{"id":"https://openalex.org/W3023819307","doi":"https://doi.org/10.1080/26896583.2020.1761204","title":"Understanding the interaction of estrogenic ligands with estrogen receptors: a survey of the functional and binding kinetic studies","display_name":"Understanding the interaction of estrogenic ligands with estrogen receptors: a survey of the functional and binding kinetic studies","publication_year":2020,"publication_date":"2020-04-02","ids":{"openalex":"https://openalex.org/W3023819307","doi":"https://doi.org/10.1080/26896583.2020.1761204","mag":"3023819307","pmid":"https://pubmed.ncbi.nlm.nih.gov/32500833"},"language":"en","primary_location":{"id":"doi:10.1080/26896583.2020.1761204","doi":"https://doi.org/10.1080/26896583.2020.1761204","is_oa":false,"landing_page_url":"https://doi.org/10.1080/26896583.2020.1761204","pdf_url":null,"source":{"id":"https://openalex.org/S4210219320","display_name":"Journal of Environmental Science and Health Part C","issn_l":"1059-0501","issn":["1059-0501","1532-4095","2689-6583","2689-6591"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","poland-140","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Environmental Science and Health, Part C","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034221832","display_name":"Jingwei Jin","orcid":"https://orcid.org/0000-0002-1512-4538","observed_orcids":["https://orcid.org/0000-0002-1512-4538"]},"institutions":[{"id":"https://openalex.org/I139024713","display_name":"Guangdong University of Technology","ror":"https://ror.org/04azbjn80","country_code":"CN","type":"education","lineage":["https://openalex.org/I139024713"]},{"id":"https://openalex.org/I4210151615","display_name":"Wuyi University","ror":"https://ror.org/0488wz367","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210151615"]},{"id":"https://openalex.org/I98834328","display_name":"Wuyi University","ror":"https://ror.org/059djzq42","country_code":"CN","type":"education","lineage":["https://openalex.org/I98834328"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingwei Jin","raw_affiliation_strings":["Institute of Natural Medicine and Green Chemistry, School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, P. R. China;","School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, P.R. China and International Healthcare Innovation Institute (Jiangmen), Jiangmen, P.R. China;"],"raw_orcid":"https://orcid.org/0000-0002-1512-4538","affiliations":[{"raw_affiliation_string":"Institute of Natural Medicine and Green Chemistry, School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, P. R. China;","institution_ids":["https://openalex.org/I139024713"]},{"raw_affiliation_string":"School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, P.R. China and International Healthcare Innovation Institute (Jiangmen), Jiangmen, P.R. China;","institution_ids":["https://openalex.org/I4210151615","https://openalex.org/I98834328"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080248278","display_name":"Panpan Wu","orcid":"https://orcid.org/0000-0002-6515-0726","observed_orcids":["https://orcid.org/0000-0002-6515-0726","https://orcid.org/0000-0003-4246-9854"]},"institutions":[{"id":"https://openalex.org/I4210151615","display_name":"Wuyi University","ror":"https://ror.org/0488wz367","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210151615"]},{"id":"https://openalex.org/I98834328","display_name":"Wuyi University","ror":"https://ror.org/059djzq42","country_code":"CN","type":"education","lineage":["https://openalex.org/I98834328"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Panpan Wu","raw_affiliation_strings":["School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, P.R. China and International Healthcare Innovation Institute (Jiangmen), Jiangmen, P.R. China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, P.R. China and International Healthcare Innovation Institute (Jiangmen), Jiangmen, P.R. China;","institution_ids":["https://openalex.org/I4210151615","https://openalex.org/I98834328"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100319971","display_name":"Xinyue Zhang","orcid":"https://orcid.org/0000-0002-8612-157X","observed_orcids":["https://orcid.org/0000-0002-8612-157X"]},"institutions":[{"id":"https://openalex.org/I4210151615","display_name":"Wuyi University","ror":"https://ror.org/0488wz367","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210151615"]},{"id":"https://openalex.org/I98834328","display_name":"Wuyi University","ror":"https://ror.org/059djzq42","country_code":"CN","type":"education","lineage":["https://openalex.org/I98834328"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyue Zhang","raw_affiliation_strings":["School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, P.R. China and International Healthcare Innovation Institute (Jiangmen), Jiangmen, P.R. China;"],"raw_orcid":"https://orcid.org/0000-0002-8612-157X","affiliations":[{"raw_affiliation_string":"School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, P.R. China and International Healthcare Innovation Institute (Jiangmen), Jiangmen, P.R. China;","institution_ids":["https://openalex.org/I4210151615","https://openalex.org/I98834328"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029592503","display_name":"Dongli Li","orcid":"https://orcid.org/0000-0001-9955-2304","observed_orcids":["https://orcid.org/0000-0001-9955-2304"]},"institutions":[{"id":"https://openalex.org/I4210151615","display_name":"Wuyi University","ror":"https://ror.org/0488wz367","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210151615"]},{"id":"https://openalex.org/I98834328","display_name":"Wuyi University","ror":"https://ror.org/059djzq42","country_code":"CN","type":"education","lineage":["https://openalex.org/I98834328"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dongli Li","raw_affiliation_strings":["School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, P.R. China and International Healthcare Innovation Institute (Jiangmen), Jiangmen, P.R. China;"],"raw_orcid":"https://orcid.org/0000-0001-9955-2304","affiliations":[{"raw_affiliation_string":"School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, P.R. China and International Healthcare Innovation Institute (Jiangmen), Jiangmen, P.R. China;","institution_ids":["https://openalex.org/I4210151615","https://openalex.org/I98834328"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029866664","display_name":"Wing\u2010Leung Wong","orcid":"https://orcid.org/0000-0001-7191-7578","observed_orcids":["https://orcid.org/0000-0001-7191-7578"]},"institutions":[{"id":"https://openalex.org/I4210151615","display_name":"Wuyi University","ror":"https://ror.org/0488wz367","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210151615"]},{"id":"https://openalex.org/I98834328","display_name":"Wuyi University","ror":"https://ror.org/059djzq42","country_code":"CN","type":"education","lineage":["https://openalex.org/I98834328"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wing-Leung Wong","raw_affiliation_strings":["School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, P.R. China and International Healthcare Innovation Institute (Jiangmen), Jiangmen, P.R. China;"],"raw_orcid":"https://orcid.org/0000-0001-7191-7578","affiliations":[{"raw_affiliation_string":"School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, P.R. China and International Healthcare Innovation Institute (Jiangmen), Jiangmen, P.R. China;","institution_ids":["https://openalex.org/I4210151615","https://openalex.org/I98834328"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081698933","display_name":"Yu\u2010Jing Lu","orcid":"https://orcid.org/0000-0003-2494-843X","observed_orcids":["https://orcid.org/0000-0003-2494-843X"]},"institutions":[{"id":"https://openalex.org/I139024713","display_name":"Guangdong University of Technology","ror":"https://ror.org/04azbjn80","country_code":"CN","type":"education","lineage":["https://openalex.org/I139024713"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yu-Jing Lu","raw_affiliation_strings":["Institute of Natural Medicine and Green Chemistry, School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, P. R. China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Natural Medicine and Green Chemistry, School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, P. R. China;","institution_ids":["https://openalex.org/I139024713"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ning Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ning Sun","raw_affiliation_strings":["The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I92039509"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100342359","display_name":"Kun Zhang","orcid":"https://orcid.org/0000-0002-7596-5224","observed_orcids":["https://orcid.org/0000-0002-7596-5224"]},"institutions":[{"id":"https://openalex.org/I4210151615","display_name":"Wuyi University","ror":"https://ror.org/0488wz367","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210151615"]},{"id":"https://openalex.org/I98834328","display_name":"Wuyi University","ror":"https://ror.org/059djzq42","country_code":"CN","type":"education","lineage":["https://openalex.org/I98834328"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kun Zhang","raw_affiliation_strings":["School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, P.R. China and International Healthcare Innovation Institute (Jiangmen), Jiangmen, P.R. China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, P.R. China and International Healthcare Innovation Institute (Jiangmen), Jiangmen, P.R. China;","institution_ids":["https://openalex.org/I4210151615","https://openalex.org/I98834328"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5029866664","https://openalex.org/A5081698933"],"corresponding_institution_ids":["https://openalex.org/I139024713","https://openalex.org/I4210151615","https://openalex.org/I92039509","https://openalex.org/I98834328"],"apc_list":null,"apc_paid":null,"fwci":1.0252,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.73587556,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"38","issue":"2","first_page":"142","last_page":"168"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11318","display_name":"Phytoestrogen effects and research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.8730000257492065},{"id":"https://openalex.org/keywords/receptor-ligand-binding-kinetics","display_name":"receptor-ligand binding kinetics","score":0.8550000190734863},{"id":"https://openalex.org/keywords/binding-affinity","display_name":"binding affinity","score":0.6579999923706055},{"id":"https://openalex.org/keywords/estrogen-response-element","display_name":"estrogen response element","score":0.7450000047683716},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6589999794960022},{"id":"https://openalex.org/keywords/ligand-activated-transcription-factors","display_name":"ligand-activated transcription factors","score":0.7749999761581421},{"id":"https://openalex.org/keywords/endogenous-estrogen","display_name":"endogenous estrogen","score":0.7730000019073486}],"concepts":[{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.8381408452987671},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.814372181892395},{"id":"https://openalex.org/C84750089","wikidata":"https://www.wikidata.org/wiki/Q21130793","display_name":"PELP-1","level":5,"score":0.6259046792984009},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6010932922363281},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5953666567802429},{"id":"https://openalex.org/C96307122","wikidata":"https://www.wikidata.org/wiki/Q15329133","display_name":"Estrogen receptor beta","level":5,"score":0.5937519073486328},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.5416169762611389},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.5290148258209229},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4523315727710724},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.444087952375412},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.439145028591156},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4331081211566925},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.42588597536087036},{"id":"https://openalex.org/C172313692","wikidata":"https://www.wikidata.org/wiki/Q14902310","display_name":"Estrogen receptor alpha","level":5,"score":0.4210914373397827},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.41387778520584106},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3270058035850525},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2948179543018341},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.19686612486839294},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.15423601865768433},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1483113169670105},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004970","descriptor_name":"Estrone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020218","descriptor_name":"Response Elements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/26896583.2020.1761204","doi":"https://doi.org/10.1080/26896583.2020.1761204","is_oa":false,"landing_page_url":"https://doi.org/10.1080/26896583.2020.1761204","pdf_url":null,"source":{"id":"https://openalex.org/S4210219320","display_name":"Journal of Environmental Science and Health Part C","issn_l":"1059-0501","issn":["1059-0501","1532-4095","2689-6583","2689-6591"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","poland-140","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Environmental Science and Health, Part C","raw_type":"journal-article"},{"id":"pmid:32500833","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32500833","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of environmental science and health. Part C, Toxicology and carcinogenesis","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6700000166893005}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":96,"referenced_works":["https://openalex.org/W8541401","https://openalex.org/W1565489784","https://openalex.org/W1939219532","https://openalex.org/W1974762120","https://openalex.org/W1979440858","https://openalex.org/W1979903836","https://openalex.org/W1981421083","https://openalex.org/W1981573666","https://openalex.org/W1985020303","https://openalex.org/W1994610843","https://openalex.org/W2000262653","https://openalex.org/W2001286676","https://openalex.org/W2002737481","https://openalex.org/W2003070275","https://openalex.org/W2005079601","https://openalex.org/W2005772074","https://openalex.org/W2008651555","https://openalex.org/W2008724101","https://openalex.org/W2010938098","https://openalex.org/W2011306206","https://openalex.org/W2015328813","https://openalex.org/W2016908879","https://openalex.org/W2018446899","https://openalex.org/W2020508605","https://openalex.org/W2024905084","https://openalex.org/W2025436728","https://openalex.org/W2033616764","https://openalex.org/W2034706088","https://openalex.org/W2035834153","https://openalex.org/W2039239108","https://openalex.org/W2039269175","https://openalex.org/W2040638528","https://openalex.org/W2042124938","https://openalex.org/W2044927758","https://openalex.org/W2048431921","https://openalex.org/W2048655519","https://openalex.org/W2049229941","https://openalex.org/W2049679696","https://openalex.org/W2049970571","https://openalex.org/W2054496710","https://openalex.org/W2056475405","https://openalex.org/W2060897125","https://openalex.org/W2061365526","https://openalex.org/W2064692473","https://openalex.org/W2069249982","https://openalex.org/W2069704192","https://openalex.org/W2073018125","https://openalex.org/W2073902476","https://openalex.org/W2073917880","https://openalex.org/W2075788654","https://openalex.org/W2078236931","https://openalex.org/W2083380173","https://openalex.org/W2085594733","https://openalex.org/W2086307226","https://openalex.org/W2087160757","https://openalex.org/W2090496772","https://openalex.org/W2091781599","https://openalex.org/W2101738855","https://openalex.org/W2105147179","https://openalex.org/W2106162177","https://openalex.org/W2108480706","https://openalex.org/W2109334879","https://openalex.org/W2112328406","https://openalex.org/W2112444654","https://openalex.org/W2112893549","https://openalex.org/W2119239708","https://openalex.org/W2122008165","https://openalex.org/W2144436995","https://openalex.org/W2149044745","https://openalex.org/W2151063137","https://openalex.org/W2151888740","https://openalex.org/W2152558568","https://openalex.org/W2152806277","https://openalex.org/W2153768616","https://openalex.org/W2155225555","https://openalex.org/W2167235960","https://openalex.org/W2167305264","https://openalex.org/W2187452737","https://openalex.org/W2222366765","https://openalex.org/W2318662954","https://openalex.org/W2321355517","https://openalex.org/W2333732234","https://openalex.org/W2343443025","https://openalex.org/W2530784802","https://openalex.org/W2575891648","https://openalex.org/W2741713758","https://openalex.org/W2765236611","https://openalex.org/W2803012641","https://openalex.org/W2883734445","https://openalex.org/W2915036480","https://openalex.org/W2942513152","https://openalex.org/W2942720838","https://openalex.org/W2944068509","https://openalex.org/W2946740467","https://openalex.org/W2949960949","https://openalex.org/W4241564115"],"related_works":["https://openalex.org/W2026927522","https://openalex.org/W2326881746","https://openalex.org/W2087901269","https://openalex.org/W2161492813","https://openalex.org/W2183785214","https://openalex.org/W40634357","https://openalex.org/W1988203552","https://openalex.org/W2876841880","https://openalex.org/W1987106638","https://openalex.org/W1574719993"],"abstract_inverted_index":{"The":[0,37],"investigation":[1],"of":[2,28,40,66,79,107,117,139,143],"estrogen":[3,10,48,72,108],"actions":[4],"and":[5,32,64,101,112,120],"their":[6],"interaction":[7,62],"characteristics":[8],"with":[9,162],"receptors":[11,49,109],"(ERs)":[12],"to":[13,23,70,85,133,152,164],"induce":[14],"unique":[15],"functional":[16],"features":[17],"inside":[18],"cells":[19],"have":[20,98],"allowed":[21],"us":[22],"understand":[24],"better":[25],"the":[26,53,58,77,87,93,105,115,137,140,147,172,178,185],"regulation":[27],"many":[29],"vital":[30],"physiological":[31],"cellular":[33],"processes":[34],"in":[35,76,110],"humans.":[36],"biological":[38,89],"effects":[39],"estrogenic":[41],"ligands":[42],"or":[43,157],"compounds":[44],"are":[45,82,182],"mediated":[46],"via":[47],"that":[50],"act":[51],"as":[52],"ligand-activated":[54],"transcription":[55],"factors.":[56],"Therefore,":[57],"study":[59,181],"on":[60,104,136],"ligand-ER":[61,67,144],"properties":[63],"mechanism":[65,116],"complexes":[68],"binding":[69,119,141,179],"specific":[71],"response":[73],"elements":[74],"located":[75],"promoters":[78],"target":[80],"genes":[81],"very":[83],"critical":[84],"realize":[86],"complicated":[88],"process":[90],"regulated":[91],"by":[92],"endogenous":[94],"estrogens.":[95],"Several":[96],"reviews":[97],"provided":[99],"comprehensive":[100],"updated":[102],"information":[103,148],"influence":[106],"health":[111],"disease.":[113],"However,":[114],"estrogen-ERs":[118],"affinity":[121],"aspects":[122],"at":[123],"molecular":[124],"level":[125],"is":[126],"relatively":[127],"under-investigated.":[128],"This":[129],"review":[130],"thus":[131],"aims":[132],"shed":[134],"light":[135],"significance":[138],"kinetics":[142],"interactions":[145],"because":[146],"provide":[149],"great":[150],"assistance":[151],"define":[153],"how":[154],"a":[155,158,166],"ligand":[156],"drug":[159],"can":[160],"communicate":[161],"physiology":[163],"produce":[165],"desired":[167],"therapeutic":[168],"response.":[169],"In":[170],"addition,":[171],"most":[173],"frequently":[174],"used":[175],"methodologies":[176],"for":[177],"kinetic":[180],"highlighted":[183],"over":[184],"last":[186],"decade.":[187]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-05-13T00:00:00"}
