{"id":"https://openalex.org/W3022759100","doi":"https://doi.org/10.1158/1538-7445.mvc2020-b15","title":"Abstract B15: Gut microbiome populations modulate neoadjuvant chemotherapy responsiveness in preclinical triple-negative breast cancer murine model","display_name":"Abstract B15: Gut microbiome populations modulate neoadjuvant chemotherapy responsiveness in preclinical triple-negative breast cancer murine model","publication_year":2020,"publication_date":"2020-04-15","ids":{"openalex":"https://openalex.org/W3022759100","doi":"https://doi.org/10.1158/1538-7445.mvc2020-b15","mag":"3022759100"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.mvc2020-b15","doi":"https://doi.org/10.1158/1538-7445.mvc2020-b15","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.mvc2020-b15","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056002934","display_name":"Kenysha Y.J. Clear","orcid":"https://orcid.org/0000-0001-6744-9687","observed_orcids":["https://orcid.org/0000-0001-6744-9687"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenysha Clear","raw_affiliation_strings":["1Department of Surgery, Wake Forest University School of Medicine, Winston-Salem, NC,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Surgery, Wake Forest University School of Medicine, Winston-Salem, NC,","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102743760","display_name":"Adam S. Wilson","orcid":"https://orcid.org/0009-0001-8408-7478","observed_orcids":["https://orcid.org/0009-0001-8408-7478"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam Wilson","raw_affiliation_strings":["1Department of Surgery, Wake Forest University School of Medicine, Winston-Salem, NC,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Surgery, Wake Forest University School of Medicine, Winston-Salem, NC,","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038187631","display_name":"Akiko Chiba","orcid":"https://orcid.org/0000-0003-0303-2799","observed_orcids":["https://orcid.org/0000-0003-0303-2799"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Akiko Chiba","raw_affiliation_strings":["2Department of Surgery, Wake Forest Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston-Salem, NC,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Surgery, Wake Forest Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston-Salem, NC,","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025967603","display_name":"Katherine Loree Cook","orcid":"https://orcid.org/0000-0001-6241-0214","observed_orcids":["https://orcid.org/0000-0001-6241-0214"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine L. Cook","raw_affiliation_strings":["3Department of Surgery, Department of Cancer Biology, Wake Forest Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston-Salem, NC,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Surgery, Department of Cancer Biology, Wake Forest Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston-Salem, NC,","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022863863","display_name":"Alaa Bawaneh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alaa Bawaneh","raw_affiliation_strings":["4Integrative Physiology and Pharmacology-Department of Surgery, Wake Forest University School of Medicine, Winston-Salem, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Integrative Physiology and Pharmacology-Department of Surgery, Wake Forest University School of Medicine, Winston-Salem, NC","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"80","issue":"8_Supplement","first_page":"B15","last_page":"B15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.9860000014305115},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9829999804496765},{"id":"https://openalex.org/keywords/neoadjuvant-chemotherapy","display_name":"neoadjuvant chemotherapy","score":0.9829999804496765},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.8809999823570251},{"id":"https://openalex.org/keywords/chemotherapy-response","display_name":"chemotherapy response","score":0.5640000104904175},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.6579999923706055},{"id":"https://openalex.org/keywords/fecal-microbiota-transplantation","display_name":"fecal microbiota transplantation","score":0.8460000157356262},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.777999997138977},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6830000281333923},{"id":"https://openalex.org/keywords/ruminococcus","display_name":"Ruminococcus","score":0.8859999775886536},{"id":"https://openalex.org/keywords/oscillospira","display_name":"Oscillospira","score":0.9520000219345093},{"id":"https://openalex.org/keywords/bacteroidales","display_name":"Bacteroidales","score":0.9139999747276306},{"id":"https://openalex.org/keywords/pseudomonas","display_name":"Pseudomonas","score":0.9629999995231628}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7061845064163208},{"id":"https://openalex.org/C2780110267","wikidata":"https://www.wikidata.org/wiki/Q7843332","display_name":"Triple-negative breast cancer","level":4,"score":0.6962151527404785},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.654447078704834},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.5937907695770264},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5707066059112549},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.527930498123169},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4867551326751709},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.46923333406448364},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.4197466969490051},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.4109693467617035},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.4109345078468323},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.4102162718772888},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.38195863366127014},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3513725996017456},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2102692425251007},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.11815926432609558},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.062074899673461914},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.mvc2020-b15","doi":"https://doi.org/10.1158/1538-7445.mvc2020-b15","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.mvc2020-b15","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2955707195","https://openalex.org/W4303621924","https://openalex.org/W7010249930","https://openalex.org/W4379285783","https://openalex.org/W2980344215","https://openalex.org/W7129663968","https://openalex.org/W4385156980","https://openalex.org/W7162093077","https://openalex.org/W4220870380","https://openalex.org/W3170594206"],"abstract_inverted_index":{"Abstract":[0],"Triple-negative":[1],"breast":[2,21,45,430],"cancer":[3,22,46,431],"(TNBC)":[4],"is":[5,225,371],"a":[6,11,80,237,263,401],"highly":[7],"aggressive":[8],"subtype":[9],"with":[10,74,107,127,139,216,227,280,296,352],"5-year":[12],"survival":[13],"rate":[14],"significantly":[15],"worse":[16],"when":[17,350],"compared":[18,351],"to":[19,33,67,86,152],"other":[20],"types.":[23],"There":[24],"are":[25],"no":[26],"targeted":[27],"therapy":[28,55],"options,":[29],"limiting":[30],"these":[31],"patients":[32,47],"cytotoxic":[34],"chemotherapy":[35,95,348,361,369,425],"regimens.":[36],"Our":[37],"group":[38,265,267],"demonstrated":[39],"increased":[40,219],"tumoral":[41],"Pseudomonas":[42],"abundance":[43,220],"in":[44,110,148,240,242,283,427],"receiving":[48,181,268],"neoadjuvant":[49,424],"chemotherapy,":[50],"suggesting":[51,355],"that":[52,368,378],"systemic":[53],"anticancer":[54],"administration":[56],"may":[57,78,389],"modulate":[58,360,423],"microbiota":[59,71,395],"populations.":[60],"The":[61],"purpose":[62],"of":[63,90,143,221,233,313,328,337,380,404,437],"our":[64,365],"study":[65],"was":[66,158],"determine":[68,87,249],"whether":[69,250],"gut":[70,253,356,374,382],"populations":[72,358,396,422],"correlate":[73],"chemotherapeutic":[75,405],"responsiveness":[76,349,426],"and":[77,146,161,176,196,204,218,223,244,306,330,333,345,376,446],"be":[79,398],"predictive":[81,402],"biomarker":[82,403],"outcome.":[83,230],"We":[84],"wanted":[85],"the":[88,92,111,149,154,166,252,284,311,314,381,438,443],"impact":[89],"shifting":[91],"microbiome":[93,254,357,375,383,421],"on":[94,442],"efficacy.":[96],"To":[97,248],"do":[98],"so,":[99],"8-week":[100],"old":[101],"female":[102],"BALB/c":[103,258],"mice":[104,120,259,293],"were":[105,121,163,170,183,260,278,294,308,318,343],"injected":[106,279],"4T1-luciferase":[108,281],"cells":[109,282],"mammary":[112,285],"fat":[113,286],"pad.":[114,287],"Once":[115,288],"tumors":[116,289,340],"reached":[117,290],"100":[118,291],"mm3,":[119,292],"either":[122],"untreated":[123],"(control":[124],"group),":[125],"treated":[126,138,295],"1x":[128,297],"weekly":[129,298],"2.5":[130,299],"mg/kg":[131,300],"doxorubicin":[132,140],"(DOX)":[133],"for":[134,302],"4":[135,303],"weeks,":[136],"or":[137,187,266,386],"+antibiotics":[141,198],"(mixture":[142],"streptomycin,":[144],"ampicillin,":[145],"colistin":[147],"drinking":[150],"water":[151],"ablate":[153],"microbiome).":[155],"Tumor":[156],"size":[157],"monitored.":[159],"Tumors":[160,305],"lungs":[162,307],"collected":[164,171,309,319],"after":[165],"study.":[167,315],"Fecal":[168,316],"samples":[169,317],"at":[172,310,320],"T0":[173,321],"(before":[174,322],"treatment)":[175],"T4":[177],"(after":[178,325],"treatment).":[179],"Mice":[180,193,277],"DOX":[182,197,245,301],"stratified":[184,261],"into":[185,262],"DOX-responders":[186,195,243],"DOX-nonresponders":[188],"based":[189],"upon":[190],"tumor":[191,202,234],"size.":[192],"from":[194,341],"groups":[199],"displayed":[200,346],"reduced":[201,347],"weight":[203],"decreased":[205],"lung":[206],"metastatic":[207],"burden.":[208],"16S-bacterial":[209],"sequencing":[210],"indicates":[211,236],"elevated":[212],"fecal":[213,271,394],"Ruminococcus":[214],"correlates":[215],"DOX-nonresponsiveness":[217],"Oscillospira":[222],"Bacteroidales":[224],"associated":[226],"better":[228],"therapeutic":[229,391],"Protein":[231],"analysis":[232],"tissue":[235],"significant":[238],"increase":[239],"apoptosis":[241],"+antibiotic":[246],"groups.":[247],"modulating":[251],"influences":[255],"drug":[256],"responsiveness,":[257],"control":[264,353],"lard":[269],"diet-derived":[270],"transplant":[272],"(LDFT)":[273],"by":[274,373],"oral":[275],"gavage.":[276],"weeks.":[304],"end":[312,336],"gavage),":[323],"T3":[324],"3":[326],"weeks":[327],"LDFT":[329],"before":[331],"DOX-treatment),":[332],"T7":[334],"(at":[335],"study).":[338],"All":[339],"LDFT-group":[342],"larger":[344],"animals,":[354],"can":[359],"resistance.":[362],"Taken":[363],"together,":[364],"data":[366],"demonstrate":[367],"efficacy":[370],"modulated":[372],"suggest":[377],"modulation":[379],"through":[384],"dietary":[385],"probiotic":[387],"interventions":[388],"affect":[390],"outcomes.":[392],"Moreover,":[393],"could":[397],"used":[399],"as":[400],"responsiveness.":[406],"Citation":[407],"Format:":[408],"Kenysha":[409],"Clear,":[410],"Adam":[411],"Wilson,":[412],"Akiko":[413],"Chiba,":[414],"Katherine":[415],"L.":[416],"Cook,":[417],"Alaa":[418],"Bawaneh.":[419],"Gut":[420],"preclinical":[428],"triple-negative":[429],"murine":[432],"model":[433],"[abstract].":[434],"In:":[435],"Proceedings":[436],"AACR":[439],"Special":[440],"Conference":[441],"Microbiome,":[444],"Viruses,":[445],"Cancer;":[447],"2020":[448],"Feb":[449],"21-24;":[450],"Orlando,":[451],"FL.":[452],"Philadelphia":[453],"(PA):":[454],"AACR;":[455],"Cancer":[456],"Res":[457],"2020;80(8":[458],"Suppl):Abstract":[459],"nr":[460],"B15.":[461]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-05-13T00:00:00"}