{"id":"https://openalex.org/W3025090657","doi":null,"title":"Cytokine Storm Syndrome in COVID-19: Diagnosis and Management Strategies","display_name":"Cytokine Storm Syndrome in COVID-19: Diagnosis and Management Strategies","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W3025090657","mag":"3025090657"},"language":"en","primary_location":{"id":"mag:3025090657","doi":null,"is_oa":false,"landing_page_url":"https://www.ijhsr.org/IJHSR_Vol.10_Issue.5_May2020/25.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S2764586180","display_name":"International Journal of Health Sciences and Research","issn_l":"2249-9571","issn":["2249-9571"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4323237698","host_organization_name":"Galore Knowledge Publication Pvt. Ltd.","host_organization_lineage":["https://openalex.org/P4323237698"],"host_organization_lineage_names":["Galore Knowledge Publication Pvt. Ltd."],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Health Sciences and Research","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075442475","display_name":"Sachin Maggo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sachin Maggo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019872183","display_name":"Pawan Dhull","orcid":"https://orcid.org/0000-0003-4514-2072","observed_orcids":["https://orcid.org/0000-0003-4514-2072"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pawan Dhull","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4514-2072","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108712061","display_name":"Amba Prasad Dubey","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amba Prasad Dubey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2199,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.67410387,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"10","issue":"5","first_page":"140","last_page":"149"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytokine-storm","display_name":"cytokine storm","score":0.8130000233650208},{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9990000128746033},{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/secondary-hemophagocytic-lymphohistiocytosis","display_name":"secondary hemophagocytic lymphohistiocytosis","score":0.9559999704360962},{"id":"https://openalex.org/keywords/h-score","display_name":"H-score","score":0.8659999966621399},{"id":"https://openalex.org/keywords/cytokine-dysregulation","display_name":"cytokine imbalance","score":0.9089999794960022},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.7009999752044678},{"id":"https://openalex.org/keywords/anti-cytokine-antibodies","display_name":"anti-cytokine antibodies","score":0.7799999713897705},{"id":"https://openalex.org/keywords/convalescent-plasma","display_name":"convalescent plasma","score":0.8159999847412109},{"id":"https://openalex.org/keywords/acute-respiratory-distress-syndrome","display_name":"acute respiratory distress syndrome","score":0.8140000104904175},{"id":"https://openalex.org/keywords/multiple-organ-failure","display_name":"multiple organ failure","score":0.796999990940094},{"id":"https://openalex.org/keywords/cytokine-measurement","display_name":"cytokine measurement","score":0.5139999985694885}],"concepts":[{"id":"https://openalex.org/C2779559532","wikidata":"https://www.wikidata.org/wiki/Q1076369","display_name":"Cytokine storm","level":5,"score":0.9531421065330505},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8524965047836304},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6688052415847778},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.6063398122787476},{"id":"https://openalex.org/C2780850621","wikidata":"https://www.wikidata.org/wiki/Q3961647","display_name":"Cytokine release syndrome","level":5,"score":0.5569667816162109},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5414022207260132},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5285871028900146},{"id":"https://openalex.org/C2776348555","wikidata":"https://www.wikidata.org/wiki/Q344873","display_name":"ARDS","level":3,"score":0.5038301348686218},{"id":"https://openalex.org/C2780252810","wikidata":"https://www.wikidata.org/wiki/Q1455316","display_name":"Immunosuppression","level":2,"score":0.49627500772476196},{"id":"https://openalex.org/C2777648638","wikidata":"https://www.wikidata.org/wiki/Q57751738","display_name":"Coronavirus","level":5,"score":0.49137750267982483},{"id":"https://openalex.org/C2777945365","wikidata":"https://www.wikidata.org/wiki/Q1891441","display_name":"Convalescence","level":2,"score":0.4478521943092346},{"id":"https://openalex.org/C89623803","wikidata":"https://www.wikidata.org/wiki/Q12184","display_name":"Pandemic","level":5,"score":0.4396498501300812},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.3605383038520813},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.26590412855148315},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.2096034586429596},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1630708873271942}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:3025090657","doi":null,"is_oa":false,"landing_page_url":"https://www.ijhsr.org/IJHSR_Vol.10_Issue.5_May2020/25.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S2764586180","display_name":"International Journal of Health Sciences and Research","issn_l":"2249-9571","issn":["2249-9571"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4323237698","host_organization_name":"Galore Knowledge Publication Pvt. Ltd.","host_organization_lineage":["https://openalex.org/P4323237698"],"host_organization_lineage_names":["Galore Knowledge Publication Pvt. Ltd."],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Health Sciences and Research","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1505641753","https://openalex.org/W2021442163","https://openalex.org/W2095807050","https://openalex.org/W2116058470","https://openalex.org/W2163067702","https://openalex.org/W2234282373","https://openalex.org/W2610356532","https://openalex.org/W2725497285","https://openalex.org/W2775550787","https://openalex.org/W2784196598","https://openalex.org/W2910405468","https://openalex.org/W2911371912","https://openalex.org/W2915839491","https://openalex.org/W2995449088","https://openalex.org/W3001118548","https://openalex.org/W3002539152","https://openalex.org/W3003154936","https://openalex.org/W3004197626","https://openalex.org/W3004280078","https://openalex.org/W3004318991","https://openalex.org/W3004919484","https://openalex.org/W3005212621","https://openalex.org/W3005403371","https://openalex.org/W3008028633","https://openalex.org/W3008649550","https://openalex.org/W3008827533","https://openalex.org/W3009314935","https://openalex.org/W3009577418","https://openalex.org/W3009912996","https://openalex.org/W3010344953","https://openalex.org/W3010449299","https://openalex.org/W3010930696","https://openalex.org/W3010992334","https://openalex.org/W3012379316","https://openalex.org/W3012455685","https://openalex.org/W3022970339","https://openalex.org/W3023991776"],"related_works":["https://openalex.org/W4229798738","https://openalex.org/W7117964685","https://openalex.org/W3197383871","https://openalex.org/W7025378465","https://openalex.org/W3120486688","https://openalex.org/W3201076763","https://openalex.org/W3152491723","https://openalex.org/W3137268571","https://openalex.org/W3087783854","https://openalex.org/W3024913291"],"abstract_inverted_index":{"Coronavirus":[0],"disease":[1,22,101,131,228],"2019":[2],"(COVID-19),":[3],"is":[4,104,113,120,158,218],"a":[5,26,75],"viral":[6],"illness":[7],"caused":[8],"by":[9,28,232],"novel":[10],"coronavirus":[11,18],"called":[12,114],"as":[13,25,74,115,142,151,201],"severe":[14,103,225],"acute":[15,87],"respiratory":[16,88],"syndrome":[17,90],"2":[19,58],"(SARS-CoV-2).":[20],"The":[21,96,137,166],"was":[23],"declared":[24],"pandemic":[27],"the":[29,45,64,128,134,152,170,196,206,210],"World":[30],"Health":[31],"Organisation":[32],"(WHO)":[33],"on":[34],"March":[35],"11,":[36],"2020.":[37],"Initial":[38],"studies":[39],"have":[40],"shown":[41],"molecular":[42],"resemblances":[43],"in":[44,111,127,143,156,195,215,235],"receptor":[46],"binding":[47],"domains":[48],"of":[49,78,130,139,163,176,178,188,209,224],"SARS-CoV":[50],"and":[51,94,107,173,186],"SARS-CoV-2":[52],"which":[53],"bind":[54],"angiotensin":[55],"converting":[56],"enzyme":[57],"(ACE":[59],"2)":[60],"receptors,":[61],"thereby":[62],"entering":[63],"host":[65],"cells":[66],"to":[67,84,102,122,132,161,221,238],"cause":[68],"infection.":[69],"COVID":[70,164,199,226],"19":[71,200,227],"can":[72,148,203],"present":[73],"broad":[76],"spectrum":[77],"illness,":[79],"from":[80,244],"mild":[81,100],"common":[82],"cold":[83],"life":[85],"threatening":[86],"distress":[89],"(ARDS),":[91],"multiorgan":[92],"dysfunction":[93,106],"shock.":[95],"key":[97,207],"step":[98],"transforming":[99],"immune":[105,211],"cytokine":[108,124,154,180],"dysregulation":[109],"resulting":[110],"what":[112],"\u201ccytokine":[116],"storm":[117,125],"syndrome\u201d.":[118],"It":[119],"prudent":[121],"diagnose":[123],"early":[126],"course":[129],"mitigate":[133],"subsequent":[135],"consequences.":[136],"use":[138,177],"H":[140],"score":[141],"secondary":[144],"haemophagocytic":[145],"lymphohistiocytosis":[146],"(sHLH)":[147],"be":[149],"helpful":[150],"inflammatory":[153],"profile":[155],"sHLH":[157],"very":[159],"similar":[160],"that":[162,191],"19.":[165],"article":[167],"also":[168,219],"discusses":[169],"past":[171],"experience":[172],"current":[174],"evidence":[175],"immunological":[179],"specific":[181],"antibodies,":[182],"new":[183],"anti-rheumatic":[184],"drugs":[185],"role":[187],"convalescent":[189],"plasma":[190],"may":[192],"prove":[193],"instrumental":[194],"fight":[197],"against":[198],"they":[202],"precisely":[204],"target":[205],"steps":[208],"response.":[212],"An":[213],"approach":[214],"this":[216,245],"regard":[217],"proposed":[220],"screen":[222],"patients":[223,240],"for":[229],"exuberant":[230],"inflammation":[231],"measuring":[233],"cytokines":[234],"an":[236],"attempt":[237],"identify":[239],"who":[241],"will":[242],"benefit":[243],"selective":[246],"immunosuppression.":[247]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2020-05-21T00:00:00"}