatrics, Nanjing University of Chinese Medicine, Nanjing 210023, China","institution_ids":["https://openalex.org/I131434179"]},{"raw_affiliation_string":"The First College of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China","institution_ids":["https://openalex.org/I131434179"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073406775","display_name":"Zhe Feng","orcid":"https://orcid.org/0000-0002-7851-8999","observed_orcids":["https://orcid.org/0000-0002-7851-8999"]},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhe Feng","raw_affiliation_strings":["The First College of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First College of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China","institution_ids":["https://openalex.org/I131434179"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054175249","display_name":"Lingling Zhou","orcid":"https://orcid.org/0000-0001-8395-9783","observed_orcids":["https://orcid.org/0000-0001-8395-9783","https://orcid.org/0009-0004-5775-8098"]},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ling-Ling Zhou","raw_affiliation_strings":["School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China","institution_ids":["https://openalex.org/I131434179"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103154132","display_name":"Jinjun Shan","orcid":"https://orcid.org/0000-0001-8079-7950","observed_orcids":["https://orcid.org/0000-0001-8079-7950"]},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jin-Jun Shan","raw_affiliation_strings":["Jiangsu Key Laboratory of Pediatric Respiratory Disease, Institute of Pediatrics, Nanjing University of Chinese Medicine, Nanjing 210023, China","The First College of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Key Laboratory of Pediatric Respiratory Disease, Institute of Pediatrics, Nanjing University of Chinese Medicine, Nanjing 210023, China","institution_ids":["https://openalex.org/I131434179"]},{"raw_affiliation_string":"The First College of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China","institution_ids":["https://openalex.org/I131434179"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I131434179"],"apc_list":null,"apc_paid":null,"fwci":0.45,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.57092614,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"41","issue":"6","first_page":"1124","last_page":"1129"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.45260000228881836,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.45260000228881836,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.23190000653266907,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.15000000596046448,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tripterygium-wilfordii","display_name":"Tripterygium wilfordii","score":0.9580000042915344},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.8410000205039978},{"id":"https://openalex.org/keywords/plasma-metabolomics","display_name":"plasma metabolomics","score":0.7369999885559082},{"id":"https://openalex.org/keywords/branched-chain-amino-acids","display_name":"branched-chain amino acids","score":0.8140000104904175},{"id":"https://openalex.org/keywords/energy-metabolism","display_name":"energy metabolism","score":0.8619999885559082},{"id":"https://openalex.org/keywords/lactic-acid","display_name":"lactic acid","score":0.7929999828338623},{"id":"https://openalex.org/keywords/panax-notoginseng","display_name":"Panax notoginseng","score":0.9290000200271606},{"id":"https://openalex.org/keywords/rehmannia-glutinosa","display_name":"Rehmannia glutinosa","score":1.0},{"id":"https://openalex.org/keywords/traditional-chinese-medicine","display_name":"traditional Chinese medicine","score":0.7039999961853027},{"id":"https://openalex.org/keywords/herbal-medicine-toxicity","display_name":"herbal medicine toxicity","score":0.7210000157356262},{"id":"https://openalex.org/keywords/hepatoprotective-effect","display_name":"hepatoprotection","score":0.8259999752044678},{"id":"https://openalex.org/keywords/protein-synthesis","display_name":"protein synthesis","score":0.5260000228881836},{"id":"https://openalex.org/keywords/energy-metabolism-regulation","display_name":"energy metabolism regulation","score":0.32899999618530273}],"concepts":[{"id":"https://openalex.org/C2780695664","wikidata":"https://www.wikidata.org/wiki/Q1424919","display_name":"Tripterygium wilfordii","level":3,"score":0.9414924383163452},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7478148937225342},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.6263272762298584},{"id":"https://openalex.org/C2775920511","wikidata":"https://www.wikidata.org/wiki/Q161249","display_name":"Lactic acid","level":3,"score":0.5493788123130798},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.5472984313964844},{"id":"https://openalex.org/C2780100526","wikidata":"https://www.wikidata.org/wiki/Q1071605","display_name":"Rehmannia glutinosa","level":4,"score":0.5113839507102966},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5013594627380371},{"id":"https://openalex.org/C2779349466","wikidata":"https://www.wikidata.org/wiki/Q181619","display_name":"Glutamine","level":3,"score":0.4915240705013275},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.4670129418373108},{"id":"https://openalex.org/C31827203","wikidata":"https://www.wikidata.org/wiki/Q874296","display_name":"Tandem mass spectrometry","level":3,"score":0.4368233382701874},{"id":"https://openalex.org/C2781212864","wikidata":"https://www.wikidata.org/wiki/Q15551438","display_name":"Panax notoginseng","level":3,"score":0.4218606948852539},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.42154648900032043},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3774591088294983},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35090434551239014},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.24620789289474487},{"id":"https://openalex.org/C188947578","wikidata":"https://www.wikidata.org/wiki/Q200253","display_name":"Traditional Chinese medicine","level":3,"score":0.21067926287651062},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11495497822761536},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.09679895639419556},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09312427043914795},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004339","descriptor_name":"Drug Compounding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008401","descriptor_name":"Gas Chromatography-Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029757","descriptor_name":"Tripterygium","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D029757","descriptor_name":"Tripterygium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4268/cjcmm20160625","doi":"https://doi.org/10.4268/cjcmm20160625","is_oa":false,"landing_page_url":"https://doi.org/10.4268/cjcmm20160625","pdf_url":null,"source":{"id":"https://openalex.org/S2756327665","display_name":"China Journal of Chinese Materia Medica","issn_l":"1001-5302","issn":["1001-5302"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["medline","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4320800687","host_organization_name":"Chinese Pharmaceutical Association","host_organization_lineage":["https://openalex.org/P4320800687"],"host_organization_lineage_names":["Chinese Pharmaceutical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"China Journal of Chinese Materia Medica","raw_type":"journal-article"},{"id":"pmid:28875681","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28875681","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2299836762","https://openalex.org/W3146662363","https://openalex.org/W7128475695","https://openalex.org/W2714565583","https://openalex.org/W2076536397","https://openalex.org/W2412794300","https://openalex.org/W2093460651","https://openalex.org/W4403082989","https://openalex.org/W4384207727","https://openalex.org/W3000017518"],"abstract_inverted_index":{"Tripterygium":[0],"wilfordii":[1,48],"Hook.":[2],"f.":[3],"induced-hepatotoxicity":[4],"was":[5,235,240,283,315],"the":[6,31,35,42,110,118,122,126,130,144,164,171,188,195,197,208,212,215,221,224,228,238,243,249,254,259,265,271,277,318,333,340,348,356,362,370],"main":[7],"limitation":[8],"for":[9,20,369,374],"its":[10,311],"usage":[11],"in":[12,22,27,53,104,150,214,343],"clinic.":[13],"Qingluo":[14,50,114,183,261,280],"Tongbi":[15,51,115,184,262,281],"formulation":[16,52,116,185,209,244,263,282],"showed":[17,117,146],"obvious":[18,119],"attenuation":[19],"hepatotoxicity":[21],"clinic":[23],"and":[24,49,77,139,143,161,176,203,207,275,293,304,361,378],"fundamental":[25],"research":[26],"vivo.":[28],"To":[29],"explore":[30],"potential":[32,349],"mechanism":[33,350],"of":[34,46,68,113,129,152,166,199,217,223,230,320,351],"attenuation,":[36],"we":[37],"conducted":[38],"a":[39,56,66,147],"study":[40],"on":[41,286],"plasma":[43,64],"metabolomic":[44,341,359],"profiles":[45],"T.":[47,167],"rats":[54],"by":[55,73,81,91,137,269],"sensitive":[57],"gas":[58],"chromatography-mass":[59],"spectrometry":[60],"(GC-MS/MS)":[61],"method.":[62],"In":[63,108],"samples,":[65],"total":[67],"72":[69],"compounds":[70,151],"were":[71,78,88,101,134,174,179,337],"analyzed":[72,136],"EI":[74],"source":[75],"MS,":[76],"successfully":[79],"identified":[80],"matching":[82],"NIST":[83],"database.":[84],"The":[85,98],"semi-quantification":[86],"results":[87,145,256,342,364],"then":[89],"calculated":[90],"OPLS-DA":[92,105],"model":[93],"with":[94,317,339],"SIMCA-P":[95],"13.0":[96],"software.":[97],"three":[99],"groups":[100],"clearly":[102],"distinguished":[103],"score":[106],"plot.":[107],"addition,":[109],"observation":[111],"values":[112],"trend":[120],"towards":[121],"control":[123],"levels,":[124],"suggesting":[125,220],"detoxicity":[127],"effect":[128,268,314],"formulation.":[131],"Variation":[132],"metabolites":[133],"further":[135],"VIP":[138],"One":[140],"Way":[141],"ANOVAs,":[142],"significant":[148],"increase":[149,246],"glycogenic":[153],"amino":[154,177,189,233,272],"acids,":[155],"such":[156],"as":[157],"alanine,":[158],"proline,":[159],"serine":[160],"glutamine":[162],"after":[163],"administration":[165],"wilfordii,":[168],"indicated":[169],"that":[170,258,310],"tissue":[172],"proteins":[173],"decomposed":[175],"acids":[178,190],"leakage":[180],"into":[181,191,248],"blood.":[182],"could":[186],"reverse":[187],"normal":[192,250],"level.":[193],"On":[194],"contrary,":[196],"levels":[198,216,274],"glucose,":[200],"lactic":[201,218],"acid":[202,234,273],"hydroxy":[204],"butyrate":[205],"decrease,":[206],"can":[210,331],"relieve":[211],"disorder":[213],"acid,":[219],"regulation":[222],"energy":[225,278,334],"metabolism.":[226,279,335],"Additionally,":[227],"level":[229],"branched":[231],"chain":[232],"decreased,":[236],"suggested":[237,257,309],"toxicity":[239,372],"induced,":[241],"but":[242],"cannot":[245],"it":[247],"levels.":[251],"Nevertheless,":[252],"all":[253],"above":[255],"classical":[260],"displayed":[264],"liver":[266,312],"protection":[267,313],"adjusting":[270],"regulating":[276],"developed":[284,358],"based":[285],"traditional":[287],"Chinese":[288],"medicine":[289],"theory":[290],"\"detoxicity":[291,352],"compatibility\",":[292],"contained":[294],"Panax":[295],"notoginseng":[296],"(Burk.)":[297],"F.":[298],"H.":[299],"Chen":[300],"to":[301],"nourish":[302],"blood":[303],"absorb":[305],"clots.":[306],"Modern":[307],"pharmacology":[308],"correlated":[316],"promotion":[319],"protein":[321],"synthesis.":[322],"Another":[323],"important":[324],"herb":[325],"is":[326],"Rehmannia":[327],"glutinosa":[328],"Libosch.,":[329],"which":[330,346],"regulate":[332],"Both":[336],"consistent":[338],"this":[344],"study,":[345],"explained":[347],"compatibility\"":[353],"theory.":[354],"Therefore,":[355],"currently":[357],"approach":[360],"obtained":[363],"would":[365],"be":[366],"highly":[367],"useful":[368],"comprehensive":[371],"studies":[373],"other":[375],"herbal":[376],"medicines":[377],"various":[379],"complex":[380],"deoxicity":[381],"formulations.":[382]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2020-05-21T00:00:00"}