{"id":"https://openalex.org/W3022893071","doi":"https://doi.org/10.1038/s41467-020-15884-8","title":"Improved GPCR ligands from nanobody tethering","display_name":"Improved GPCR ligands from nanobody tethering","publication_year":2020,"publication_date":"2020-04-29","ids":{"openalex":"https://openalex.org/W3022893071","doi":"https://doi.org/10.1038/s41467-020-15884-8","mag":"3022893071","pmid":"https://pubmed.ncbi.nlm.nih.gov/32350260","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7190724"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-020-15884-8","doi":"https://doi.org/10.1038/s41467-020-15884-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-020-15884-8","pdf_url":"https://www.nature.com/articles/s41467-020-15884-8.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-020-15884-8.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018356508","display_name":"Ross W. Cheloha","orcid":"https://orcid.org/0000-0001-9871-8333","observed_orcids":["https://orcid.org/0000-0001-9871-8333"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ross W. Cheloha","raw_affiliation_strings":["Boston Children's Hospital and Harvard Medical School, 1 Blackfan Circle, Boston, MA, 02115, USA"],"raw_orcid":"https://orcid.org/0000-0001-9871-8333","affiliations":[{"raw_affiliation_string":"Boston Children's Hospital and Harvard Medical School, 1 Blackfan Circle, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039071922","display_name":"Fabian A. Fischer","orcid":"https://orcid.org/0000-0002-4116-9879","observed_orcids":["https://orcid.org/0000-0002-4116-9879"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fabian A. Fischer","raw_affiliation_strings":["Boston Children's Hospital and Harvard Medical School, 1 Blackfan Circle, Boston, MA, 02115, USA"],"raw_orcid":"https://orcid.org/0000-0002-4116-9879","affiliations":[{"raw_affiliation_string":"Boston Children's Hospital and Harvard Medical School, 1 Blackfan Circle, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022276443","display_name":"Andrew W. Woodham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew W. Woodham","raw_affiliation_strings":["Boston Children's Hospital and Harvard Medical School, 1 Blackfan Circle, Boston, MA, 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston Children's Hospital and Harvard Medical School, 1 Blackfan Circle, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081066448","display_name":"Eileen J. Daley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eileen Daley","raw_affiliation_strings":["Massachusetts General Hospital and Harvard Medical School, 50 Blossom Street, Boston, MA, 02114, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital and Harvard Medical School, 50 Blossom Street, Boston, MA, 02114, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029781242","display_name":"Naomi Suminski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Naomi Suminski","raw_affiliation_strings":["Boston Children's Hospital and Harvard Medical School, 1 Blackfan Circle, Boston, MA, 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston Children's Hospital and Harvard Medical School, 1 Blackfan Circle, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015542125","display_name":"Thomas James Gardella","orcid":"https://orcid.org/0000-0002-2163-5772","observed_orcids":["https://orcid.org/0000-0002-2163-5772"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Thomas J. Gardella","raw_affiliation_strings":["Massachusetts General Hospital and Harvard Medical School, 50 Blossom Street, Boston, MA, 02114, USA. gardella@helix.mgh.harvard.edu","Massachusetts General Hospital and Harvard Medical School, 50 Blossom Street, Boston, MA, 02114, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital and Harvard Medical School, 50 Blossom Street, Boston, MA, 02114, USA. gardella@helix.mgh.harvard.edu","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Massachusetts General Hospital and Harvard Medical School, 50 Blossom Street, Boston, MA, 02114, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081514135","display_name":"Hidde L. Ploegh","orcid":"https://orcid.org/0000-0002-1090-6071","observed_orcids":["https://orcid.org/0000-0002-1090-6071"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hidde L. Ploegh","raw_affiliation_strings":["Boston Children's Hospital and Harvard Medical School, 1 Blackfan Circle, Boston, MA, 02115, USA. hidde.ploegh@childrens.harvard.edu","Boston Children's Hospital and Harvard Medical School, 1 Blackfan Circle, Boston, MA, 02115, USA"],"raw_orcid":"https://orcid.org/0000-0002-1090-6071","affiliations":[{"raw_affiliation_string":"Boston Children's Hospital and Harvard Medical School, 1 Blackfan Circle, Boston, MA, 02115, USA. hidde.ploegh@childrens.harvard.edu","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Boston Children's Hospital and Harvard Medical School, 1 Blackfan Circle, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5015542125","https://openalex.org/A5081514135"],"corresponding_institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984","https://openalex.org/I4210087915"],"apc_list":{"value":5380,"currency":"USD","value_usd":5380},"apc_paid":{"value":5380,"currency":"USD","value_usd":5380},"fwci":2.9183,"has_fulltext":true,"cited_by_count":67,"citation_normalized_percentile":{"value":0.92733279,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"11","issue":"1","first_page":"2087","last_page":"2087"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.5557000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.5557000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.35280001163482666,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.061400000005960464,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.9010000228881836},{"id":"https://openalex.org/keywords/nanobodies","display_name":"nanobodies","score":0.8140000104904175},{"id":"https://openalex.org/keywords/vhh-fragments","display_name":"VHH fragments","score":0.7490000128746033},{"id":"https://openalex.org/keywords/parathyroid-hormone-receptor-1","display_name":"parathyroid hormone type 1 receptor","score":0.8619999885559082},{"id":"https://openalex.org/keywords/clamps","display_name":"clamps","score":0.47600001096725464},{"id":"https://openalex.org/keywords/receptor-activation","display_name":"receptor activation","score":0.5910000205039978},{"id":"https://openalex.org/keywords/ligand-specificity","display_name":"ligand specificity","score":0.7369999885559082},{"id":"https://openalex.org/keywords/membrane-protein-targeting","display_name":"membrane protein targeting","score":0.4749999940395355}],"concepts":[{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.7343071103096008},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.7093310952186584},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6646944284439087},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5639818906784058},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.5005834102630615},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4673106372356415},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.45950907468795776},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.4482736587524414},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4418524503707886},{"id":"https://openalex.org/C168557967","wikidata":"https://www.wikidata.org/wiki/Q24772254","display_name":"Parathyroid hormone receptor","level":5,"score":0.4215788245201111},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.41790586709976196},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3370581865310669},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25079146027565},{"id":"https://openalex.org/C23589133","wikidata":"https://www.wikidata.org/wiki/Q412005","display_name":"Hormone receptor","level":4,"score":0.1883309781551361},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.06673598289489746},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010281","descriptor_name":"Parathyroid Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D044168","descriptor_name":"Receptor, Parathyroid Hormone, Type 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061905","descriptor_name":"Single-Domain Antibodies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1038/s41467-020-15884-8","doi":"https://doi.org/10.1038/s41467-020-15884-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-020-15884-8","pdf_url":"https://www.nature.com/articles/s41467-020-15884-8.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"doi:10.26434/chemrxiv.9619823.v1","doi":"https://doi.org/10.26434/chemrxiv.9619823.v1","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv.9619823.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:7190724","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7190724","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmid:32350260","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32350260","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-15884-8","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-020-15884-8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:2ec526511b22420986044ab4ea9c3e47","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/2ec526511b22420986044ab4ea9c3e47","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/9619823","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/Improved_GPCR_Ligands_Based_on_Genetically_Impossible_Nanobody-Peptide_Fusions/9619823","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/s41467-020-15884-8","doi":"https://doi.org/10.1038/s41467-020-15884-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-020-15884-8","pdf_url":"https://www.nature.com/articles/s41467-020-15884-8.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3483810560","display_name":"Sortase-mediated protein engineering for the study of host-pathogen interactions","funder_award_id":"R01AI087879","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3552353607","display_name":"Hormonal Control of Calcium Metabolism","funder_award_id":"P01DK011794","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G541476781","display_name":"CENTER FOR SKELETAL RESEARCH","funder_award_id":"P30AR066261","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G645124401","display_name":"Imposing order on the family of ubiquitin-conjugating (E2) enzymes through intracellular perturbation with nanobodies","funder_award_id":"DP1AI150593","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000155577","display_name":null,"funder_award_id":"AR066261","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000224774","display_name":null,"funder_award_id":"DK011794","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000890720","display_name":"Training Program in Endocrinology","funder_award_id":"T32DK007028","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306155","display_name":"Cancer Research Institute","ror":"https://ror.org/02f3xk561"},{"id":"https://openalex.org/F4320308349","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78"},{"id":"https://openalex.org/F4320310174","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332530","display_name":"Medical Center, University of Pittsburgh","ror":"https://ror.org/04ehecz88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3022893071.pdf","grobid_xml":"https://content.openalex.org/works/W3022893071.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1484748810","https://openalex.org/W1538704784","https://openalex.org/W1724443945","https://openalex.org/W1908188316","https://openalex.org/W1966403223","https://openalex.org/W1997730366","https://openalex.org/W2027378819","https://openalex.org/W2029356366","https://openalex.org/W2034663072","https://openalex.org/W2048553889","https://openalex.org/W2073769248","https://openalex.org/W2081231410","https://openalex.org/W2082817154","https://openalex.org/W2089788910","https://openalex.org/W2103897951","https://openalex.org/W2114049739","https://openalex.org/W2130536801","https://openalex.org/W2133572151","https://openalex.org/W2141777375","https://openalex.org/W2146442033","https://openalex.org/W2148345073","https://openalex.org/W2151686341","https://openalex.org/W2156257459","https://openalex.org/W2156674480","https://openalex.org/W2158646902","https://openalex.org/W2187899263","https://openalex.org/W2221707331","https://openalex.org/W2288077045","https://openalex.org/W2333223032","https://openalex.org/W2336359492","https://openalex.org/W2417431203","https://openalex.org/W2485636647","https://openalex.org/W2511475001","https://openalex.org/W2550623601","https://openalex.org/W2557128364","https://openalex.org/W2734750805","https://openalex.org/W2765153686","https://openalex.org/W2765712976","https://openalex.org/W2767550123","https://openalex.org/W2774294088","https://openalex.org/W2788753373","https://openalex.org/W2789780246","https://openalex.org/W2792245061","https://openalex.org/W2887064975","https://openalex.org/W2899995053","https://openalex.org/W2901348230","https://openalex.org/W2902933072","https://openalex.org/W2911446286","https://openalex.org/W2919234929","https://openalex.org/W2920392315","https://openalex.org/W2939681516","https://openalex.org/W2965468477","https://openalex.org/W2972952141","https://openalex.org/W4241780253"],"related_works":["https://openalex.org/W4396849605","https://openalex.org/W4396850035","https://openalex.org/W4399257513","https://openalex.org/W4254894369","https://openalex.org/W7162990290","https://openalex.org/W4396850130","https://openalex.org/W7160879836","https://openalex.org/W4404679119","https://openalex.org/W3205837077","https://openalex.org/W4416510677"],"abstract_inverted_index":{"Antibodies":[0],"conjugated":[1],"to":[2,10,74,87,125],"bioactive":[3],"compounds":[4],"allow":[5],"targeted":[6],"delivery":[7],"of":[8,13,26,30,50,62,69,89,127,134],"therapeutics":[9],"cell":[11],"types":[12],"choice":[14],"based":[15],"on":[16],"that":[17,28,77,88,126],"antibody's":[18],"specificity.":[19,149],"Here":[20],"we":[21],"develop":[22],"a":[23,31,34,38,102],"new":[24],"type":[25],"conjugate":[27,105,118],"consists":[29],"nanobody":[32],"and":[33,55,60,136,148],"peptidic":[35],"ligand":[36],"for":[37,122,138],"G":[39],"protein-coupled":[40],"receptor":[41],"(GPCR),":[42],"fused":[43],"via":[44],"their":[45],"C-termini.":[46],"We":[47],"address":[48],"activation":[49],"parathyroid":[51],"hormone":[52],"receptor-1":[53],"(PTHR1)":[54],"improve":[56],"the":[57,90,110],"signaling":[58],"activity":[59,85],"specificity":[61],"otherwise":[63],"poorly":[64],"active":[65],"N-terminal":[66],"peptide":[67,93,104,113],"fragments":[68],"PTH":[70],"by":[71],"conjugating":[72],"them":[73],"nanobodies":[75],"(VHHs)":[76],"recognize":[78],"PTHR1.":[79],"These":[80],"C-to-C":[81],"conjugates":[82],"show":[83],"biological":[84,107],"superior":[86,124],"parent":[91],"fragment":[92],"in":[94,100],"vitro.":[95],"In":[96],"an":[97],"exploratory":[98],"experiment":[99],"mice,":[101],"VHH-PTH":[103],"showed":[106],"activity,":[108],"whereas":[109],"corresponding":[111],"free":[112],"did":[114],"not.":[115],"The":[116],"lead":[117],"also":[119],"possesses":[120],"selectivity":[121],"PTHR1":[123],"PTH(1-34).":[128],"This":[129],"design":[130],"approach,":[131],"dubbed":[132],"\"conjugation":[133],"ligands":[135,144],"antibodies":[137],"membrane":[139],"proteins\"":[140],"(CLAMP),":[141],"can":[142],"yield":[143],"with":[145],"high":[146],"potency":[147]},"counts_by_year":[{"year":2026,"cited_by_count":13},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-05-13T00:00:00"}