{"id":"https://openalex.org/W3023916575","doi":"https://doi.org/10.20900/mo20200003","title":"The Non-Coding RNA Repressor GAS5 of the Glucocorticoid Receptor: Insights to Its Role in Human Malignancies","display_name":"The Non-Coding RNA Repressor GAS5 of the Glucocorticoid Receptor: Insights to Its Role in Human Malignancies","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W3023916575","doi":"https://doi.org/10.20900/mo20200003","mag":"3023916575"},"language":"en","primary_location":{"id":"doi:10.20900/mo20200003","doi":"https://doi.org/10.20900/mo20200003","is_oa":true,"landing_page_url":"https://doi.org/10.20900/mo20200003","pdf_url":null,"source":{"id":"https://openalex.org/S4210188423","display_name":"Med One","issn_l":"2397-9119","issn":["2397-9119"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Med One","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.20900/mo20200003","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000679969","display_name":"Kyriaki Hatziagapiou","orcid":"https://orcid.org/0000-0002-1469-1928","observed_orcids":["https://orcid.org/0000-0002-1469-1928"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kyriaki Hatziagapiou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060665424","display_name":"Tomoshige Kino","orcid":"https://orcid.org/0000-0003-0220-9396","observed_orcids":["https://orcid.org/0000-0003-0220-9396"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tomoshige Kino","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5072379918","display_name":"George \u0399. Lambrou","orcid":"https://orcid.org/0000-0001-8389-1360","observed_orcids":["https://orcid.org/0000-0001-8389-1360"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"George I. Lambrou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5072379918"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.03269415,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.033399999141693115,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gas5","display_name":"GAS5","score":0.9959999918937683},{"id":"https://openalex.org/keywords/non-coding-rna","display_name":"non-coding RNA","score":0.8489999771118164},{"id":"https://openalex.org/keywords/glucocorticoid-receptor","display_name":"glucocorticoid receptor","score":0.875},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.9629999995231628},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.6399999856948853},{"id":"https://openalex.org/keywords/mir-222","display_name":"miR-222","score":0.9769999980926514},{"id":"https://openalex.org/keywords/mir-21","display_name":"miR-21","score":1.0},{"id":"https://openalex.org/keywords/tumor-markers","display_name":"tumor markers","score":0.7039999961853027},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8299999833106995},{"id":"https://openalex.org/keywords/diagnostic-biomarkers","display_name":"diagnostic biomarkers","score":0.7929999828338623},{"id":"https://openalex.org/keywords/rna-structure","display_name":"RNA structure","score":0.5400000214576721}],"concepts":[{"id":"https://openalex.org/C2776941990","wikidata":"https://www.wikidata.org/wiki/Q18045451","display_name":"GAS5","level":5,"score":0.9872361421585083},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.5780341625213623},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5119979977607727},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4722304344177246},{"id":"https://openalex.org/C62203573","wikidata":"https://www.wikidata.org/wiki/Q15087973","display_name":"Long non-coding RNA","level":4,"score":0.41774576902389526},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4138683080673218},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39633944630622864},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.37320253252983093},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.35035866498947144},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.29203641414642334},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18522214889526367}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.20900/mo20200003","doi":"https://doi.org/10.20900/mo20200003","is_oa":true,"landing_page_url":"https://doi.org/10.20900/mo20200003","pdf_url":null,"source":{"id":"https://openalex.org/S4210188423","display_name":"Med One","issn_l":"2397-9119","issn":["2397-9119"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Med One","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.20900/mo20200003","doi":"https://doi.org/10.20900/mo20200003","is_oa":true,"landing_page_url":"https://doi.org/10.20900/mo20200003","pdf_url":null,"source":{"id":"https://openalex.org/S4210188423","display_name":"Med One","issn_l":"2397-9119","issn":["2397-9119"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Med One","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":136,"referenced_works":["https://openalex.org/W176140544","https://openalex.org/W193359792","https://openalex.org/W284592717","https://openalex.org/W1484277981","https://openalex.org/W1686333409","https://openalex.org/W1774685902","https://openalex.org/W1864729394","https://openalex.org/W1882221199","https://openalex.org/W1886775400","https://openalex.org/W1932653806","https://openalex.org/W1968131184","https://openalex.org/W1968812902","https://openalex.org/W1984675364","https://openalex.org/W1985235104","https://openalex.org/W1987713409","https://openalex.org/W1988031492","https://openalex.org/W1989117479","https://openalex.org/W1990895545","https://openalex.org/W1994248538","https://openalex.org/W1996336635","https://openalex.org/W2002124496","https://openalex.org/W2006936482","https://openalex.org/W2009818318","https://openalex.org/W2014974052","https://openalex.org/W2017313617","https://openalex.org/W2027010998","https://openalex.org/W2030428074","https://openalex.org/W2040015982","https://openalex.org/W2048515321","https://openalex.org/W2051766943","https://openalex.org/W2052039819","https://openalex.org/W2054616484","https://openalex.org/W2063155123","https://openalex.org/W2071271349","https://openalex.org/W2075702353","https://openalex.org/W2086202922","https://openalex.org/W2090542518","https://openalex.org/W2103550200","https://openalex.org/W2105292164","https://openalex.org/W2105362408","https://openalex.org/W2109586899","https://openalex.org/W2110321876","https://openalex.org/W2113234463","https://openalex.org/W2121352589","https://openalex.org/W2121563344","https://openalex.org/W2122911180","https://openalex.org/W2123716946","https://openalex.org/W2132605816","https://openalex.org/W2135976134","https://openalex.org/W2146857332","https://openalex.org/W2162825358","https://openalex.org/W2183183868","https://openalex.org/W2196023497","https://openalex.org/W2207064026","https://openalex.org/W2224913144","https://openalex.org/W2266413788","https://openalex.org/W2268917047","https://openalex.org/W2272802678","https://openalex.org/W2314065766","https://openalex.org/W2398593123","https://openalex.org/W2409190592","https://openalex.org/W2465067923","https://openalex.org/W2471532817","https://openalex.org/W2497141050","https://openalex.org/W2507321490","https://openalex.org/W2515752888","https://openalex.org/W2518804156","https://openalex.org/W2530295635","https://openalex.org/W2532794119","https://openalex.org/W2555172741","https://openalex.org/W2569065262","https://openalex.org/W2579945087","https://openalex.org/W2592460794","https://openalex.org/W2594404528","https://openalex.org/W2603000633","https://openalex.org/W2606541769","https://openalex.org/W2607446674","https://openalex.org/W2610830446","https://openalex.org/W2614596258","https://openalex.org/W2724575993","https://openalex.org/W2731476752","https://openalex.org/W2734988762","https://openalex.org/W2745200634","https://openalex.org/W2753949488","https://openalex.org/W2765486298","https://openalex.org/W2766621857","https://openalex.org/W2773381134","https://openalex.org/W2788432893","https://openalex.org/W2791279201","https://openalex.org/W2792639542","https://openalex.org/W2792918693","https://openalex.org/W2793517117","https://openalex.org/W2795902755","https://openalex.org/W2797187374","https://openalex.org/W2802279690","https://openalex.org/W2803659841","https://openalex.org/W2804154867","https://openalex.org/W2883114613","https://openalex.org/W2883440661","https://openalex.org/W2883686416","https://openalex.org/W2885561478","https://openalex.org/W2892235817","https://openalex.org/W2895471159","https://openalex.org/W2895614383","https://openalex.org/W2896961621","https://openalex.org/W2898156787","https://openalex.org/W2899679680","https://openalex.org/W2905192034","https://openalex.org/W2905407753","https://openalex.org/W2908615622","https://openalex.org/W2913359338","https://openalex.org/W2919397231","https://openalex.org/W2923244791","https://openalex.org/W2928968412","https://openalex.org/W2932763931","https://openalex.org/W2942495572","https://openalex.org/W2943695944","https://openalex.org/W2944433097","https://openalex.org/W2945899778","https://openalex.org/W2946520530","https://openalex.org/W2947425925","https://openalex.org/W2948011254","https://openalex.org/W2951399521","https://openalex.org/W2951580718","https://openalex.org/W2953517735","https://openalex.org/W2954654882","https://openalex.org/W2956118662","https://openalex.org/W2962071094","https://openalex.org/W2962999636","https://openalex.org/W2964948828","https://openalex.org/W2964981238","https://openalex.org/W2968428215","https://openalex.org/W2981708274","https://openalex.org/W2983746804","https://openalex.org/W3009325222","https://openalex.org/W4300551069"],"related_works":["https://openalex.org/W4286422334","https://openalex.org/W1528730016","https://openalex.org/W4283646102","https://openalex.org/W2917125237","https://openalex.org/W3093206413","https://openalex.org/W2928968412","https://openalex.org/W1988031492","https://openalex.org/W4405737127","https://openalex.org/W3040472985","https://openalex.org/W2183183868"],"abstract_inverted_index":{"Background:":[0],"GAS5":[1,23,53,127,156,169,235],"is":[2],"expressed":[3],"in":[4,21,27,54,217,227,236,240,245],"growth":[5,15],"arrested":[6],"cells":[7],"as":[8,157],"a":[9,28,55,158,209],"result":[10],"of":[11,30,35,49,52,57,82,104,146,149,155,211,234],"nutrient":[12],"deprivation":[13],"or":[14],"factor":[16],"withdrawal.":[17],"Besides":[18],"its":[19,134,177],"roles":[20,51],"metabolism,":[22],"has":[24],"been":[25],"studied":[26],"variety":[29,56,210],"human":[31,126],"cancers.":[32],"The":[33],"aim":[34],"the":[36,42,50,67,70,89,100,105,114,125,144,153,232,242,247],"present":[37],"work":[38],"was":[39,64,85],"to":[40,109,176,229],"review":[41],"literature":[43,62],"and":[44,73,75,94,99,102,195,199,205,239],"report":[45],"all":[46],"recent":[47,164],"findings":[48,165],"tumors.":[58],"Methods:":[59],"An":[60],"electronic":[61],"search":[63],"conducted":[65],"by":[66,88],"authors":[68],"using":[69],"keywords":[71],"\u201cGAS5\u201d":[72],"\u201ccancer\u201d,":[74],"then":[76],"individually":[77],"searched":[78],"for":[79,129,208],"each":[80],"type":[81],"cancer":[83,218],"that":[84,143],"brought":[86],"up":[87,190],"first":[90],"search.":[91],"Original":[92],"articles":[93],"systematic":[95],"reviews":[96],"were":[97,107],"selected,":[98],"titles":[101],"abstracts":[103],"papers":[106],"screened":[108],"determine":[110],"whether":[111],"they":[112],"met":[113],"eligibility":[115],"criteria.":[116],"In":[117,181],"addition,":[118],"we":[119,183],"performed":[120],"computer-based":[121],"structural":[122],"analysis":[123],"on":[124,133],"RNA":[128],"extending":[130],"our":[131,192],"understanding":[132],"biological":[135],"and/or":[136],"pathological":[137],"actions.":[138],"Results:":[139],"We":[140],"have":[141,166],"found":[142],"majority":[145],"studies,":[147],"irrespectively":[148],"tumor":[150,159,178,237],"types,":[151],"confirm":[152],"role":[154,233],"suppressor":[160],"gene.":[161],"Especially,":[162],"more":[163,175,223],"also":[167],"highlighted":[168],"interaction":[170],"with":[171],"miRNAs":[172],"contributing":[173],"even":[174],"inhibiting":[179],"role.":[180],"particular,":[182],"could":[184,201],"outline":[185],"two":[186],"miRNAs,":[187],"which":[188,246],"came":[189],"throughout":[191],"review;":[193],"miR-222":[194,198],"miR-21.":[196],"GAS5,":[197],"miR-21":[200],"pose":[202],"potential":[203],"prognostic":[204],"diagnostic":[206],"biomarkers":[207],"tumors,":[212],"making":[213],"them":[214],"quite":[215],"useful":[216],"clinic.":[219],"Conclusions:":[220],"For":[221],"certain,":[222],"studies":[224],"are":[225],"required":[226],"order":[228],"better":[230],"understand":[231],"biology,":[238],"particular":[241],"signaling":[243],"pathways":[244],"gene":[248],"participates.":[249]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2020-05-13T00:00:00"}