{"id":"https://openalex.org/W3023123774","doi":"https://doi.org/10.1016/j.jalz.2007.04.110","title":"P\u2010205: Valproate therapy to attenuate the clinical progression of Alzheimer's disease: Design of the ADCS valproate neuroprotection trial","display_name":"P\u2010205: Valproate therapy to attenuate the clinical progression of Alzheimer's disease: Design of the ADCS valproate neuroprotection trial","publication_year":2007,"publication_date":"2007-06-04","ids":{"openalex":"https://openalex.org/W3023123774","doi":"https://doi.org/10.1016/j.jalz.2007.04.110","mag":"3023123774"},"language":"en","primary_location":{"id":"doi:10.1016/j.jalz.2007.04.110","doi":"https://doi.org/10.1016/j.jalz.2007.04.110","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2007.04.110","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002451678","display_name":"Pierre N. Tariot","orcid":"https://orcid.org/0000-0002-6058-8032","observed_orcids":["https://orcid.org/0000-0002-6058-8032"]},"institutions":[{"id":"https://openalex.org/I4387152203","display_name":"Banner Alzheimer\u2019s Institute","ror":"https://ror.org/023jwkg52","country_code":"US","type":"facility","lineage":["https://openalex.org/I2802412784","https://openalex.org/I4387152203"]},{"id":"https://openalex.org/I4405259572","display_name":"University of Arizona College of Medicine- Phoenix","ror":"https://ror.org/02drhvq25","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243","https://openalex.org/I4405259572"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Pierre N. Tariot","raw_affiliation_strings":["Banner Alzheimer's Institute, Phoenix, AZ, USA","University of Arizona College of Medicine, Phoenix, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Banner Alzheimer's Institute, Phoenix, AZ, USA","institution_ids":["https://openalex.org/I4387152203"]},{"raw_affiliation_string":"University of Arizona College of Medicine, Phoenix, AZ, USA","institution_ids":["https://openalex.org/I4405259572"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110118407","display_name":"Leon J. Thal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leon Thal","raw_affiliation_strings":["UCSD, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCSD, San Diego, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054323118","display_name":"Laura J. Jakimovich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387152203","display_name":"Banner Alzheimer\u2019s Institute","ror":"https://ror.org/023jwkg52","country_code":"US","type":"facility","lineage":["https://openalex.org/I2802412784","https://openalex.org/I4387152203"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura Jakimovich","raw_affiliation_strings":["Banner Alzheimer's Institute, Phoenix, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Banner Alzheimer's Institute, Phoenix, AZ, USA","institution_ids":["https://openalex.org/I4387152203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103077621","display_name":"Lon S. Schneider","orcid":"https://orcid.org/0000-0002-1875-3735","observed_orcids":["https://orcid.org/0000-0002-1875-3735"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lon Schneider","raw_affiliation_strings":["USC Keck School of Medicine, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"USC Keck School of Medicine, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060487287","display_name":"Jeffrey L. Cummings","orcid":"https://orcid.org/0000-0001-8944-4158","observed_orcids":["https://orcid.org/0000-0001-8944-4158"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey Cummings","raw_affiliation_strings":["UCLA, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCLA, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068057129","display_name":"Rema Raman","orcid":"https://orcid.org/0000-0002-4096-6390","observed_orcids":["https://orcid.org/0000-0002-4096-6390"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rema Raman","raw_affiliation_strings":["UCSD, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCSD, San Diego, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090943173","display_name":"Steven D. Edland","orcid":"https://orcid.org/0000-0002-1153-7335","observed_orcids":["https://orcid.org/0000-0002-1153-7335"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven Edland","raw_affiliation_strings":["UCSD, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCSD, San Diego, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5002451678"],"corresponding_institution_ids":["https://openalex.org/I4387152203","https://openalex.org/I4405259572"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.44295705,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"3","issue":"3S_Part_3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.6220999956130981,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.6220999956130981,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.3765000104904175,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8930000066757202},{"id":"https://openalex.org/keywords/valproic-acid","display_name":"valproic acid","score":0.906000018119812}],"concepts":[{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.7622543573379517},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6372933387756348},{"id":"https://openalex.org/C2779727114","wikidata":"https://www.wikidata.org/wiki/Q170082","display_name":"Psychosis","level":2,"score":0.5725381374359131},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5455670952796936},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.5411434173583984},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4669685661792755},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.45115435123443604},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.4313713312149048},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.3683018684387207},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.32668203115463257},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28673240542411804}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jalz.2007.04.110","doi":"https://doi.org/10.1016/j.jalz.2007.04.110","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2007.04.110","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/study-protocol","display_name":"Study Protocol"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2048836842","https://openalex.org/W2107522606","https://openalex.org/W2043922703","https://openalex.org/W2090603038","https://openalex.org/W2518518396","https://openalex.org/W2033183262","https://openalex.org/W1559005264","https://openalex.org/W2413131755","https://openalex.org/W2032178361","https://openalex.org/W3041862775"],"abstract_inverted_index":{"Alzheimer's":[0],"disease":[1,267],"(AD)":[2],"is":[3,80,173,223,282],"multi-dimensional":[4],"in":[5,95,146,151,168,329],"nature,":[6],"characterized":[7],"not":[8],"only":[9],"by":[10,65,210,235,320],"cognitive":[11,237],"and":[12,21,31,36,49,106,133,155,160,185,244],"functional":[13,239],"decline,":[14],"but":[15],"neuropsychiatric":[16],"symptoms":[17],"that":[18,67,174,224,314],"develop":[19],"commonly":[20],"are":[22,255],"associated":[23,292,342],"with":[24,98,118,180,293,343],"considerable":[25],"morbidity.":[26],"These":[27],"include":[28],"agitation,":[29],"aggression":[30],"psychosis,":[32],"which":[33],"often":[34],"co-occur":[35],"have":[37,68,111,203,317],"a":[38,46,81,115,302,334],"particularly":[39],"high":[40],"persistence":[41],"rate.":[42],"This":[43,76,332],"trial":[44,79,88,326],"represents":[45,333],"novel":[47,335],"design":[48],"new":[50],"clinical":[51,153,230],"trials":[52],"methodology":[53],"to":[54,100,178,258,265,287,308,337],"address":[55,288,309],"whether":[56],"emergence":[57,192,311],"of":[58,89,128,139,157,193,199,217,232,246,274,276,280,312,340],"agitation":[59,105,145,184,194],"and/or":[60,195],"psychosis":[61,107,186],"can":[62],"be":[63,251,301],"delayed":[64],"agents":[66],"psychotropic":[69],"as":[70,72,121,123,268,270],"well":[71,122,269],"possible":[73,141,289,310],"neuroprotective":[74,166],"properties.":[75],"NIA-ADCS":[77],"conducted":[78],"randomized,":[82],"placebo-controlled,":[83],"double":[84],"blind,":[85],"multicenter,":[86],"two-year":[87],"low-dose":[90,248],"(10mg/kg/d)":[91],"sodium":[92],"valproate":[93,176,226],"therapy":[94,227,249],"300":[96],"outpatients":[97],"mild":[99],"moderate":[101],"AD":[102,181],"who":[103,182],"lacked":[104],"at":[108,187],"baseline.":[109],"Participants":[110],"been":[112,318],"followed":[113],"on":[114],"regular":[116],"basis":[117],"clinic":[119],"visits":[120],"telephone":[124],"contacts":[125],"providing":[126],"assessments":[127],"behavior,":[129],"cognition,":[130],"function,":[131],"safety":[132,149,243],"tolerability.":[134],"Valproate":[135],"was":[136,327],"selected":[137,261],"because":[138,156],"its":[140,165],"symptomatic":[142],"efficacy":[143],"for":[144,208,262,324],"AD,":[147,233],"known":[148],"profile":[150],"numerous":[152],"samples,":[154],"recent":[158],"preclinical":[159],"basic":[161],"science":[162],"evidence":[163],"supporting":[164],"potential":[167],"AD.":[169,344],"The":[170],"primary":[171],"hypothesis":[172,222],"chronic":[175,225,247],"administration":[177],"patients":[179],"lack":[183],"baseline":[188],"will":[189,228,250,300],"delay":[190],"the":[191,266,271,296,325],"psychosis.":[196],"An":[197,219],"effect":[198],"this":[200],"kind":[201],"may":[202],"significant":[204],"public":[205],"health":[206],"implications,":[207],"instance,":[209],"delaying":[211],"institutionalization":[212],"or":[213,238],"maintaining":[214],"health-related":[215],"quality":[216],"life.":[218],"important":[220],"secondary":[221,338],"attenuate":[229],"progression":[231],"measured":[234],"reduced":[236],"decline.":[240],"In":[241],"addition,":[242],"tolerability":[245],"addressed.":[252],"Biological":[253],"specimens":[254],"being":[256],"obtained":[257],"study":[259],"markers":[260],"their":[263],"relevance":[264],"postulated":[272],"mechanism":[273],"action":[275],"valproate.":[277],"A":[278],"subset":[279],"participants":[281],"undergoing":[283],"repeated":[284],"MRI":[285],"scans":[286],"volumetric":[290],"changes":[291],"treatment.":[294],"After":[295],"double-blind":[297],"phase,":[298],"there":[299],"two-month":[303],"single-blind":[304],"placebo-controlled":[305],"washout":[306],"phase":[307],"psychopathology":[313,341],"previously":[315],"might":[316],"suppressed":[319],"active":[321],"therapy.":[322],"Enrollment":[323],"completed":[328],"December,":[330],"2006.":[331],"approach":[336],"prevention":[339]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2020-05-13T00:00:00"}
