{"id":"https://openalex.org/W3024325832","doi":"https://doi.org/10.31083/ph.2019.8242","title":"An Isolated Method and Assignment for Critical Impurities in Semi-Synthetic Process of Arbekacin Sulfate","display_name":"An Isolated Method and Assignment for Critical Impurities in Semi-Synthetic Process of Arbekacin Sulfate","publication_year":2019,"publication_date":"2019-06-01","ids":{"openalex":"https://openalex.org/W3024325832","doi":"https://doi.org/10.31083/ph.2019.8242","mag":"3024325832","pmid":"https://pubmed.ncbi.nlm.nih.gov/31138373"},"language":"en","primary_location":{"id":"doi:10.31083/ph.2019.8242","doi":"https://doi.org/10.31083/ph.2019.8242","is_oa":true,"landing_page_url":"https://doi.org/10.31083/ph.2019.8242","pdf_url":"https://storage.imrpress.com/IMR/hmed/application/10.1691/ph.2019.8242.pdf","source":{"id":"https://openalex.org/S175310056","display_name":"Die Pharmazie","issn_l":"0031-7144","issn":["0031-7144","3053-691X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320695","host_organization_name":"Avoxa","host_organization_lineage":["https://openalex.org/P4310320695"],"host_organization_lineage_names":["Avoxa"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Die Pharmazie","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://storage.imrpress.com/IMR/hmed/application/10.1691/ph.2019.8242.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012383883","display_name":"Z H Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405271766","display_name":"State Key Laboratory of Chemical Resource Engineering","ror":"https://ror.org/030ec4b63","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405271766"]},{"id":"https://openalex.org/I75390827","display_name":"Beijing University of Chemical Technology","ror":"https://ror.org/00df5yc52","country_code":"CN","type":"education","lineage":["https://openalex.org/I75390827"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Z. H. Chen","raw_affiliation_strings":["State Key Laboratory of Chemical Resource Engineering 1 , Beijing University of Chemical Technology ; Yangtze River Pharmaceutical Group , Beijing Haiyan Pharmaceutical Co., Ltd 2 . , Beijing , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Chemical Resource Engineering 1 , Beijing University of Chemical Technology ; Yangtze River Pharmaceutical Group , Beijing Haiyan Pharmaceutical Co., Ltd 2 . , Beijing , China","institution_ids":["https://openalex.org/I4405271766","https://openalex.org/I75390827"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061116818","display_name":"Hongping Zhou","orcid":"https://orcid.org/0000-0003-3502-6836","observed_orcids":["https://orcid.org/0000-0003-3502-6836"]},"institutions":[{"id":"https://openalex.org/I4405271766","display_name":"State Key Laboratory of Chemical Resource Engineering","ror":"https://ror.org/030ec4b63","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405271766"]},{"id":"https://openalex.org/I75390827","display_name":"Beijing University of Chemical Technology","ror":"https://ror.org/00df5yc52","country_code":"CN","type":"education","lineage":["https://openalex.org/I75390827"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"H. Zhou","raw_affiliation_strings":["State Key Laboratory of Chemical Resource Engineering 1 , Beijing University of Chemical Technology ; Yangtze River Pharmaceutical Group , Beijing Haiyan Pharmaceutical Co., Ltd 2 . , Beijing , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Chemical Resource Engineering 1 , Beijing University of Chemical Technology ; Yangtze River Pharmaceutical Group , Beijing Haiyan Pharmaceutical Co., Ltd 2 . , Beijing , China","institution_ids":["https://openalex.org/I4405271766","https://openalex.org/I75390827"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100328309","display_name":"Shuai Wang","orcid":"https://orcid.org/0000-0002-7303-5509","observed_orcids":["https://orcid.org/0000-0002-7303-5509"]},"institutions":[{"id":"https://openalex.org/I4405271766","display_name":"State Key Laboratory of Chemical Resource Engineering","ror":"https://ror.org/030ec4b63","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405271766"]},{"id":"https://openalex.org/I75390827","display_name":"Beijing University of Chemical Technology","ror":"https://ror.org/00df5yc52","country_code":"CN","type":"education","lineage":["https://openalex.org/I75390827"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"S. Wang","raw_affiliation_strings":["State Key Laboratory of Chemical Resource Engineering 1 , Beijing University of Chemical Technology ; Yangtze River Pharmaceutical Group , Beijing Haiyan Pharmaceutical Co., Ltd 2 . , Beijing , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Chemical Resource Engineering 1 , Beijing University of Chemical Technology ; Yangtze River Pharmaceutical Group , Beijing Haiyan Pharmaceutical Co., Ltd 2 . , Beijing , China","institution_ids":["https://openalex.org/I4405271766","https://openalex.org/I75390827"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022979393","display_name":"Guanting Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405271766","display_name":"State Key Laboratory of Chemical Resource Engineering","ror":"https://ror.org/030ec4b63","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405271766"]},{"id":"https://openalex.org/I75390827","display_name":"Beijing University of Chemical Technology","ror":"https://ror.org/00df5yc52","country_code":"CN","type":"education","lineage":["https://openalex.org/I75390827"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"G. Li","raw_affiliation_strings":["State Key Laboratory of Chemical Resource Engineering 1 , Beijing University of Chemical Technology ; Yangtze River Pharmaceutical Group , Beijing Haiyan Pharmaceutical Co., Ltd 2 . , Beijing , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Chemical Resource Engineering 1 , Beijing University of Chemical Technology ; Yangtze River Pharmaceutical Group , Beijing Haiyan Pharmaceutical Co., Ltd 2 . , Beijing , China","institution_ids":["https://openalex.org/I4405271766","https://openalex.org/I75390827"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073935002","display_name":"J Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405271766","display_name":"State Key Laboratory of Chemical Resource Engineering","ror":"https://ror.org/030ec4b63","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405271766"]},{"id":"https://openalex.org/I75390827","display_name":"Beijing University of Chemical Technology","ror":"https://ror.org/00df5yc52","country_code":"CN","type":"education","lineage":["https://openalex.org/I75390827"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"J. Zhang","raw_affiliation_strings":["State Key Laboratory of Chemical Resource Engineering 1 , Beijing University of Chemical Technology ; Yangtze River Pharmaceutical Group , Beijing Haiyan Pharmaceutical Co., Ltd 2 . , Beijing , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Chemical Resource Engineering 1 , Beijing University of Chemical Technology ; Yangtze River Pharmaceutical Group , Beijing Haiyan Pharmaceutical Co., Ltd 2 . , Beijing , China","institution_ids":["https://openalex.org/I4405271766","https://openalex.org/I75390827"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078488073","display_name":"F Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405271766","display_name":"State Key Laboratory of Chemical Resource Engineering","ror":"https://ror.org/030ec4b63","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405271766"]},{"id":"https://openalex.org/I75390827","display_name":"Beijing University of Chemical Technology","ror":"https://ror.org/00df5yc52","country_code":"CN","type":"education","lineage":["https://openalex.org/I75390827"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"F. Wang","raw_affiliation_strings":["State Key Laboratory of Chemical Resource Engineering , Beijing University of Chemical Technology , Beijing 100029 , P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Chemical Resource Engineering , Beijing University of Chemical Technology , Beijing 100029 , P. R. China","institution_ids":["https://openalex.org/I4405271766","https://openalex.org/I75390827"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044738121","display_name":"Cunhao Li","orcid":"https://orcid.org/0009-0007-4963-3801","observed_orcids":["https://orcid.org/0009-0007-4963-3801"]},"institutions":[{"id":"https://openalex.org/I4405271766","display_name":"State Key Laboratory of Chemical Resource Engineering","ror":"https://ror.org/030ec4b63","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405271766"]},{"id":"https://openalex.org/I75390827","display_name":"Beijing University of Chemical Technology","ror":"https://ror.org/00df5yc52","country_code":"CN","type":"education","lineage":["https://openalex.org/I75390827"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"C. Li","raw_affiliation_strings":["State Key Laboratory of Chemical Resource Engineering , Beijing University of Chemical Technology , Beijing 100029 , P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Chemical Resource Engineering , Beijing University of Chemical Technology , Beijing 100029 , P. R. China","institution_ids":["https://openalex.org/I4405271766","https://openalex.org/I75390827"]}]},{"author_position":"last","author":{"id":null,"display_name":"R. Z. Qiao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405271766","display_name":"State Key Laboratory of Chemical Resource Engineering","ror":"https://ror.org/030ec4b63","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405271766"]},{"id":"https://openalex.org/I75390827","display_name":"Beijing University of Chemical Technology","ror":"https://ror.org/00df5yc52","country_code":"CN","type":"education","lineage":["https://openalex.org/I75390827"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"R. Z. Qiao","raw_affiliation_strings":["State Key Laboratory of Chemical Resource Engineering , Beijing University of Chemical Technology , Beijing 100029 , P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Chemical Resource Engineering , Beijing University of Chemical Technology , Beijing 100029 , P. R. China","institution_ids":["https://openalex.org/I4405271766","https://openalex.org/I75390827"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1026,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.28577228,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"74","issue":"6","first_page":"352","last_page":"356"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/process-related-impurities","display_name":"process-related impurities","score":0.7860000133514404},{"id":"https://openalex.org/keywords/impurity-profiling","display_name":"impurity profiling","score":0.722000002861023},{"id":"https://openalex.org/keywords/aminoglycosides","display_name":"aminoglycosides","score":0.8610000014305115},{"id":"https://openalex.org/keywords/dibekacin","display_name":"dibekacin","score":0.8920000195503235},{"id":"https://openalex.org/keywords/impurity-isolation","display_name":"impurity isolation","score":0.5920000076293945},{"id":"https://openalex.org/keywords/impurity-identification","display_name":"impurity identification","score":0.527999997138977},{"id":"https://openalex.org/keywords/hplc-elsd","display_name":"HPLC-ELSD","score":0.7730000019073486},{"id":"https://openalex.org/keywords/cation-exchange-resin","display_name":"cation exchange resin","score":0.5389999747276306},{"id":"https://openalex.org/keywords/structure-elucidation","display_name":"structure elucidation","score":0.652999997138977}],"concepts":[{"id":"https://openalex.org/C71987851","wikidata":"https://www.wikidata.org/wiki/Q7216430","display_name":"Impurity","level":2,"score":0.741573691368103},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6158218383789062},{"id":"https://openalex.org/C2777787772","wikidata":"https://www.wikidata.org/wiki/Q45355603","display_name":"Aminoglycoside","level":3,"score":0.4900549650192261},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.4599885046482086},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.38638827204704285},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.24876171350479126},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.17314383387565613},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12068670988082886}],"mesh":[{"descriptor_ui":"D002626","descriptor_name":"Chemistry, Pharmaceutical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D003982","descriptor_name":"Dibekacin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D003982","descriptor_name":"Dibekacin","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D003982","descriptor_name":"Dibekacin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004340","descriptor_name":"Drug Contamination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.31083/ph.2019.8242","doi":"https://doi.org/10.31083/ph.2019.8242","is_oa":true,"landing_page_url":"https://doi.org/10.31083/ph.2019.8242","pdf_url":"https://storage.imrpress.com/IMR/hmed/application/10.1691/ph.2019.8242.pdf","source":{"id":"https://openalex.org/S175310056","display_name":"Die Pharmazie","issn_l":"0031-7144","issn":["0031-7144","3053-691X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320695","host_organization_name":"Avoxa","host_organization_lineage":["https://openalex.org/P4310320695"],"host_organization_lineage_names":["Avoxa"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Die Pharmazie","raw_type":"journal-article"},{"id":"pmid:31138373","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31138373","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Die Pharmazie","raw_type":"Journal Article"},{"id":"mag:3024325832","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31138373","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"doi:10.31083/ph.2019.8242","doi":"https://doi.org/10.31083/ph.2019.8242","is_oa":true,"landing_page_url":"https://doi.org/10.31083/ph.2019.8242","pdf_url":"https://storage.imrpress.com/IMR/hmed/application/10.1691/ph.2019.8242.pdf","source":{"id":"https://openalex.org/S175310056","display_name":"Die Pharmazie","issn_l":"0031-7144","issn":["0031-7144","3053-691X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320695","host_organization_name":"Avoxa","host_organization_lineage":["https://openalex.org/P4310320695"],"host_organization_lineage_names":["Avoxa"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Die Pharmazie","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1100099241","display_name":"\"DNA-\u7279\u5f02\u6027\u914d\u4f53\"\u6742\u5408\u624b\u6027\u50ac\u5316\u5242\u7684\u8bbe\u8ba1\u53ca\u50ac\u5316\u6027\u80fd\u7814\u7a76","funder_award_id":"21372024","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2391540162","display_name":null,"funder_award_id":"21572018","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2790076937","display_name":null,"funder_award_id":"21672021","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7872622214","display_name":"\u751f\u7269\u5927\u5206\u5b50\u7279\u5f02\u8bc6\u522b\u4e0e\u8c03\u63a7\u7684\u6709\u673a\u5c0f\u5206\u5b50\u7814\u7a76","funder_award_id":"21232005","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3024325832.pdf","grobid_xml":"https://content.openalex.org/works/W3024325832.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2854987671","https://openalex.org/W2317449229","https://openalex.org/W416588572","https://openalex.org/W2319943540","https://openalex.org/W2904162271","https://openalex.org/W4404664452","https://openalex.org/W2554869612","https://openalex.org/W2078208842","https://openalex.org/W4375867090","https://openalex.org/W2120431510"],"abstract_inverted_index":{"Four":[0],"potential":[1],"process":[2,21,62],"related":[3],"impurities":[4,28,82,96],"were":[5,53,83],"detected":[6],"during":[7],"the":[8,26,41,56,66,78],"impurity":[9],"profiling":[10],"study":[11],"of":[12,60,80,94,116],"a":[13,109],"semi-synthetic":[14],"aminoglycoside":[15,117],"antibiotic,":[16],"arbekacin.":[17],"The":[18,92],"current":[19,103],"preparation":[20],"from":[22],"3',4'-didehydro-dibekacin":[23],"easily":[24],"generates":[25],"specific":[27],"with":[29],"similar":[30],"structures":[31,79],"to":[32,37,107],"arbekacin":[33],"that":[34],"makes":[35],"hard":[36],"separate":[38],"and":[39,44,58,68,76,90,101,114],"identify":[40],"residues.":[42],"HPLC-ELSD":[43],"column":[45],"chromatography":[46],"loading":[47],"weakly":[48],"acidic":[49],"cation":[50],"exchange":[51],"resin":[52],"used":[54],"for":[55,112],"detection":[57],"isolation":[59,113],"these":[61,81,95],"impurities.":[63],"Based":[64],"on":[65],"synthesis":[67],"spectral":[69],"data":[70],"(ESI-MS/MS,":[71],"1H":[72],"NMR,":[73],"13C":[74],"NMR":[75],"2D-NMR),":[77],"characterized":[84],"as":[85],"dibekacin,":[86],"3-N-\u03b3-aminohydroxybutyric":[87],"(AHB)-dibekacin,":[88],"3''-N-AHB-dibekacin":[89],"1,3-N,N-di-AHB-dibekacin.":[91],"characterization":[93],"is":[97],"discussed":[98],"in":[99],"detail":[100],"our":[102],"efforts":[104],"may":[105],"help":[106],"develop":[108],"general":[110],"strategy":[111],"identification":[115],"products.":[118]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-05-21T00:00:00"}
