{"id":"https://openalex.org/W3022540927","doi":"https://doi.org/10.1089/mdr.2019.0412","title":"Regulatory Role of the Two-Component System BasSR in the Expression of the EmrD Multidrug Efflux in Escherichia coli","display_name":"Regulatory Role of the Two-Component System BasSR in the Expression of the EmrD Multidrug Efflux in Escherichia coli","publication_year":2020,"publication_date":"2020-05-07","ids":{"openalex":"https://openalex.org/W3022540927","doi":"https://doi.org/10.1089/mdr.2019.0412","mag":"3022540927","pmid":"https://pubmed.ncbi.nlm.nih.gov/32379525"},"language":"en","primary_location":{"id":"doi:10.1089/mdr.2019.0412","doi":"https://doi.org/10.1089/mdr.2019.0412","is_oa":false,"landing_page_url":"https://doi.org/10.1089/mdr.2019.0412","pdf_url":null,"source":{"id":"https://openalex.org/S178647319","display_name":"Microbial Drug Resistance","issn_l":"1076-6294","issn":["1076-6294","1931-8448"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbial Drug Resistance","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006934179","display_name":"Lumin Yu","orcid":"https://orcid.org/0000-0002-2578-7968","observed_orcids":["https://orcid.org/0000-0002-2578-7968"]},"institutions":[{"id":"https://openalex.org/I140221134","display_name":"Anhui Agricultural University","ror":"https://ror.org/0327f3359","country_code":"CN","type":"education","lineage":["https://openalex.org/I140221134"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lumin Yu","raw_affiliation_strings":["School of Life Sciences, Anhui Agricultural University, Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, Anhui Agricultural University, Hefei, China","institution_ids":["https://openalex.org/I140221134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087641663","display_name":"Wenchang Li","orcid":"https://orcid.org/0000-0002-1179-6636","observed_orcids":["https://orcid.org/0000-0002-1179-6636"]},"institutions":[{"id":"https://openalex.org/I140221134","display_name":"Anhui Agricultural University","ror":"https://ror.org/0327f3359","country_code":"CN","type":"education","lineage":["https://openalex.org/I140221134"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenchang Li","raw_affiliation_strings":["School of Life Sciences, Anhui Agricultural University, Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, Anhui Agricultural University, Hefei, China","institution_ids":["https://openalex.org/I140221134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100745711","display_name":"Mei Xue","orcid":"https://orcid.org/0000-0002-2901-2801","observed_orcids":["https://orcid.org/0000-0002-2901-2801"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mei Xue","raw_affiliation_strings":["Anhui Province Key Laboratory of Veterinary Pathobiology and Disease Control, Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anhui Province Key Laboratory of Veterinary Pathobiology and Disease Control, Hefei, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100640142","display_name":"Jing Li","orcid":"https://orcid.org/0000-0002-4413-8197","observed_orcids":["https://orcid.org/0000-0002-4413-8197"]},"institutions":[{"id":"https://openalex.org/I140221134","display_name":"Anhui Agricultural University","ror":"https://ror.org/0327f3359","country_code":"CN","type":"education","lineage":["https://openalex.org/I140221134"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Li","raw_affiliation_strings":["School of Life Sciences, Anhui Agricultural University, Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, Anhui Agricultural University, Hefei, China","institution_ids":["https://openalex.org/I140221134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100693585","display_name":"Xiaolin Chen","orcid":"https://orcid.org/0000-0002-5492-516X","observed_orcids":["https://orcid.org/0000-0002-5492-516X"]},"institutions":[{"id":"https://openalex.org/I140221134","display_name":"Anhui Agricultural University","ror":"https://ror.org/0327f3359","country_code":"CN","type":"education","lineage":["https://openalex.org/I140221134"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaolin Chen","raw_affiliation_strings":["School of Life Sciences, Anhui Agricultural University, Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, Anhui Agricultural University, Hefei, China","institution_ids":["https://openalex.org/I140221134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073354744","display_name":"Jingtian Ni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I140221134","display_name":"Anhui Agricultural University","ror":"https://ror.org/0327f3359","country_code":"CN","type":"education","lineage":["https://openalex.org/I140221134"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingtian Ni","raw_affiliation_strings":["School of Life Sciences, Anhui Agricultural University, Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, Anhui Agricultural University, Hefei, China","institution_ids":["https://openalex.org/I140221134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103190209","display_name":"Fei Shang","orcid":"https://orcid.org/0000-0002-5948-0753","observed_orcids":["https://orcid.org/0000-0002-5948-0753"]},"institutions":[{"id":"https://openalex.org/I140221134","display_name":"Anhui Agricultural University","ror":"https://ror.org/0327f3359","country_code":"CN","type":"education","lineage":["https://openalex.org/I140221134"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Fei Shang","raw_affiliation_strings":["School of Life Sciences, Anhui Agricultural University, Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, Anhui Agricultural University, Hefei, China","institution_ids":["https://openalex.org/I140221134"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028982829","display_name":"Ting Xue","orcid":"https://orcid.org/0000-0002-5644-6613","observed_orcids":["https://orcid.org/0000-0002-5644-6613"]},"institutions":[{"id":"https://openalex.org/I140221134","display_name":"Anhui Agricultural University","ror":"https://ror.org/0327f3359","country_code":"CN","type":"education","lineage":["https://openalex.org/I140221134"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ting Xue","raw_affiliation_strings":["School of Life Sciences, Anhui Agricultural University, Hefei, China","Ting Xue, PhD, School of Life Sciences, Anhui Agricultural University, Changjiang Road, Hefei 230036, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, Anhui Agricultural University, Hefei, China","institution_ids":["https://openalex.org/I140221134"]},{"raw_affiliation_string":"Ting Xue, PhD, School of Life Sciences, Anhui Agricultural University, Changjiang Road, Hefei 230036, China","institution_ids":["https://openalex.org/I140221134"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5028982829","https://openalex.org/A5103190209"],"corresponding_institution_ids":["https://openalex.org/I140221134"],"apc_list":null,"apc_paid":null,"fwci":1.5291,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.79643798,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"26","issue":"10","first_page":"1163","last_page":"1173"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.6865000128746033,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.6865000128746033,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.17579999566078186,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.13459999859333038,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9350000023841858},{"id":"https://openalex.org/keywords/antimicrobial-resistance","display_name":"antimicrobial resistance","score":0.7390000224113464},{"id":"https://openalex.org/keywords/major-facilitator-superfamily","display_name":"major facilitator superfamily","score":0.8569999933242798},{"id":"https://openalex.org/keywords/cationic-antimicrobial-peptides","display_name":"cationic antimicrobial peptides","score":0.6700000166893005},{"id":"https://openalex.org/keywords/polymyxin-b","display_name":"polymyxin B","score":0.7120000123977661},{"id":"https://openalex.org/keywords/deoxycholic-acid","display_name":"deoxycholic acid","score":0.9750000238418579},{"id":"https://openalex.org/keywords/fluoroquinolones","display_name":"fluoroquinolones","score":0.6589999794960022},{"id":"https://openalex.org/keywords/tetracycline","display_name":"tetracycline","score":0.9110000133514404},{"id":"https://openalex.org/keywords/erythromycin","display_name":"erythromycin","score":0.8069999814033508},{"id":"https://openalex.org/keywords/sodium-dodecyl-sulfate","display_name":"sodium dodecyl sulfate","score":0.8009999990463257}],"concepts":[{"id":"https://openalex.org/C200082930","wikidata":"https://www.wikidata.org/wiki/Q22327148","display_name":"Efflux","level":2,"score":0.8320267200469971},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.6167550683021545},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6162468194961548},{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.581948459148407},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5787253379821777},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.5602697730064392},{"id":"https://openalex.org/C62465871","wikidata":"https://www.wikidata.org/wiki/Q1886097","display_name":"Major facilitator superfamily","level":4,"score":0.5486983060836792},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.4433269202709198},{"id":"https://openalex.org/C540938839","wikidata":"https://www.wikidata.org/wiki/Q1201508","display_name":"Antimicrobial peptides","level":3,"score":0.4112699627876282},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.33747684955596924},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32786625623703003},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.31945884227752686},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.26621490716934204},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2267410159111023},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08877676725387573}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024202","descriptor_name":"Electrophoretic Mobility Shift Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024901","descriptor_name":"Drug Resistance, Multiple, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1089/mdr.2019.0412","doi":"https://doi.org/10.1089/mdr.2019.0412","is_oa":false,"landing_page_url":"https://doi.org/10.1089/mdr.2019.0412","pdf_url":null,"source":{"id":"https://openalex.org/S178647319","display_name":"Microbial Drug Resistance","issn_l":"1076-6294","issn":["1076-6294","1931-8448"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbial Drug Resistance","raw_type":"journal-article"},{"id":"pmid:32379525","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32379525","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbial drug resistance (Larchmont, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1522037109","https://openalex.org/W1547922007","https://openalex.org/W1573080626","https://openalex.org/W1981044688","https://openalex.org/W1982693554","https://openalex.org/W1997155084","https://openalex.org/W1998776122","https://openalex.org/W1999189021","https://openalex.org/W2000470168","https://openalex.org/W2017161161","https://openalex.org/W2025311938","https://openalex.org/W2056390769","https://openalex.org/W2091813080","https://openalex.org/W2092941764","https://openalex.org/W2097952974","https://openalex.org/W2098299258","https://openalex.org/W2098708380","https://openalex.org/W2106192857","https://openalex.org/W2107250776","https://openalex.org/W2108559568","https://openalex.org/W2113412170","https://openalex.org/W2116137883","https://openalex.org/W2123286413","https://openalex.org/W2134640814","https://openalex.org/W2135929916","https://openalex.org/W2142193549","https://openalex.org/W2142324789","https://openalex.org/W2144371848","https://openalex.org/W2147051160","https://openalex.org/W2149144044","https://openalex.org/W2169110988","https://openalex.org/W2169420134","https://openalex.org/W2328724428","https://openalex.org/W2766522535","https://openalex.org/W2794378507","https://openalex.org/W2937251491"],"related_works":["https://openalex.org/W2054047881","https://openalex.org/W2099153693","https://openalex.org/W4319915907","https://openalex.org/W2020589081","https://openalex.org/W2107089464","https://openalex.org/W2097952974","https://openalex.org/W3083225497","https://openalex.org/W4378527957","https://openalex.org/W2000470168","https://openalex.org/W2171455103"],"abstract_inverted_index":{"Due":[0],"to":[1,17,45,54,68,97,147,170,202,212,223,231],"excessive":[2],"use":[3],"of":[4,10,25,31,35,50,103,122,191,218],"antimicrobial":[5,56,71,99,131,172,233],"agents":[6,100,234],"in":[7,82,109,235],"the":[8,32,46,69,76,90,114,119,149,156,164,188,203,210],"treatment":[9],"infectious":[11],"diseases,":[12],"bacteria":[13],"have":[14],"developed":[15],"resistance":[16,53,96],"antibacterial":[18,134],"drugs":[19],"and":[20,75,101,125,129,141,182,227,240],"toxic":[21],"compounds.":[22],"The":[23],"development":[24],"multidrug":[26,40,158],"efflux":[27,41,159],"pumps":[28],"is":[29],"one":[30],"important":[33],"mechanisms":[34],"bacterial":[36],"drug":[37],"resistance.":[38],"A":[39],"pump,":[42],"EmrD,":[43],"belonging":[44],"major":[47],"facilitator":[48],"superfamily":[49],"transporters,":[51],"confers":[52],"many":[55],"agents.":[57],"BasSR,":[58],"a":[59],"typical":[60],"two-component":[61],"signal":[62],"transduction":[63],"system":[64],"(TCS),":[65],"regulates":[66,155],"susceptibility":[67,94,132,169,230],"cationic":[70],"peptide,":[72],"polymyxin":[73],"B,":[74],"anionic":[77],"bile":[78],"detergent,":[79],"deoxycholic":[80],"acid,":[81],"Escherichia":[83],"coli":[84,111,237],".":[85,112,193],"However,":[86],"whether":[87],"or":[88,95],"not":[89,106],"BasSR":[91,154,215],"TCS":[92],"affects":[93],"other":[98],"transcription":[102,217],"emrD":[104,192,204,219],"has":[105],"been":[107],"reported":[108],"E.":[110,236],"In":[113],"present":[115],"study,":[116],"we":[117],"constructed":[118],"basSR":[120,165],"mutants":[121],"wild-type":[123],"MG1655":[124],"clinical":[126],"strain":[127],"APECX40":[128,239],"performed":[130],"testing,":[133],"activity":[135],"assays,":[136],"real-time":[137],"reverse":[138],"transcription\u2013PCR":[139],"experiments":[140],"electrophoretic":[142],"mobility":[143],"shift":[144],"assays":[145],"(EMSA)":[146],"investigate":[148],"molecular":[150],"mechanism":[151],"by":[152,186,220],"which":[153],"EmrD":[157],"pump.":[160],"Results":[161],"showed":[162],"that":[163,197,214],"mutation":[166],"increased":[167],"cell":[168],"eight":[171],"agents,":[173],"including":[174],"ciprofloxacin,":[175],"norfloxacin,":[176],"doxycycline,":[177],"tetracycline,":[178],"clindamycin,":[179],"lincomycin,":[180],"erythromycin,":[181],"sodium":[183],"dodecyl":[184],"sulfate,":[185],"downregulating":[187],"transcriptional":[189],"levels":[190],"Furthermore,":[194],"EMSA":[195],"indicated":[196],"BasR":[198],"could":[199],"directly":[200,222],"bind":[201],"promoter.":[205],"Therefore,":[206],"this":[207],"study":[208],"was":[209],"first":[211],"demonstrate":[213],"activates":[216],"binding":[221],"its":[224],"promoter":[225],"region,":[226],"then":[228],"decreases":[229],"various":[232],"strains,":[238],"MG1655.":[241]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2020-05-13T00:00:00"}