{"id":"https://openalex.org/W3022337494","doi":null,"title":"Improving Outcomes in NF1 Spine Fusion","display_name":"Improving Outcomes in NF1 Spine Fusion","publication_year":2018,"publication_date":"2018-03-01","ids":{"openalex":"https://openalex.org/W3022337494","mag":"3022337494"},"language":"en","primary_location":{"id":"pmh:oai:ses.library.usyd.edu.au:2123/19629","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2123/19629","pdf_url":"http://hdl.handle.net/2123/19629","source":{"id":"https://openalex.org/S4306402414","display_name":"The Sydney eScholarship Repository (The University of Sydney)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I129604602","host_organization_name":"The University of Sydney","host_organization_lineage":["https://openalex.org/I129604602"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2123/19629","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038717276","display_name":"Justin D. Bobyn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Justin D. Bobyn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5038717276"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.5023999810218811,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.5023999810218811,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10238","display_name":"Spine and Intervertebral Disc Pathology","score":0.17489999532699585,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11030","display_name":"Scoliosis diagnosis and treatment","score":0.11620000004768372,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neurofibromatosis-type-1","display_name":"neurofibromatosis type 1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/spinal-fusion","display_name":"spinal fusion","score":0.5849999785423279},{"id":"https://openalex.org/keywords/nonunion","display_name":"nonunion","score":0.8169999718666077},{"id":"https://openalex.org/keywords/bone-regeneration","display_name":"bone regeneration","score":0.671999990940094},{"id":"https://openalex.org/keywords/bmp-2","display_name":"BMP-2","score":0.8420000076293945},{"id":"https://openalex.org/keywords/posterolateral-fusion","display_name":"posterolateral fusion","score":0.7889999747276306},{"id":"https://openalex.org/keywords/bisphosphonates","display_name":"bisphosphonates","score":0.9710000157356262},{"id":"https://openalex.org/keywords/mek-inhibitors","display_name":"MEK inhibitors","score":0.7670000195503235},{"id":"https://openalex.org/keywords/pd0325901","display_name":"PD0325901","score":0.9459999799728394},{"id":"https://openalex.org/keywords/osteoclasts","display_name":"osteoclasts","score":0.8159999847412109},{"id":"https://openalex.org/keywords/bone-volume","display_name":"bone volume","score":0.3499999940395355},{"id":"https://openalex.org/keywords/scoliosis","display_name":"scoliosis","score":0.6010000109672546},{"id":"https://openalex.org/keywords/reoperation","display_name":"reoperation","score":0.42800000309944153},{"id":"https://openalex.org/keywords/hardware-failure","display_name":"hardware failure","score":0.6069999933242798}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.36441922187805176},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.35927480459213257},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32396823167800903}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:ses.library.usyd.edu.au:2123/19629","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2123/19629","pdf_url":"http://hdl.handle.net/2123/19629","source":{"id":"https://openalex.org/S4306402414","display_name":"The Sydney eScholarship Repository (The University of Sydney)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I129604602","host_organization_name":"The University of Sydney","host_organization_lineage":["https://openalex.org/I129604602"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:3022337494","doi":null,"is_oa":false,"landing_page_url":"https://ses.library.usyd.edu.au/bitstream/2123/19629/1/ex_final_thesis_bobyn.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:ses.library.usyd.edu.au:2123/19629","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2123/19629","pdf_url":"http://hdl.handle.net/2123/19629","source":{"id":"https://openalex.org/S4306402414","display_name":"The Sydney eScholarship Repository (The University of Sydney)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I129604602","host_organization_name":"The University of Sydney","host_organization_lineage":["https://openalex.org/I129604602"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307778","display_name":"Novartis","ror":"https://ror.org/02f9zrr09"},{"id":"https://openalex.org/F4320314720","display_name":"David and Elaine Potter Foundation","ror":"https://ror.org/0152k4249"},{"id":"https://openalex.org/F4320320543","display_name":"Cancer Institute NSW","ror":"https://ror.org/029a54f25"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"},{"id":"https://openalex.org/F4320334913","display_name":"Sydney Medical School","ror":"https://ror.org/0384j8v12"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3022337494.pdf","grobid_xml":"https://content.openalex.org/works/W3022337494.grobid-xml"},"referenced_works_count":303,"referenced_works":["https://openalex.org/W36192317","https://openalex.org/W42317101","https://openalex.org/W49726960","https://openalex.org/W86729096","https://openalex.org/W97531587","https://openalex.org/W99471555","https://openalex.org/W110659814","https://openalex.org/W135216744","https://openalex.org/W142118788","https://openalex.org/W207126484","https://openalex.org/W322115694","https://openalex.org/W384166580","https://openalex.org/W1025431016","https://openalex.org/W1482408012","https://openalex.org/W1504707262","https://openalex.org/W1598952686","https://openalex.org/W1601407383","https://openalex.org/W1608153977","https://openalex.org/W1755479008","https://openalex.org/W1897577213","https://openalex.org/W1900951750","https://openalex.org/W1912045171","https://openalex.org/W1916572066","https://openalex.org/W1931761759","https://openalex.org/W1935346479","https://openalex.org/W1951641979","https://openalex.org/W1955777007","https://openalex.org/W1963017444","https://openalex.org/W1964092665","https://openalex.org/W1965883473","https://openalex.org/W1965928609","https://openalex.org/W1966639987","https://openalex.org/W1969142291","https://openalex.org/W1969251725","https://openalex.org/W1971425911","https://openalex.org/W1973962596","https://openalex.org/W1974308921","https://openalex.org/W1975878890","https://openalex.org/W1976009942","https://openalex.org/W1977932913","https://openalex.org/W1979883349","https://openalex.org/W1980609837","https://openalex.org/W1982276813","https://openalex.org/W1982529531","https://openalex.org/W1982859926","https://openalex.org/W1983569024","https://openalex.org/W1983991575","https://openalex.org/W1984701700","https://openalex.org/W1985934723","https://openalex.org/W1986006836","https://openalex.org/W1986532020","https://openalex.org/W1986695347","https://openalex.org/W1987113787","https://openalex.org/W1987118864","https://openalex.org/W1989388708","https://openalex.org/W1989480169","https://openalex.org/W1989796644","https://openalex.org/W1989981411","https://openalex.org/W1991354830","https://openalex.org/W1992141537","https://openalex.org/W1993553171","https://openalex.org/W1993913999","https://openalex.org/W1993961824","https://openalex.org/W1994396134","https://openalex.org/W1995077100","https://openalex.org/W1995691656","https://openalex.org/W1995753103","https://openalex.org/W1996363353","https://openalex.org/W1997036108","https://openalex.org/W1997390496","https://openalex.org/W1997526887","https://openalex.org/W1997549639","https://openalex.org/W1998216604","https://openalex.org/W1998224433","https://openalex.org/W1999884166","https://openalex.org/W2000053231","https://openalex.org/W2002266390","https://openalex.org/W2002979237","https://openalex.org/W2003189934","https://openalex.org/W2003291578","https://openalex.org/W2003886757","https://openalex.org/W2004482902","https://openalex.org/W2004706898","https://openalex.org/W2004965145","https://openalex.org/W2005640989","https://openalex.org/W2005811962","https://openalex.org/W2006434260","https://openalex.org/W2006867952","https://openalex.org/W2007218601","https://openalex.org/W2007353429","https://openalex.org/W2007511061","https://openalex.org/W2007801151","https://openalex.org/W2008453935","https://openalex.org/W2008943389","https://openalex.org/W2008952772","https://openalex.org/W2009214237","https://openalex.org/W2010888588","https://openalex.org/W2011220054","https://openalex.org/W2011785865","https://openalex.org/W2012333093","https://openalex.org/W2013436917","https://openalex.org/W2014172138","https://openalex.org/W2015917668","https://openalex.org/W2017444651","https://openalex.org/W2017786636","https://openalex.org/W2021483187","https://openalex.org/W2022562215","https://openalex.org/W2022679333","https://openalex.org/W2023662052","https://openalex.org/W2023680421","https://openalex.org/W2025283556","https://openalex.org/W2027003966","https://openalex.org/W2027030154","https://openalex.org/W2032940634","https://openalex.org/W2034453630","https://openalex.org/W2036176224","https://openalex.org/W2036734184","https://openalex.org/W2039037835","https://openalex.org/W2039806744","https://openalex.org/W2039955422","https://openalex.org/W2040053082","https://openalex.org/W2041302276","https://openalex.org/W2043277144","https://openalex.org/W2043952117","https://openalex.org/W2044162320","https://openalex.org/W2045021204","https://openalex.org/W2046074704","https://openalex.org/W2047032063","https://openalex.org/W2049477401","https://openalex.org/W2049870142","https://openalex.org/W2050622412","https://openalex.org/W2050724926","https://openalex.org/W2050948800","https://openalex.org/W2051085471","https://openalex.org/W2051676691","https://openalex.org/W2052095991","https://openalex.org/W2052327266","https://openalex.org/W2053372607","https://openalex.org/W2054778208","https://openalex.org/W2056984915","https://openalex.org/W2057523915","https://openalex.org/W2058086606","https://openalex.org/W2058942784","https://openalex.org/W2060910232","https://openalex.org/W2061707990","https://openalex.org/W2063032387","https://openalex.org/W2063445980","https://openalex.org/W2064302505","https://openalex.org/W2065885294","https://openalex.org/W2067028423","https://openalex.org/W2067612136","https://openalex.org/W2068978246","https://openalex.org/W2071893342","https://openalex.org/W2072100512","https://openalex.org/W2072455411","https://openalex.org/W2072953611","https://openalex.org/W2073165102","https://openalex.org/W2074645659","https://openalex.org/W2075145355","https://openalex.org/W2075346785","https://openalex.org/W2075473552","https://openalex.org/W2077659966","https://openalex.org/W2077686012","https://openalex.org/W2077709639","https://openalex.org/W2078113367","https://openalex.org/W2079027396","https://openalex.org/W2079080229","https://openalex.org/W2079308378","https://openalex.org/W2079752932","https://openalex.org/W2079941700","https://openalex.org/W2080401999","https://openalex.org/W2080415283","https://openalex.org/W2081757224","https://openalex.org/W2082049512","https://openalex.org/W2083446839","https://openalex.org/W2083480667","https://openalex.org/W2084612017","https://openalex.org/W2084954724","https://openalex.org/W2086519895","https://openalex.org/W2087472570","https://openalex.org/W2088923877","https://openalex.org/W2089085053","https://openalex.org/W2089870628","https://openalex.org/W2091342622","https://openalex.org/W2091750967","https://openalex.org/W2092864149","https://openalex.org/W2093252878","https://openalex.org/W2093856706","https://openalex.org/W2093867725","https://openalex.org/W2094157167","https://openalex.org/W2094427465","https://openalex.org/W2094766832","https://openalex.org/W2095327120","https://openalex.org/W2095826496","https://openalex.org/W2096046981","https://openalex.org/W2096701673","https://openalex.org/W2096986655","https://openalex.org/W2097716284","https://openalex.org/W2099933061","https://openalex.org/W2100039503","https://openalex.org/W2100339435","https://openalex.org/W2100380960","https://openalex.org/W2101430383","https://openalex.org/W2103492381","https://openalex.org/W2104135721","https://openalex.org/W2104389955","https://openalex.org/W2104974378","https://openalex.org/W2108615403","https://openalex.org/W2109840550","https://openalex.org/W2111017231","https://openalex.org/W2112796714","https://openalex.org/W2113679184","https://openalex.org/W2115516793","https://openalex.org/W2115922568","https://openalex.org/W2117677113","https://openalex.org/W2120203403","https://openalex.org/W2120989136","https://openalex.org/W2124090816","https://openalex.org/W2125190962","https://openalex.org/W2126800859","https://openalex.org/W2128351535","https://openalex.org/W2130127002","https://openalex.org/W2130634454","https://openalex.org/W2130635700","https://openalex.org/W2130690907","https://openalex.org/W2134849200","https://openalex.org/W2135571875","https://openalex.org/W2136114366","https://openalex.org/W2138999315","https://openalex.org/W2139078309","https://openalex.org/W2140754284","https://openalex.org/W2140892832","https://openalex.org/W2141069547","https://openalex.org/W2142668667","https://openalex.org/W2144147624","https://openalex.org/W2144870421","https://openalex.org/W2145882426","https://openalex.org/W2147052103","https://openalex.org/W2147256573","https://openalex.org/W2147834547","https://openalex.org/W2149346727","https://openalex.org/W2150649911","https://openalex.org/W2153353344","https://openalex.org/W2153623499","https://openalex.org/W2154767933","https://openalex.org/W2154833555","https://openalex.org/W2155216263","https://openalex.org/W2157288494","https://openalex.org/W2159562139","https://openalex.org/W2161771297","https://openalex.org/W2162405918","https://openalex.org/W2163768016","https://openalex.org/W2164486535","https://openalex.org/W2164851664","https://openalex.org/W2170039745","https://openalex.org/W2171087727","https://openalex.org/W2171149582","https://openalex.org/W2171708959","https://openalex.org/W2172099875","https://openalex.org/W2181653402","https://openalex.org/W2209876008","https://openalex.org/W2211861814","https://openalex.org/W2229381877","https://openalex.org/W2246647439","https://openalex.org/W2258034682","https://openalex.org/W2272870230","https://openalex.org/W2273990438","https://openalex.org/W2280269944","https://openalex.org/W2283694670","https://openalex.org/W2283762250","https://openalex.org/W2288911367","https://openalex.org/W2301546793","https://openalex.org/W2313971463","https://openalex.org/W2315885991","https://openalex.org/W2317471812","https://openalex.org/W2321018715","https://openalex.org/W2321941869","https://openalex.org/W2325891751","https://openalex.org/W2329575366","https://openalex.org/W2329641157","https://openalex.org/W2330573005","https://openalex.org/W2336583262","https://openalex.org/W2396134644","https://openalex.org/W2419362778","https://openalex.org/W2419675327","https://openalex.org/W2434366154","https://openalex.org/W2441301171","https://openalex.org/W2496542349","https://openalex.org/W2555625607","https://openalex.org/W2589387659","https://openalex.org/W2591551761","https://openalex.org/W2597325383","https://openalex.org/W2605553993","https://openalex.org/W2616502174","https://openalex.org/W2740318324","https://openalex.org/W2741548122","https://openalex.org/W2745608765","https://openalex.org/W2770127492","https://openalex.org/W2772979776","https://openalex.org/W4242835275","https://openalex.org/W4299798482","https://openalex.org/W4317640763","https://openalex.org/W4319308262"],"related_works":["https://openalex.org/W3044842447","https://openalex.org/W2144870421","https://openalex.org/W2740318324","https://openalex.org/W1989480169","https://openalex.org/W2576020488","https://openalex.org/W2036179014","https://openalex.org/W2077709639","https://openalex.org/W2149346727","https://openalex.org/W1986006836","https://openalex.org/W2072455411"],"abstract_inverted_index":{"NF1":[0,44,129,371],"(neurofibromatosis":[1],"type":[2],"1)":[3],"is":[4],"a":[5,88,108,116,156,178,226,251,254,282,327,379,423,466,475,487],"relatively":[6],"common":[7],"genetic":[8,381,504],"disease":[9,508],"which":[10,73,331,361,491,516],"may":[11,511],"be":[12,223,363],"characterized":[13],"by":[14],"the":[15,39,48,63,67,84,189,195,199,209,231,244,269,276,338,353,404,427,433],"presence":[16],"of":[17,41,91,110,144,158,198,230,279,285,341,346,383,406,432,463,474,478,506],"scoliosis":[18,464],"and":[19,37,50,58,65,102,132,170,173,205,234,290,372,403],"altered":[20],"bone":[21,45,54,196,287,312,320,446],"metabolism,":[22],"amongst":[23],"its":[24],"many":[25],"orthopaedic":[26,180],"manifestations.":[27],"Traditionally,":[28],"spine":[29,51,85,130,271,357,374,479],"fusion":[30,146,200,272,358,396,434,480],"procedures":[31],"have":[32,217],"been":[33],"used":[34,364],"to":[35,71,126,134,154,166,268,332,336,351,356,365,426,492,496,517],"correct":[36],"limit":[38],"progression":[40],"this":[42,94,138,238,305,324,347,519],"deformity.":[43],"healing":[46,131],"at":[47],"tibia":[49,64],"feature":[52],"impaired":[53],"anabolism,":[55],"excessive":[56],"catabolism,":[57],"fibrosis.":[59],"Fibrotic":[60],"tissue":[61,293],"in":[62,93,137,202,213,243,261,304,314,359,400,468,481,499,503,509,515],"between":[66],"vertebrae":[68],"can":[69,74,86,222],"lead":[70],"pseudarthrosis,":[72,281],"require":[75],"substantive":[76,291],"clinical":[77,277],"intervention.":[78],"In":[79,322,460],"particular,":[80],"complications":[81],"associated":[82,224],"with":[83,98,182,188,225,275,298,418,440,452,470],"represent":[87],"significant":[89],"source":[90,109],"morbidity":[92],"population,":[95],"often":[96,113],"presenting":[97],"persistent":[99],"deformity,":[100],"pain,":[101],"hardware":[103],"failure.":[104],"Revision":[105],"procedures,":[106],"themselves":[107],"morbidity,":[111],"are":[112],"required":[114],"when":[115],"primary":[117,424],"procedure":[118],"has":[119],"failed.":[120],"This":[121,161,264,388],"thesis":[122],"explores":[123],"systematic":[124],"approaches":[125],"modelling":[127],"deficient":[128,484],"treatment":[133,462],"improve":[135,497],"outcomes":[136,498],"patient":[139],"population.":[140],"A":[141,343],"murine":[142,380],"model":[143,162,252,325,382,477],"posterolateral":[145],"using":[147,411],"rhBMP-2":[148,286],"(bone":[149],"morphogenetic":[150],"protein-2)":[151],"was":[152,163,171,211,265,288,294,350,386],"developed":[153],"test":[155,333,493],"range":[157],"pharmacological":[159],"interventions.":[160],"first":[164],"applied":[165,267],"Nf1":[167,232,483],"heterozygous":[168],"mice":[169,176],"reproducible":[172],"reliable.":[174],"Nf1+/-":[175,206],"exhibited":[177],"mild":[179],"phenotype":[181,340],"increased":[183,194,311,319],"osteoclasts":[184,428],"on":[185],"histology.":[186],"Treatment":[187],"bisphosphonate":[190],"Zoledronic":[191],"acid":[192],"(ZA)":[193],"volume":[197,313],"masses":[201],"both":[203,369],"control":[204],"mice,":[207,402],"though":[208],"improvement":[210],"larger":[212],"controls.":[214],"Several":[215],"studies":[216],"shown":[218],"that":[219,237],"tibial":[220],"pseudarthroses":[221],"localized":[227],"double":[228,259],"inactivation":[229,260],"gene,":[233],"we":[235,249],"speculated":[236],"could":[239,362],"underlie":[240],"local":[241,258],"lesions":[242],"spine.":[245],"To":[246,376],"recapitulate":[247],"this,":[248,378],"utilized":[250],"where":[253],"Cre-expressing":[255],"adenovirus":[256],"induced":[257],"Nf1flox/flox":[262],"mice.":[263,394],"then":[266],"established":[270],"model.":[273,306],"Consistent":[274],"presentation":[278],"spinal":[280],"limited":[283],"amount":[284],"formed":[289],"fibrous":[292],"present.":[295],"Targeted":[296],"treatments":[297,368],"pharmaceutical":[299],"agents":[300],"were":[301,398,409],"next":[302],"trialled":[303],"The":[307,472],"MEK":[308],"inhibitor":[309],"PD0325901":[310],"all":[315],"groups":[316],"while":[317],"ZA":[318],"density.":[321],"summary,":[323],"represents":[326,486],"robust":[328,488],"platform":[329,489],"upon":[330,490],"targeted":[334,494],"interventions":[335,495],"reduce":[337],"fibroproliferative":[339,476],"NF1.":[342,471,500],"second":[344],"goal":[345],"research":[348],"project":[349],"investigate":[352,518],"cellular":[354],"contributors":[355],"general,":[360],"design":[366],"new":[367,445,513],"for":[370],"non-NF1":[373],"fusion.":[375],"accomplish":[377],"lineage":[384,415,437],"tracking":[385],"employed.":[387],"featured":[389],"Tie2-":[390],"-creERT2:Col2.3-":[391],"GFP:Ai9":[392],"reporter":[393],"Spine":[395],"operations":[397],"performed":[399],"these":[401],"distribution":[405],"lineage-labelled":[407],"cells":[408,416,438,451,457],"traced":[410],"fluorescence.":[412],"Notably,":[413],"Tie2":[414],"co-labelled":[417,439],"TRAP":[419],"positive":[420],"cells,":[421],"suggesting":[422,444],"contribution":[425],"but":[429],"not":[430],"osteoblasts":[431],"mass.":[435],"Conversely,":[436],"Col2.3-GFP":[441],"expressing":[442],"osteoblasts,":[443],"primarily":[447],"arises":[448],"from":[449,455],"mesenchymal":[450],"negligible":[453],"input":[454],"endothelial":[456],"undergoing":[458],"transdifferentiation.":[459],"conclusion,":[461],"remains":[465],"challenge":[467],"individuals":[469],"development":[473],"an":[482],"mouse":[485],"Additionally,":[501],"advancements":[502],"modeling":[505],"human":[507],"animals":[510],"provide":[512],"models":[514],"process.":[520]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-05-13T00:00:00"}