{"id":"https://openalex.org/W3023297341","doi":"https://doi.org/10.1186/s12916-020-01582-1","title":"Target Product Profiles for medical tests: a systematic review of current methods","display_name":"Target Product Profiles for medical tests: a systematic review of current methods","publication_year":2020,"publication_date":"2020-05-11","ids":{"openalex":"https://openalex.org/W3023297341","doi":"https://doi.org/10.1186/s12916-020-01582-1","mag":"3023297341","pmid":"https://pubmed.ncbi.nlm.nih.gov/32389127","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7212678"},"language":"en","primary_location":{"id":"doi:10.1186/s12916-020-01582-1","doi":"https://doi.org/10.1186/s12916-020-01582-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12916-020-01582-1","pdf_url":"https://bmcmedicine.biomedcentral.com/counter/pdf/10.1186/s12916-020-01582-1","source":{"id":"https://openalex.org/S135560524","display_name":"BMC Medicine","issn_l":"1741-7015","issn":["1741-7015"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medicine","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcmedicine.biomedcentral.com/counter/pdf/10.1186/s12916-020-01582-1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058836705","display_name":"Paola Cocco","orcid":"https://orcid.org/0000-0002-0652-6877","observed_orcids":["https://orcid.org/0000-0002-0652-6877"]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Paola Cocco","raw_affiliation_strings":["Test Evaluation Group, Academic Unit of Health Economics, Leeds Institute for Health Sciences, University of Leeds, Leeds, UK. umpc@leeds.ac.uk","Test Evaluation Group, Academic Unit of Health Economics, Leeds Institute for Health Sciences, University of Leeds, Leeds, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Test Evaluation Group, Academic Unit of Health Economics, Leeds Institute for Health Sciences, University of Leeds, Leeds, UK. umpc@leeds.ac.uk","institution_ids":["https://openalex.org/I130828816"]},{"raw_affiliation_string":"Test Evaluation Group, Academic Unit of Health Economics, Leeds Institute for Health Sciences, University of Leeds, Leeds, UK","institution_ids":["https://openalex.org/I130828816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066289935","display_name":"Anam A. Ayaz-Shah","orcid":"https://orcid.org/0000-0001-6258-947X","observed_orcids":["https://orcid.org/0000-0001-6258-947X"]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anam Ayaz-Shah","raw_affiliation_strings":["","Academic Unit of Primary Care, Leeds Institute for Health Sciences, University of Leeds, Leeds, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Academic Unit of Primary Care, Leeds Institute for Health Sciences, University of Leeds, Leeds, UK","institution_ids":["https://openalex.org/I130828816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080593778","display_name":"Michael Paul Messenger","orcid":"https://orcid.org/0000-0002-4975-0158","observed_orcids":["https://orcid.org/0000-0002-4975-0158"]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]},{"id":"https://openalex.org/I4210109306","display_name":"NIHR Leeds In Vitro Diagnostics Co-operative","ror":"https://ror.org/01ykn4490","country_code":"GB","type":"facility","lineage":["https://openalex.org/I34931013","https://openalex.org/I4210109306"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michael Paul Messenger","raw_affiliation_strings":["","Centre for Personalised Health and Medicine, University of Leeds, Leeds, UK","NIHR Leeds In Vitro Diagnostic (IVD) Co-operative, Leeds, UK","https://www.cantest.org/"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Centre for Personalised Health and Medicine, University of Leeds, Leeds, UK","institution_ids":["https://openalex.org/I130828816"]},{"raw_affiliation_string":"NIHR Leeds In Vitro Diagnostic (IVD) Co-operative, Leeds, UK","institution_ids":["https://openalex.org/I4210109306"]},{"raw_affiliation_string":"https://www.cantest.org/","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042509596","display_name":"Robert Michael West","orcid":"https://orcid.org/0000-0001-7305-3654","observed_orcids":["https://orcid.org/0000-0001-7305-3654"]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Robert Michael West","raw_affiliation_strings":["Leeds Institute for Health Sciences, University of Leeds, Leeds, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leeds Institute for Health Sciences, University of Leeds, Leeds, UK","institution_ids":["https://openalex.org/I130828816"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060521987","display_name":"Bethany Shinkins","orcid":"https://orcid.org/0000-0001-5350-1018","observed_orcids":["https://orcid.org/0000-0001-5350-1018"]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]},{"id":"https://openalex.org/I4210109306","display_name":"NIHR Leeds In Vitro Diagnostics Co-operative","ror":"https://ror.org/01ykn4490","country_code":"GB","type":"facility","lineage":["https://openalex.org/I34931013","https://openalex.org/I4210109306"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Bethany Shinkins","raw_affiliation_strings":["","NIHR Leeds In Vitro Diagnostic (IVD) Co-operative, Leeds, UK","Test Evaluation Group, Academic Unit of Health Economics, Leeds Institute for Health Sciences, University of Leeds, Leeds, UK","https://www.cantest.org/"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"NIHR Leeds In Vitro Diagnostic (IVD) Co-operative, Leeds, UK","institution_ids":["https://openalex.org/I4210109306"]},{"raw_affiliation_string":"Test Evaluation Group, Academic Unit of Health Economics, Leeds Institute for Health Sciences, University of Leeds, Leeds, UK","institution_ids":["https://openalex.org/I130828816"]},{"raw_affiliation_string":"https://www.cantest.org/","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5058836705"],"corresponding_institution_ids":["https://openalex.org/I130828816"],"apc_list":{"value":3490,"currency":"USD","value_usd":3490},"apc_paid":{"value":3490,"currency":"USD","value_usd":3490},"fwci":0.8922,"has_fulltext":true,"cited_by_count":63,"citation_normalized_percentile":{"value":0.77820025,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"18","issue":"1","first_page":"119","last_page":"119"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":0.31029999256134033,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":0.31029999256134033,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T12443","display_name":"Delphi Technique in Research","score":0.20000000298023224,"subfield":{"id":"https://openalex.org/subfields/3312","display_name":"Sociology and Political Science"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11393","display_name":"Biosensors and Analytical Detection","score":0.12250000238418579,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/target-product-profile","display_name":"target product profile","score":0.9330000281333923},{"id":"https://openalex.org/keywords/medical-tests","display_name":"medical testing","score":0.8289999961853027},{"id":"https://openalex.org/keywords/diagnostic-testing","display_name":"diagnostic testing","score":0.8259999752044678},{"id":"https://openalex.org/keywords/infectious-disease-diagnostics","display_name":"infectious disease diagnostics","score":0.7620000243186951},{"id":"https://openalex.org/keywords/unmet-medical-need","display_name":"unmet clinical needs","score":0.9520000219345093},{"id":"https://openalex.org/keywords/analytical-performance","display_name":"analytical performance","score":0.8610000014305115},{"id":"https://openalex.org/keywords/clinical-validity","display_name":"clinical validity","score":0.9909999966621399},{"id":"https://openalex.org/keywords/clinical-utility","display_name":"clinical utility","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cost-effectiveness","display_name":"cost-effectiveness","score":0.9990000128746033},{"id":"https://openalex.org/keywords/consensus-building","display_name":"consensus building","score":0.4959999918937683},{"id":"https://openalex.org/keywords/specialist-consultation","display_name":"expert consultation","score":0.6320000290870667}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7771515846252441},{"id":"https://openalex.org/C2777267654","wikidata":"https://www.wikidata.org/wiki/Q3519023","display_name":"Test (biology)","level":2,"score":0.5585778951644897},{"id":"https://openalex.org/C90673727","wikidata":"https://www.wikidata.org/wiki/Q901718","display_name":"Product (mathematics)","level":2,"score":0.532464325428009},{"id":"https://openalex.org/C19351080","wikidata":"https://www.wikidata.org/wiki/Q1395034","display_name":"New product development","level":2,"score":0.4441494047641754},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.36951592564582825},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.33672478795051575},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C162853370","wikidata":"https://www.wikidata.org/wiki/Q39809","display_name":"Marketing","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D003955","descriptor_name":"Diagnostic Tests, Routine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D003955","descriptor_name":"Diagnostic Tests, Routine","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12916-020-01582-1","doi":"https://doi.org/10.1186/s12916-020-01582-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12916-020-01582-1","pdf_url":"https://bmcmedicine.biomedcentral.com/counter/pdf/10.1186/s12916-020-01582-1","source":{"id":"https://openalex.org/S135560524","display_name":"BMC Medicine","issn_l":"1741-7015","issn":["1741-7015"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7212678","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7212678","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Med","raw_type":"Text"},{"id":"pmid:32389127","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32389127","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC medicine","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.whiterose.ac.uk:159062","doi":null,"is_oa":false,"landing_page_url":"https://orcid.org/0000-0002-0652-6877>,","pdf_url":null,"source":{"id":"https://openalex.org/S4306400854","display_name":"White Rose Research Online (University of Leeds, The University of Sheffield, University of York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2800616092","host_organization_name":"White Rose University Consortium","host_organization_lineage":["https://openalex.org/I2800616092"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:5d7af6cb98044e7080a5a9fc1ad7a8d8","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5d7af6cb98044e7080a5a9fc1ad7a8d8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Medicine, Vol 18, Iss 1, Pp 1-12 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12916-020-01582-1","doi":"https://doi.org/10.1186/s12916-020-01582-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12916-020-01582-1","pdf_url":"https://bmcmedicine.biomedcentral.com/counter/pdf/10.1186/s12916-020-01582-1","source":{"id":"https://openalex.org/S135560524","display_name":"BMC Medicine","issn_l":"1741-7015","issn":["1741-7015"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9074000120162964}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"}],"awards":[{"id":"https://openalex.org/G3805307900","display_name":"MICA: Accelerating Development of Infection Diagnostics for Patient Management and Reduction of Antibiotic Misuse","funder_award_id":"MR/N029976/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G3832996911","display_name":null,"funder_award_id":"(C8640/A23385)","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G4409889252","display_name":null,"funder_award_id":"MR/N029976/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G8806731970","display_name":null,"funder_award_id":"23385","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"}],"funders":[{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320320298","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33"},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3023297341.pdf","grobid_xml":"https://content.openalex.org/works/W3023297341.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W158727920","https://openalex.org/W1852143235","https://openalex.org/W1979891829","https://openalex.org/W2037480459","https://openalex.org/W2105542701","https://openalex.org/W2112768419","https://openalex.org/W2122231541","https://openalex.org/W2129860743","https://openalex.org/W2131361607","https://openalex.org/W2131434481","https://openalex.org/W2131885284","https://openalex.org/W2138060269","https://openalex.org/W2151700469","https://openalex.org/W2166273484","https://openalex.org/W2207407425","https://openalex.org/W2289847303","https://openalex.org/W2353253986","https://openalex.org/W2470108114","https://openalex.org/W2475260219","https://openalex.org/W2494748655","https://openalex.org/W2509224054","https://openalex.org/W2516050586","https://openalex.org/W2558254411","https://openalex.org/W2584282592","https://openalex.org/W2590919366","https://openalex.org/W2604418387","https://openalex.org/W2753207086","https://openalex.org/W2756244676","https://openalex.org/W2766360815","https://openalex.org/W2774158031","https://openalex.org/W2792168989","https://openalex.org/W2805815535","https://openalex.org/W2884622859","https://openalex.org/W2884854824","https://openalex.org/W2885206533","https://openalex.org/W2890391722","https://openalex.org/W2960962831","https://openalex.org/W4292157289"],"related_works":["https://openalex.org/W7215114402","https://openalex.org/W6939394329","https://openalex.org/W4401158091","https://openalex.org/W4412440655","https://openalex.org/W2121708883","https://openalex.org/W4416741570","https://openalex.org/W2750438295","https://openalex.org/W4390199508","https://openalex.org/W3099394734","https://openalex.org/W4405464806"],"abstract_inverted_index":{"BACKGROUND:":[0],"A":[1,66],"Target":[2],"Product":[3],"Profile":[4],"(TPP)":[5],"outlines":[6],"the":[7,29,38,73,83,91,163,167,186],"necessary":[8],"characteristics":[9,93,124],"of":[10,31,137,171],"an":[11,16,120,245],"innovative":[12],"product":[13],"to":[14,24,47,57,71,77,86],"address":[15],"unmet":[17,178],"clinical":[18,179,189,197],"need.":[19],"TPPs":[20,79,108,133,152,174,193,238],"could":[21,212],"be":[22,213],"used":[23,76,85,209],"better":[25],"guide":[26],"manufacturers":[27],"in":[28,105,110,218],"development":[30],"'fit":[32],"for":[33,62,80,94,112,143,150,196,215,222,247],"purpose'":[34],"tests,":[35,82],"thus":[36],"increasing":[37],"likelihood":[39],"that":[40,211],"novel":[41],"tests":[42,142],"will":[43],"progress":[44],"from":[45],"bench":[46],"bedside.":[48],"However,":[49],"there":[50],"is":[51],"currently":[52,75],"no":[53],"guidance":[54],"on":[55,119,140,177],"how":[56],"produce":[58],"a":[59,207,220,223],"TPP":[60,221],"specifically":[61],"medical":[63,81,114,224],"tests.":[64],"METHODS:":[65],"systematic":[67],"review":[68],"was":[69],"conducted":[70,104],"summarise":[72],"methods":[74],"develop":[78],"sources":[84],"inform":[87],"these":[88],"recommendations":[89],"and":[90,100,157,162,169,181,185,199,232,240],"test":[92,115,123],"which":[95,138],"targets":[96],"are":[97,234],"made.":[98],"Database":[99],"website":[101],"searches":[102],"were":[103,116,125,134,153],"November":[106],"2018.":[107],"written":[109],"English":[111],"any":[113],"included.":[117],"Based":[118],"existing":[121],"framework,":[122],"clustered":[126],"into":[127],"commonly":[128,208],"recognised":[129],"themes.":[130],"RESULTS:":[131],"Forty-four":[132],"identified,":[135],"all":[136],"focused":[139],"diagnostic":[141],"infectious":[144],"diseases.":[145],"Three":[146],"core":[147],"decision-making":[148],"phases":[149],"developing":[151],"identified:":[154],"scoping,":[155],"drafting":[156,170,219],"consensus-building.":[158],"Consultations":[159],"with":[160],"experts":[161],"literature":[164],"mostly":[165],"informed":[166],"scoping":[168],"TPPs.":[172],"All":[173],"provided":[175],"information":[176],"need":[180],"desirable":[182],"analytical":[183],"performance,":[184],"majority":[187],"specified":[188],"validity":[190],"characteristics.":[191],"Few":[192],"described":[194],"specifications":[195],"utility,":[198],"none":[200],"included":[201],"cost-effectiveness.":[202],"CONCLUSIONS:":[203],"We":[204],"have":[205],"identified":[206],"framework":[210],"beneficial":[214],"anyone":[216],"interested":[217],"test.":[225],"Currently,":[226],"key":[227],"outcomes":[228],"such":[229],"as":[230,244],"utility":[231],"cost-effectiveness":[233],"largely":[235],"overlooked":[236],"within":[237],"though":[239],"we":[241],"foresee":[242],"this":[243],"area":[246],"further":[248],"improvement.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":18},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-05-13T00:00:00"}