{"id":"https://openalex.org/W3022201611","doi":"https://doi.org/10.1136/jech-2019-ssmabstracts.103","title":"OP100 Association between hypertensive disorders of pregnancy and attention deficit hyperactivity disorder: a population-based and sibling-matched cohort study","display_name":"OP100 Association between hypertensive disorders of pregnancy and attention deficit hyperactivity disorder: a population-based and sibling-matched cohort study","publication_year":2019,"publication_date":"2019-09-01","ids":{"openalex":"https://openalex.org/W3022201611","doi":"https://doi.org/10.1136/jech-2019-ssmabstracts.103","mag":"3022201611"},"language":"en","primary_location":{"id":"doi:10.1136/jech-2019-ssmabstracts.103","doi":"https://doi.org/10.1136/jech-2019-ssmabstracts.103","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jech-2019-ssmabstracts.103","pdf_url":"https://jech.bmj.com/content/jech/73/Suppl_1/A49.1.full.pdf","source":{"id":"https://openalex.org/S4306521614","display_name":"Oral Presentations","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oral Presentations","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://jech.bmj.com/content/jech/73/Suppl_1/A49.1.full.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022578555","display_name":"GM Maher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27577105","display_name":"University College Cork","ror":"https://ror.org/03265fv13","country_code":"IE","type":"education","lineage":["https://openalex.org/I27577105"]},{"id":"https://openalex.org/I4210101467","display_name":"Infant","ror":"https://ror.org/00men8398","country_code":"IE","type":"facility","lineage":["https://openalex.org/I4210101467"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"GM Maher","raw_affiliation_strings":["School of Public Health, University College Cork, Cork, Ireland","The Irish Centre for Fetal and Neonatal Translational Research (INFANT), Cork University Maternity Hospital and University College Cork, Cork, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, University College Cork, Cork, Ireland","institution_ids":["https://openalex.org/I27577105"]},{"raw_affiliation_string":"The Irish Centre for Fetal and Neonatal Translational Research (INFANT), Cork University Maternity Hospital and University College Cork, Cork, Ireland","institution_ids":["https://openalex.org/I27577105","https://openalex.org/I4210101467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072336887","display_name":"Christina Dalman","orcid":"https://orcid.org/0000-0002-3579-2357","observed_orcids":["https://orcid.org/0000-0002-3579-2357"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"C Dalman","raw_affiliation_strings":["Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058165350","display_name":"Patricia M. Kearney","orcid":"https://orcid.org/0000-0001-9599-3540","observed_orcids":["https://orcid.org/0000-0001-9599-3540"]},"institutions":[{"id":"https://openalex.org/I27577105","display_name":"University College Cork","ror":"https://ror.org/03265fv13","country_code":"IE","type":"education","lineage":["https://openalex.org/I27577105"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"PM Kearney","raw_affiliation_strings":["School of Public Health, University College Cork, Cork, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, University College Cork, Cork, Ireland","institution_ids":["https://openalex.org/I27577105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025229027","display_name":"GW O\u2019Keeffe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27577105","display_name":"University College Cork","ror":"https://ror.org/03265fv13","country_code":"IE","type":"education","lineage":["https://openalex.org/I27577105"]},{"id":"https://openalex.org/I4210101467","display_name":"Infant","ror":"https://ror.org/00men8398","country_code":"IE","type":"facility","lineage":["https://openalex.org/I4210101467"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"GW O\u2019Keeffe","raw_affiliation_strings":["Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland","The Irish Centre for Fetal and Neonatal Translational Research (INFANT), Cork University Maternity Hospital and University College Cork, Cork, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland","institution_ids":["https://openalex.org/I27577105"]},{"raw_affiliation_string":"The Irish Centre for Fetal and Neonatal Translational Research (INFANT), Cork University Maternity Hospital and University College Cork, Cork, Ireland","institution_ids":["https://openalex.org/I27577105","https://openalex.org/I4210101467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080594604","display_name":"Fergus P. McCarthy","orcid":"https://orcid.org/0000-0001-5062-6851","observed_orcids":["https://orcid.org/0000-0001-5062-6851"]},"institutions":[{"id":"https://openalex.org/I27577105","display_name":"University College Cork","ror":"https://ror.org/03265fv13","country_code":"IE","type":"education","lineage":["https://openalex.org/I27577105"]},{"id":"https://openalex.org/I4210101467","display_name":"Infant","ror":"https://ror.org/00men8398","country_code":"IE","type":"facility","lineage":["https://openalex.org/I4210101467"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"FP McCarthy","raw_affiliation_strings":["The Irish Centre for Fetal and Neonatal Translational Research (INFANT), Cork University Maternity Hospital and University College Cork, Cork, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Irish Centre for Fetal and Neonatal Translational Research (INFANT), Cork University Maternity Hospital and University College Cork, Cork, Ireland","institution_ids":["https://openalex.org/I27577105","https://openalex.org/I4210101467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015809298","display_name":"Louise C. Kenny","orcid":"https://orcid.org/0000-0002-9011-759X","observed_orcids":["https://orcid.org/0000-0002-9011-759X"]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"LC Kenny","raw_affiliation_strings":["Department of Women\u2019s and Children\u2019s Health, University of Liverpool, Liverpool, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Women\u2019s and Children\u2019s Health, University of Liverpool, Liverpool, UK","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084151874","display_name":"Ali S. Khashan","orcid":"https://orcid.org/0000-0002-7499-9406","observed_orcids":["https://orcid.org/0000-0002-7499-9406"]},"institutions":[{"id":"https://openalex.org/I27577105","display_name":"University College Cork","ror":"https://ror.org/03265fv13","country_code":"IE","type":"education","lineage":["https://openalex.org/I27577105"]},{"id":"https://openalex.org/I4210101467","display_name":"Infant","ror":"https://ror.org/00men8398","country_code":"IE","type":"facility","lineage":["https://openalex.org/I4210101467"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"AS Khashan","raw_affiliation_strings":["School of Public Health, University College Cork, Cork, Ireland","The Irish Centre for Fetal and Neonatal Translational Research (INFANT), Cork University Maternity Hospital and University College Cork, Cork, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, University College Cork, Cork, Ireland","institution_ids":["https://openalex.org/I27577105"]},{"raw_affiliation_string":"The Irish Centre for Fetal and Neonatal Translational Research (INFANT), Cork University Maternity Hospital and University College Cork, Cork, Ireland","institution_ids":["https://openalex.org/I27577105","https://openalex.org/I4210101467"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"A49.1","last_page":"A49"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10537","display_name":"Attention Deficit Hyperactivity Disorder","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10786","display_name":"Maternal Mental Health During Pregnancy and Postpartum","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypertensive-disorders-of-pregnancy","display_name":"hypertensive disorders of pregnancy","score":0.996999979019165},{"id":"https://openalex.org/keywords/attention-deficit-hyperactivity-disorder","display_name":"attention deficit hyperactivity disorder","score":0.9229999780654907},{"id":"https://openalex.org/keywords/preeclampsia","display_name":"preeclampsia","score":1.0},{"id":"https://openalex.org/keywords/chronic-hypertension-in-pregnancy","display_name":"chronic hypertension in pregnancy","score":0.9340000152587891},{"id":"https://openalex.org/keywords/small-for-gestational-age","display_name":"small for gestational age","score":0.9929999709129333},{"id":"https://openalex.org/keywords/uteroplacental-dysfunction","display_name":"uteroplacental dysfunction","score":0.9470000267028809},{"id":"https://openalex.org/keywords/neurodevelopmental-outcomes","display_name":"neurodevelopmental outcomes","score":0.8140000104904175},{"id":"https://openalex.org/keywords/adhd-medication","display_name":"ADHD medication","score":0.47200000286102295},{"id":"https://openalex.org/keywords/birth-cohort","display_name":"birth cohort","score":0.3490000069141388},{"id":"https://openalex.org/keywords/adhd-risk-factors","display_name":"ADHD risk factors","score":0.4129999876022339},{"id":"https://openalex.org/keywords/maternal-health-during-pregnancy","display_name":"maternal health during pregnancy","score":0.35499998927116394}],"concepts":[{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.694113552570343},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6907063722610474},{"id":"https://openalex.org/C2780783007","wikidata":"https://www.wikidata.org/wiki/Q181923","display_name":"Attention deficit hyperactivity disorder","level":2,"score":0.6032201051712036},{"id":"https://openalex.org/C2776194465","wikidata":"https://www.wikidata.org/wiki/Q31184","display_name":"Sibling","level":2,"score":0.5798235535621643},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.4534076750278473},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4440067410469055},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.43262654542922974},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.36111852526664734},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.17476707696914673},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1574448049068451},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.10325279831886292},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.09049871563911438},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07792136073112488},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1136/jech-2019-ssmabstracts.103","doi":"https://doi.org/10.1136/jech-2019-ssmabstracts.103","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jech-2019-ssmabstracts.103","pdf_url":"https://jech.bmj.com/content/jech/73/Suppl_1/A49.1.full.pdf","source":{"id":"https://openalex.org/S4306521614","display_name":"Oral Presentations","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oral Presentations","raw_type":"proceedings-article"}],"best_oa_location":{"id":"doi:10.1136/jech-2019-ssmabstracts.103","doi":"https://doi.org/10.1136/jech-2019-ssmabstracts.103","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jech-2019-ssmabstracts.103","pdf_url":"https://jech.bmj.com/content/jech/73/Suppl_1/A49.1.full.pdf","source":{"id":"https://openalex.org/S4306521614","display_name":"Oral Presentations","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oral Presentations","raw_type":"proceedings-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8100000023841858,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3022201611.pdf","grobid_xml":"https://content.openalex.org/works/W3022201611.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W6902099131","https://openalex.org/W2584451035","https://openalex.org/W2530133093","https://openalex.org/W3158913701","https://openalex.org/W3005830057","https://openalex.org/W2744176948","https://openalex.org/W3095972408","https://openalex.org/W2807447863","https://openalex.org/W3137217846","https://openalex.org/W4411205995"],"abstract_inverted_index":{"Background":[0],"Hypertensive":[1],"disorders":[2],"of":[3,21,48,73,112,120,147,153,171,177,184,203,259,266,283,300,392],"pregnancy":[4],"(HDP)":[5],"have":[6],"been":[7],"linked":[8],"to":[9,31,35,52,67,79,91,125,208,294,297,360,368],"adverse":[10],"neurodevelopmental":[11],"outcomes,":[12],"including":[13,76],"attention":[14],"deficit":[15],"hyperactivity":[16],"disorder":[17],"(ADHD).":[18],"However,":[19],"limitations":[20],"the":[22,46,54,96,104,144,151,161,189,251,269,281,301,329,339,354,390,395],"literature":[23],"such":[24],"as":[25,140],"residual":[26],"confounding,":[27],"and":[28,58,108,127,132,165,226,242,318,332],"confounding":[29,74,77,244],"due":[30,78],"shared":[32,80,240],"genetics":[33],"need":[34],"be":[36,43,385],"addressed":[37],"before":[38],"more":[39],"definitive":[40],"conclusions":[41],"can":[42],"reached.":[44],"Therefore,":[45],"objective":[47],"this":[49],"study":[50],"was":[51,158,173,186,200,220,248,274,322,347,370,377],"examine":[53],"association":[55,247,397],"between":[56],"HDP":[57,100],"ADHD,":[59,373],"using":[60,193],"large":[61],"Swedish-based":[62],"registry":[63],"data,":[64],"allowing":[65],"us":[66],"control":[68],"for":[69,134,143,223,239,316,344],"a":[70,141,182,230,277,386],"wide":[71],"range":[72],"factors":[75],"genetics.":[81],"Methods":[82],"All":[83],"singleton":[84],"live":[85],"births":[86],"in":[87,95,150,175,188,201,250,280,328,338,353],"Sweden":[88],"from":[89,103,160,232],"1990":[90],"2010":[92],"were":[93,101,122],"included":[94,109],"study.":[97],"Data":[98,155],"on":[99,156],"obtained":[102,159],"Medical":[105],"Birth":[106],"Register,":[107,192],"three":[110],"exposures":[111],"interest:":[113],"1.":[114,180],"Preeclampsia":[115,131],"2.":[116,196],"Chronic":[117],"hypertension":[118,376],"(both":[119],"which":[121],"classified":[123,206],"according":[124,207],"ICD-9":[126],"ICD-10":[128,194],"coding)":[129],"3.":[130],"small":[133],"gestational":[135],"age":[136],"(SGA)":[137],"combined,":[138],"used":[139],"proxy":[142],"recent":[145],"inclusion":[146],"uteroplacental":[148],"dysfunction":[149],"definition":[152],"preeclampsia.":[154,298],"ADHD":[157,172,185,204,284,393],"National":[162,190],"Patient":[163,191],"Register":[164],"Prescribed":[166],"Drug":[167],"Register.":[168],"A":[169],"diagnosis":[170,183],"determined":[174],"one":[176],"two":[178],"ways:":[179],"If":[181,197],"present":[187,249],"coding.":[195],"an":[198,246],"individual":[199],"receipt":[202],"medication,":[205],"Anatomical":[209],"Therapeutic":[210],"Chemical":[211],"classification":[212],"system.":[213],"Multivariate":[214],"Cox":[215,253,271,356],"proportional":[216],"hazards":[217],"regression":[218],"analysis":[219,236,303],"conducted,":[221],"adjusting":[222],"several":[224],"perinatal":[225],"sociodemographic":[227],"factors,":[228],"selected":[229],"priori":[231],"previous":[233],"literature.":[234],"Sibling-matched":[235],"further":[237],"controlled":[238],"genetic":[241],"familial":[243],"when":[245],"adjusted":[252,270,330,355],"model.":[254,357],"Results":[255],"The":[256,314,342],"cohort":[257],"consisted":[258],"2,047,619":[260],"children,":[261],"with":[262,276,372,380,398],"114,934":[263],"(5.6%)":[264],"cases":[265],"ADHD.":[267,381],"In":[268],"model,":[272,331],"preeclampsia":[273,317,361,401],"associated":[275,371,379],"15%":[278],"increase":[279],"likelihood":[282,391],"(Hazard":[285],"Ratio":[286],"(HR):":[287],"1.15,":[288],"95%":[289,310],"CI:":[290,311,325,335,350],"1.12,":[291],"1.19)":[292],"compared":[293],"those":[295,319],"unexposed":[296],"Result":[299],"sibling-matched":[302,340],"did":[304],"not":[305,378],"change":[306],"materially":[307],"(HR:":[308],"1.13,":[309],"1.05,":[312],"1.22).":[313],"HR":[315,343],"born":[320],"SGA":[321,365],"1.43":[323],"(95%":[324,334,349],"1.31,":[326],"1.55)":[327],"1.55":[333],"1.28,":[336],"1.88)":[337],"analysis.":[341],"chronic":[345,375],"hypertension-ADHD":[346],"1.07":[348],"0.97,":[351],"1.18)":[352],"Conclusion":[358],"Exposure":[359],"or":[362],"preeclampsia/SGA":[363,399],"(i.e.":[364],"baby":[366],"exposed":[367],"preeclampsia)":[369],"while":[374],"Placental":[382],"pathology":[383],"may":[384],"common":[387],"factor":[388],"increasing":[389],"given":[394],"stronger":[396],"than":[400],"alone.":[402]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2020-05-13T00:00:00"}
