{"id":"https://openalex.org/W3023816668","doi":"https://doi.org/10.3233/jad-191293","title":"Novel Markers of Angiogenesis in the Setting of Cognitive Impairment and Dementia","display_name":"Novel Markers of Angiogenesis in the Setting of Cognitive Impairment and Dementia","publication_year":2020,"publication_date":"2020-05-04","ids":{"openalex":"https://openalex.org/W3023816668","doi":"https://doi.org/10.3233/jad-191293","mag":"3023816668","pmid":"https://pubmed.ncbi.nlm.nih.gov/32390626","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8351220"},"language":"en","primary_location":{"id":"doi:10.3233/jad-191293","doi":"https://doi.org/10.3233/jad-191293","is_oa":false,"landing_page_url":"https://doi.org/10.3233/jad-191293","pdf_url":null,"source":{"id":"https://openalex.org/S25155249","display_name":"Journal of Alzheimer s Disease","issn_l":"1387-2877","issn":["1387-2877","1875-8908"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer\u2019s Disease","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8351220","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022515998","display_name":"Christopher M. Callahan","orcid":"https://orcid.org/0000-0002-4617-6672","observed_orcids":["https://orcid.org/0000-0002-4617-6672"]},"institutions":[{"id":"https://openalex.org/I1324682000","display_name":"Regenstrief Institute","ror":"https://ror.org/05f2ywb48","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1324682000"]},{"id":"https://openalex.org/I4387930283","display_name":"Eskenazi Health","ror":"https://ror.org/0046t1019","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210130353","https://openalex.org/I4387930232","https://openalex.org/I4387930283"]},{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christopher M. Callahan","raw_affiliation_strings":["Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA","Eskenazi Health, Indianapolis, IN, USA","Indiana Alzheimer Disease Center, Indianapolis, IN, USA","Indiana University Center for Aging Research, Indianapolis, IN, USA","Regenstrief Institute, Inc., Indianapolis, IN, USA","Eskenazi Health, Indianapolis, IN, USA; Indiana Alzheimer Disease Center, Indianapolis, IN, USA; Indiana University Center for Aging Research, Indianapolis, IN, USA; Regenstrief Institute, Inc., Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Eskenazi Health, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I4387930283"]},{"raw_affiliation_string":"Indiana Alzheimer Disease Center, Indianapolis, IN, USA","institution_ids":[]},{"raw_affiliation_string":"Indiana University Center for Aging Research, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I4388446366"]},{"raw_affiliation_string":"Regenstrief Institute, Inc., Indianapolis, IN, USA","institution_ids":["https://openalex.org/I1324682000"]},{"raw_affiliation_string":"Eskenazi Health, Indianapolis, IN, USA; Indiana Alzheimer Disease Center, Indianapolis, IN, USA; Indiana University Center for Aging Research, Indianapolis, IN, USA; Regenstrief Institute, Inc., Indianapolis, IN, USA","institution_ids":["https://openalex.org/I1324682000","https://openalex.org/I4387930283"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033942521","display_name":"Liana G. Apostolova","orcid":"https://orcid.org/0000-0003-1823-2451","observed_orcids":["https://orcid.org/0000-0003-1823-2451"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liana G. Apostolova","raw_affiliation_strings":["Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA","Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA","Indiana Alzheimer Disease Center, Indianapolis, IN, USA","Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA; Indiana Alzheimer Disease Center, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Indiana Alzheimer Disease Center, Indianapolis, IN, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA; Indiana Alzheimer Disease Center, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039635718","display_name":"Sujuan Gao","orcid":"https://orcid.org/0000-0002-6741-6380","observed_orcids":["https://orcid.org/0000-0002-6741-6380","https://orcid.org/0000-0002-8807-9248"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sujuan Gao","raw_affiliation_strings":["Department of Biostatistics, Indiana University School of Medicine, Indianapolis, IN, USA","Indiana Alzheimer Disease Center, Indianapolis, IN, USA","Department of Biostatistics, Indiana University School of Medicine, Indianapolis, IN, USA; Indiana Alzheimer Disease Center, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Indiana University School of Medicine, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Indiana Alzheimer Disease Center, Indianapolis, IN, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Biostatistics, Indiana University School of Medicine, Indianapolis, IN, USA; Indiana Alzheimer Disease Center, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I4394709130","https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018610871","display_name":"Shannon L. Risacher","orcid":"https://orcid.org/0000-0002-3304-7943","observed_orcids":["https://orcid.org/0000-0002-3304-7943"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shannon L. Risacher","raw_affiliation_strings":["Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA","Indiana Alzheimer Disease Center, Indianapolis, IN, USA","Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA; Indiana Alzheimer Disease Center, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Indiana Alzheimer Disease Center, Indianapolis, IN, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA; Indiana Alzheimer Disease Center, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077164595","display_name":"Jamie Case","orcid":"https://orcid.org/0000-0002-6721-0307","observed_orcids":["https://orcid.org/0000-0002-6721-0307"]},"institutions":[{"id":"https://openalex.org/I4210109568","display_name":"Scripps Clinic Medical Group","ror":"https://ror.org/01z719741","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210109568"]},{"id":"https://openalex.org/I4210146328","display_name":"Scripps Clinic","ror":"https://ror.org/05kwjwj05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1311914864","https://openalex.org/I4210146328"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jamie Case","raw_affiliation_strings":["Scripps Clinic Bio-Repository and Bio-Informatics Core, Scripps Clinic Medical Group, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scripps Clinic Bio-Repository and Bio-Informatics Core, Scripps Clinic Medical Group, La Jolla, CA, USA","institution_ids":["https://openalex.org/I4210109568","https://openalex.org/I4210146328"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026257338","display_name":"Andrew J. Saykin","orcid":"https://orcid.org/0000-0002-1376-8532","observed_orcids":["https://orcid.org/0000-0002-1376-8532"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew J. Saykin","raw_affiliation_strings":["Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA","Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA","Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA","Indiana Alzheimer Disease Center, Indianapolis, IN, USA","Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA; Indiana Alzheimer Disease Center, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Indiana Alzheimer Disease Center, Indianapolis, IN, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA; Indiana Alzheimer Disease Center, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049840158","display_name":"Kathleen A. Lane","orcid":"https://orcid.org/0000-0001-8784-2590","observed_orcids":["https://orcid.org/0000-0001-8784-2590"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathleen A. Lane","raw_affiliation_strings":["Department of Biostatistics, Indiana University School of Medicine, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Indiana University School of Medicine, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070974682","display_name":"Cecily G. Swinford","orcid":"https://orcid.org/0000-0001-8489-4467","observed_orcids":["https://orcid.org/0000-0001-8489-4467"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cecily G. Swinford","raw_affiliation_strings":["Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA","Indiana Alzheimer Disease Center, Indianapolis, IN, USA","Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA; Indiana Alzheimer Disease Center, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Indiana Alzheimer Disease Center, Indianapolis, IN, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA; Indiana Alzheimer Disease Center, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041006794","display_name":"Mervin C. Y\u00f6der","orcid":"https://orcid.org/0000-0003-4354-7631","observed_orcids":["https://orcid.org/0000-0003-4354-7631"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mervin C. Yoder","raw_affiliation_strings":["Indiana Center for Regenerative Medicine and Engineering, Indiana University School of Medicine, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana Center for Regenerative Medicine and Engineering, Indiana University School of Medicine, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I4394709130"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5022515998"],"corresponding_institution_ids":["https://openalex.org/I1324682000","https://openalex.org/I4387930283","https://openalex.org/I4388446366","https://openalex.org/I4394709130"],"apc_list":null,"apc_paid":null,"fwci":2.1382,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.86201615,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"75","issue":"3","first_page":"959","last_page":"969"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.8871999979019165,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.8871999979019165,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.07850000262260437,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.016599999740719795,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.9440000057220459},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9269999861717224}],"concepts":[{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.7933647632598877},{"id":"https://openalex.org/C2984915365","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive impairment","level":3,"score":0.7740989327430725},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.5653629302978516},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.4597409665584564},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40692758560180664},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.37258702516555786},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.35820508003234863},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.16609707474708557},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.135316401720047},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13096585869789124}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.3233/jad-191293","doi":"https://doi.org/10.3233/jad-191293","is_oa":false,"landing_page_url":"https://doi.org/10.3233/jad-191293","pdf_url":null,"source":{"id":"https://openalex.org/S25155249","display_name":"Journal of Alzheimer s Disease","issn_l":"1387-2877","issn":["1387-2877","1875-8908"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer\u2019s Disease","raw_type":"journal-article"},{"id":"pmid:32390626","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32390626","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer's disease : JAD","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8351220","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8351220","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Alzheimers Dis","raw_type":"Text"},{"id":"pmh:oai:scholarworks.indianapolis.iu.edu:1805/31361","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1805/31361","pdf_url":"https://scholarworks.indianapolis.iu.edu/bitstreams/6805d282-d5c3-4f80-90ff-90b454acb5cb/download","source":{"id":"https://openalex.org/S4306400987","display_name":"IUScholarWorks (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PMC","raw_type":"Article"},{"id":"pmh:oai:scholarworks.iupui.edu:1805/31361","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1805/31361","pdf_url":null,"source":{"id":"https://openalex.org/S4306402593","display_name":"Purdue University Indianapolis (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PMC","raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8351220","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8351220","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Alzheimers Dis","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1218922180","display_name":null,"funder_award_id":"UL1TR001108","funder_id":"https://openalex.org/F4320309408","funder_display_name":"Indiana Clinical and Translational Sciences Institute"},{"id":"https://openalex.org/G135197880","display_name":"Indiana Alzheimer Disease Center","funder_award_id":"P30AG010133","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2036057130","display_name":"Angiogenesis and Alzheimer\u2019s Disease","funder_award_id":"R21AG051932","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2560545833","display_name":"Indiana Clinical and Translational Sciences Institute","funder_award_id":"UL1TR001108","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3011083507","display_name":"Sensory and Perceptual Measures as Biomarkers of Alzheimer's Disease Pathology","funder_award_id":"K01AG049050","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7519322963","display_name":"Memory Circuitry in MCI and Early Alzheimer\u00e2\u0080\u0099s Disease Prodrome: Molecular Drivers","funder_award_id":"R01AG019771","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320309408","display_name":"Indiana Clinical and Translational Sciences Institute","ror":"https://ror.org/022t7q367"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333230","display_name":"Melvin and Bren Simon Cancer Center, Indiana University","ror":"https://ror.org/00g1d7b60"},{"id":"https://openalex.org/F4320333592","display_name":"Avid Radiopharmaceuticals","ror":"https://ror.org/00szax507"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3023816668.pdf","grobid_xml":"https://content.openalex.org/works/W3023816668.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1739467516","https://openalex.org/W1864888580","https://openalex.org/W1989298176","https://openalex.org/W1992112921","https://openalex.org/W2023535740","https://openalex.org/W2028500111","https://openalex.org/W2040078017","https://openalex.org/W2042902316","https://openalex.org/W2042978638","https://openalex.org/W2044614452","https://openalex.org/W2047601088","https://openalex.org/W2048468641","https://openalex.org/W2048918162","https://openalex.org/W2049206418","https://openalex.org/W2052221015","https://openalex.org/W2084117610","https://openalex.org/W2086079719","https://openalex.org/W2105128106","https://openalex.org/W2115017507","https://openalex.org/W2124030567","https://openalex.org/W2144026946","https://openalex.org/W2147875948","https://openalex.org/W2153283070","https://openalex.org/W2167609020","https://openalex.org/W2169832046","https://openalex.org/W2170712855","https://openalex.org/W2274582236","https://openalex.org/W2292673340","https://openalex.org/W2594052307","https://openalex.org/W2755024874","https://openalex.org/W2759724754","https://openalex.org/W2771829217","https://openalex.org/W2774400961","https://openalex.org/W2787131077","https://openalex.org/W2792470298","https://openalex.org/W2809120353","https://openalex.org/W2905135245","https://openalex.org/W2911533792","https://openalex.org/W2946791655","https://openalex.org/W4231337587"],"related_works":["https://openalex.org/W4409982644","https://openalex.org/W1997978227","https://openalex.org/W1989839696","https://openalex.org/W2041540662","https://openalex.org/W1990096485","https://openalex.org/W24552139","https://openalex.org/W4392644917","https://openalex.org/W2105128106","https://openalex.org/W2115099590","https://openalex.org/W4406881648"],"abstract_inverted_index":{"BACKGROUND:":[0],"Aberrant":[1],"angiogenesis":[2,22,88,112,145,161,172],"may":[3],"play":[4],"a":[5,157],"role":[6],"in":[7,95],"the":[8,19,169],"development":[9],"of":[10,26,34,104,171],"Alzheimer's":[11,48],"disease":[12],"and":[13,24,71,102,106,142,163],"related":[14],"dementia.":[15],"OBJECTIVE:":[16],"To":[17,166],"explore":[18],"relationship":[20],"between":[21,160],"activity":[23,113,146,162],"evidence":[25],"neurodegeneration":[27],"among":[28,127],"older":[29,36],"adults.":[30],"METHODS:":[31],"Cross-sectional":[32],"study":[33],"49":[35],"adults":[37],"clinically":[38],"characterized":[39],"as":[40,173],"cognitively":[41],"normal,":[42],"mild":[43,130],"cognitive":[44,96,131],"impairment,":[45],"or":[46],"early":[47],"disease.":[49,165],"In":[50,133],"addition":[51],"to":[52,81,86,124],"neuroimaging,":[53,101],"we":[54,92],"completed":[55],"assays":[56],"on":[57,100,108],"peripheral":[58],"blood,":[59],"including:":[60],"vascular":[61],"endothelial":[62],"growth":[63,69],"factor,":[64,67,70],"tumor":[65],"necrosis":[66],"fibroblast":[68],"amyloid-\u03b2":[72],"peptide":[73],"40.":[74],"We":[75,155],"used":[76],"advanced":[77],"polychromatic":[78],"flow":[79],"cytometry":[80],"phenotype":[82],"circulating":[83],"mononuclear":[84],"cells":[85],"assess":[87],"activity.":[89],"RESULTS:":[90],"Although":[91],"documented":[93],"differences":[94],"performance,":[97],"structural":[98],"changes":[99],"burden":[103],"amyloid":[105],"tau":[107],"positron":[109],"emission":[110],"tomography,":[111],"did":[114],"not":[115],"vary":[116],"by":[117],"group.":[118],"Interestingly,":[119],"VEGF":[120],"levels":[121],"were":[122],"shown":[123],"be":[125],"increased":[126,150],"subjects":[128],"with":[129,149],"impairment.":[132],"ANCOVA":[134],"models":[135],"controlling":[136],"for":[137],"age,":[138],"sex,":[139],"intracranial":[140],"volume,":[141],"monocyte":[143],"subpopulations,":[144],"was":[147],"correlated":[148],"white":[151],"matter":[152],"hyperintensities.":[153],"CONCLUSION:":[154],"demonstrate":[156],"significant":[158],"association":[159],"cerebrovascular":[164],"better":[167],"understand":[168],"potential":[170],"an":[174],"intervention":[175],"target,":[176],"longitudinal":[177],"studies":[178],"are":[179],"needed.":[180]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-05-13T00:00:00"}
