{"id":"https://openalex.org/W3024945503","doi":null,"title":"A three-dimensional scaffold from decellularized human umbilical artery for bile duct reconstruction.","display_name":"A three-dimensional scaffold from decellularized human umbilical artery for bile duct reconstruction.","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W3024945503","mag":"3024945503","pmid":"https://pubmed.ncbi.nlm.nih.gov/30530984"},"language":"en","primary_location":{"id":"pmid:30530984","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30530984","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annali italiani di chirurgia","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044872874","display_name":"Konstantine Chakhunashvili","orcid":"https://orcid.org/0000-0003-0939-9479","observed_orcids":["https://orcid.org/0000-0003-0939-9479"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Konstantine Chakhunashvili","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112636922","display_name":"Merab A Kiladze","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Merab Kiladze","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018095518","display_name":"David Chakhunashvili","orcid":"https://orcid.org/0000-0002-0167-1258","observed_orcids":["https://orcid.org/0000-0002-0167-1258"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David G Chakhunashvili","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055610611","display_name":"Lia Karalashvili","orcid":"https://orcid.org/0000-0002-4956-5550","observed_orcids":["https://orcid.org/0000-0002-4956-5550"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lia Karalashvili","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5054887477","display_name":"Zurab Kakabadze","orcid":"https://orcid.org/0000-0001-9038-5220","observed_orcids":["https://orcid.org/0000-0001-9038-5220"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zurab Kakabadze","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9387,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.72247742,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"90","issue":null,"first_page":"165","last_page":"173"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10518","display_name":"Gallbladder and Bile Duct Disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biliary-reconstruction","display_name":"biliary reconstruction","score":0.9940000176429749},{"id":"https://openalex.org/keywords/common-bile-duct-obstruction","display_name":"common bile duct obstruction","score":0.9110000133514404},{"id":"https://openalex.org/keywords/cholangiocytes","display_name":"cholangiocytes","score":0.9150000214576721},{"id":"https://openalex.org/keywords/decellularization","display_name":"decellularization","score":0.7599999904632568},{"id":"https://openalex.org/keywords/3d-scaffolds","display_name":"3D scaffolds","score":0.7440000176429749},{"id":"https://openalex.org/keywords/pig-model","display_name":"porcine model","score":0.8069999814033508}],"concepts":[{"id":"https://openalex.org/C190672674","wikidata":"https://www.wikidata.org/wiki/Q3866591","display_name":"Decellularization","level":3,"score":0.8690648078918457},{"id":"https://openalex.org/C2779777945","wikidata":"https://www.wikidata.org/wiki/Q851111","display_name":"Bile duct","level":2,"score":0.8459654450416565},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8105502128601074},{"id":"https://openalex.org/C2777891700","wikidata":"https://www.wikidata.org/wiki/Q2084566","display_name":"Sphincter of Oddi","level":2,"score":0.7815507054328918},{"id":"https://openalex.org/C2778964498","wikidata":"https://www.wikidata.org/wiki/Q1724233","display_name":"Umbilical artery","level":4,"score":0.591566801071167},{"id":"https://openalex.org/C2776884468","wikidata":"https://www.wikidata.org/wiki/Q1263617","display_name":"Common bile duct","level":2,"score":0.5617499351501465},{"id":"https://openalex.org/C2776820930","wikidata":"https://www.wikidata.org/wiki/Q9655","display_name":"Artery","level":2,"score":0.5422334671020508},{"id":"https://openalex.org/C2781212128","wikidata":"https://www.wikidata.org/wiki/Q2256181","display_name":"Duct (anatomy)","level":2,"score":0.4125930368900299},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3849984109401703},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.34984850883483887},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.22271502017974854},{"id":"https://openalex.org/C89429830","wikidata":"https://www.wikidata.org/wiki/Q735710","display_name":"Scaffold","level":2,"score":0.1595413088798523},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06781873106956482},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.05763694643974304},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002779","descriptor_name":"Cholestasis","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D003135","descriptor_name":"Common Bile Duct","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D003584","descriptor_name":"Cytological Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009803","descriptor_name":"Sphincter of Oddi","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014469","descriptor_name":"Umbilical Arteries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054457","descriptor_name":"Tissue Scaffolds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059351","descriptor_name":"Organ Sparing Treatments","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:30530984","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30530984","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annali italiani di chirurgia","raw_type":"Journal Article"},{"id":"mag:3024945503","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30530984","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3030544290","https://openalex.org/W2002147033","https://openalex.org/W2566941238","https://openalex.org/W3166480314","https://openalex.org/W2138281891","https://openalex.org/W2468487743","https://openalex.org/W4385972008","https://openalex.org/W2437075185","https://openalex.org/W6986743821","https://openalex.org/W2375765700"],"abstract_inverted_index":{"AIM:":[0],"The":[1],"main":[2],"purpose":[3],"of":[4,16,33,35,48,60,72,98,112,122,143,173,185,240,243],"the":[5,49,57,61,99,113,136,141,162,183,186,193,209,241],"study":[6,65,180,195],"was":[7,66,92,129,133,149],"to":[8,25,181,214],"create":[9],"in":[10,83,94],"vitro":[11],"bile":[12,28,88,137,190,217,235],"duct":[13,29,89,138,167,191,218,236],"equivalent":[14,84,139,219],"out":[15],"decellularized":[17,62,224],"human":[18,225],"umbilical":[19,226],"cord":[20],"artery":[21,227],"and":[22,41,68,107,131,155,201,228],"use":[23],"it":[24],"reconstruct":[26],"common":[27],"obstruction":[30,90],"with":[31,135,140,161,208,223,238],"preservation":[32],"sphincter":[34,242],"Oddi.":[36],"MATERIAL":[37],"AND":[38],"METHODS:":[39],"SDS":[40],"Triton":[42],"X-100":[43],"were":[44,54,78,81,108],"used":[45,233],"for":[46,189,234],"decellularization":[47],"artery.":[50,63],"Allogeneic":[51],"isolated":[52],"cholangiocytes":[53,229],"seeded":[55],"onto":[56],"inner":[58],"surface":[59],"Experimental":[64],"held":[67],"12":[69],"domestic":[70],"pigs":[71],"both":[73],"sexes,":[74],"weighing":[75],"25-30":[76],"kg":[77],"used.":[79],"They":[80],"divided":[82],"two":[85,120],"groups.":[86],"Common":[87],"model":[91],"created":[93,220],"all":[95],"animals.":[96],"Animals":[97,111],"first":[100],"group":[101,115],"(n=6)":[102,116],"received":[103],"no":[104],"further":[105],"treatment":[106],"under":[109],"observation.":[110],"second":[114],"underwent":[117],"relaparotomy":[118],"after":[119],"days":[121],"initial":[123],"intervention,":[124],"lesion":[125],"site":[126],"(2":[127],"cm)":[128],"incised":[130],"defect":[132],"reconstructed":[134],"size":[142],"2-2,5":[144],"cm.":[145],"Maximum":[146],"observation":[147],"period":[148],"84":[150],"days.":[151],"RESULTS:":[152],"Laboratory,":[153],"morphologic":[154,200],"radiologic":[156,202],"investigations":[157],"showed":[158],"good":[159],"integration":[160],"host":[163],"organism.":[164],"DISCUSSION:":[165],"Bile":[166,247,250],"reconstruction":[168,192,237],"is":[169],"still":[170],"a":[171],"major":[172],"HPB":[174],"surgery.":[175],"This":[176],"fact":[177],"prompted":[178],"this":[179],"assess":[182],"efficacy":[184],"novel":[187],"method":[188,211],"experimental":[194],"by":[196,221],"using":[197],"appropriate":[198],"laboratory,":[199],"investigations.":[203],"CONCLUSION:":[204],"Preliminary":[205],"results":[206],"obtained":[207],"described":[210],"allows":[212],"us":[213,222],"say":[215],"that":[216],"can":[230],"be":[231],"successfully":[232],"inclusion":[239],"oddi.":[244],"KEY":[245],"WORDS:":[246],"Duct":[248,251],"Obstruction,":[249],"Reconstruction,":[252],"Decellularization,":[253],"Human":[254],"Umbilical":[255],"Artery.":[256]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-05-21T00:00:00"}