{"id":"https://openalex.org/W3024809249","doi":"https://doi.org/10.1038/s41386-020-0706-z","title":"Proof of mechanism and target engagement of glutamatergic drugs for the treatment of schizophrenia: RCTs of pomaglumetad and TS-134 on ketamine-induced psychotic symptoms and pharmacoBOLD in healthy volunteers","display_name":"Proof of mechanism and target engagement of glutamatergic drugs for the treatment of schizophrenia: RCTs of pomaglumetad and TS-134 on ketamine-induced psychotic symptoms and pharmacoBOLD in healthy volunteers","publication_year":2020,"publication_date":"2020-05-13","ids":{"openalex":"https://openalex.org/W3024809249","doi":"https://doi.org/10.1038/s41386-020-0706-z","mag":"3024809249","pmid":"https://pubmed.ncbi.nlm.nih.gov/32403118"},"language":"en","primary_location":{"id":"doi:10.1038/s41386-020-0706-z","doi":"https://doi.org/10.1038/s41386-020-0706-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41386-020-0706-z","pdf_url":"https://www.nature.com/articles/s41386-020-0706-z.pdf","source":{"id":"https://openalex.org/S175030738","display_name":"Neuropsychopharmacology","issn_l":"0893-133X","issn":["0893-133X","1740-634X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychopharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/s41386-020-0706-z.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008479872","display_name":"Joshua T. Kantrowitz","orcid":"https://orcid.org/0000-0003-1127-7016","observed_orcids":["https://orcid.org/0000-0003-1127-7016"]},"institutions":[{"id":"https://openalex.org/I125043107","display_name":"Nathan Kline Institute for Psychiatric Research","ror":"https://ror.org/01s434164","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I125043107"]},{"id":"https://openalex.org/I4388891851","display_name":"New York State Psychiatric Institute","ror":"https://ror.org/04aqjf708","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4388891851"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua T. Kantrowitz","raw_affiliation_strings":["Columbia University, New York, NY, USA","Nathan Kline Institute, Orangeburg, NY, USA","New York State Psychiatric Institute, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Nathan Kline Institute, Orangeburg, NY, USA","institution_ids":["https://openalex.org/I125043107"]},{"raw_affiliation_string":"New York State Psychiatric Institute, New York, NY, USA","institution_ids":["https://openalex.org/I4388891851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066820418","display_name":"Jack Grinband","orcid":"https://orcid.org/0000-0001-7658-6755","observed_orcids":["https://orcid.org/0000-0001-7658-6755"]},"institutions":[{"id":"https://openalex.org/I4388891851","display_name":"New York State Psychiatric Institute","ror":"https://ror.org/04aqjf708","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4388891851"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jack Grinband","raw_affiliation_strings":["Columbia University, New York, NY, USA","New York State Psychiatric Institute, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"New York State Psychiatric Institute, New York, NY, USA","institution_ids":["https://openalex.org/I4388891851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110870340","display_name":"DONALD C. GOFF","orcid":"https://orcid.org/0000-0002-4845-2327","observed_orcids":["https://orcid.org/0000-0002-4845-2327"]},"institutions":[{"id":"https://openalex.org/I125043107","display_name":"Nathan Kline Institute for Psychiatric Research","ror":"https://ror.org/01s434164","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I125043107"]},{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald C. Goff","raw_affiliation_strings":["NYU Langone Medical Center, New York, NY, USA","Nathan Kline Institute, Orangeburg, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NYU Langone Medical Center, New York, NY, USA","institution_ids":["https://openalex.org/I4210086933"]},{"raw_affiliation_string":"Nathan Kline Institute, Orangeburg, NY, USA","institution_ids":["https://openalex.org/I125043107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034093325","display_name":"Adrienne Carol Lahti","orcid":"https://orcid.org/0000-0002-5565-7662","observed_orcids":["https://orcid.org/0000-0002-5565-7662"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adrienne C. Lahti","raw_affiliation_strings":["University of Alabama at Birmingham, Birmingham, AL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Alabama at Birmingham, Birmingham, AL, USA","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088564036","display_name":"Stephen R. Marder","orcid":"https://orcid.org/0000-0003-0288-309X","observed_orcids":["https://orcid.org/0000-0003-0288-309X"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen R. Marder","raw_affiliation_strings":["UCLA, Los Angeles, CA, USA"],"raw_orcid":"https://orcid.org/0000-0003-0288-309X","affiliations":[{"raw_affiliation_string":"UCLA, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058205666","display_name":"Lawrence S. Kegeles","orcid":"https://orcid.org/0000-0002-8083-1167","observed_orcids":["https://orcid.org/0000-0002-8083-1167"]},"institutions":[{"id":"https://openalex.org/I4388891851","display_name":"New York State Psychiatric Institute","ror":"https://ror.org/04aqjf708","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4388891851"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lawrence S. Kegeles","raw_affiliation_strings":["Columbia University, New York, NY, USA","New York State Psychiatric Institute, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"New York State Psychiatric Institute, New York, NY, USA","institution_ids":["https://openalex.org/I4388891851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074474145","display_name":"Ragy R. Girgis","orcid":"https://orcid.org/0000-0001-5715-8982","observed_orcids":["https://orcid.org/0000-0001-5715-8982"]},"institutions":[{"id":"https://openalex.org/I4388891851","display_name":"New York State Psychiatric Institute","ror":"https://ror.org/04aqjf708","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4388891851"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ragy R. Girgis","raw_affiliation_strings":["Columbia University, New York, NY, USA","New York State Psychiatric Institute, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"New York State Psychiatric Institute, New York, NY, USA","institution_ids":["https://openalex.org/I4388891851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006873713","display_name":"Tarek M. Sobeih","orcid":"https://orcid.org/0000-0002-9694-2646","observed_orcids":["https://orcid.org/0000-0002-9694-2646"]},"institutions":[{"id":"https://openalex.org/I125043107","display_name":"Nathan Kline Institute for Psychiatric Research","ror":"https://ror.org/01s434164","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I125043107"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tarek Sobeih","raw_affiliation_strings":["Nathan Kline Institute, Orangeburg, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nathan Kline Institute, Orangeburg, NY, USA","institution_ids":["https://openalex.org/I125043107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088797464","display_name":"Melanie M. Wall","orcid":"https://orcid.org/0000-0001-6673-3467","observed_orcids":["https://orcid.org/0000-0001-6673-3467"]},"institutions":[{"id":"https://openalex.org/I4388891851","display_name":"New York State Psychiatric Institute","ror":"https://ror.org/04aqjf708","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4388891851"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melanie M. Wall","raw_affiliation_strings":["Columbia University, New York, NY, USA","New York State Psychiatric Institute, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"New York State Psychiatric Institute, New York, NY, USA","institution_ids":["https://openalex.org/I4388891851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086344811","display_name":"Tse-Hwei J. Choo","orcid":"https://orcid.org/0000-0001-5068-9799","observed_orcids":["https://orcid.org/0000-0001-5068-9799"]},"institutions":[{"id":"https://openalex.org/I4388891851","display_name":"New York State Psychiatric Institute","ror":"https://ror.org/04aqjf708","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4388891851"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tse-Hwei Choo","raw_affiliation_strings":["Columbia University, New York, NY, USA","New York State Psychiatric Institute, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"New York State Psychiatric Institute, New York, NY, USA","institution_ids":["https://openalex.org/I4388891851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003154905","display_name":"Michael Foster Green","orcid":"https://orcid.org/0000-0001-5620-8562","observed_orcids":["https://orcid.org/0000-0001-5620-8562"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael F. Green","raw_affiliation_strings":["UCLA, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCLA, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040680099","display_name":"Yvonne S. Yang","orcid":"https://orcid.org/0000-0001-8581-0624","observed_orcids":["https://orcid.org/0000-0001-8581-0624"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yvonne S. Yang","raw_affiliation_strings":["UCLA, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCLA, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100435060","display_name":"Junghee Lee","orcid":"https://orcid.org/0000-0001-9567-8700","observed_orcids":["https://orcid.org/0000-0001-9567-8700"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Junghee Lee","raw_affiliation_strings":["UCLA, Los Angeles, CA, USA"],"raw_orcid":"https://orcid.org/0000-0001-9567-8700","affiliations":[{"raw_affiliation_string":"UCLA, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055811550","display_name":"Guillermo Horga","orcid":"https://orcid.org/0000-0002-9049-9786","observed_orcids":["https://orcid.org/0000-0002-9049-9786"]},"institutions":[{"id":"https://openalex.org/I4388891851","display_name":"New York State Psychiatric Institute","ror":"https://ror.org/04aqjf708","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4388891851"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guillermo Horga","raw_affiliation_strings":["Columbia University, New York, NY, USA","New York State Psychiatric Institute, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"New York State Psychiatric Institute, New York, NY, USA","institution_ids":["https://openalex.org/I4388891851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071039477","display_name":"John Harrison Krystal","orcid":"https://orcid.org/0000-0001-6952-1726","observed_orcids":["https://orcid.org/0000-0001-6952-1726"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John H. Krystal","raw_affiliation_strings":["Yale University School of Medicine, New Haven, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University School of Medicine, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069167318","display_name":"William Z. Potter","orcid":"https://orcid.org/0000-0003-2529-6568","observed_orcids":["https://orcid.org/0000-0003-2529-6568"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Z. Potter","raw_affiliation_strings":["National Institutes of Health, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045818277","display_name":"Daniel C. Javitt","orcid":"https://orcid.org/0000-0003-2711-8239","observed_orcids":["https://orcid.org/0000-0003-2711-8239"]},"institutions":[{"id":"https://openalex.org/I125043107","display_name":"Nathan Kline Institute for Psychiatric Research","ror":"https://ror.org/01s434164","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I125043107"]},{"id":"https://openalex.org/I4388891851","display_name":"New York State Psychiatric Institute","ror":"https://ror.org/04aqjf708","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4388891851"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel C. Javitt","raw_affiliation_strings":["Columbia University, New York, NY, USA","Nathan Kline Institute, Orangeburg, NY, USA","New York State Psychiatric Institute, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Nathan Kline Institute, Orangeburg, NY, USA","institution_ids":["https://openalex.org/I125043107"]},{"raw_affiliation_string":"New York State Psychiatric Institute, New York, NY, USA","institution_ids":["https://openalex.org/I4388891851"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075093461","display_name":"Jeffrey Alan Lieberman","orcid":"https://orcid.org/0000-0002-1899-1776","observed_orcids":["https://orcid.org/0000-0002-1899-1776"]},"institutions":[{"id":"https://openalex.org/I4388891851","display_name":"New York State Psychiatric Institute","ror":"https://ror.org/04aqjf708","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4388891851"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jeffrey A. Lieberman","raw_affiliation_strings":["Columbia University, New York, NY, USA. Jeffrey.Lieberman@nyspi.columbia.edu","New York State Psychiatric Institute, New York, NY, USA. Jeffrey.Lieberman@nyspi.columbia.edu","New York State Psychiatric Institute, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia University, New York, NY, USA. Jeffrey.Lieberman@nyspi.columbia.edu","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"New York State Psychiatric Institute, New York, NY, USA. Jeffrey.Lieberman@nyspi.columbia.edu","institution_ids":["https://openalex.org/I4388891851"]},{"raw_affiliation_string":"New York State Psychiatric Institute, New York, NY, USA","institution_ids":["https://openalex.org/I4388891851"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5075093461"],"corresponding_institution_ids":["https://openalex.org/I4388891851","https://openalex.org/I78577930"],"apc_list":{"value":3760,"currency":"USD","value_usd":3760},"apc_paid":{"value":3760,"currency":"USD","value_usd":3760},"fwci":5.2555,"has_fulltext":true,"cited_by_count":52,"citation_normalized_percentile":{"value":0.96680398,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"45","issue":"11","first_page":"1842","last_page":"1850"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.5569999814033508},{"id":"https://openalex.org/keywords/ketamine-induced-psychosis","display_name":"ketamine-induced psychosis","score":0.8730000257492065},{"id":"https://openalex.org/keywords/dorsal-anterior-cingulate-cortex","display_name":"dorsal anterior cingulate cortex","score":0.9480000138282776},{"id":"https://openalex.org/keywords/glutamatergic-neurotransmission","display_name":"glutamatergic neurotransmission","score":0.734000027179718},{"id":"https://openalex.org/keywords/target-engagement","display_name":"target engagement","score":0.7429999709129333},{"id":"https://openalex.org/keywords/positive-symptoms","display_name":"positive symptoms","score":0.6700000166893005},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.38499999046325684},{"id":"https://openalex.org/keywords/antipsychotic-drug-development","display_name":"antipsychotic drug development","score":0.8510000109672546}],"concepts":[{"id":"https://openalex.org/C2780795376","wikidata":"https://www.wikidata.org/wiki/Q243547","display_name":"Ketamine","level":2,"score":0.772968053817749},{"id":"https://openalex.org/C2778528637","wikidata":"https://www.wikidata.org/wiki/Q4967025","display_name":"Brief Psychiatric Rating Scale","level":3,"score":0.7520191669464111},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.7473194599151611},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.6209964752197266},{"id":"https://openalex.org/C119128870","wikidata":"https://www.wikidata.org/wiki/Q4859538","display_name":"Metabotropic glutamate receptor 2","level":5,"score":0.6157503128051758},{"id":"https://openalex.org/C2778402161","wikidata":"https://www.wikidata.org/wiki/Q2121931","display_name":"Anterior cingulate cortex","level":3,"score":0.6034414768218994},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.5481059551239014},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4956473112106323},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49427151679992676},{"id":"https://openalex.org/C2780648746","wikidata":"https://www.wikidata.org/wiki/Q28208871","display_name":"Glutamatergic","level":4,"score":0.4658789038658142},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.4511888325214386},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.37889641523361206},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.37348881363868713},{"id":"https://openalex.org/C2779727114","wikidata":"https://www.wikidata.org/wiki/Q170082","display_name":"Psychosis","level":2,"score":0.354690819978714},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.353007048368454},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3398445248603821},{"id":"https://openalex.org/C49051014","wikidata":"https://www.wikidata.org/wiki/Q2033959","display_name":"Metabotropic glutamate receptor","level":4,"score":0.3373280167579651},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.25564661622047424},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.16377195715904236},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07949316501617432},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007649","descriptor_name":"Ketamine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007649","descriptor_name":"Ketamine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007649","descriptor_name":"Ketamine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007649","descriptor_name":"Ketamine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016037","descriptor_name":"Single-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016037","descriptor_name":"Single-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016037","descriptor_name":"Single-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016037","descriptor_name":"Single-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064368","descriptor_name":"Healthy Volunteers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064368","descriptor_name":"Healthy Volunteers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064368","descriptor_name":"Healthy Volunteers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064368","descriptor_name":"Healthy Volunteers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1038/s41386-020-0706-z","doi":"https://doi.org/10.1038/s41386-020-0706-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41386-020-0706-z","pdf_url":"https://www.nature.com/articles/s41386-020-0706-z.pdf","source":{"id":"https://openalex.org/S175030738","display_name":"Neuropsychopharmacology","issn_l":"0893-133X","issn":["0893-133X","1740-634X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychopharmacology","raw_type":"journal-article"},{"id":"doi:10.1101/2020.03.09.20029827","doi":"https://doi.org/10.1101/2020.03.09.20029827","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2020.03.09.20029827","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2020/03/12/2020.03.09.20029827.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},{"id":"pmid:32403118","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32403118","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7608251","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7608251","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neuropsychopharmacology","raw_type":"Text"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt6q02z4dg","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/6q02z4dg","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, vol 45, iss 11","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt6q02z4dg","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/6q02z4dg","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neuropsychopharmacology, vol 45, iss 11","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41386-020-0706-z","doi":"https://doi.org/10.1038/s41386-020-0706-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41386-020-0706-z","pdf_url":"https://www.nature.com/articles/s41386-020-0706-z.pdf","source":{"id":"https://openalex.org/S175030738","display_name":"Neuropsychopharmacology","issn_l":"0893-133X","issn":["0893-133X","1740-634X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychopharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8600000143051147}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4767077767","display_name":null,"funder_award_id":"HHSN271201200007C","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G6968037508","display_name":null,"funder_award_id":"HHSN271201200007I","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G8630450421","display_name":null,"funder_award_id":"FAST-PS contract (HHSN271201200007I)","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320323880","display_name":"Taisho Toyama Pharmaceutical Company","ror":"https://ror.org/033nw2736"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3024809249.pdf","grobid_xml":"https://content.openalex.org/works/W3024809249.grobid-xml"},"referenced_works_count":75,"referenced_works":["https://openalex.org/W15772355","https://openalex.org/W1563615702","https://openalex.org/W1592395635","https://openalex.org/W1914381346","https://openalex.org/W1971460793","https://openalex.org/W1977139958","https://openalex.org/W1983118933","https://openalex.org/W1984141645","https://openalex.org/W1989025308","https://openalex.org/W1991288075","https://openalex.org/W1991362566","https://openalex.org/W1997751011","https://openalex.org/W2001063043","https://openalex.org/W2008908272","https://openalex.org/W2012531942","https://openalex.org/W2017259777","https://openalex.org/W2019358247","https://openalex.org/W2020333990","https://openalex.org/W2020844317","https://openalex.org/W2023986042","https://openalex.org/W2026410709","https://openalex.org/W2026653320","https://openalex.org/W2027817574","https://openalex.org/W2027858713","https://openalex.org/W2028884770","https://openalex.org/W2035611331","https://openalex.org/W2038615690","https://openalex.org/W2039127578","https://openalex.org/W2043532758","https://openalex.org/W2049139447","https://openalex.org/W2055297542","https://openalex.org/W2055518130","https://openalex.org/W2056603806","https://openalex.org/W2061506085","https://openalex.org/W2062657302","https://openalex.org/W2068256291","https://openalex.org/W2069849124","https://openalex.org/W2087728812","https://openalex.org/W2089126361","https://openalex.org/W2090969443","https://openalex.org/W2103784702","https://openalex.org/W2103903531","https://openalex.org/W2113113845","https://openalex.org/W2119151345","https://openalex.org/W2140506009","https://openalex.org/W2144463664","https://openalex.org/W2147937603","https://openalex.org/W2158137297","https://openalex.org/W2159039084","https://openalex.org/W2159155203","https://openalex.org/W2217483770","https://openalex.org/W2259684659","https://openalex.org/W2312770619","https://openalex.org/W2327693359","https://openalex.org/W2475864443","https://openalex.org/W2606941164","https://openalex.org/W2607182730","https://openalex.org/W2623131989","https://openalex.org/W2732930884","https://openalex.org/W2758640643","https://openalex.org/W2768811819","https://openalex.org/W2770367203","https://openalex.org/W2783894827","https://openalex.org/W2791092622","https://openalex.org/W2791444586","https://openalex.org/W2807268163","https://openalex.org/W2884510193","https://openalex.org/W2891810482","https://openalex.org/W2893587285","https://openalex.org/W2913142180","https://openalex.org/W2914698032","https://openalex.org/W2957311488","https://openalex.org/W4247665917","https://openalex.org/W4322703206","https://openalex.org/W7074079951"],"related_works":["https://openalex.org/W2087426469","https://openalex.org/W1995275141","https://openalex.org/W2059164249","https://openalex.org/W1601482951","https://openalex.org/W4318215219","https://openalex.org/W4313199413","https://openalex.org/W2079300654","https://openalex.org/W2147197593","https://openalex.org/W1969820268","https://openalex.org/W4394249152"],"abstract_inverted_index":{"Glutamate":[0],"neurotransmission":[1],"is":[2],"a":[3,46,71,226],"prioritized":[4],"target":[5,223,245],"for":[6,53,258],"antipsychotic":[7],"drug":[8],"development.":[9],"Two":[10],"metabotropic":[11],"glutamate":[12],"receptor":[13],"2/3":[14],"(mGluR2/3)":[15],"agonists":[16],"(pomaglumetad":[17],"[POMA]":[18],"and":[19,34,39,100,122,135,169,191,244,254],"TS-134)":[20],"were":[21,88,112,118],"assessed":[22],"in":[23,45,91,93,173],"two":[24],"Phase":[25],"Ib":[26],"proof":[27],"of":[28,31,57,76,237,241,252],"mechanism":[29],"studies":[30],"comparable":[32],"designs":[33],"using":[35,207],"identical":[36],"clinical":[37,218],"assessments":[38],"pharmacoBOLD":[40,92,193],"methodology.":[41],"POMA":[42,62,121,127,152,213],"was":[43,70],"examined":[44],"randomized":[47,119],"controlled":[48],"trial":[49,69],"under":[50],"double-blind":[51],"conditions":[52],"10-days":[54],"at":[55],"doses":[56],"80":[58],"or":[59,78],"320":[60],"mg/d":[61,80],"versus":[63,82],"placebo":[64,83,210],"(1:1:1":[65],"ratio).":[66,85],"The":[67],"TS-134":[68,81,162,238],"randomized,":[72],"single-blind,":[73],"6-day":[74],"study":[75],"20":[77],"60":[79],"(5:5:2":[84],"Primary":[86],"outcomes":[87],"ketamine-induced":[89,130,156],"changes":[90],"the":[94,104,234],"dorsal":[95],"anterior":[96],"cingulate":[97],"cortex":[98],"(dACC)":[99],"symptoms":[101,133,177],"reflected":[102],"on":[103,217,222],"Brief":[105],"Psychiatric":[106],"Rating":[107],"Scale":[108],"(BPRS).":[109],"Both":[110],"trials":[111],"conducted":[113],"contemporaneously.":[114],"95":[115],"healthy":[116],"volunteers":[117],"to":[120,124,164,166],"63":[123],"TS-134.":[125],"High-dose":[126,212],"significantly":[128,154],"reduced":[129],"BPRS":[131,175],"total":[132],"within":[134,168],"between-groups":[136],"(p":[137,178,194],"<":[138],"0.01,":[139],"d":[140,146,181,187,197,203],"=":[141,144,147,179,182,185,188,195,198,201,204],"-0.41;":[142],"p":[143,184,200],"0.04,":[145],"-0.44,":[148],"respectively),":[149],"but":[150,220],"neither":[151],"dose":[153,228,236],"suppressed":[155],"dACC":[157,192],"pharmacoBOLD.":[158],"In":[159],"contrast,":[160],"low-dose":[161],"led":[163],"moderate":[165],"large":[167],"between":[170],"group":[171],"reductions":[172],"both":[174],"positive":[176],"0.02,":[180],"-0.36;":[183],"0.008,":[186],"-0.82,":[189],"respectively)":[190,206],"0.004,":[196],"-0.56;":[199],"0.079,":[202],"-0.50,":[205],"pooled":[208],"across-study":[209],"data.":[211],"exerted":[214],"significant":[215],"effects":[216],"symptoms,":[219],"not":[221],"engagement,":[224],"suggesting":[225],"higher":[227],"may":[229],"yet":[230],"be":[231],"needed,":[232],"while":[233],"low":[235],"showed":[239],"evidence":[240],"symptom":[242],"reduction":[243],"engagement.":[246],"These":[247],"results":[248],"support":[249],"further":[250],"investigation":[251],"mGluR2/3":[253],"other":[255],"glutamate-targeted":[256],"treatments":[257],"schizophrenia.":[259]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":5}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}