{"id":"https://openalex.org/W3024524063","doi":"https://doi.org/10.1097/hco.0000000000000757","title":"2019 clinical trials in lipid lowering","display_name":"2019 clinical trials in lipid lowering","publication_year":2020,"publication_date":"2020-05-13","ids":{"openalex":"https://openalex.org/W3024524063","doi":"https://doi.org/10.1097/hco.0000000000000757","mag":"3024524063","pmid":"https://pubmed.ncbi.nlm.nih.gov/32412963"},"language":"en","primary_location":{"id":"doi:10.1097/hco.0000000000000757","doi":"https://doi.org/10.1097/hco.0000000000000757","is_oa":false,"landing_page_url":"https://doi.org/10.1097/hco.0000000000000757","pdf_url":null,"source":{"id":"https://openalex.org/S57372075","display_name":"Current Opinion in Cardiology","issn_l":"0268-4705","issn":["0268-4705","1080-787X","1531-7080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Cardiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"David I. Feldman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David I. Feldman","raw_affiliation_strings":["Ciccarone Center for the Prevention of Cardiovascular Disease, Department of Medicine, The Johns Hopkins Hospital, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ciccarone Center for the Prevention of Cardiovascular Disease, Department of Medicine, The Johns Hopkins Hospital, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083873874","display_name":"Justin Pacor","orcid":"https://orcid.org/0000-0002-4412-2654","observed_orcids":["https://orcid.org/0000-0002-4412-2654"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Justin M. Pacor","raw_affiliation_strings":["Department of Medicine, Yale School of Medicine, New Haven, Connecticut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Yale School of Medicine, New Haven, Connecticut","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087095202","display_name":"Roger Scott Blumenthal","orcid":"https://orcid.org/0000-0003-1910-3168","observed_orcids":["https://orcid.org/0000-0003-1910-3168"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roger S. Blumenthal","raw_affiliation_strings":["Ciccarone Center for the Prevention of Cardiovascular Disease, Department of Cardiology, The Johns Hopkins Hospital, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ciccarone Center for the Prevention of Cardiovascular Disease, Department of Cardiology, The Johns Hopkins Hospital, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210150714"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072663918","display_name":"Khurram Nasir","orcid":"https://orcid.org/0000-0001-5376-2269","observed_orcids":["https://orcid.org/0000-0001-5376-2269","https://orcid.org/0000-0002-2632-1318"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]},{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Khurram Nasir","raw_affiliation_strings":["Division of Cardiovascular Prevention and Wellness; Houston Methodist DeBakey Heart and Vascular Center, Center for Outcomes Research, Houston Methodist Research Institute, Houston, Texas, USA","Division of Cardiovascular Prevention and Wellness"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiovascular Prevention and Wellness; Houston Methodist DeBakey Heart and Vascular Center, Center for Outcomes Research, Houston Methodist Research Institute, Houston, Texas, USA","institution_ids":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]},{"raw_affiliation_string":"Division of Cardiovascular Prevention and Wellness","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5072663918"],"corresponding_institution_ids":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"],"apc_list":null,"apc_paid":null,"fwci":0.224,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.50304681,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"35","issue":"4","first_page":"319","last_page":"324"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipid-lowering-therapy","display_name":"lipid-lowering therapy","score":0.9869999885559082},{"id":"https://openalex.org/keywords/atherosclerotic-cardiovascular-disease","display_name":"atherosclerotic cardiovascular disease","score":0.9610000252723694},{"id":"https://openalex.org/keywords/ldl-cholesterol-lowering","display_name":"LDL cholesterol lowering","score":0.921999990940094},{"id":"https://openalex.org/keywords/statin-therapy","display_name":"statin therapy","score":0.7910000085830688},{"id":"https://openalex.org/keywords/pcsk9-inhibitors","display_name":"PCSK9 inhibitors","score":0.9940000176429749},{"id":"https://openalex.org/keywords/inclisiran","display_name":"inclisiran","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bempedoic-acid","display_name":"bempedoic acid","score":0.9980000257492065},{"id":"https://openalex.org/keywords/icosapent-ethyl","display_name":"icosapent ethyl","score":1.0},{"id":"https://openalex.org/keywords/major-adverse-cardiovascular-events","display_name":"major adverse cardiovascular events","score":0.953000009059906},{"id":"https://openalex.org/keywords/cardiovascular-risk-reduction","display_name":"cardiovascular risk reduction","score":0.5609999895095825},{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.7319999933242798}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9375869035720825},{"id":"https://openalex.org/C2776839432","wikidata":"https://www.wikidata.org/wiki/Q954845","display_name":"Statin","level":2,"score":0.7209520936012268},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6515923738479614},{"id":"https://openalex.org/C2909478654","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Atherosclerotic cardiovascular disease","level":3,"score":0.613064169883728},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5754172205924988},{"id":"https://openalex.org/C2780948078","wikidata":"https://www.wikidata.org/wiki/Q21130010","display_name":"PCSK9","level":5,"score":0.503070056438446},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4543669521808624},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.42983508110046387},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42594611644744873},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.36868226528167725},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.24887239933013916},{"id":"https://openalex.org/C43554185","wikidata":"https://www.wikidata.org/wiki/Q425649","display_name":"LDL receptor","level":4,"score":0.1244058609008789}],"mesh":[{"descriptor_ui":"D000071449","descriptor_name":"Proprotein Convertase 9","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000924","descriptor_name":"Anticholesteremic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008078","descriptor_name":"Cholesterol, LDL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/hco.0000000000000757","doi":"https://doi.org/10.1097/hco.0000000000000757","is_oa":false,"landing_page_url":"https://doi.org/10.1097/hco.0000000000000757","pdf_url":null,"source":{"id":"https://openalex.org/S57372075","display_name":"Current Opinion in Cardiology","issn_l":"0268-4705","issn":["0268-4705","1080-787X","1531-7080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Cardiology","raw_type":"journal-article"},{"id":"pmid:32412963","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32412963","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in cardiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1520609538","https://openalex.org/W1962272706","https://openalex.org/W2001328643","https://openalex.org/W2019071303","https://openalex.org/W2093391254","https://openalex.org/W2096075279","https://openalex.org/W2098890974","https://openalex.org/W2148577580","https://openalex.org/W2155259933","https://openalex.org/W2580792129","https://openalex.org/W2595169180","https://openalex.org/W2596179513","https://openalex.org/W2800492785","https://openalex.org/W2899669642","https://openalex.org/W2899997727","https://openalex.org/W2900034165","https://openalex.org/W2900103074","https://openalex.org/W2913705661","https://openalex.org/W2922038538","https://openalex.org/W2923928888","https://openalex.org/W2940327706","https://openalex.org/W2943382228","https://openalex.org/W2970625233","https://openalex.org/W2987850771","https://openalex.org/W4236673002","https://openalex.org/W6640798808","https://openalex.org/W6756602680","https://openalex.org/W7074223243"],"related_works":["https://openalex.org/W4414526568","https://openalex.org/W4390918249","https://openalex.org/W4283525317","https://openalex.org/W3016388449","https://openalex.org/W3147589974","https://openalex.org/W4327920428","https://openalex.org/W4288060117","https://openalex.org/W4400000010","https://openalex.org/W4383342581","https://openalex.org/W4405451366"],"abstract_inverted_index":{"PURPOSE":[0],"OF":[1],"REVIEW:":[2],"Lipid-lowering":[3],"therapies":[4,137],"play":[5],"a":[6,28],"major":[7,57],"role":[8],"in":[9,48],"reducing":[10,88],"atherosclerotic":[11],"cardiovascular":[12,59],"disease":[13],"(ASCVD).":[14],"This":[15],"article":[16],"reviews":[17],"the":[18,53,68,149],"most":[19],"recent":[20],"lipid-lowering":[21],"therapy":[22,65,129,164],"trials,":[23],"many":[24,77,79],"of":[25,44,55,70,116,125],"which":[26],"provide":[27],"unique":[29],"opportunity":[30],"to":[31,142,147,193,198],"further":[32,51,87,114],"reduce":[33,199],"low-density":[34],"lipoprotein":[35],"cholesterol":[36],"(LDL-C)":[37],"levels":[38,75,118],"and":[39,47,100,107,119,159,187],"ASCVD":[40,139],"risk":[41,120,158,195],"on":[42,92,123,155,178],"top":[43,124],"statin":[45,64,128,163,175],"therapy,":[46,176],"doing":[49],"so":[50],"decrease":[52],"number":[54],"future":[56],"adverse":[58,200],"events.":[60],"RECENT":[61],"FINDINGS:":[62],"Although":[63],"has":[66],"been":[67],"mainstay":[69],"treatment":[71,151],"for":[72,76,86,113,121,138,152],"lowering":[73,115],"LDL-C":[74,117],"years,":[78],"individuals":[80,153],"require":[81],"additional":[82],"or":[83,169],"alternative":[84],"options":[85],"their":[89,156],"risk.":[90],"Trials":[91],"previously":[93],"studied":[94],"therapies,":[95,102,180],"such":[96,181],"as":[97,182],"PCSK9":[98],"inhibitors,":[99],"new":[101],"including":[103],"inclisiran,":[104,184],"bempedoic":[105,185],"acid":[106,186],"icosapent":[108,188],"ethyl":[109],"demonstrate":[110],"significant":[111],"potential":[112],"events":[122],"maximally":[126],"tolerated":[127],"with":[130],"favourable":[131],"side":[132],"effect":[133],"profiles.":[134],"SUMMARY:":[135],"As":[136],"prevention":[140],"continue":[141],"emerge,":[143],"clinicians":[144],"will":[145,190],"need":[146],"identify":[148],"appropriate":[150],"based":[154],"estimated":[157],"risk-enhancing":[160],"factors.":[161],"When":[162],"is":[165],"either":[166],"not":[167,172],"sufficient":[168],"patients":[170],"do":[171],"tolerate":[173],"adequate":[174],"relying":[177],"newer":[179],"PCSK9-inhibitors,":[183],"ethyl,":[189],"be":[191],"critical":[192],"maximize":[194],"factor":[196],"profiles":[197],"outcomes.":[201]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-05-21T00:00:00"}