{"id":"https://openalex.org/W3024669012","doi":"https://doi.org/10.1038/s41467-020-16078-y","title":"Integration of multiple biological contexts reveals principles of synthetic lethality that affect reproducibility","display_name":"Integration of multiple biological contexts reveals principles of synthetic lethality that affect reproducibility","publication_year":2020,"publication_date":"2020-05-12","ids":{"openalex":"https://openalex.org/W3024669012","doi":"https://doi.org/10.1038/s41467-020-16078-y","mag":"3024669012","pmid":"https://pubmed.ncbi.nlm.nih.gov/32398776","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7217969"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-020-16078-y","doi":"https://doi.org/10.1038/s41467-020-16078-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-020-16078-y","pdf_url":"https://www.nature.com/articles/s41467-020-16078-y.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-020-16078-y.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034955907","display_name":"Angel A. Ku","orcid":"https://orcid.org/0000-0002-3830-2798","observed_orcids":["https://orcid.org/0000-0002-3830-2798"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angel A. Ku","raw_affiliation_strings":["Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, 94158, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, 94158, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017014846","display_name":"Hsien\u2010Ming Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hsien-Ming Hu","raw_affiliation_strings":["Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, 94158, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, 94158, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100625556","display_name":"Xin Zhao","orcid":"https://orcid.org/0000-0002-1768-7780","observed_orcids":["https://orcid.org/0000-0002-1768-7780","https://orcid.org/0009-0004-6185-9393"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xin Zhao","raw_affiliation_strings":["Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, 94158, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, 94158, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022256892","display_name":"Khyati Niral Shah","orcid":"https://orcid.org/0000-0002-2510-803X","observed_orcids":["https://orcid.org/0000-0002-2510-803X"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Khyati N. Shah","raw_affiliation_strings":["Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, 94158, USA"],"raw_orcid":"https://orcid.org/0000-0002-2510-803X","affiliations":[{"raw_affiliation_string":"Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, 94158, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112529092","display_name":"Sameera Kongara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sameera Kongara","raw_affiliation_strings":["Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, 94158, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, 94158, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107394233","display_name":"Di Wu","orcid":"https://orcid.org/0009-0001-7369-0220","observed_orcids":["https://orcid.org/0009-0001-7369-0220","https://orcid.org/0000-0002-0390-2750"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210167126","display_name":"UCSF Helen Diller Family Comprehensive Cancer Center","ror":"https://ror.org/05yndxy10","country_code":"US","type":"facility","lineage":["https://openalex.org/I180670191","https://openalex.org/I4210110664","https://openalex.org/I4210167126"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Di Wu","raw_affiliation_strings":["Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, 94158, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, 94158, USA","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210167126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082685256","display_name":"Frank P. McCormick","orcid":"https://orcid.org/0000-0002-6619-7120","observed_orcids":["https://orcid.org/0000-0002-6619-7120"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210167126","display_name":"UCSF Helen Diller Family Comprehensive Cancer Center","ror":"https://ror.org/05yndxy10","country_code":"US","type":"facility","lineage":["https://openalex.org/I180670191","https://openalex.org/I4210110664","https://openalex.org/I4210167126"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frank McCormick","raw_affiliation_strings":["Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, 94158, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, 94158, USA","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210167126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050117160","display_name":"Allan Balmain","orcid":"https://orcid.org/0000-0001-6549-7861","observed_orcids":["https://orcid.org/0000-0001-6549-7861"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210167126","display_name":"UCSF Helen Diller Family Comprehensive Cancer Center","ror":"https://ror.org/05yndxy10","country_code":"US","type":"facility","lineage":["https://openalex.org/I180670191","https://openalex.org/I4210110664","https://openalex.org/I4210167126"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allan Balmain","raw_affiliation_strings":["Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, 94158, USA"],"raw_orcid":"https://orcid.org/0000-0001-6549-7861","affiliations":[{"raw_affiliation_string":"Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, 94158, USA","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210167126"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028835470","display_name":"Sourav Bandyopadhyay","orcid":"https://orcid.org/0000-0003-3120-923X","observed_orcids":["https://orcid.org/0000-0003-3120-923X"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210167126","display_name":"UCSF Helen Diller Family Comprehensive Cancer Center","ror":"https://ror.org/05yndxy10","country_code":"US","type":"facility","lineage":["https://openalex.org/I180670191","https://openalex.org/I4210110664","https://openalex.org/I4210167126"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sourav Bandyopadhyay","raw_affiliation_strings":["Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, 94158, USA. Sourav.bandyopadhyay@ucsf.edu","Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, 94158, USA. Sourav.bandyopadhyay@ucsf.edu","Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, 94158, USA"],"raw_orcid":"https://orcid.org/0000-0003-3120-923X","affiliations":[{"raw_affiliation_string":"Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, 94158, USA. Sourav.bandyopadhyay@ucsf.edu","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, 94158, USA. Sourav.bandyopadhyay@ucsf.edu","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210167126"]},{"raw_affiliation_string":"Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, 94158, USA","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210167126"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5028835470"],"corresponding_institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210167126"],"apc_list":{"value":5380,"currency":"USD","value_usd":5380},"apc_paid":{"value":5380,"currency":"USD","value_usd":5380},"fwci":1.8425,"has_fulltext":true,"cited_by_count":38,"citation_normalized_percentile":{"value":0.85963144,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"11","issue":"1","first_page":"2375","last_page":"2375"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.8008000254631042,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.8008000254631042,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.04969999939203262,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.03539999946951866,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/synthetic-lethality","display_name":"synthetic lethality","score":1.0},{"id":"https://openalex.org/keywords/kras-mutation","display_name":"KRAS mutation","score":0.7429999709129333},{"id":"https://openalex.org/keywords/reproducibility","display_name":"reproducibility","score":0.7549999952316284},{"id":"https://openalex.org/keywords/protein-networks","display_name":"protein networks","score":0.753000020980835},{"id":"https://openalex.org/keywords/brca1","display_name":"BRCA1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cancer-vulnerability","display_name":"cancer vulnerability","score":0.6290000081062317},{"id":"https://openalex.org/keywords/genetic-context","display_name":"genetic context","score":0.4790000021457672}],"concepts":[{"id":"https://openalex.org/C2778502085","wikidata":"https://www.wikidata.org/wiki/Q7662767","display_name":"Synthetic lethality","level":4,"score":0.9466167688369751},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.7033827304840088},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.60831618309021},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6020485758781433},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.5668748021125793},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.53572016954422},{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.4973132908344269},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.49163204431533813},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.42497795820236206},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4061524271965027},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3164573311805725},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000072020","descriptor_name":"Synthetic Lethal Mutations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000078332","descriptor_name":"Data Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D019313","descriptor_name":"BRCA1 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1038/s41467-020-16078-y","doi":"https://doi.org/10.1038/s41467-020-16078-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-020-16078-y","pdf_url":"https://www.nature.com/articles/s41467-020-16078-y.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"doi:10.1101/591677","doi":"https://doi.org/10.1101/591677","is_oa":true,"landing_page_url":"https://doi.org/10.1101/591677","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2019/03/28/591677.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:7217969","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7217969","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmid:32398776","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32398776","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-16078-y","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-020-16078-y","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:b6264ed197d149c5a5e05804786dbdb6","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b6264ed197d149c5a5e05804786dbdb6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt5qw87476","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/5qw87476","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, vol 11, iss 1","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt3g68t5cs","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/3g68t5cs","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, vol 11, iss 1","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41467-020-16078-y","doi":"https://doi.org/10.1038/s41467-020-16078-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-020-16078-y","pdf_url":"https://www.nature.com/articles/s41467-020-16078-y.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8376593020","display_name":"Bay Area Cancer Target Discovery and Development Network","funder_award_id":"U01CA168370","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000883091","display_name":"Systems genetics analysis of tumor evolution in the mouse","funder_award_id":"R35CA210018","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306080","display_name":"Foundation for the National Institutes of Health","ror":"https://ror.org/00k86s890"},{"id":"https://openalex.org/F4320308797","display_name":"University of California Institute for Mexico and the United States","ror":"https://ror.org/03nawhv43"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3024669012.pdf","grobid_xml":"https://content.openalex.org/works/W3024669012.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W1970383854","https://openalex.org/W1971617980","https://openalex.org/W1973268287","https://openalex.org/W1975717070","https://openalex.org/W1984863053","https://openalex.org/W1988263223","https://openalex.org/W1997653472","https://openalex.org/W2008854410","https://openalex.org/W2009007206","https://openalex.org/W2009931781","https://openalex.org/W2015936619","https://openalex.org/W2042468422","https://openalex.org/W2042678758","https://openalex.org/W2050086663","https://openalex.org/W2053094576","https://openalex.org/W2062185406","https://openalex.org/W2080541934","https://openalex.org/W2091999960","https://openalex.org/W2098737737","https://openalex.org/W2108068107","https://openalex.org/W2110065044","https://openalex.org/W2117148975","https://openalex.org/W2121371748","https://openalex.org/W2123879591","https://openalex.org/W2124877282","https://openalex.org/W2125118217","https://openalex.org/W2126604711","https://openalex.org/W2126702649","https://openalex.org/W2133102806","https://openalex.org/W2133656476","https://openalex.org/W2136076059","https://openalex.org/W2136850043","https://openalex.org/W2148043260","https://openalex.org/W2150749732","https://openalex.org/W2153574614","https://openalex.org/W2160738354","https://openalex.org/W2163357890","https://openalex.org/W2163798887","https://openalex.org/W2182456467","https://openalex.org/W2284405698","https://openalex.org/W2522417827","https://openalex.org/W2526506448","https://openalex.org/W2531499154","https://openalex.org/W2586917786","https://openalex.org/W2594163481","https://openalex.org/W2620099337","https://openalex.org/W2752346384","https://openalex.org/W2760524909","https://openalex.org/W2766955181","https://openalex.org/W2786093695","https://openalex.org/W2810280645","https://openalex.org/W2886855629","https://openalex.org/W2892164761","https://openalex.org/W2918086501","https://openalex.org/W2947775439","https://openalex.org/W2993251899","https://openalex.org/W3157357317","https://openalex.org/W4211006558"],"related_works":["https://openalex.org/W2922960379","https://openalex.org/W4387805888","https://openalex.org/W2948885283","https://openalex.org/W2766798501","https://openalex.org/W4399504413","https://openalex.org/W4409833901","https://openalex.org/W4401834367","https://openalex.org/W4414127565","https://openalex.org/W2030825362","https://openalex.org/W4404940657"],"abstract_inverted_index":{"ABSTRACT":[0],"Synthetic":[1,155],"lethal":[2,36,56,80,109,156,189],"screens":[3,37,157],"have":[4,17,158,168],"the":[5,41,93,159,195],"potential":[6],"to":[7,161,182],"identify":[8,162],"new":[9,163,199],"vulnerabilities":[10],"incurred":[11],"by":[12,20,85,127],"specific":[13],"cancer":[14],"mutations":[15],"but":[16],"been":[18],"hindered":[19],"lack":[21],"of":[22,48,67,174,197],"agreement":[23],"between":[24],"studies.":[25],"Using":[26],"KRAS":[27],"as":[28,51,77],"a":[29,97,119,128,148],"model,":[30],"we":[31],"identified":[32,54,103],"that":[33,58,102,106,191],"published":[34],"synthetic":[35,55,79,108,139,188],"significantly":[38],"overlap":[39,68],"at":[40],"pathway":[42],"rather":[43,73],"than":[44,62,74],"gene":[45],"level.":[46],"Analysis":[47],"pathways":[49],"encoded":[50],"protein":[52],"networks":[53],"candidates":[57],"were":[59,82],"more":[60],"reproducible":[61,143],"those":[63],"previously":[64],"reported.":[65],"Lack":[66],"likely":[69],"stems":[70],"from":[71],"biological":[72],"technical":[75],"limitations":[76],"most":[78,137],"phenotypes":[81],"strongly":[83],"modulated":[84],"changes":[86],"in":[87,123,165,194],"cellular":[88,114],"conditions":[89],"or":[90],"genetic":[91,99,116],"context,":[92],"latter":[94],"determined":[95],"using":[96,147],"pairwise":[98],"interaction":[100],"map":[101],"numerous":[104],"interactions":[105],"suppress":[107],"effects.":[110],"Accounting":[111],"for":[112,135,185,202],"pathway,":[113],"and":[115,179],"context":[117],"nominates":[118],"DNA":[120],"repair":[121],"dependency":[122],"KRAS-mutant":[124],"cells,":[125],"mediated":[126],"network":[129],"containing":[130],"BRCA1.":[131],"We":[132,176],"provide":[133],"evidence":[134],"why":[136],"reported":[138],"lethals":[140],"are":[141],"not":[142],"which":[144],"is":[145],"addressable":[146],"multi-faceted":[149],"testing":[150],"framework.":[151],"STATEMENT":[152],"OF":[153],"SIGNIFICANCE":[154],"power":[160],"targets":[164,190],"cancer,":[166],"although":[167],"thus":[169],"far":[170],"come":[171],"up":[172],"short":[173],"expectation.":[175],"use":[177],"computational":[178],"experimental":[180],"approaches":[181],"delineate":[183],"principles":[184],"identifying":[186],"robust":[187],"could":[192],"aid":[193],"development":[196],"effective":[198],"therapeutic":[200],"strategies":[201],"genetically":[203],"defined":[204],"cancers.":[205]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2020-05-21T00:00:00"}
