{"id":"https://openalex.org/W3022249552","doi":"https://doi.org/10.1016/j.ejmech.2020.112368","title":"Synthesis, in vitro evaluation and molecular docking of a new class of indolylpropyl benzamidopiperazines as dual AChE and SERT ligands for Alzheimer\u2019s disease","display_name":"Synthesis, in vitro evaluation and molecular docking of a new class of indolylpropyl benzamidopiperazines as dual AChE and SERT ligands for Alzheimer\u2019s disease","publication_year":2020,"publication_date":"2020-04-29","ids":{"openalex":"https://openalex.org/W3022249552","doi":"https://doi.org/10.1016/j.ejmech.2020.112368","mag":"3022249552","pmid":"https://pubmed.ncbi.nlm.nih.gov/32388114"},"language":"en","primary_location":{"id":"doi:10.1016/j.ejmech.2020.112368","doi":"https://doi.org/10.1016/j.ejmech.2020.112368","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ejmech.2020.112368","pdf_url":null,"source":{"id":"https://openalex.org/S4210169613","display_name":"European Journal of Medicinal Chemistry","issn_l":"0223-5234","issn":["0223-5234","1768-3254"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://repositorio.uchile.cl/handle/2250/176046","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055270569","display_name":"Julio Rodr\u00edguez-Lavado","orcid":"https://orcid.org/0000-0003-2728-9433","observed_orcids":["https://orcid.org/0000-0003-2728-9433"]},"institutions":[{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Julio Rodr\u00edguez-Lavado","raw_affiliation_strings":["Departamento de Qu\u00edmica Org\u00e1nica y Fisicoqu\u00edmica, Facultad de Ciencias Qu\u00edmicas y Farmac\u00e9uticas, Universidad de Chile, Olivos, 1007, Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Qu\u00edmica Org\u00e1nica y Fisicoqu\u00edmica, Facultad de Ciencias Qu\u00edmicas y Farmac\u00e9uticas, Universidad de Chile, Olivos, 1007, Santiago, Chile","institution_ids":["https://openalex.org/I69737025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017994267","display_name":"Carlos Gallardo\u2010Garrido","orcid":"https://orcid.org/0000-0002-7837-6003","observed_orcids":["https://orcid.org/0000-0002-7837-6003"]},"institutions":[{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Carlos Gallardo-Garrido","raw_affiliation_strings":["Departamento de Qu\u00edmica Org\u00e1nica y Fisicoqu\u00edmica, Facultad de Ciencias Qu\u00edmicas y Farmac\u00e9uticas, Universidad de Chile, Olivos, 1007, Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Qu\u00edmica Org\u00e1nica y Fisicoqu\u00edmica, Facultad de Ciencias Qu\u00edmicas y Farmac\u00e9uticas, Universidad de Chile, Olivos, 1007, Santiago, Chile","institution_ids":["https://openalex.org/I69737025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067945483","display_name":"Michael Mallea","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Michael Mallea","raw_affiliation_strings":["Departamento de Qu\u00edmica Org\u00e1nica y Fisicoqu\u00edmica, Facultad de Ciencias Qu\u00edmicas y Farmac\u00e9uticas, Universidad de Chile, Olivos, 1007, Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Qu\u00edmica Org\u00e1nica y Fisicoqu\u00edmica, Facultad de Ciencias Qu\u00edmicas y Farmac\u00e9uticas, Universidad de Chile, Olivos, 1007, Santiago, Chile","institution_ids":["https://openalex.org/I69737025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059968730","display_name":"Victor Bustos","orcid":"https://orcid.org/0000-0002-2251-8295","observed_orcids":["https://orcid.org/0000-0002-2251-8295"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victor Bustos","raw_affiliation_strings":["Laboratory of Cellular and Molecular Neuroscience, The Rockefeller University, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular and Molecular Neuroscience, The Rockefeller University, New York, USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039512235","display_name":"Rodrigo Osorio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Rodrigo Osorio","raw_affiliation_strings":["Departamento de Qu\u00edmica Org\u00e1nica y Fisicoqu\u00edmica, Facultad de Ciencias Qu\u00edmicas y Farmac\u00e9uticas, Universidad de Chile, Olivos, 1007, Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Qu\u00edmica Org\u00e1nica y Fisicoqu\u00edmica, Facultad de Ciencias Qu\u00edmicas y Farmac\u00e9uticas, Universidad de Chile, Olivos, 1007, Santiago, Chile","institution_ids":["https://openalex.org/I69737025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089356704","display_name":"Mart\u00edn H\u00f6dar-Salazar","orcid":"https://orcid.org/0000-0002-4266-5647","observed_orcids":["https://orcid.org/0000-0002-4266-5647"]},"institutions":[{"id":"https://openalex.org/I11944219","display_name":"Universidad de La Frontera","ror":"https://ror.org/04v0snf24","country_code":"CL","type":"education","lineage":["https://openalex.org/I11944219"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Mart\u00edn H\u00f6dar-Salazar","raw_affiliation_strings":["Departamento de Ciencias Qu\u00edmicas y Recursos Naturales, Facultad de Ingenier\u00eda Ciencias, Universidad de la Frontera, Temuco, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Ciencias Qu\u00edmicas y Recursos Naturales, Facultad de Ingenier\u00eda Ciencias, Universidad de la Frontera, Temuco, Chile","institution_ids":["https://openalex.org/I11944219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043782468","display_name":"Hery Chung","orcid":"https://orcid.org/0000-0001-8992-0337","observed_orcids":["https://orcid.org/0000-0001-8992-0337"]},"institutions":[{"id":"https://openalex.org/I162148367","display_name":"Pontificia Universidad Cat\u00f3lica de Chile","ror":"https://ror.org/04teye511","country_code":"CL","type":"education","lineage":["https://openalex.org/I162148367"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Hery Chung","raw_affiliation_strings":["Departamento de Farmacia, Facultad de Qu\u00edmica, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Farmacia, Facultad de Qu\u00edmica, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile","institution_ids":["https://openalex.org/I162148367"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069461717","display_name":"Ramiro Araya\u2010Maturana","orcid":"https://orcid.org/0000-0002-5082-9146","observed_orcids":["https://orcid.org/0000-0002-5082-9146"]},"institutions":[{"id":"https://openalex.org/I134695357","display_name":"Universidad de Talca","ror":"https://ror.org/01s4gpq44","country_code":"CL","type":"education","lineage":["https://openalex.org/I134695357"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Ramiro Araya-Maturana","raw_affiliation_strings":["Instituto de Qu\u00edmica de Recursos Naturales, Universidad de Talca, Talca, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Qu\u00edmica de Recursos Naturales, Universidad de Talca, Talca, Chile","institution_ids":["https://openalex.org/I134695357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073927568","display_name":"Marcos Lorca","orcid":"https://orcid.org/0000-0003-3729-0980","observed_orcids":["https://orcid.org/0000-0003-3729-0980"]},"institutions":[{"id":"https://openalex.org/I200284239","display_name":"Universidade de Santiago de Compostela","ror":"https://ror.org/030eybx10","country_code":"ES","type":"education","lineage":["https://openalex.org/I200284239"]},{"id":"https://openalex.org/I79274474","display_name":"University of Valpara\u00edso","ror":"https://ror.org/00h9jrb69","country_code":"CL","type":"education","lineage":["https://openalex.org/I79274474"]}],"countries":["CL","ES"],"is_corresponding":false,"raw_author_name":"Marcos Lorca","raw_affiliation_strings":["Centro Singular de Investigaci\u00f3n en Qu\u00edmica Biol\u00f3xica e Materiais Moleculares, Universidade de Santiago de Compostela, Santiago de Compostela, Spain; Instituto de Qu\u00edmica y Bioqu\u00edmica, Facultad de Ciencias, Universidad de Valpara\u00edso, Valpara\u00edso, Chile","Centro Singular de Investigaci\u00f3n en Qu\u00edmica Biol\u00f3xica e Materiais Moleculares, Universidade de Santiago de Compostela, Santiago de Compostela, Spain","Instituto de Qu\u00edmica y Bioqu\u00edmica, Facultad de Ciencias, Universidad de Valpara\u00edso, Valpara\u00edso, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Singular de Investigaci\u00f3n en Qu\u00edmica Biol\u00f3xica e Materiais Moleculares, Universidade de Santiago de Compostela, Santiago de Compostela, Spain; Instituto de Qu\u00edmica y Bioqu\u00edmica, Facultad de Ciencias, Universidad de Valpara\u00edso, Valpara\u00edso, Chile","institution_ids":["https://openalex.org/I200284239","https://openalex.org/I79274474"]},{"raw_affiliation_string":"Centro Singular de Investigaci\u00f3n en Qu\u00edmica Biol\u00f3xica e Materiais Moleculares, Universidade de Santiago de Compostela, Santiago de Compostela, Spain","institution_ids":["https://openalex.org/I200284239"]},{"raw_affiliation_string":"Instituto de Qu\u00edmica y Bioqu\u00edmica, Facultad de Ciencias, Universidad de Valpara\u00edso, Valpara\u00edso, Chile","institution_ids":["https://openalex.org/I79274474"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081599854","display_name":"Carlos David Pessoa-Mahana","orcid":"https://orcid.org/0000-0002-9571-0173","observed_orcids":["https://orcid.org/0000-0002-9571-0173"]},"institutions":[{"id":"https://openalex.org/I162148367","display_name":"Pontificia Universidad Cat\u00f3lica de Chile","ror":"https://ror.org/04teye511","country_code":"CL","type":"education","lineage":["https://openalex.org/I162148367"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"C. David Pessoa-Mahana","raw_affiliation_strings":["Departamento de Farmacia, Facultad de Qu\u00edmica, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Farmacia, Facultad de Qu\u00edmica, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile","institution_ids":["https://openalex.org/I162148367"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039270117","display_name":"Jaime Mella","orcid":"https://orcid.org/0000-0002-2434-8461","observed_orcids":["https://orcid.org/0000-0002-2434-8461"]},"institutions":[{"id":"https://openalex.org/I79274474","display_name":"University of Valpara\u00edso","ror":"https://ror.org/00h9jrb69","country_code":"CL","type":"education","lineage":["https://openalex.org/I79274474"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Jaime Mella-Raip\u00e1n","raw_affiliation_strings":["Instituto de Qu\u00edmica y Bioqu\u00edmica, Facultad de Ciencias, Universidad de Valpara\u00edso, Valpara\u00edso, Chile; Centro de Investigaci\u00f3n Farmacopea Chilena (CIFAR), Universidad de Valpara\u00edso, Santa Marta, Valpara\u00edso, Chile","Centro de Investigaci\u00f3n Farmacopea Chilena (CIFAR), Universidad de Valpara\u00edso, Santa Marta, Valpara\u00edso, Chile","Instituto de Qu\u00edmica y Bioqu\u00edmica, Facultad de Ciencias, Universidad de Valpara\u00edso, Valpara\u00edso, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Qu\u00edmica y Bioqu\u00edmica, Facultad de Ciencias, Universidad de Valpara\u00edso, Valpara\u00edso, Chile; Centro de Investigaci\u00f3n Farmacopea Chilena (CIFAR), Universidad de Valpara\u00edso, Santa Marta, Valpara\u00edso, Chile","institution_ids":["https://openalex.org/I79274474"]},{"raw_affiliation_string":"Centro de Investigaci\u00f3n Farmacopea Chilena (CIFAR), Universidad de Valpara\u00edso, Santa Marta, Valpara\u00edso, Chile","institution_ids":["https://openalex.org/I79274474"]},{"raw_affiliation_string":"Instituto de Qu\u00edmica y Bioqu\u00edmica, Facultad de Ciencias, Universidad de Valpara\u00edso, Valpara\u00edso, Chile","institution_ids":["https://openalex.org/I79274474"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022856313","display_name":"Claudio Saitz","orcid":"https://orcid.org/0000-0002-2601-2064","observed_orcids":["https://orcid.org/0000-0002-2601-2064"]},"institutions":[{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Claudio Saitz","raw_affiliation_strings":["Departamento de Qu\u00edmica Org\u00e1nica y Fisicoqu\u00edmica, Facultad de Ciencias Qu\u00edmicas y Farmac\u00e9uticas, Universidad de Chile, Olivos, 1007, Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Qu\u00edmica Org\u00e1nica y Fisicoqu\u00edmica, Facultad de Ciencias Qu\u00edmicas y Farmac\u00e9uticas, Universidad de Chile, Olivos, 1007, Santiago, Chile","institution_ids":["https://openalex.org/I69737025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010120357","display_name":"Pablo Jaque","orcid":"https://orcid.org/0000-0002-4055-3553","observed_orcids":["https://orcid.org/0000-0002-4055-3553"]},"institutions":[{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Pablo Jaque","raw_affiliation_strings":["Departamento de Qu\u00edmica Org\u00e1nica y Fisicoqu\u00edmica, Facultad de Ciencias Qu\u00edmicas y Farmac\u00e9uticas, Universidad de Chile, Olivos, 1007, Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Qu\u00edmica Org\u00e1nica y Fisicoqu\u00edmica, Facultad de Ciencias Qu\u00edmicas y Farmac\u00e9uticas, Universidad de Chile, Olivos, 1007, Santiago, Chile","institution_ids":["https://openalex.org/I69737025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004785517","display_name":"Miguel Iv\u00e1n Reyes-Parada","orcid":"https://orcid.org/0000-0002-2376-990X","observed_orcids":["https://orcid.org/0000-0002-2376-990X"]},"institutions":[{"id":"https://openalex.org/I10457146","display_name":"Universidad de Santiago de Chile","ror":"https://ror.org/02ma57s91","country_code":"CL","type":"education","lineage":["https://openalex.org/I10457146"]},{"id":"https://openalex.org/I3121512035","display_name":"Universidad Aut\u00f3noma de Chile","ror":"https://ror.org/010r9dy59","country_code":"CL","type":"education","lineage":["https://openalex.org/I3121512035"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Miguel Reyes-Parada","raw_affiliation_strings":["Centro de Investigaci\u00f3n Biom\u00e9dica y Aplicada (CIBAP), Escuela de Medicina, Facultad de Ciencias M\u00e9dicas, Universidad de Santiago de Chile, Chile; Facultad de Ciencias de la Salud, Universidad Aut\u00f3noma de Chile, Santiago, Chile","Centro de Investigaci\u00f3n Biom\u00e9dica y Aplicada (CIBAP), Escuela de Medicina, Facultad de Ciencias M\u00e9dicas, Universidad de Santiago de Chile, Chile","Facultad de Ciencias de la Salud, Universidad Aut\u00f3noma de Chile, Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n Biom\u00e9dica y Aplicada (CIBAP), Escuela de Medicina, Facultad de Ciencias M\u00e9dicas, Universidad de Santiago de Chile, Chile; Facultad de Ciencias de la Salud, Universidad Aut\u00f3noma de Chile, Santiago, Chile","institution_ids":["https://openalex.org/I10457146","https://openalex.org/I3121512035"]},{"raw_affiliation_string":"Centro de Investigaci\u00f3n Biom\u00e9dica y Aplicada (CIBAP), Escuela de Medicina, Facultad de Ciencias M\u00e9dicas, Universidad de Santiago de Chile, Chile","institution_ids":["https://openalex.org/I10457146"]},{"raw_affiliation_string":"Facultad de Ciencias de la Salud, Universidad Aut\u00f3noma de Chile, Santiago, Chile","institution_ids":["https://openalex.org/I3121512035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036458915","display_name":"Patricio Iturriaga\u2010V\u00e1squez","orcid":"https://orcid.org/0000-0003-0553-1014","observed_orcids":["https://orcid.org/0000-0003-0553-1014"]},"institutions":[{"id":"https://openalex.org/I11944219","display_name":"Universidad de La Frontera","ror":"https://ror.org/04v0snf24","country_code":"CL","type":"education","lineage":["https://openalex.org/I11944219"]}],"countries":["CL"],"is_corresponding":true,"raw_author_name":"Patricio Iturriaga-V\u00e1squez","raw_affiliation_strings":["Departamento de Ciencias Qu\u00edmicas y Recursos Naturales, Facultad de Ingenier\u00eda Ciencias, Universidad de la Frontera, Temuco, Chile; Center of Excellence in Biotechnology Research Applied to the Environment, Universidad de La Frontera, Temuco, Chile. Electronic address: patricio.iturriaga@ufrontera.cl","Center of Excellence in Biotechnology Research Applied to the Environment, Universidad de La Frontera, Temuco, Chile","Departamento de Ciencias Qu\u00edmicas y Recursos Naturales, Facultad de Ingenier\u00eda Ciencias, Universidad de la Frontera, Temuco, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Ciencias Qu\u00edmicas y Recursos Naturales, Facultad de Ingenier\u00eda Ciencias, Universidad de la Frontera, Temuco, Chile; Center of Excellence in Biotechnology Research Applied to the Environment, Universidad de La Frontera, Temuco, Chile. Electronic address: patricio.iturriaga@ufrontera.cl","institution_ids":["https://openalex.org/I11944219"]},{"raw_affiliation_string":"Center of Excellence in Biotechnology Research Applied to the Environment, Universidad de La Frontera, Temuco, Chile","institution_ids":["https://openalex.org/I11944219"]},{"raw_affiliation_string":"Departamento de Ciencias Qu\u00edmicas y Recursos Naturales, Facultad de Ingenier\u00eda Ciencias, Universidad de la Frontera, Temuco, Chile","institution_ids":["https://openalex.org/I11944219"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108430051","display_name":"Hern\u00e1n Armando Pessoa-Mahana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":true,"raw_author_name":"Hern\u00e1n Pessoa-Mahana","raw_affiliation_strings":["Departamento de Qu\u00edmica Org\u00e1nica y Fisicoqu\u00edmica, Facultad de Ciencias Qu\u00edmicas y Farmac\u00e9uticas, Universidad de Chile, Olivos, 1007, Santiago, Chile. Electronic address: hpessoa@ciq.uchile.cl","Departamento de Qu\u00edmica Org\u00e1nica y Fisicoqu\u00edmica, Facultad de Ciencias Qu\u00edmicas y Farmac\u00e9uticas, Universidad de Chile, Olivos, 1007, Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Qu\u00edmica Org\u00e1nica y Fisicoqu\u00edmica, Facultad de Ciencias Qu\u00edmicas y Farmac\u00e9uticas, Universidad de Chile, Olivos, 1007, Santiago, Chile. Electronic address: hpessoa@ciq.uchile.cl","institution_ids":["https://openalex.org/I69737025"]},{"raw_affiliation_string":"Departamento de Qu\u00edmica Org\u00e1nica y Fisicoqu\u00edmica, Facultad de Ciencias Qu\u00edmicas y Farmac\u00e9uticas, Universidad de Chile, Olivos, 1007, Santiago, Chile","institution_ids":["https://openalex.org/I69737025"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5036458915","https://openalex.org/A5108430051"],"corresponding_institution_ids":["https://openalex.org/I11944219","https://openalex.org/I69737025"],"apc_list":{"value":3400,"currency":"USD","value_usd":3400},"apc_paid":null,"fwci":2.5773,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.88303098,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"198","issue":null,"first_page":"112368","last_page":"112368"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.925000011920929},{"id":"https://openalex.org/keywords/acetylcholinesterase-inhibition","display_name":"acetylcholinesterase inhibition","score":0.9769999980926514},{"id":"https://openalex.org/keywords/serotonin-transporter","display_name":"serotonin transporter","score":0.9279999732971191},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.6740000247955322},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.7870000004768372},{"id":"https://openalex.org/keywords/citalopram","display_name":"citalopram","score":0.6439999938011169},{"id":"https://openalex.org/keywords/donepezil","display_name":"donepezil","score":0.859000027179718}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8297726511955261},{"id":"https://openalex.org/C2778816929","wikidata":"https://www.wikidata.org/wiki/Q22676679","display_name":"Acetylcholinesterase","level":3,"score":0.7354850769042969},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.5914018154144287},{"id":"https://openalex.org/C2779059548","wikidata":"https://www.wikidata.org/wiki/Q383701","display_name":"Ach\u00e9","level":4,"score":0.5517197251319885},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.543615996837616},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5416032075881958},{"id":"https://openalex.org/C2780904820","wikidata":"https://www.wikidata.org/wiki/Q415081","display_name":"Donepezil","level":4,"score":0.5051615834236145},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.4768011271953583},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.474433571100235},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.47268229722976685},{"id":"https://openalex.org/C2778897192","wikidata":"https://www.wikidata.org/wiki/Q410142","display_name":"Serotonin transporter","level":4,"score":0.44443055987358093},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.43018126487731934},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4020713269710541},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2740674316883087},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.2343476116657257},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1769115924835205},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1059359610080719},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.08538451790809631},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08230006694793701},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000077265","descriptor_name":"Donepezil","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000110","descriptor_name":"Acetylcholinesterase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002800","descriptor_name":"Cholinesterase Inhibitors","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D002800","descriptor_name":"Cholinesterase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017367","descriptor_name":"Selective Serotonin Reuptake Inhibitors","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D017367","descriptor_name":"Selective Serotonin Reuptake Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D050486","descriptor_name":"Serotonin Plasma Membrane Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.ejmech.2020.112368","doi":"https://doi.org/10.1016/j.ejmech.2020.112368","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ejmech.2020.112368","pdf_url":null,"source":{"id":"https://openalex.org/S4210169613","display_name":"European Journal of Medicinal Chemistry","issn_l":"0223-5234","issn":["0223-5234","1768-3254"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:32388114","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32388114","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of medicinal chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:repositorio.uchile.cl:2250/176046","doi":null,"is_oa":true,"landing_page_url":"https://repositorio.uchile.cl/handle/2250/176046","pdf_url":null,"source":{"id":"https://openalex.org/S4306481413","display_name":"Universidad de Chile","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"European Journal of Medicinal Chemistry","raw_type":"Art\u00edculo de revista"},{"id":"pmh:oai:repositorio.ufro.cl:9636","doi":null,"is_oa":true,"landing_page_url":"https://repositorio.ufro.cl/s/repositorio-ufro/item/9636","pdf_url":null,"source":{"id":"https://openalex.org/S7407063275","display_name":"Omeka S (Universidad de La Frontera)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY","raw_type":"art\u00edculo original"}],"best_oa_location":{"id":"pmh:oai:repositorio.uchile.cl:2250/176046","doi":null,"is_oa":true,"landing_page_url":"https://repositorio.uchile.cl/handle/2250/176046","pdf_url":null,"source":{"id":"https://openalex.org/S4306481413","display_name":"Universidad de Chile","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"European Journal of Medicinal Chemistry","raw_type":"Art\u00edculo de revista"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3309662383","display_name":null,"funder_award_id":"1170662","funder_id":"https://openalex.org/F4320338073","funder_display_name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico"},{"id":"https://openalex.org/G3939835507","display_name":null,"funder_award_id":"1170269","funder_id":"https://openalex.org/F4320338073","funder_display_name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico"},{"id":"https://openalex.org/G5528889889","display_name":null,"funder_award_id":"3170264","funder_id":"https://openalex.org/F4320338073","funder_display_name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico"}],"funders":[{"id":"https://openalex.org/F4320306696","display_name":"Fisher Center for Alzheimer's Research Foundation","ror":"https://ror.org/008bs5r20"},{"id":"https://openalex.org/F4320334812","display_name":"Comisi\u00f3n Nacional de Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","ror":"https://ror.org/02ap3w078"},{"id":"https://openalex.org/F4320338073","display_name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","ror":"https://ror.org/02ap3w078"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":79,"referenced_works":["https://openalex.org/W1554329005","https://openalex.org/W1677762000","https://openalex.org/W1808513053","https://openalex.org/W1820073353","https://openalex.org/W1862854239","https://openalex.org/W1927262698","https://openalex.org/W1933643218","https://openalex.org/W1964822121","https://openalex.org/W1969838378","https://openalex.org/W1970084030","https://openalex.org/W1975691556","https://openalex.org/W1977085392","https://openalex.org/W1979823761","https://openalex.org/W1984417882","https://openalex.org/W1985097707","https://openalex.org/W1993672505","https://openalex.org/W1996512945","https://openalex.org/W1996874773","https://openalex.org/W1997288864","https://openalex.org/W2004465970","https://openalex.org/W2013533632","https://openalex.org/W2023591147","https://openalex.org/W2028195884","https://openalex.org/W2029667189","https://openalex.org/W2053288363","https://openalex.org/W2054059195","https://openalex.org/W2059309243","https://openalex.org/W2077338272","https://openalex.org/W2093378782","https://openalex.org/W2095367777","https://openalex.org/W2102377211","https://openalex.org/W2106383417","https://openalex.org/W2109559465","https://openalex.org/W2112006614","https://openalex.org/W2134967712","https://openalex.org/W2137777161","https://openalex.org/W2143450384","https://openalex.org/W2143546082","https://openalex.org/W2149196013","https://openalex.org/W2151585937","https://openalex.org/W2170124061","https://openalex.org/W2322796880","https://openalex.org/W2328961664","https://openalex.org/W2331264465","https://openalex.org/W2333346687","https://openalex.org/W2340026231","https://openalex.org/W2345866556","https://openalex.org/W2353776455","https://openalex.org/W2520082135","https://openalex.org/W2524130802","https://openalex.org/W2553774099","https://openalex.org/W2564288682","https://openalex.org/W2610795807","https://openalex.org/W2616578069","https://openalex.org/W2621769828","https://openalex.org/W2707932262","https://openalex.org/W2762868189","https://openalex.org/W2775724624","https://openalex.org/W2795741829","https://openalex.org/W2796303051","https://openalex.org/W2808628286","https://openalex.org/W2841390334","https://openalex.org/W2891367558","https://openalex.org/W2900885821","https://openalex.org/W2903433826","https://openalex.org/W2921921085","https://openalex.org/W2938480571","https://openalex.org/W2954623283","https://openalex.org/W2957558461","https://openalex.org/W2958260438","https://openalex.org/W2966392303","https://openalex.org/W2966431778","https://openalex.org/W2967799495","https://openalex.org/W2982314601","https://openalex.org/W2996164725","https://openalex.org/W3126638370","https://openalex.org/W4211213171","https://openalex.org/W6727132534","https://openalex.org/W6770102774"],"related_works":["https://openalex.org/W2054059195","https://openalex.org/W4412518431","https://openalex.org/W4377224618","https://openalex.org/W4416920975","https://openalex.org/W4387357696","https://openalex.org/W2911230186","https://openalex.org/W4316174712","https://openalex.org/W2025223727","https://openalex.org/W2093648716","https://openalex.org/W7133326971"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2020-05-13T00:00:00"}
