{"id":"https://openalex.org/W3024701774","doi":"https://doi.org/10.1016/s0022-5347(17)47229-6","title":"Modulation of Reticuloendothelial Activity With Liposomes","display_name":"Modulation of Reticuloendothelial Activity With Liposomes","publication_year":1985,"publication_date":"1985-08-01","ids":{"openalex":"https://openalex.org/W3024701774","doi":"https://doi.org/10.1016/s0022-5347(17)47229-6","mag":"3024701774","pmid":"https://pubmed.ncbi.nlm.nih.gov/3992015"},"language":"en","primary_location":{"id":"doi:10.1016/s0022-5347(17)47229-6","doi":"https://doi.org/10.1016/s0022-5347(17)47229-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-5347(17)47229-6","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W3024701774"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100533109","display_name":"H Hojo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H. Hojo","raw_affiliation_strings":["Department of Hygienic Chemistry, Pharmaceutical Institute, Tohoku University, Aobayama, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hygienic Chemistry, Pharmaceutical Institute, Tohoku University, Aobayama, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007760286","display_name":"Yuta Hoshino","orcid":"https://orcid.org/0000-0002-0827-2102","observed_orcids":["https://orcid.org/0000-0002-0827-2102"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y. Hoshino","raw_affiliation_strings":["Department of Hygienic Chemistry, Pharmaceutical Institute, Tohoku University, Aobayama, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hygienic Chemistry, Pharmaceutical Institute, Tohoku University, Aobayama, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043580894","display_name":"Takashi Kurita","orcid":"https://orcid.org/0000-0002-2983-0732","observed_orcids":["https://orcid.org/0000-0002-2983-0732"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T. Kurita","raw_affiliation_strings":["Department of Hygienic Chemistry, Pharmaceutical Institute, Tohoku University, Aobayama, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hygienic Chemistry, Pharmaceutical Institute, Tohoku University, Aobayama, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012278399","display_name":"Yosuke Hashimoto","orcid":"https://orcid.org/0000-0003-3008-9563","observed_orcids":["https://orcid.org/0000-0003-3008-9563"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y. Hashimoto","raw_affiliation_strings":["Department of Hygienic Chemistry, Pharmaceutical Institute, Tohoku University, Aobayama, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hygienic Chemistry, Pharmaceutical Institute, Tohoku University, Aobayama, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I201537933"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.3372,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.44423792,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"134","issue":"2","first_page":"438","last_page":"438"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9574999809265137,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9574999809265137,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12672","display_name":"Phagocytosis and Immune Regulation","score":0.029999999329447746,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reticuloendothelial-system","display_name":"reticuloendothelial system","score":0.9079999923706055},{"id":"https://openalex.org/keywords/liposomes","display_name":"liposomes","score":0.9169999957084656},{"id":"https://openalex.org/keywords/multilamellar-vesicles","display_name":"multilamellar vesicles","score":0.9980000257492065},{"id":"https://openalex.org/keywords/carbon-clearance","display_name":"carbon clearance","score":0.8500000238418579},{"id":"https://openalex.org/keywords/dicetyl-phosphate","display_name":"dicetyl phosphate","score":0.875},{"id":"https://openalex.org/keywords/octadecylamine","display_name":"octadecylamine","score":0.9869999885559082},{"id":"https://openalex.org/keywords/dipalmitoylphosphatidylcholine","display_name":"DPPC","score":0.949999988079071},{"id":"https://openalex.org/keywords/cholesterol","display_name":"cholesterol","score":0.8370000123977661},{"id":"https://openalex.org/keywords/vesicle-surface-charge","display_name":"vesicle surface charge","score":0.6949999928474426},{"id":"https://openalex.org/keywords/drug-carriers","display_name":"drug carriers","score":0.5659999847412109},{"id":"https://openalex.org/keywords/mice","display_name":"mice","score":0.5440000295639038}],"concepts":[{"id":"https://openalex.org/C19702531","wikidata":"https://www.wikidata.org/wiki/Q929966","display_name":"Mononuclear phagocyte system","level":2,"score":0.859731137752533},{"id":"https://openalex.org/C185154212","wikidata":"https://www.wikidata.org/wiki/Q410454","display_name":"Liposome","level":2,"score":0.8171335458755493},{"id":"https://openalex.org/C2777132085","wikidata":"https://www.wikidata.org/wiki/Q46220103","display_name":"Phosphate","level":2,"score":0.6442283391952515},{"id":"https://openalex.org/C2776330855","wikidata":"https://www.wikidata.org/wiki/Q650187","display_name":"Phosphatidylcholine","level":4,"score":0.6288920640945435},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5202580690383911},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.4493456780910492},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.42182764410972595},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4098699688911438},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.37531888484954834},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3476768136024475},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.32063204050064087},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24130898714065552},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.23532575368881226},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.22695493698120117},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.21100261807441711},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20234188437461853},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.12636366486549377}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003864","descriptor_name":"Depression, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010587","descriptor_name":"Phagocytosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012157","descriptor_name":"Mononuclear Phagocyte System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012157","descriptor_name":"Mononuclear Phagocyte System","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0022-5347(17)47229-6","doi":"https://doi.org/10.1016/s0022-5347(17)47229-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-5347(17)47229-6","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},{"id":"pmid:3992015","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3992015","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research communications in chemical pathology and pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1978032048","https://openalex.org/W2430249457","https://openalex.org/W2017885511","https://openalex.org/W2058615744","https://openalex.org/W1993945357","https://openalex.org/W192404939","https://openalex.org/W2010587003","https://openalex.org/W1884652411","https://openalex.org/W1973485706","https://openalex.org/W2416981545"],"abstract_inverted_index":{"The":[0,127],"effect":[1],"of":[2,27,49,88,99,106,132,139,154,171],"multilamellar":[3],"vesicles":[4],"(MLV)":[5],"on":[6],"reticuloendothelial":[7],"(RE)":[8],"activity,":[9],"as":[10,173],"measured":[11],"by":[12,136],"the":[13,72,104,121,130,137,169],"carbon":[14],"clearance":[15],"method,":[16],"was":[17,40],"investigated":[18],"in":[19],"mice.":[20],"MLV":[21,51,55,61,66,76,81,94,107,140],"were":[22,144],"prepared":[23],"with":[24,56,62,77,82,108,141],"a":[25,32,68,85,152,174],"mixture":[26],"dipalmitoyl":[28],"phosphatidylcholine,":[29],"cholesterol":[30],"and":[31,64,116,129,149,157],"charged":[33,54,60,69],"agent":[34],"(7:2:1":[35],"molar":[36],"ratio).":[37],"RE":[38,100,133],"activity":[39,101,134],"moderately":[41],"depressed":[42],"shortly":[43],"(1-4":[44],"hr)":[45],"after":[46,114],"i.v.":[47],"injection":[48,115],"all":[50],"tested;":[52],"negatively":[53],"dicetyl":[57,78,109,142],"phosphate,":[58],"positively":[59],"stearylamine":[63,83],"neutral":[65,93],"without":[67],"agent.":[70],"In":[71],"later":[73],"time,":[74],"either":[75],"phosphate":[79,110,143],"or":[80,177],"caused":[84],"marked":[86],"stimulation":[87],"reticulo-endothelial":[89],"system":[90],"(RES),":[91],"but":[92],"did":[95],"not.":[96],"A":[97],"peak":[98],"resulted":[102],"from":[103],"treatment":[105,138],"appeared":[111],"48":[112],"hr":[113],"then":[117],"gradually":[118],"returned":[119],"to":[120,146],"normal":[122],"level":[123],"within":[124],"7":[125],"days.":[126],"depression":[128],"enhancement":[131],"induced":[135],"observed":[145],"be":[147,164],"dose-related":[148],"significant":[150],"at":[151],"dose":[153],"1":[155],"mg/mouse":[156],"0.3":[158],"mg/mouse,":[159],"respectively.":[160],"These":[161],"results":[162],"should":[163],"taken":[165],"into":[166],"consideration":[167],"upon":[168],"use":[170],"liposomes":[172],"drug":[175],"carrier,":[176],"for":[178],"blocking":[179],"RES.":[180]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-05-21T00:00:00"}
