{"id":"https://openalex.org/W3022870261","doi":"https://doi.org/10.1016/j.jalz.2006.05.2035","title":"P4\u2013296: Amyloid\u2013\u03b2 peptide remnants in AN\u20131792\u2013immunized Alzheimer's disease patients","display_name":"P4\u2013296: Amyloid\u2013\u03b2 peptide remnants in AN\u20131792\u2013immunized Alzheimer's disease patients","publication_year":2006,"publication_date":"2006-07-01","ids":{"openalex":"https://openalex.org/W3022870261","doi":"https://doi.org/10.1016/j.jalz.2006.05.2035","mag":"3022870261"},"language":"en","primary_location":{"id":"doi:10.1016/j.jalz.2006.05.2035","doi":"https://doi.org/10.1016/j.jalz.2006.05.2035","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2006.05.2035","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077900199","display_name":"Tyler A. Kokjohn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Tyler A. Kokjohn","raw_affiliation_strings":["Midwestern University, Glendale, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Midwestern University, Glendale, AZ, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072613176","display_name":"Thomas G. Beach","orcid":"https://orcid.org/0000-0003-3296-6128","observed_orcids":["https://orcid.org/0000-0003-3296-6128"]},"institutions":[{"id":"https://openalex.org/I4210145600","display_name":"Banner Sun Health Research Institute","ror":"https://ror.org/04gjkkf30","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802412784","https://openalex.org/I4210145600"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas G. Beach","raw_affiliation_strings":["Sun Health Research Institute, Sun City, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sun Health Research Institute, Sun City, AZ, USA","institution_ids":["https://openalex.org/I4210145600"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008783995","display_name":"Chera L. Esh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145600","display_name":"Banner Sun Health Research Institute","ror":"https://ror.org/04gjkkf30","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802412784","https://openalex.org/I4210145600"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chera L. Esh","raw_affiliation_strings":["Sun Health Research Institute, Sun City, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sun Health Research Institute, Sun City, AZ, USA","institution_ids":["https://openalex.org/I4210145600"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052690813","display_name":"Rebekah Patton","orcid":"https://orcid.org/0000-0001-5544-5128","observed_orcids":["https://orcid.org/0000-0001-5544-5128"]},"institutions":[{"id":"https://openalex.org/I4210145600","display_name":"Banner Sun Health Research Institute","ror":"https://ror.org/04gjkkf30","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802412784","https://openalex.org/I4210145600"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R.L. Patton","raw_affiliation_strings":["Sun Health Research Institute, Sun City, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sun Health Research Institute, Sun City, AZ, USA","institution_ids":["https://openalex.org/I4210145600"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066909801","display_name":"Walter M. Kalback","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Walter M. Kalback","raw_affiliation_strings":["Sun Health, Sun City, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sun Health, Sun City, AZ, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011629792","display_name":"Gregory D. Van Vickle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145600","display_name":"Banner Sun Health Research Institute","ror":"https://ror.org/04gjkkf30","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802412784","https://openalex.org/I4210145600"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory D. Van Vickle","raw_affiliation_strings":["Sun Health Research Institute, Sun City, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sun Health Research Institute, Sun City, AZ, USA","institution_ids":["https://openalex.org/I4210145600"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088826311","display_name":"Alex E. Roher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145600","display_name":"Banner Sun Health Research Institute","ror":"https://ror.org/04gjkkf30","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802412784","https://openalex.org/I4210145600"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alex E. Roher","raw_affiliation_strings":["Sun Health Research Institute, Sun City, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sun Health Research Institute, Sun City, AZ, USA","institution_ids":["https://openalex.org/I4210145600"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5077900199"],"corresponding_institution_ids":[],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.45166211,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2","issue":"3S_Part_20","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9380000233650208}],"concepts":[{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.623115062713623},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6079071164131165},{"id":"https://openalex.org/C2778621254","wikidata":"https://www.wikidata.org/wiki/Q2346415","display_name":"Meningoencephalitis","level":2,"score":0.5675890445709229},{"id":"https://openalex.org/C68026918","wikidata":"https://www.wikidata.org/wiki/Q1970256","display_name":"Senile plaques","level":4,"score":0.5237157940864563},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.44837814569473267},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.42827075719833374},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38460737466812134},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2306179702281952},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.11922770738601685},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jalz.2006.05.2035","doi":"https://doi.org/10.1016/j.jalz.2006.05.2035","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2006.05.2035","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1546526125","https://openalex.org/W1964176358","https://openalex.org/W2121886693","https://openalex.org/W7095738114","https://openalex.org/W1970073006","https://openalex.org/W2945016564","https://openalex.org/W2000917982","https://openalex.org/W2002417737","https://openalex.org/W2108906052","https://openalex.org/W2016763378"],"abstract_inverted_index":{"Alzheimer's":[0],"Disease":[1],"(AD)":[2],"is":[3],"associated":[4],"with":[5],"amyloid":[6,51,157,171,191,222,238,251,263,287,299],"deposits":[7,242],"in":[8,40,75,136,215,223,233,306],"the":[9,88,107,137,170],"extracellular":[10],"spaces":[11],"and":[12,18,30,32,53,99,116,134,139,144,155,169,181,185,200,220,230,285,309],"cerebral":[13],"blood":[14],"vessels.":[15],"Both":[16],"fibrillar":[17],"soluble":[19,250],"forms":[20],"of":[21,44,62,84,91,110,119,124,271,294],"A\u2013beta":[22],"peptides":[23,135,192,300],"are":[24,102],"recognized":[25],"to":[26,165,195,257],"disturb":[27],"brain":[28],"structure":[29],"function":[31,57],"produce":[33,303],"a":[34,81],"slowly":[35],"evolving":[36],"dementia.":[37],"Experiments":[38],"undertaken":[39],"transgenic":[41],"mouse":[42],"models":[43],"AD":[45,94,216,258,272],"revealed":[46,69,247],"that":[47,70,248,277],"A\u2013beta42":[48,67],"immunization":[49,280],"disrupted":[50,281],"plaques":[52],"allowed":[54],"apparent":[55],"cognitive":[56],"recovery.":[58],"A":[59,113],"clinical":[60],"study":[61],"patients":[63],"vaccinated":[64,225],"against":[65],"purified":[66],"(AN\u20131792)":[68],"senile":[71,283],"plaque":[72,284],"disruption":[73],"occurred":[74],"immunized":[76],"humans":[77],"as":[78,158,160],"well.":[79],"Although":[80,236],"high":[82],"incidence":[83],"aseptic":[85],"meningoencephalitis":[86],"forced":[87],"early":[89],"termination":[90],"this":[92],"study,":[93],"immunotherapy":[95],"shows":[96],"great":[97],"promise":[98],"new":[100],"approaches":[101],"under":[103],"investigation.":[104],"To":[105],"assess":[106],"biochemical":[108,117],"outcomes":[109],"amyloid\u2013beta":[111],"immunotherapy.":[112],"combined":[114],"histologic":[115],"dissection":[118],"two":[120],"AN\u20131792\u2013immunized":[121],"patients,":[122],"one":[123],"whom":[125],"developed":[126],"meningoencephalitis.":[127],"Amyloid\u2013beta":[128],"levels":[129,252,264],"were":[130,148,163,174,193,227,253,265],"quantified":[131],"by":[132],"ELISA":[133,245],"cortical":[138],"leptomeningeal":[140],"vessels,":[141],"gray":[142,308],"matter":[143,146],"white":[145,310],"(WM)":[147],"characterized.":[149],"Senile":[150],"plaque,":[151],"diffuse":[152,221,286],"(fraction":[153],"P3)":[154],"vascular":[156,241,289],"well":[159],"WM":[161,262],"samples":[162],"subjected":[164,194],"differing":[166],"extraction":[167],"regimens":[168],"species":[172],"present":[173],"isolated":[175],"using":[176],"sequential":[177],"FPLC":[178],"size":[179,186],"exclusion":[180,187],"HPLC":[182],"reverse":[183],"phase":[184],"chromatographic":[188],"methods.":[189],"HPLC\u2013purified":[190],"automated":[196],"amino":[197],"acid":[198],"sequencing":[199],"MALDI\u2013TOF/SELDI\u2013TOF":[201],"mass":[202],"spectrometric":[203],"analyses.":[204],"The":[205],"pathologic":[206],"findings":[207],"we":[208],"observed":[209],"deviated":[210],"from":[211],"those":[212,269],"classically":[213],"found":[214],"patients.":[217,273],"Compact":[218],"core":[219],"both":[224,282,307],"individuals":[226],"dramatically":[228],"altered":[229],"virtually":[231],"absent":[232],"some":[234],"regions.":[235],"parenchymal":[237],"was":[239],"disaggregated,":[240],"apparently":[243],"increased.":[244],"quantification":[246],"total":[249],"sharply":[254],"elevated":[255],"compared":[256],"cases.":[259],"In":[260],"addition,":[261],"significantly":[266],"higher":[267],"than":[268],"typical":[270],"Our":[274],"experiments":[275],"suggest":[276],"although":[278],"AN\u20131992":[279],"deposits,":[288],"failure":[290],"prevented":[291],"large\u2013scale":[292],"egress":[293],"solubilzed":[295],"material.":[296],"Trapped":[297],"solubilized":[298],"may":[301],"ultimately":[302],"toxic":[304],"effects":[305],"matter.":[311]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-05-13T00:00:00"}