{"id":"https://openalex.org/W3024748869","doi":"https://doi.org/10.1021/acs.est.0c00662","title":"A Tiered Approach for Screening and Assessment of Environmental Mixtures by Omics and In Vitro Assays","display_name":"A Tiered Approach for Screening and Assessment of Environmental Mixtures by Omics and In Vitro Assays","publication_year":2020,"publication_date":"2020-05-13","ids":{"openalex":"https://openalex.org/W3024748869","doi":"https://doi.org/10.1021/acs.est.0c00662","mag":"3024748869","pmid":"https://pubmed.ncbi.nlm.nih.gov/32401503"},"language":"en","primary_location":{"id":"doi:10.1021/acs.est.0c00662","doi":"https://doi.org/10.1021/acs.est.0c00662","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.est.0c00662","pdf_url":null,"source":{"id":"https://openalex.org/S13479253","display_name":"Environmental Science & Technology","issn_l":"0013-936X","issn":["0013-936X","1520-5851"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","fnege-4","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Science &amp; Technology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086203587","display_name":"Wendi Fang","orcid":"https://orcid.org/0000-0002-8682-3002","observed_orcids":["https://orcid.org/0000-0002-8682-3002"]},"institutions":[{"id":"https://openalex.org/I4210090489","display_name":"State Key Laboratory of Pollution Control and Resource Reuse","ror":"https://ror.org/00073tb80","country_code":"CN","type":"facility","lineage":["https://openalex.org/I116953780","https://openalex.org/I4210090489","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wendi Fang","raw_affiliation_strings":["Nanjing University , , , ,","State Key Laboratory of Pollution Control & Resource Reuse, School of the Environment, Nanjing University, Nanjing, P. R. China, 210023"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nanjing University , , , ,","institution_ids":["https://openalex.org/I881766915"]},{"raw_affiliation_string":"State Key Laboratory of Pollution Control & Resource Reuse, School of the Environment, Nanjing University, Nanjing, P. R. China, 210023","institution_ids":["https://openalex.org/I4210090489","https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073000247","display_name":"Ying Peng","orcid":"https://orcid.org/0000-0002-7958-8067","observed_orcids":["https://orcid.org/0000-0002-7958-8067"]},"institutions":[{"id":"https://openalex.org/I4210090489","display_name":"State Key Laboratory of Pollution Control and Resource Reuse","ror":"https://ror.org/00073tb80","country_code":"CN","type":"facility","lineage":["https://openalex.org/I116953780","https://openalex.org/I4210090489","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Peng","raw_affiliation_strings":["Nanjing University , , , ,","State Key Laboratory of Pollution Control & Resource Reuse, School of the Environment, Nanjing University, Nanjing, P. R. China, 210023"],"raw_orcid":"https://orcid.org/0000-0002-7958-8067","affiliations":[{"raw_affiliation_string":"Nanjing University , , , ,","institution_ids":["https://openalex.org/I881766915"]},{"raw_affiliation_string":"State Key Laboratory of Pollution Control & Resource Reuse, School of the Environment, Nanjing University, Nanjing, P. R. China, 210023","institution_ids":["https://openalex.org/I4210090489","https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100641092","display_name":"Yan Lu","orcid":"https://orcid.org/0000-0002-7558-1634","observed_orcids":["https://orcid.org/0000-0002-7558-1634"]},"institutions":[{"id":"https://openalex.org/I4210090489","display_name":"State Key Laboratory of Pollution Control and Resource Reuse","ror":"https://ror.org/00073tb80","country_code":"CN","type":"facility","lineage":["https://openalex.org/I116953780","https://openalex.org/I4210090489","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lu Yan","raw_affiliation_strings":["Nanjing University , , , ,","State Key Laboratory of Pollution Control & Resource Reuse, School of the Environment, Nanjing University, Nanjing, P. R. China, 210023"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nanjing University , , , ,","institution_ids":["https://openalex.org/I881766915"]},{"raw_affiliation_string":"State Key Laboratory of Pollution Control & Resource Reuse, School of the Environment, Nanjing University, Nanjing, P. R. China, 210023","institution_ids":["https://openalex.org/I4210090489","https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068635461","display_name":"Pu Xia","orcid":"https://orcid.org/0000-0002-1186-378X","observed_orcids":["https://orcid.org/0000-0002-1186-378X"]},"institutions":[{"id":"https://openalex.org/I4210090489","display_name":"State Key Laboratory of Pollution Control and Resource Reuse","ror":"https://ror.org/00073tb80","country_code":"CN","type":"facility","lineage":["https://openalex.org/I116953780","https://openalex.org/I4210090489","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pu Xia","raw_affiliation_strings":["Nanjing University , , , ,","State Key Laboratory of Pollution Control & Resource Reuse, School of the Environment, Nanjing University, Nanjing, P. R. China, 210023"],"raw_orcid":"https://orcid.org/0000-0002-1186-378X","affiliations":[{"raw_affiliation_string":"Nanjing University , , , ,","institution_ids":["https://openalex.org/I881766915"]},{"raw_affiliation_string":"State Key Laboratory of Pollution Control & Resource Reuse, School of the Environment, Nanjing University, Nanjing, P. R. China, 210023","institution_ids":["https://openalex.org/I4210090489","https://openalex.org/I881766915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100353432","display_name":"Xiaowei Zhang","orcid":"https://orcid.org/0000-0001-8974-9963","observed_orcids":["https://orcid.org/0000-0001-8974-9963"]},"institutions":[{"id":"https://openalex.org/I4210090489","display_name":"State Key Laboratory of Pollution Control and Resource Reuse","ror":"https://ror.org/00073tb80","country_code":"CN","type":"facility","lineage":["https://openalex.org/I116953780","https://openalex.org/I4210090489","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaowei Zhang","raw_affiliation_strings":["Nanjing University , , , ,","State Key Laboratory of Pollution Control & Resource Reuse, School of the Environment, Nanjing University, Nanjing, P. R. China, 210023"],"raw_orcid":"https://orcid.org/0000-0001-8974-9963","affiliations":[{"raw_affiliation_string":"Nanjing University , , , ,","institution_ids":["https://openalex.org/I881766915"]},{"raw_affiliation_string":"State Key Laboratory of Pollution Control & Resource Reuse, School of the Environment, Nanjing University, Nanjing, P. R. China, 210023","institution_ids":["https://openalex.org/I4210090489","https://openalex.org/I881766915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100353432"],"corresponding_institution_ids":["https://openalex.org/I4210090489","https://openalex.org/I881766915"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":2.1484,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.86626167,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"54","issue":"12","first_page":"7430","last_page":"7439"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":0.9419000148773193,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":0.9419000148773193,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.03220000118017197,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/environmental-mixtures","display_name":"environmental mixtures","score":0.8939999938011169},{"id":"https://openalex.org/keywords/in-vitro-bioassay","display_name":"in vitro bioassay","score":0.9160000085830688},{"id":"https://openalex.org/keywords/combined-toxicity","display_name":"combined toxicity","score":0.49799999594688416},{"id":"https://openalex.org/keywords/toxicant-identification","display_name":"toxicant identification","score":0.7080000042915344},{"id":"https://openalex.org/keywords/solid-phase-extraction","display_name":"solid-phase extraction","score":0.5350000262260437},{"id":"https://openalex.org/keywords/hepg2-cells","display_name":"HepG2 cells","score":0.8169999718666077},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/aryl-hydrocarbon-receptor","display_name":"aryl hydrocarbon receptor","score":0.7670000195503235},{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.9869999885559082},{"id":"https://openalex.org/keywords/androgen-receptor","display_name":"androgen receptor","score":0.9980000257492065},{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.9459999799728394},{"id":"https://openalex.org/keywords/p53-signaling-pathway","display_name":"p53 pathway","score":0.7960000038146973},{"id":"https://openalex.org/keywords/relative-potency","display_name":"relative potency","score":0.35100001096725464},{"id":"https://openalex.org/keywords/chemical-mixtures","display_name":"chemical mixtures","score":0.4180000126361847}],"concepts":[{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.48746800422668457},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.45044106245040894},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.3748677968978882},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33402979373931885},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3315945267677307},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3192194104194641},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.27606573700904846},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14520332217216492}],"mesh":[{"descriptor_ui":"D001681","descriptor_name":"Biological Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014874","descriptor_name":"Water Pollutants, Chemical","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D052616","descriptor_name":"Solid Phase Extraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060753","descriptor_name":"Water Quality","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/acs.est.0c00662","doi":"https://doi.org/10.1021/acs.est.0c00662","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.est.0c00662","pdf_url":null,"source":{"id":"https://openalex.org/S13479253","display_name":"Environmental Science & Technology","issn_l":"0013-936X","issn":["0013-936X","1520-5851"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","fnege-4","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Science &amp; Technology","raw_type":"journal-article"},{"id":"pmid:32401503","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32401503","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental science & technology","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/25e0e528-a5bc-4881-8d06-57f760a8f1cb","doi":null,"is_oa":false,"landing_page_url":"https://research.birmingham.ac.uk/en/publications/25e0e528-a5bc-4881-8d06-57f760a8f1cb","pdf_url":null,"source":{"id":"https://openalex.org/S4306402634","display_name":"University of Birmingham Research Portal (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Fang, W, Peng, Y, Yan, L, Xia, P & Zhang, X 2020, 'A Tiered Approach for Screening and Assessment of Environmental Mixtures by Omics and in Vitro Assays', Environmental Science and Technology, vol. 54, no. 12, pp. 7430-7439. https://doi.org/10.1021/acs.est.0c00662","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.428600013256073,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1822177894","display_name":null,"funder_award_id":"2016017","funder_id":"https://openalex.org/F4320321605","funder_display_name":"Government of Jiangsu Province"},{"id":"https://openalex.org/G3463088389","display_name":null,"funder_award_id":"2017ZX07602\u2013002","funder_id":"https://openalex.org/F4320335682","funder_display_name":"Major Science and Technology Program for Water Pollution Control and Treatment"},{"id":"https://openalex.org/G3517215519","display_name":null,"funder_award_id":"2018YFC1801606","funder_id":"https://openalex.org/F4320321540","funder_display_name":"Ministry of Science and Technology of the People's Republic of China"},{"id":"https://openalex.org/G5068454862","display_name":null,"funder_award_id":"BK20160650","funder_id":"https://openalex.org/F4320322769","funder_display_name":"Natural Science Foundation of Jiangsu Province"}],"funders":[{"id":"https://openalex.org/F4320321106","display_name":"Ministry of Education of the People's Republic of China","ror":"https://ror.org/01mv9t934"},{"id":"https://openalex.org/F4320321540","display_name":"Ministry of Science and Technology of the People's Republic of China","ror":"https://ror.org/027s68j25"},{"id":"https://openalex.org/F4320321605","display_name":"Government of Jiangsu Province","ror":"https://ror.org/004svx814"},{"id":"https://openalex.org/F4320322769","display_name":"Natural Science Foundation of Jiangsu Province","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335682","display_name":"Major Science and Technology Program for Water Pollution Control and Treatment","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W29324485","https://openalex.org/W1492638942","https://openalex.org/W1883300828","https://openalex.org/W1964646267","https://openalex.org/W1966773608","https://openalex.org/W1970355511","https://openalex.org/W1992301911","https://openalex.org/W2004556005","https://openalex.org/W2013025233","https://openalex.org/W2017918116","https://openalex.org/W2017933502","https://openalex.org/W2025894728","https://openalex.org/W2039023381","https://openalex.org/W2051622237","https://openalex.org/W2063616586","https://openalex.org/W2095016596","https://openalex.org/W2112425978","https://openalex.org/W2118610649","https://openalex.org/W2126248794","https://openalex.org/W2126997165","https://openalex.org/W2141628779","https://openalex.org/W2151494136","https://openalex.org/W2154341508","https://openalex.org/W2155617007","https://openalex.org/W2169900825","https://openalex.org/W2214074259","https://openalex.org/W2339873869","https://openalex.org/W2344578960","https://openalex.org/W2519830558","https://openalex.org/W2555539164","https://openalex.org/W2570727619","https://openalex.org/W2606882354","https://openalex.org/W2611885040","https://openalex.org/W2731889197","https://openalex.org/W2734404515","https://openalex.org/W2771529970","https://openalex.org/W2786571932","https://openalex.org/W2788898240","https://openalex.org/W2793609956","https://openalex.org/W2810377262","https://openalex.org/W2919023285","https://openalex.org/W2995473177"],"related_works":["https://openalex.org/W2734404515","https://openalex.org/W3026584794","https://openalex.org/W2999552632","https://openalex.org/W2969062227","https://openalex.org/W4410362017","https://openalex.org/W6963602183","https://openalex.org/W4304843079","https://openalex.org/W2078871475","https://openalex.org/W6907644693","https://openalex.org/W2991102299"],"abstract_inverted_index":{"Abstract":[0],"New":[1],"methodology":[2],"approaches":[3],"with":[4,122,133],"a":[5,29,78],"broad":[6],"coverage":[7],"of":[8,19,22,63,93,101,125,153,157,195],"the":[9,17,20,46,61,98,102,123,134,147,158,167,179,193],"biological":[10,48,171],"effects":[11],"are":[12,50],"urgently":[13],"needed":[14],"to":[15,38,59,81,182],"evaluate":[16,71],"safety":[18],"universe":[21],"environmentally":[23],"relevant":[24],"chemicals.":[25],"Here,":[26],"we":[27,75],"propose":[28],"tiered":[30],"approach":[31],"incorporating":[32],"transcriptomics":[33,118],"and":[34,45,56,87,108,146,164],"in":[35,64,106,110],"vitro":[36,65],"bioassays":[37,66,127,154],"assess":[39],"environmental":[40],"mixtures.":[41],"The":[42,90,112],"mixture":[43,83,103,130,175],"samples":[44,84,131],"perturbed":[47],"pathways":[49,172],"prioritized":[51],"by":[52,85,117,174],"concentration-dependent":[53,196],"transcriptome":[54],"(CDT)":[55],"then":[57],"used":[58],"guide":[60],"selection":[62],"for":[67,155,198],"toxicant":[68],"identification.":[69],"To":[70],"omics\u2019":[72],"screening":[73],"capability,":[74],"first":[76],"applied":[77],"CDT":[79,168],"technique":[80],"test":[82],"HepG2":[86,107],"MCF7":[88],"cells.":[89],"effect":[91],"recoveries":[92],"large-volume":[94],"solid-phase":[95],"extraction":[96],"on":[97],"overall":[99,113],"bioactivity":[100,114],"were":[104,119],"48.9%":[105],"58.3%":[109],"MCF7.":[111],"potencies":[115],"obtained":[116],"positively":[120],"correlated":[121],"panel":[124],"8":[126],"among":[128],"14":[129],"combined":[132],"previous":[135],"data.":[136],"Transcriptomics":[137],"could":[138],"predict":[139],"their":[140],"activation":[141],"status":[142],"(AUC":[143],"=":[144],"0.783)":[145],"relative":[148],"potency":[149],"(p":[150],"<":[151],"0.05)":[152],"four":[156],"eight":[159],"receptors":[160],"(AhR,":[161],"ER,":[162],"AR,":[163],"Nrf2).":[165],"Furthermore,":[166],"identified":[169],"other":[170],"perturbated":[173],"samples,":[176],"such":[177],"as":[178],"pathway":[180],"related":[181],"TP53,":[183],"CAR,":[184],"FXR,":[185],"HIF,":[186],"THRA,":[187],"etc.":[188],"Overall,":[189],"this":[190],"study":[191],"demonstrates":[192],"potential":[194],"omics":[197],"effect-based":[199],"water":[200],"quality":[201],"assessment.":[202]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-05-21T00:00:00"}
