{"id":"https://openalex.org/W3022013336","doi":null,"title":"Loss of PRRX1 induces epithelial-mesenchymal transition and cancer stem cell-like properties in A549 cells.","display_name":"Loss of PRRX1 induces epithelial-mesenchymal transition and cancer stem cell-like properties in A549 cells.","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W3022013336","mag":"3022013336","pmid":"https://pubmed.ncbi.nlm.nih.gov/28469771","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5411914"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5411914","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5411914","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5411914","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102426772","display_name":"Hongbin Zhu","orcid":"https://orcid.org/0009-0003-1606-2978","observed_orcids":["https://orcid.org/0009-0003-1606-2978"]},"institutions":[{"id":"https://openalex.org/I4210113277","display_name":"Chaohu Hospital of Anhui Medical University","ror":"https://ror.org/0234wv516","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210113277"]},{"id":"https://openalex.org/I4210136596","display_name":"First Affiliated Hospital of Anhui Medical University","ror":"https://ror.org/03t1yn780","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210136596"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongbin Zhu","raw_affiliation_strings":["Department of Respiratory Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui, China; Now Working at Chaohu Hospital of Anhui Medical UniversityChaohu 238000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui, China; Now Working at Chaohu Hospital of Anhui Medical UniversityChaohu 238000, China","institution_ids":["https://openalex.org/I4210113277","https://openalex.org/I4210136596"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101453391","display_name":"Gengyun Sun","orcid":"https://orcid.org/0000-0001-9886-6563","observed_orcids":["https://orcid.org/0000-0001-9886-6563","https://orcid.org/0009-0008-6115-1407"]},"institutions":[{"id":"https://openalex.org/I4210136596","display_name":"First Affiliated Hospital of Anhui Medical University","ror":"https://ror.org/03t1yn780","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210136596"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Gengyun Sun","raw_affiliation_strings":["Department of Respiratory Medicine, The First Affiliated Hospital of Anhui Medical UniversityHefei 230022, Anhui, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, The First Affiliated Hospital of Anhui Medical UniversityHefei 230022, Anhui, China","institution_ids":["https://openalex.org/I4210136596"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7854,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.74602847,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"9","issue":"4","first_page":"1641","last_page":"1650"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prrx1","display_name":"PRRX1","score":1.0},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9739999771118164},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.925000011920929},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.8799999952316284},{"id":"https://openalex.org/keywords/a549-cells","display_name":"A549 cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/n-cadherin","display_name":"N-cadherin","score":0.9629999995231628},{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":1.0},{"id":"https://openalex.org/keywords/vimentin","display_name":"vimentin","score":1.0},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.9169999957084656},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.949999988079071},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7799999713897705},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.7329999804496765}],"concepts":[{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.7939506769180298},{"id":"https://openalex.org/C81729549","wikidata":"https://www.wikidata.org/wiki/Q4649475","display_name":"A549 cell","level":3,"score":0.6226065754890442},{"id":"https://openalex.org/C147447768","wikidata":"https://www.wikidata.org/wiki/Q411624","display_name":"Vimentin","level":3,"score":0.6097740530967712},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.5831734538078308},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.5528136491775513},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5482677221298218},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5057177543640137},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5051310658454895},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.49511638283729553},{"id":"https://openalex.org/C121587040","wikidata":"https://www.wikidata.org/wiki/Q898769","display_name":"Homeobox","level":4,"score":0.4825376868247986},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4660414755344391},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4285411834716797},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4160548150539398},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.3716077506542206},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3534737527370453},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1726970374584198},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10360673069953918},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.09785810112953186},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09610739350318909},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.09579044580459595},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0648350715637207}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:5411914","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5411914","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},{"id":"pmid:28469771","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28469771","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of translational research","raw_type":"Journal Article"},{"id":"mag:3022013336","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28469771","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5411914","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5411914","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1777707460","https://openalex.org/W1970265228","https://openalex.org/W1985339653","https://openalex.org/W1989197013","https://openalex.org/W2014691022","https://openalex.org/W2019788071","https://openalex.org/W2043797012","https://openalex.org/W2053811187","https://openalex.org/W2057826382","https://openalex.org/W2059158933","https://openalex.org/W2070058781","https://openalex.org/W2071985567","https://openalex.org/W2073643307","https://openalex.org/W2073940524","https://openalex.org/W2085312694","https://openalex.org/W2097880716","https://openalex.org/W2102707911","https://openalex.org/W2106787323","https://openalex.org/W2113860186","https://openalex.org/W2117577488","https://openalex.org/W2137159332","https://openalex.org/W2142351815","https://openalex.org/W2151879335","https://openalex.org/W2152627545","https://openalex.org/W2164358503","https://openalex.org/W2172713850"],"related_works":["https://openalex.org/W3035885430","https://openalex.org/W2113860186","https://openalex.org/W3178998527","https://openalex.org/W2047515711","https://openalex.org/W1571530189","https://openalex.org/W2019788071","https://openalex.org/W2979128760","https://openalex.org/W3030532824","https://openalex.org/W4389694835","https://openalex.org/W3133214099"],"abstract_inverted_index":{"Epithelial-mesenchymal":[0],"transition":[1],"(EMT)":[2],"plays":[3,25],"crucial":[4],"role":[5],"in":[6,28,38,59,78,124],"tumor":[7,30],"metastasis":[8],"and":[9,62,76,89,106,120],"patient":[10],"prognosis.":[11],"Previous":[12],"studies":[13],"indicated":[14],"that":[15,51,116],"paired-related":[16],"homeobox":[17],"1":[18],"(PRRX1),":[19],"a":[20,63,92],"newly":[21],"identified":[22],"EMT":[23,68,72,119],"inducer,":[24],"opposing":[26],"roles":[27],"different":[29],"cell":[31,86,103],"types.":[32],"However,":[33],"the":[34,46,52,71,97,108],"function":[35],"of":[36,55,65,94,100,110],"PRRX1":[37,56,66,95,117],"lung":[39],"cancer":[40,101],"has":[41],"not":[42],"been":[43],"elucidated.":[44],"In":[45],"present":[47],"study,":[48],"we":[49],"observed":[50],"expression":[53,98],"level":[54],"was":[57],"high":[58],"A549":[60,79,125],"cells,":[61],"loss":[64,82,93],"induced":[67],"by":[69],"regulating":[70],"markers":[73,105],"N-cadherin,":[74],"E-cadherin":[75],"vimentin":[77],"cells.":[80,112,126],"This":[81],"also":[83],"distinctly":[84],"affected":[85],"morphology,":[87],"migration":[88],"invasion.":[90],"Moreover,":[91],"increased":[96],"levels":[99],"stem":[102],"(CSC)":[104],"promoted":[107],"proliferation":[109],"these":[111],"These":[113],"findings":[114],"demonstrated":[115],"inhibits":[118],"induces":[121],"CSC-like":[122],"properties":[123]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-05-13T00:00:00"}
