{"id":"https://openalex.org/W3024939360","doi":null,"title":"Putative cancer stem cells are present in surgical margins of oral squamous cell carcinoma.","display_name":"Putative cancer stem cells are present in surgical margins of oral squamous cell carcinoma.","publication_year":2018,"publication_date":"2018-11-01","ids":{"openalex":"https://openalex.org/W3024939360","mag":"3024939360","pmid":"https://pubmed.ncbi.nlm.nih.gov/30610795"},"language":"en","primary_location":{"id":"pmid:30610795","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30610795","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of B.U.ON. : official journal of the Balkan Union of Oncology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038300018","display_name":"Milo\u0161 M. Lazarevi\u0107","orcid":"https://orcid.org/0000-0003-1330-5332","observed_orcids":["https://orcid.org/0000-0003-1330-5332"]},"institutions":[{"id":"https://openalex.org/I4068193","display_name":"University of Belgrade","ror":"https://ror.org/02qsmb048","country_code":"RS","type":"education","lineage":["https://openalex.org/I4068193"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Milos Lazarevic","raw_affiliation_strings":["Department of Human Genetics, School of Dental Medicine, University of Belgrade, Dr Subotica 8, 11000 Belgrade, Serbia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, School of Dental Medicine, University of Belgrade, Dr Subotica 8, 11000 Belgrade, Serbia","institution_ids":["https://openalex.org/I4068193"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Maja Milosevic","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maja Milosevic","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109656582","display_name":"Dijana D. Tri\u0161i\u0107","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dijana Trisic","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000362818","display_name":"Bo\u0161ko Tolji\u0107","orcid":"https://orcid.org/0000-0002-6664-2829","observed_orcids":["https://orcid.org/0000-0002-6664-2829"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bosko Toljic","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030463244","display_name":"Jelena Simonovi\u0107","orcid":"https://orcid.org/0000-0003-4506-3470","observed_orcids":["https://orcid.org/0000-0003-4506-3470"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jelena Simonovic","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039367398","display_name":"Nadja Nikoli\u0107","orcid":"https://orcid.org/0000-0002-8513-9313","observed_orcids":["https://orcid.org/0000-0002-8513-9313"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nadja Nikolic","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017564523","display_name":"Nikola Mikovic","orcid":"https://orcid.org/0009-0005-8150-4685","observed_orcids":["https://orcid.org/0009-0005-8150-4685","https://orcid.org/0000-0003-0630-0664"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nikola Mikovic","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073878050","display_name":"Drago B. Jelovac","orcid":"https://orcid.org/0000-0002-4236-4967","observed_orcids":["https://orcid.org/0000-0002-4236-4967"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Drago Jelovac","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101742118","display_name":"Milan Petrovi\u0107","orcid":"https://orcid.org/0000-0001-6109-263X","observed_orcids":["https://orcid.org/0000-0001-6109-263X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Milan Petrovic","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114032506","display_name":"Miroslav Vukadinovi\u0107","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Miroslav Vukadinovic","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5077680461","display_name":"Jelena Mila\u0161in","orcid":"https://orcid.org/0000-0002-6225-7210","observed_orcids":["https://orcid.org/0000-0002-6225-7210"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jelena Milasin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9394,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.78380722,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"23","issue":"6","first_page":"1686","last_page":"1692"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oral-squamous-cell-carcinoma","display_name":"oral squamous cell carcinoma","score":0.9150000214576721},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.9340000152587891},{"id":"https://openalex.org/keywords/stem-cell-markers","display_name":"stem cell markers","score":0.8629999756813049},{"id":"https://openalex.org/keywords/cd133","display_name":"CD133","score":0.9100000262260437},{"id":"https://openalex.org/keywords/nanog","display_name":"Nanog","score":0.9779999852180481},{"id":"https://openalex.org/keywords/sox2","display_name":"SOX2","score":0.9639999866485596},{"id":"https://openalex.org/keywords/cd44","display_name":"CD44","score":0.9980000257492065},{"id":"https://openalex.org/keywords/oct4","display_name":"Oct4","score":0.9990000128746033},{"id":"https://openalex.org/keywords/self-renewal","display_name":"self-renewal","score":0.7990000247955322},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.953000009059906},{"id":"https://openalex.org/keywords/spheroid-formation","display_name":"spheroid formation","score":0.8270000219345093},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.4860000014305115}],"concepts":[{"id":"https://openalex.org/C207701140","wikidata":"https://www.wikidata.org/wiki/Q420522","display_name":"Homeobox protein NANOG","level":5,"score":0.8966231346130371},{"id":"https://openalex.org/C2777933648","wikidata":"https://www.wikidata.org/wiki/Q21114866","display_name":"SOX2","level":4,"score":0.825101375579834},{"id":"https://openalex.org/C2780932548","wikidata":"https://www.wikidata.org/wiki/Q1056532","display_name":"CD44","level":3,"score":0.7965493202209473},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6238988637924194},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.622761607170105},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6104076504707336},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.55755615234375},{"id":"https://openalex.org/C136302470","wikidata":"https://www.wikidata.org/wiki/Q7607299","display_name":"Stem cell marker","level":3,"score":0.5247768759727478},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5231358408927917},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5129978060722351},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.48821738362312317},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4725629687309265},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.4642214775085449},{"id":"https://openalex.org/C2777306565","wikidata":"https://www.wikidata.org/wiki/Q15917291","display_name":"Tumour heterogeneity","level":3,"score":0.42790094017982483},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.22998735308647156},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22442525625228882},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.214121013879776},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.17505788803100586},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.1726817786693573},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.10862511396408081},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07290974259376526}],"mesh":[{"descriptor_ui":"D000071317","descriptor_name":"Nanog Homeobox Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000071317","descriptor_name":"Nanog Homeobox Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000072662","descriptor_name":"Margins of Excision","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009062","descriptor_name":"Mouth Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009062","descriptor_name":"Mouth Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009062","descriptor_name":"Mouth Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018960","descriptor_name":"Hyaluronan Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018960","descriptor_name":"Hyaluronan Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050814","descriptor_name":"Octamer Transcription Factor-3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050814","descriptor_name":"Octamer Transcription Factor-3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055748","descriptor_name":"SOXB1 Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055748","descriptor_name":"SOXB1 Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:30610795","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30610795","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of B.U.ON. : official journal of the Balkan Union of Oncology","raw_type":"Journal Article"},{"id":"pmh:oai:smile.stomf.bg.ac.rs:123456789/2271","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/21.15107/rcub_smile_2271","pdf_url":null,"source":{"id":"https://openalex.org/S4306400719","display_name":"SMILE \u2013 School of dental Medicine dIgitaL archivE (University of Belgrade, School of Dental Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4068193","host_organization_name":"University of Belgrade","host_organization_lineage":["https://openalex.org/I4068193"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of BUON","raw_type":"article"},{"id":"mag:3024939360","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30610795","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7053503468","https://openalex.org/W3171427832","https://openalex.org/W4415616649","https://openalex.org/W7163760180","https://openalex.org/W4283646666","https://openalex.org/W4411607574","https://openalex.org/W1979884550","https://openalex.org/W2374071649","https://openalex.org/W2074998746","https://openalex.org/W1982580620"],"abstract_inverted_index":{"PURPOSE:":[0],"Recent":[1],"evidence":[2],"suggests":[3],"that":[4,44],"small":[5],"subpopulations":[6],"of":[7,27,50,61,67,153,174,187,189],"stem-like":[8],"cells":[9,73,86,142,176],"are":[10],"accountable":[11],"for":[12],"tumour":[13,33,36,51,148],"initiation,":[14],"progression":[15],"and":[16,47,79,95,110,117,132,147,161,169],"metastasis.":[17],"Until":[18],"now,":[19],"studies":[20],"were":[21,38,70,102,135],"focused":[22],"exclusively":[23],"on":[24],"the":[25,32,45,59,62,65,68,151,164,185],"characterization":[26],"these":[28,85],"cell":[29,77,155],"populations":[30],"within":[31],"itself,":[34],"while":[35],"margins":[37,52,149],"neglected,":[39],"although":[40],"it":[41],"is":[42],"known":[43],"histological":[46],"molecular":[48],"status":[49],"may":[53],"play":[54],"a":[55],"significant":[56],"role":[57],"in":[58],"course":[60],"disease.":[63],"Therefore,":[64],"aims":[66],"study":[69],"to":[71,83,90,166,178],"isolate":[72],"from":[74,104,144],"oral":[75],"squamous":[76],"carcinomas":[78],"their":[80,92,97],"respective":[81],"margins,":[82],"characterize":[84],"using":[87],"specific":[88],"markers,":[89],"assess":[91],"self-renewal":[93],"potential":[94],"determine":[96],"chemoresistance.":[98,171],"METHODS:":[99],"Cell":[100],"cultures":[101],"obtained":[103],"12":[105],"tissue":[106],"specimens":[107],"(6":[108],"tumours":[109,146],"6":[111],"margins).":[112],"Total":[113],"RNA":[114],"was":[115,121],"extracted":[116],"gene":[118],"expression":[119],"analysis":[120],"done":[122],"by":[123],"real-time":[124],"PCR":[125],"(RT-PCR).":[126],"Flow":[127],"cytometry,":[128],"immunocytometry,":[129],"sphere":[130],"formation":[131],"MTT":[133],"assays":[134],"also":[136],"applied.":[137],"RESULTS:":[138],"With":[139],"minor":[140],"differences,":[141],"originating":[143],"both":[145],"showed":[150,170],"presence":[152],"stem":[154],"markers":[156],"CD133,":[157],"Nanog,":[158],"Sox2,":[159],"CD44,":[160],"Oct4,":[162],"had":[163],"capacity":[165],"form":[167],"spheroids":[168],"CONCLUSIONS:":[172],"Subpopulations":[173],"margin":[175],"appeared":[177],"have":[179],"stemness":[180],"properties":[181],"which":[182],"might":[183],"raise":[184],"question":[186],"re-evaluation":[188],"optimal":[190],"surgical":[191],"management.":[192]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-05-21T00:00:00"}