{"id":"https://openalex.org/W302425889","doi":null,"title":"Changes in volume, muscle compartment, and compliance of the lower extremities in man following 30 days of exposure to simulated microgravity.","display_name":"Changes in volume, muscle compartment, and compliance of the lower extremities in man following 30 days of exposure to simulated microgravity.","publication_year":1989,"publication_date":"1989-07-01","ids":{"openalex":"https://openalex.org/W302425889","mag":"302425889","pmid":"https://pubmed.ncbi.nlm.nih.gov/2764848"},"language":"en","primary_location":{"id":"pmid:2764848","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2764848","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aviation, space, and environmental medicine","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089261354","display_name":"V\u00edctor A. Convertino","orcid":"https://orcid.org/0000-0001-9246-0554","observed_orcids":["https://orcid.org/0000-0001-9246-0554","https://orcid.org/0000-0003-4627-136X"]},"institutions":[{"id":"https://openalex.org/I2799863703","display_name":"Kennedy Space Center","ror":"https://ror.org/03kjpzv42","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799863703","https://openalex.org/I4210124779"]},{"id":"https://openalex.org/I4210124779","display_name":"National Aeronautics and Space Administration","ror":"https://ror.org/027ka1x80","country_code":"US","type":"government","lineage":["https://openalex.org/I4210124779"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V A Convertino","raw_affiliation_strings":["Biomedical Operations and Research Office, NASA, Kennedy Space Center, FL 32899"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Operations and Research Office, NASA, Kennedy Space Center, FL 32899","institution_ids":["https://openalex.org/I2799863703","https://openalex.org/I4210124779"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014938768","display_name":"Donald F. Doerr","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D F Doerr","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027353260","display_name":"Karen L. Mathes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K L Mathes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044326672","display_name":"S L Stein","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S L Stein","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5009302896","display_name":"Paul Buchanan","orcid":"https://orcid.org/0000-0002-9055-2794","observed_orcids":["https://orcid.org/0000-0002-9055-2794"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Buchanan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.0661,"has_fulltext":false,"cited_by_count":110,"citation_normalized_percentile":{"value":0.87142655,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"60","issue":"7","first_page":"653","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11950","display_name":"Cardiovascular Syncope and Autonomic Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14214","display_name":"Space Exploration and Technology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2202","display_name":"Aerospace Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/simulated-microgravity","display_name":"simulated microgravity","score":0.8230000138282776},{"id":"https://openalex.org/keywords/head-down-bed-rest","display_name":"head-down bed rest","score":0.9010000228881836},{"id":"https://openalex.org/keywords/leg-compliance","display_name":"leg compliance","score":0.609000027179718},{"id":"https://openalex.org/keywords/leg-volume","display_name":"leg volume","score":0.546999990940094},{"id":"https://openalex.org/keywords/triceps-surae","display_name":"triceps surae","score":0.609000027179718},{"id":"https://openalex.org/keywords/thigh-muscle","display_name":"thigh muscle","score":0.921999990940094},{"id":"https://openalex.org/keywords/long-duration-spaceflight","display_name":"long-duration spaceflight","score":0.7179999947547913},{"id":"https://openalex.org/keywords/muscle-atrophy","display_name":"muscle atrophy","score":0.5559999942779541},{"id":"https://openalex.org/keywords/vascular-compliance","display_name":"vascular compliance","score":0.5329999923706055}],"concepts":[{"id":"https://openalex.org/C2779018429","wikidata":"https://www.wikidata.org/wiki/Q129757","display_name":"Thigh","level":2,"score":0.7953721880912781},{"id":"https://openalex.org/C203635412","wikidata":"https://www.wikidata.org/wiki/Q17007432","display_name":"Compartment (ship)","level":2,"score":0.7519654035568237},{"id":"https://openalex.org/C2781460075","wikidata":"https://www.wikidata.org/wiki/Q1399332","display_name":"Compliance (psychology)","level":2,"score":0.6908388137817383},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.600134551525116},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5937070250511169},{"id":"https://openalex.org/C165268517","wikidata":"https://www.wikidata.org/wiki/Q12176598","display_name":"Posterior compartment of thigh","level":3,"score":0.5353577136993408},{"id":"https://openalex.org/C103888896","wikidata":"https://www.wikidata.org/wiki/Q5916","display_name":"Spaceflight","level":2,"score":0.4626280963420868},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.44421085715293884},{"id":"https://openalex.org/C3019295976","wikidata":"https://www.wikidata.org/wiki/Q6027402","display_name":"Leg muscle","level":2,"score":0.43934208154678345},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.42699044942855835},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3434189260005951},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2638532817363739},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.07736313343048096},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.0},{"id":"https://openalex.org/C146978453","wikidata":"https://www.wikidata.org/wiki/Q3798668","display_name":"Aerospace engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.0},{"id":"https://openalex.org/C111368507","wikidata":"https://www.wikidata.org/wiki/Q43518","display_name":"Oceanography","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C77805123","wikidata":"https://www.wikidata.org/wiki/Q161272","display_name":"Social psychology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007866","descriptor_name":"Leg","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D007866","descriptor_name":"Leg","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007866","descriptor_name":"Leg","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012039","descriptor_name":"Regional Blood Flow","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013026","descriptor_name":"Space Flight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014893","descriptor_name":"Weightlessness","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D015431","descriptor_name":"Weight Loss","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2764848","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2764848","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aviation, space, and environmental medicine","raw_type":"Journal Article"},{"id":"mag:302425889","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2764848","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2160004239","https://openalex.org/W66445543","https://openalex.org/W213176264","https://openalex.org/W7021212893","https://openalex.org/W2117084611","https://openalex.org/W302876678","https://openalex.org/W2054999322","https://openalex.org/W2406532636","https://openalex.org/W2433068544","https://openalex.org/W7133697472"],"abstract_inverted_index":{"The":[0],"purpose":[1],"of":[2,13,34,41,47,58,67,206],"these":[3],"experiments":[4],"was":[5,151,179],"to":[6,20,107,140,154,177],"test":[7],"the":[8,14,42,48,74,95,101,167,207],"hypothesis":[9],"that":[10],"reduced":[11,204],"size":[12,205],"leg":[15,28,87,125,196,208],"muscle":[16,156,172,209],"compartment":[17,110,157,173],"following":[18,198],"exposure":[19],"long-duration":[21,199],"microgravity":[22],"would":[23],"be":[24],"associated":[25,202],"with":[26,182,203],"increased":[27,131],"compliance.":[29],"Eight":[30],"men,":[31],"31-45":[32],"years":[33],"age,":[35],"were":[36,78],"measured":[37,146],"for":[38],"vascular":[39],"compliance":[40,126,145,187,197],"calf":[43,51,77,96,120,155,171,186],"and":[44,50,54,70,76,81,99,122,148,166],"serial":[45],"circumferences":[46],"thigh":[49,75,102,123],"before,":[52],"during":[53],"after":[55,149],"30":[56],"d":[57],"continuous":[59],"6":[60],"degrees":[61],"head-down":[62],"bedrest.":[63],"Cross-sectional":[64],"areas":[65],"(CSA)":[66],"muscle,":[68],"fat,":[69],"bone":[71],"compartments":[72],"in":[73,94,100,118,170,185],"determined":[79],"pre-":[80,106,176],"post-bedrest":[82,178],"by":[83,97,103],"computed":[84],"tomography.":[85],"Calculated":[86],"volumes":[88],"decreased":[89,113],"(p":[90,114,132],"less":[91,115,133,163,192],"than":[92,116,134,164,193],"0.05)":[93,117,135,165],"9.9%":[98],"4.5%":[104],"from":[105,136,175],"post-bedrest.":[108],"Muscle":[109],"CSA":[111,158,174],"also":[112],"both":[119],"(-4.8%)":[121],"(-8.1%);":[124],"(vol%/mm":[127],"Hg":[128],"x":[129],"100)":[130],"3.9":[137],"+/-":[138,142],"0.7":[139],"4.9":[141],"0.5.":[143],"Calf":[144],"before":[147],"bedrest":[150],"inversely":[152,180],"related":[153],"(r":[159,188],"=":[160,189],"-0.61,":[161],"p":[162,191],"percent":[168],"decrease":[169],"correlated":[181],"an":[183],"increase":[184],"-0.72,":[190],"0.05).":[194],"Increased":[195],"spaceflight":[200],"is":[201],"compartment.":[210]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}